- Antidonor antibodies and transplantation: how to deal with them before and after transplantationDenis Glotz
Department of Nephrology and Kidney Transplantation, Hopital Saint Louis, Paris, France
Transplantation 79:S30-2. 2005..However, recent advances both in the ABO and human leukocyte antigen settings, detailed in this paper, have led to successful transplantations in the presence of antidonor antibodies, with preliminary evidence of accommodation...
- Intravenous immunoglobulins and transplantation for patients with anti-HLA antibodiesDenis Glotz
Department of Nephrology, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75015, Paris, France
Transpl Int 17:1-8. 2004....
- Endothelial cells as targets of allograft rejectionDenis Glotz
Department of Nephrology and Transplantation, Hopital Saint Louis, Paris, France
Transplantation 82:S19-21. 2006....
- Desensitization and subsequent kidney transplantation of patients using intravenous immunoglobulins (IVIg)Denis Glotz
Department of Nephrology, INSERM U 430, Hĵpital Européen Georges Pompidou, Paris, France
Am J Transplant 2:758-60. 2002..All other patients had uneventful courses, without any episodes of rejection, with a follow-up of more than 1 year. Thus, IVIg therapy allows safe and prompt kidney transplantation of immunized patients...
- Calcineurin inhibitor-free monotherapy in human leukocyte antigen–identical live donor renal transplantationMarion Venot
Nephrology and Transplantation Department, Saint Louis Hospital, Paris, France
Transplantation 91:330-3. 2011....
- [Renal biopsy practice: results of a French study and recommendations]Guillaume Bollée
UMR970, INSERM, Universite Paris Descartes, Paris, France
Nephrol Ther 8:168-76. 2012..Our working group, appointed by the scientific commission of the Société de néphrologie in France, aimed to depict the main aspects of the practice of RB in adults in France, before establishing some guidelines...
- Complement-binding anti-HLA antibodies and kidney-allograft survivalAlexandre Loupy
Paris Translational Research Center for Organ Transplantation, INSERM Unité 970, Department of Kidney Transplantation, Hopital Necker, Universite Paris Descartes, and Assistance Publique Hôpitaux de Paris AP HP, Paris, France
N Engl J Med 369:1215-26. 2013..We investigated whether the complement-binding capacity of anti-HLA antibodies plays a role in kidney-allograft failure...
- Pulsatile perfusion preservation for expanded-criteria donors kidneys: Impact on delayed graft function rateImad Abboud
Nephrology and Transplantation, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, Paris, France
Int J Artif Organs 34:513-8. 2011..We conducted a prospective controlled study aiming to evaluate the impact of pulsatile perfusion preservation (PPP) on DGF rate...
- Kidney graft dysfunction in simultaneous pancreas-kidney recipients after pancreas failure: analysis of early and late protocol biopsiesDenis Viglietti
Service de Nephrologie et Transplantation, Hopital Saint Louis, Paris, France
Clin Transplant 27:E249-55. 2013..Kidney graft survival in simultaneous pancreas-kidney (SPK) recipients is known to decrease after pancreas graft failure...
- Antibody-mediated vascular rejection of kidney allografts: a population-based studyCarmen Lefaucheur
Nephrology and Kidney Transplantation, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, INSERM U940, Paris, France
Lancet 381:313-9. 2013..We aimed to improve characterisation of different kidney-allograft rejection phenotypes, identify how each one is associated with anti-HLA antibodies, and investigate their distinct prognoses...
- Donor-specific antibodies accelerate arteriosclerosis after kidney transplantationGary S Hill
Laboratoire d Anatomie Pathologique, Hopital Europeen Georges Pompidou, APHP, Paris, France
J Am Soc Nephrol 22:975-83. 2011..In conclusion, these data support the hypothesis that donor-specific antibodies dramatically accelerate post-transplant progression of arteriosclerosis...
