Pascale Gaussem

Summary

Country: France

Publications

  1. doi request reprint Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study
    Pascale Gaussem
    Universite Paris Descartes, Paris, France
    Thromb Haemost 105:560-7. 2011
  2. ncbi request reprint The specific thromboxane receptor antagonist S18886: pharmacokinetic and pharmacodynamic studies
    P Gaussem
    Service d Hematologie Biologique, Hôpital Européen Georges Pompidou AP HP, Paris, France
    J Thromb Haemost 3:1437-45. 2005
  3. ncbi request reprint [Acquired mutation of JAK2 tyrosine kinase and polycythaemia vera]
    V Pargade
    Service d Hematologie Biologique, Hopital Europeen Georges Pompidou, Paris
    Ann Biol Clin (Paris) 64:3-9. 2006
  4. ncbi request reprint Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    Jean Sebastien Hulot
    INSERM U 765, Service d Hématologie Biologique A, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75908 Paris Cedex 15, France
    Blood 108:2244-7. 2006
  5. ncbi request reprint [Assessment of platelet function in man]
    Pascale Gaussem
    INSERM U 765, Faculte de Pharmacie, Université Paris 5 et AP HP, Service d Hematologie Biologique, Hopital Europeen Georges Pompidou, Paris, France
    Therapie 61:395-400. 2006
  6. doi request reprint The Wnt antagonist Dickkopf-1 increases endothelial progenitor cell angiogenic potential
    David M Smadja
    Universite Paris Descartes, Paris, France
    Arterioscler Thromb Vasc Biol 30:2544-52. 2010
  7. doi request reprint Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells
    David M Smadja
    Universite Paris Descartes, Faculte de Pharmacie, Paris, France
    J Cell Mol Med 13:2534-46. 2009
  8. ncbi request reprint Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers
    Pierre Fontana
    INSERM Unité 765, Hôpital Européen Georges Pompidou AP HP, Paris, France
    Thromb Haemost 96:356-60. 2006
  9. doi request reprint Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic properties
    David M Smadja
    Universite Paris Descartes, Paris, France
    Arterioscler Thromb Vasc Biol 31:551-9. 2011
  10. doi request reprint The effectiveness of platelet supplementation for the reversal of ticagrelor-induced inhibition of platelet aggregation: An in-vitro study
    Anne Céline Martin
    From the Inserm UMR S1140, Faculté de Pharmacie A CM, CB, LC, Bd, PG, IG T, C MS, CB L, AG, Universite Paris Descartes, Sorbonne Paris Cité A CM, CB, LC, Bd, PG, IG T, C MS, CB L, AG, Hopital Val de Grace, Service de Cardiologie A CM, AP HP, Hopital Cochin, Laboratoire d hématologie LC, IG T, Institut Mutualiste Montsouris, Service d Anesthésie Réanimation IP, AP HP, Hopital Europeen Georges Pompidou, Service d Hématologie Biologique PG, AP HP, Hopital Cochin, Service d Anesthésie Réanimation C MS, Kansas City
    Eur J Anaesthesiol 33:361-7. 2016