- Value of Donor-Specific Anti-HLA Antibody Monitoring and Characterization for Risk Stratification of Kidney Allograft LossDenis Viglietti
Departments of Nephrology and Kidney Transplantation and Paris Translational Research Center for Organ Transplantation, Institut National de la Sante et de la Recherche Medicale, UMR S970, Paris, France
J Am Soc Nephrol . 2016..33; 95% CI, 1.03 to 1.62; P<0.001 and 0.95; 95% CI, 0.62 to 1.28; P<0.001, respectively). Thus, pre- and post-transplant DSA monitoring and characterization may improve individual risk stratification for kidney allograft loss...
- Regulatory T cells in kidney allograft infiltrates correlate with initial inflammation and graft functionCécile Taflin
Institut National de la Santé et de la Recherche Médicale INSERM U940, Hopital Saint Louis, Paris, France
Transplantation 89:194-9. 2010..Several studies have shown in BL and SCR the presence of a Th1 immune response, qualitatively similar to but quantitatively reduced in comparison with infiltrates typical of acute cellular rejection (ACR)...
- IgG Donor-Specific Anti-Human HLA Antibody Subclasses and Kidney Allograft Antibody-Mediated InjuryCarmen Lefaucheur
Department of Nephrology and Kidney Transplantation, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, Paris, France Paris Translational Research Center for Organ Transplantation, National Institute of Health and Medical Research, Mixed Research Unit S970, Paris, France
J Am Soc Nephrol 27:293-304. 2016..These results suggest IgG iDSA subclasses identify distinct phenotypes of kidney allograft antibody-mediated injury. ..
- Determinants and Outcomes of Accelerated Arteriosclerosis: Major Impact of Circulating AntibodiesAlexandre Loupy
From the Paris Translational Research Center for Organ Transplantation and Cardiovascular Disease, INSERM, UMR S970, Paris, France A L, D Viglietti, O A, J P D V H, J P E, P B, D G, C Legendre, X J, C Lefaucheur Paris Descartes University, Sorbonne Paris Cité and Necker Hospital A L, J P D V H, C Legendre and Department of Transplantation, Saint Louis Hospital D Viglietti, D G, C Lefaucheur, Assistance Publique Hopitaux de Paris, Paris, France Methodology Unit EA 3181 CHRU de Besançon, Besancon, France D Vernerey Department of Pathology, Necker Hospital, Paris, France J P D V H and Department of Pathology P B and Department of Cardiology X J, Georges Pompidou European Hospital, Paris, France
Circ Res 117:470-82. 2015..The role of circulating antibodies in addition to traditional cardiovascular risk factors in the development of accelerated arteriosclerosis and their long-term clinical consequences have not been demonstrated...
- Kidney allograft fibrosis after transplantation from uncontrolled circulatory death donorsDenis Viglietti
1 Nephrology and Kidney Transplantation, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, Paris, France 2 Department of Pathology, Georges Pompidou European Hospital, Paris, France 3 Biostatistics Unit, Paris Cardiovascular Research Centre, L Université Paris Descartes, Paris, France 4 Surgical Intensive Care Unit, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, Paris, France 5 Department of Pathology, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, Paris, France 6 Department of Urology, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, Paris, France 7 Department of Kidney Transplantation, Necker Hospital, Assistance Publique Hopitaux de Paris, Paris, France Deceased
Transplantation 99:409-15. 2015..Existing data suggest that increased interstitial fibrosis may occur abnormally in renal transplants from donations after uncontrolled circulatory death (uDCD)...
- Early steroid withdrawal and optimization of mycophenolic acid exposure in kidney transplant recipients receiving mycophenolate mofetilYannick Le Meur
Department of Nephrology, University Hospital, Brest, France
Transplantation 92:1244-51. 2011..We assessed the feasibility and safety of early steroid withdrawal in low-risk patients receiving cyclosporine A (CsA) and the impact of optimization of mycophenolic acid exposure on steroid withdrawal success...
- Prospective assessment of renal histopathological lesions in patients with end-stage liver disease: effects on long-term renal function after liver transplantationYvon Calmus
Liver Transplant Unit, Hopital Saint Antoine, Assistance Publique Hôpitaux de Paris and Université Paris Descartes, Paris, France
J Hepatol 57:572-6. 2012..The goal of this study was to make a prospective evaluation of renal histological lesions in a group of unselected patients awaiting liver transplantation...