Detail Information

Publications52

  1. doi request reprint Haemostatic effects of a new combined oral contraceptive, nomegestrol acetate/17β-estradiol, compared with those of levonorgestrel/ethinyl estradiol. A double-blind, randomised study
    Pascale Gaussem
    Universite Paris Descartes, Paris, France
    Thromb Haemost 105:560-7. 2011
    ..This suggests that NOMAC/E2 could have a more favourable venous thromboembolism risk profile than LNG/EE; further epidemiological data are required to confirm this...
  2. ncbi request reprint The specific thromboxane receptor antagonist S18886: pharmacokinetic and pharmacodynamic studies
    P Gaussem
    Service d Hematologie Biologique, Hôpital Européen Georges Pompidou AP HP, Paris, France
    J Thromb Haemost 3:1437-45. 2005
    ..5, 5, 10 or 30 mg) for 12 weeks (83 days). Primary objective was to determine the effect of S18886 on platelet aggregation ex vivo...
  3. ncbi request reprint [Acquired mutation of JAK2 tyrosine kinase and polycythaemia vera]
    V Pargade
    Service d Hematologie Biologique, Hopital Europeen Georges Pompidou, Paris
    Ann Biol Clin (Paris) 64:3-9. 2006
    ....
  4. ncbi request reprint Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    Jean Sebastien Hulot
    INSERM U 765, Service d Hématologie Biologique A, Hopital Europeen Georges Pompidou, 20 rue Leblanc, 75908 Paris Cedex 15, France
    Blood 108:2244-7. 2006
    ....
  5. ncbi request reprint [Assessment of platelet function in man]
    Pascale Gaussem
    INSERM U 765, Faculte de Pharmacie, Université Paris 5 et AP HP, Service d Hematologie Biologique, Hopital Europeen Georges Pompidou, Paris, France
    Therapie 61:395-400. 2006
    ..It also allows the measure of the function of the ADP receptor P2Y12 by the phosphorylation level of the VASP protein, method currently under evaluation to monitor the platelet response to clopidogrel treatment...
  6. doi request reprint The Wnt antagonist Dickkopf-1 increases endothelial progenitor cell angiogenic potential
    David M Smadja
    Universite Paris Descartes, Paris, France
    Arterioscler Thromb Vasc Biol 30:2544-52. 2010
    ..To determine the role of Wnt antagonist Dickkopf (DKK) 1 in human endothelial colony-forming cells (ECFCs) in view of the emerging importance of Wnt pathways in vascular biology...
  7. doi request reprint Interleukin 8 is differently expressed and modulated by PAR-1 activation in early and late endothelial progenitor cells
    David M Smadja
    Universite Paris Descartes, Faculte de Pharmacie, Paris, France
    J Cell Mol Med 13:2534-46. 2009
    ..In conclusion, PAR-1 activation induces IL-8 synthesis by late EPC. This could potentially enhance cooperation between late and early EPC during neovascularization, through a paracrine effect...
  8. ncbi request reprint Identification of functional polymorphisms of the thromboxane A2 receptor gene in healthy volunteers
    Pierre Fontana
    INSERM Unité 765, Hôpital Européen Georges Pompidou AP HP, Paris, France
    Thromb Haemost 96:356-60. 2006
    ..As C795T and C924T have been linked to clinical disorders in which TxA2 plays a key role, the possible role of the G1686A and T1712C SNP should also be examined in selected diseases...
  9. doi request reprint Thrombospondin-1 is a plasmatic marker of peripheral arterial disease that modulates endothelial progenitor cell angiogenic properties
    David M Smadja
    Universite Paris Descartes, Paris, France
    Arterioscler Thromb Vasc Biol 31:551-9. 2011
    ..We examined whether plasma levels of angiogenic factors are altered in plasma of patients with peripheral arterial disease (PAD) and whether these factors affect endothelial progenitor cell-induced angiogenesis...
  10. doi request reprint The effectiveness of platelet supplementation for the reversal of ticagrelor-induced inhibition of platelet aggregation: An in-vitro study
    Anne Céline Martin
    From the Inserm UMR S1140, Faculté de Pharmacie A CM, CB, LC, Bd, PG, IG T, C MS, CB L, AG, Universite Paris Descartes, Sorbonne Paris Cité A CM, CB, LC, Bd, PG, IG T, C MS, CB L, AG, Hopital Val de Grace, Service de Cardiologie A CM, AP HP, Hopital Cochin, Laboratoire d hématologie LC, IG T, Institut Mutualiste Montsouris, Service d Anesthésie Réanimation IP, AP HP, Hopital Europeen Georges Pompidou, Service d Hématologie Biologique PG, AP HP, Hopital Cochin, Service d Anesthésie Réanimation C MS, Kansas City
    Eur J Anaesthesiol 33:361-7. 2016
    ..Management of ticagrelor-induced bleeding is challenging, as no antidote is currently available. Platelet transfusion, usually proposed to reverse antiplatelet drugs, has been suggested to be ineffective but few data are available...
  11. doi request reprint Bone morphogenetic proteins 2 and 4 are selectively expressed by late outgrowth endothelial progenitor cells and promote neoangiogenesis
    David M Smadja
    Universite Paris Descartes, Faculte de Pharmacie, INSERM UMRS 765, 4 avenue de l Observatoire, F 75006 Paris, France
    Arterioscler Thromb Vasc Biol 28:2137-43. 2008
    ..Given the potential usefulness of CFU-Hill and ECFCs as cell therapy products, their thorough characterization is of major importance...