- Biopsy-confirmed de novo renal cell carcinoma (RCC) in renal grafts: a single-centre management experience in a 2396 recipient cohortGuillaume Ploussard
Service d Urologie, Département DUNE, IUH Université Paris Denis Diderot Hôpital Saint Louis, France
BJU Int 109:195-9. 2012..To study the natural history of renal cell carcinoma (RCC) development in renal grafts and their management...
- Study of the allogeneic response induced by endothelial cells expressing HLA class II after lentiviral transductionCécile Taflin
INSERM UMR S 940 Institut Universitaire d Hématologie, Paris, France
Methods Mol Biol 960:461-72. 2013....
- Preexisting donor-specific HLA antibodies predict outcome in kidney transplantationCarmen Lefaucheur
Département de Néphrologie et Transplantation Rénale, Hopital Saint Louis, Paris, France
J Am Soc Nephrol 21:1398-406. 2010..Quantification of HLA antibodies allows stratification of immunologic risk, which should help guide selection of acceptable grafts for sensitized patients...
- Molecular microscope strategy to improve risk stratification in early antibody-mediated kidney allograft rejectionAlexandre Loupy
Paris Descartes University and Hôpital Necker and Paris Translational Research Center for Organ Transplantation, Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche S970, Paris, France
J Am Soc Nephrol 25:2267-77. 2014..16; P<0.001). Compared with conventional assessment, the addition of gene expression measurement in kidney transplants with ABMR improves stratification of patients at high risk for graft loss. ..
- Human endothelial cells generate Th17 and regulatory T cells under inflammatory conditionsCécile Taflin
Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche Santé 940, Hopital Saint Louis, 75010 Paris, France
Proc Natl Acad Sci U S A 108:2891-6. 2011..Finally, these data open therapeutic perspectives in human organ transplantation based on targeting the IL-6/STAT-3 pathway and/or promoting CD54 dependent Treg proliferation...
- Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroidsDenis Glotz
Department of Nephrology, Saint Louis Hospital, Paris, France
Transplantation 89:1511-7. 2010....
- The Seville expert workshop for progress in posttransplant lymphoproliferative disordersDenis Glotz
Nephrology and Transplantation Service, Hopital Saint Louis, Paris, France
Transplantation 94:784-93. 2012..Finally, new classification criteria were outlined that may help facilitate standardized reporting and improve our understanding of PTLD...
- Renal histopathological lesions after orthotopic liver transplantation (OLT)Evangeline Pillebout
Hopital Saint Louis, Nephrology and Kidney Transplantation, Paris, France
Am J Transplant 5:1120-9. 2005..These investigations have therapeutic potential, that is, they may lead to a more aggressive treatment of hypertension and/or diabetes...
- A three-arm study comparing immediate tacrolimus therapy with antithymocyte globulin induction therapy followed by tacrolimus or cyclosporine A in adult renal transplant recipientsBernard Charpentier
Service de Nephrologie, Hopital de Bicetre, Le Kremlin Bicetre, France
Transplantation 75:844-51. 2003..A study was undertaken to assess the efficacy and safety of ATG induction on tacrolimus-based and cyclosporine A (CsA)-based therapies compared with immediate tacrolimus triple therapy in kidney transplant recipients...
- Chronic kidney dysfunction in patients alive without relapse 2 years after allogeneic hematopoietic stem cell transplantationImad Abboud
Department of Nephrology and Transplantation, St Louis Hospital, Paris, France
Biol Blood Marrow Transplant 15:1251-7. 2009..Renal impairement was correlated with TBI and cGVHD. Minor incidence of CKD and a relative stability of renal function were noted between 2 and 5 years after HSCT...
- Regulation of the CD4+ T cell allo-immune response by endothelial cellsCécile Taflin
Sorbonne Paris Cité, INSERM UMR940, Institut Universitaire d Hematologie, Universite Paris Diderot, 75010 Paris, France
Hum Immunol 73:1269-74. 2012..This review provides an update on the characteristics of the endothelial cell activation of the CD4(+) T cell response and an analysis of the factors, which can modify this activity in favor of either graft rejection or tolerance...