  12. doi request reprint Early endothelial progenitor cells in bone marrow are a biomarker of cell therapy success in patients with critical limb ischemia
    David M Smadja
    Universite Paris Descartes, Paris, France Sorbonne Paris Cite, France
    Cytotherapy 14:232-9. 2012
    ....
  13. doi request reprint Effect of clopidogrel on circulating biomarkers of angiogenesis and endothelial activation
    David M Smadja
    Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    J Cardiol 59:30-5. 2012
    ..These results show that circulating angiogenic factor level in healthy subjects is not driven by P2Y12 platelet receptor-induced activation and clopidogrel does not modify in a significant way the endothelial activation level...
  14. doi request reprint Comparison of endothelial biomarkers according to reversibility of pulmonary hypertension secondary to congenital heart disease
    David M Smadja
    Universite Paris Descartes, Paris, France
    Pediatr Cardiol 31:657-62. 2010
    ....
  15. pmc Circulating endothelial cells in refractory pulmonary hypertension in children: markers of treatment efficacy and clinical worsening
    Marilyne Levy
    Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    PLoS ONE 8:e65114. 2013
    ..We now hypothesized that an efficient PAH-specific vasodilator therapy might decrease CEC level...
  16. ncbi request reprint Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects
    Pierre Fontana
    Service d Hématologie Biologique A, Hôpital Européen Georges Pompidou and Inserm Unité 428, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris V, Paris, France
    Circulation 108:989-95. 2003
    ..Some studies have shown interindividual differences in ADP-induced platelet aggregation responses ex vivo, but the mechanisms underlying this variability are unknown...
  17. pmc Increased VEGFR2 expression during human late endothelial progenitor cells expansion enhances in vitro angiogenesis with up-regulation of integrin alpha(6)
    David M Smadja
    AP HP, Service d Hématologie Biologique A, Hopital Europeen Georges Pompidou, Paris, France
    J Cell Mol Med 11:1149-61. 2007
    ..In vitro expansion of late EPCs increases the expression of VEGFR2, the main VEGF receptor, with possible implications for EPC-based angiogenic therapy...
  18. doi request reprint Effects of rabeprazole on the antiplatelet effects and pharmacokinetics of clopidogrel in healthy volunteers
    Christian Funck-Brentano
    INSERM, CIC 9304 and UMRS 956, Paris, France AP HP, Pitie Salpetriere Hospital, Department of Pharmacology and CIC 9304, Paris, France UPMC Univ Paris 06, Faculty of Medicine, Department of Pharmacology and UMRS 956, Paris, France Electronic address
    Arch Cardiovasc Dis 106:661-71. 2013
    ..Whether this occurs with all PPIs is a matter of debate. As rabeprazole is a less potent CYP2C19 inhibitor than other PPIs, we studied the interaction between rabeprazole and the antiplatelet actions and pharmacokinetics of clopidogrel...
  19. doi request reprint Bone marrow-derived mononuclear cell therapy induces distal angiogenesis after local injection in critical leg ischemia
    Jean Paul Duong Van Huyen
    University Paris Descartes, Paris, France
    Mod Pathol 21:837-46. 2008
    ....
  20. pmc Thrombin bound to a fibrin clot confers angiogenic and haemostatic properties on endothelial progenitor cells
    David M Smadja
    AP HP, Hopital Europeen Georges Pompidou, Service d Hématologie Biologique A, Paris, France
    J Cell Mol Med 12:975-86. 2008
    ..Overall, our data show that EPCs, in addition to their angiogenic potential, have both anticoagulant and antifibrinolytic properties. Thrombin may modulate these properties and contribute to thrombus recanalization by EPCs...
  21. doi request reprint Evaluation of recombinant activated factor VII, prothrombin complex concentrate, and fibrinogen concentrate to reverse apixaban in a rabbit model of bleeding and thrombosis
    Anne Céline Martin
    INSERM UMR S765, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France Department of Cardiology, Hopital du Val de Grace, Paris, France
    Int J Cardiol 168:4228-33. 2013
    ..Objectives were to study efficacy and safety of recombinant activated factor VII (rFVIIa), prothrombin complex concentrate (PCC), and fibrinogen concentrate (Fib) to reverse apixaban in a rabbit model of bleeding and thrombosis...
  22. ncbi request reprint P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study
    Pierre Fontana
    INSERM U 428, Hôpital Européen Georges Pompidou et Université Paris V, Paris, France
    Circulation 108:2971-3. 2003
    ..Because platelets play a key role in atherosclerosis and arterial thrombosis, we tested the possible link between the H2 haplotype and the risk of peripheral arterial disease (PAD) in a case-control study...
  23. doi request reprint Imbalance of circulating endothelial cells and progenitors in idiopathic pulmonary fibrosis
    David M Smadja
    Hematology Department, European Georges Pompidou Hospital, Universite Paris Descartes, France