- What is the relevance of systematic aorto-femoral Doppler ultrasound in the preoperative assessment of patients awaiting first kidney transplantation: a monocentric prospective studyGuillaume Ploussard
Department of Urology and Paris 7 University, Saint Louis Hospital, Paris, France
Nephrol Dial Transplant 25:270-4. 2010..The purpose of our study was to study the relevance of a systematic aorto-femoral colour Doppler ultrasound (DUS) in the evaluation of first renal transplant receivers...
- Access to, and outcome of, renal transplantation according to treatment modality of end-stage renal disease in FranceYlana Chalem
Etablissement francais des greffes, Paris, France
Kidney Int 67:2448-53. 2005....
- A case report of adenovirus-related acute interstitial nephritis in a patient with AIDSElodie Mazoyer
Service de Nephrologie, Hopital Saint Louis, AP HP, Paris, France
Am J Kidney Dis 51:121-6. 2008..This case illustrates another cause of acute kidney disease in very immunosuppressed patients with AIDS, probably underdiagnosed...
- Evidence for an important role of both complement-binding and noncomplement-binding donor-specific antibodies in renal transplantationDenis Viglietti
aDepartment of Nephrology and Kidney Transplantation, Saint Louis Hospital, Assistance Publique Hôpitaux de Paris bParis Translational Research Center for Organ Transplantation, INSERM, UMR S970, Paris, France
Curr Opin Organ Transplant 21:433-40. 2016....
- Donor Specific Antibodies are not only directed against HLA-DR: Minding your Ps and QsAmy R Cross
INSERM UMRs 1160, Institut Universitaire d Hematologie, Universite Paris Diderot, Hopital Saint Louis, Paris 75010, France LabEx Transplantex, AP HP, Hopital Saint Louis, Paris 75010, France
Hum Immunol 77:1092-1100. 2016..We also consider existing data in hematopoietic stem cell transplantation concerning HLA directed DSA...
- Successful outcome using rituximab as the only immunomodulation in Henoch-Schonlein purpura: case reportEvangeline Pillebout
Department of Nephrology, CHU St Louis, Paris, France
Nephrol Dial Transplant 26:2044-6. 2011..Complete and sustained skin and renal remission resulted from the treatment. Thus, further studies are required to confirm the efficacy of rituximab as first-line treatment in HSP, and it might be an interesting new therapeutic option...
- Optimization of an elispot assay to detect cytomegalovirus-specific CD8+ T lymphocytesBrigitte Godard
Unité d Immunologie Biologique, Hopital Europeen Georges Pompidou, AP HP, Paris, France
Hum Immunol 65:1307-18. 2004..This highly sensitive test may be a useful tool to assess T-cell immunity directed against CMV in immunodepressed patients...
- Chronic interstitial nephritis in an HIV type-1-infected patient receiving ritonavir-boosted atazanavirDenis Viglietti
Néphrologie Transplantation, Hopital Saint Louis, Paris, France
Antivir Ther 16:119-21. 2011..Many reports have described atazanavir-associated urolithiasis, but this is the first case that describes chronic granulomatous nephropathy...
- Acute vascular humoral rejection in a sensitized cardiac graft recipient: diagnostic value of C4d immunofluorescenceJean Paul Duong Van Huyen
Department of Pathology, Unit of Cardiac Transplantation, Hopital Europeen Georges Pompidou, Paris, France
Hum Pathol 35:385-8. 2004..This case shows that C4d deposits represent a sensitive marker of acute humoral rejection in cardiac transplantation. Therefore, C4d immunofluorescence should be more frequently assessed in endomyocardial biopsies...
- Candida albicans arteritis transmitted by conservative liquid after renal transplantation: a report of four cases and review of the literatureHoa Mai
Nephrology Unit, Bicetre Hospital Le Kremlin Bicetre, Paris, France
Transplantation 82:1163-7. 2006..We report four cases of mycotic arteritis due to C. albicans after renal transplantation but which have been inoculated during organ harvesting or conservation...
- Renal biopsy practice in France: results of a nationwide studyGuillaume Bollée
Paris Descartes University, APHP, Department of Nephrology and Transplantation, Necker Enfants Malades Hospital, Paris, France
Nephrol Dial Transplant 25:3579-85. 2010..Practices vary widely among nephrologists, depending on personal experience and the availability of particular techniques. The purpose of our study was to depict the main aspects of the practice of RB in adults in France...
- Dual Invasive Infection with Phaeoacremonium parasiticum and Paraconiothyrium cyclothyrioides in a Renal Transplant Recipient: Case Report and Comprehensive Review of the Literature of Phaeoacremonium PhaeohyphomycosisMarie Alice Colombier
Service de Maladies Infectieuses et Tropicales, Hôpital Saint Louis APHP, Paris, France
J Clin Microbiol 53:2084-94. 2015..The death rate was 19% (n = 8). Management of Phaeoacremonium infections is complex because of slow laboratory identification and limited clinical data, and treatment relies on a combination of surgery and systemic antifungal therapy. ..
- New insights in antibody-mediated rejectionClément Gosset
aNephrology and Kidney Transplantation bINSERM U 1160 cLabEx TRANSPLANTEX, Saint Louis Hospital, Assistance Publique Hopitaux de Paris, Paris, France dUniversité Paris Diderot 7, Paris, France
Curr Opin Nephrol Hypertens 23:597-604. 2014....
- Oxidative stress mediates a reduced expression of the activating receptor NKG2D in NK cells from end-stage renal disease patientsMarie Noelle Peraldi
Institut National de la Sante et de la Recherche Medicale, U662, Paris, France
J Immunol 182:1696-705. 2009..Taken together, these studies suggest for the first time that both low NKG2D expression and up-regulation of its ligand MICA are related to ROS production and may be involved in the immune deficiency of ESRD patients...
- Detection and quantitation of BK virus DNA by real-time polymerase chain reaction in the LT-ag gene in adult renal transplant recipientsAli Si-Mohamed
Laboratoire de Microbiologie, Unité de virologie, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75908 Paris Cedex 15, France
J Virol Methods 131:21-7. 2006....
- Are peroxisome proliferator-activated receptors new therapeutic targets in diabetic and non-diabetic nephropathies?Henri Boulanger
Department of Nephrology and Transplantation, Saint Louis Hospital, 1 avenue Claude Vellefaux, 75475 Paris Cedex 10, France
Nephrol Dial Transplant 21:2696-702. 2006
- Outcome of relapse in lupus nephritis: roles of reversal of renal fibrosis and response of inflammation to therapyGary S Hill
Hôpital Broussais and INSERM Unité 430, Hopital St Louis, and Hôpital Bichat, Paris, France
Kidney Int 61:2176-86. 2002..However, not all patients do so. This report explores the roles of response of inflammation to therapy and of glomerular scarring and interstitial fibrosis and their potential reversal to outcome of renal relapse...
- Early epithelial phenotypic changes predict graft fibrosisAlexandre Hertig
Urgences Néphrologiques and Transplantation Rénale, Hopital Tenon, 4 rue de la Chine, 75020 Paris, France
J Am Soc Nephrol 19:1584-91. 2008..In conclusion, early phenotypic changes indicative of epithelial-to-mesenchymal transition predict the progression toward interstitial fibrosis in human renal allografts...
- Therapeutic failure of cinacalcet in a renal transplant patient presenting hyperparathyroidism with severe hypercalcaemiaHenri Boulanger
Nephrol Dial Transplant 20:2865. 2005
- Antibody-mediated rejection criteria - an addition to the Banff 97 classification of renal allograft rejectionLorraine C Racusen
The Johns Hopkins University School of Medicine, Baltimore, MD, USA
Am J Transplant 3:708-14. 2003..This classification represents a working formulation, to be revisited as additional data accumulate in this important area of renal transplantation...