    Angiogenesis 16:147-57. 2013
    ..Respective abundance of circulating endothelial cells (CEC) and endothelial progenitor cells (EPC) might reflect the balance between vascular injury and repair and potentially serve as biomarkers of the disease...
  24. doi request reprint [Characterization of endothelial progenitor cells and putative strategies to improve their expansion]
    David M Smadja
    Université Paris Descartes Inserm Unité 765, Faculté de Pharmacie AP HP, Hopital Europeen Georges Pompidou, Service d Hematologie Biologique, 75000 Paris, France
    J Soc Biol 203:197-207. 2009
    ..Indeed, PAR-1 activation increases angiogenic properties of EPC through activation of SDF-1, angiopoietin and IL-8 pathways. This review summarizes the characterization of EPC and different methods of ex vivo expansion...
  25. pmc Treprostinil increases the number and angiogenic potential of endothelial progenitor cells in children with pulmonary hypertension
    David M Smadja
    Universite Paris Descartes, Paris, France
    Angiogenesis 14:17-27. 2011
    ..In the present study, objectives were to determine whether EPC may contribute to vasodilator treatment efficacy in PAH...
  26. doi request reprint Forearm ischemia decreases endothelial colony-forming cell angiogenic potential
    Laetitia Mauge
    Universite Paris Descartes, Sorbonne Paris Cité, Paris, France Inserm UMR_S765, Faculte de Pharmacie, Paris, France AP HP, Hopital Europeen Georges Pompidou, Service d Hematologie Biologique, Paris, France
    Cytotherapy 16:213-24. 2014
    ....
  27. ncbi request reprint The TF-603A/G gene promoter polymorphism and circulating monocyte tissue factor gene expression in healthy volunteers
    Jean Luc Reny
    Service d Hématologie Biologique A, Hôpital Européen Georges Pompidou INSERM Unité 428, Paris, France
    Thromb Haemost 91:248-54. 2004
    ..The TF-603A/G gene promoter polymorphism thus significantly influences constitutive TF gene expression in human monocytes but has no major effect on TF gene expression or on WBCT in LPS stimulated conditions...
  28. ncbi request reprint An intronic polymorphism in the PAR-1 gene is associated with platelet receptor density and the response to SFLLRN
    Annabelle Dupont
    Service d Hématologie Biologique and INSERM Unité 428, Hopital Europeen Georges Pompidou, Faculte des Sciences Pharmaceutiques et Biologiques, Universite Paris V, Paris, France
    Blood 101:1833-40. 2003
    ..The IVSn-14 A/T intronic variation may therefore be clinically relevant...
  29. doi request reprint Thrombin receptor PAR-1 activation on endothelial progenitor cells enhances chemotaxis-associated genes expression and leukocyte recruitment by a COX-2-dependent mechanism
    Clément d'Audigier
    Sorbonne Paris Cité, Universite Paris Descartes, Paris, France
    Angiogenesis 18:347-59. 2015
    ..However, little is known about ECFC proinflammatory potential...
  30. ncbi request reprint PAR-1 activation on human late endothelial progenitor cells enhances angiogenesis in vitro with upregulation of the SDF-1/CXCR4 system
    David M Smadja
    INSERM Unite 428, Hôpital Européen Georges Pompidou AP HP, Universite Paris V, Paris, France
    Arterioscler Thromb Vasc Biol 25:2321-7. 2005
    ..As endothelial progenitor cells (EPCs) are involved in postnatal vasculogenesis, we examined whether they express PAR-1 and whether stimulation by the peptide SFLLRN modulates their angiogenic properties...
  31. doi request reprint MRP4 (ABCC4) as a potential pharmacologic target for cardiovascular disease
    Tiphaine Belleville-Rolland
    Inserm UMR S1140, Faculte de Pharmacie, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France AP HP, Hopital Europeen Georges Pompidou, Service d Hematologie Biologique, Paris, France
    Pharmacol Res 107:381-9. 2016
    ..In this review, we discuss the therapeutic potential of direct pharmacological inhibition of MRP4 in atherothrombotic disease, via its vasodilating and antiplatelet effects. ..
  32. doi request reprint Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells
    David M Smadja
    Prof David Smadja, Georges Pompidou European Hospital, Hematology Department, 20 rue Leblanc, 75015 Paris, France, Tel 31 56093933, Fax 31 56093393, E mail
    Thromb Haemost 114:735-47. 2015
    ..Moreover, our results suggest that VEGF-A level in patients could be a surrogate biomarker of treprostinil efficacy. ..
  33. pmc Influence of genetic variations on levels of inflammatory markers of healthy subjects at baseline and one week after clopidogrel therapy; results of a preliminary study
    Payman Shahabi
    UMR INSERM U 1122, IGE PCV, Faculte de Pharmacie, Université de Lorraine, 30 rue Lionnois, Nancy 54000, France
    Int J Mol Sci 14:16402-13. 2013
    ..Moreover, our results did not support the hypothesis that CYP2C19 2 polymorphism is associated with the variability in response to the anti-inflammatory properties of clopidogrel...
  34. doi request reprint Recombinant activated factor VII does not reduce bleeding in rabbits treated with aspirin and clopidogrel
    Clemence Hindy-François
    INSERM UMRS 765, Pharmaceutical Sciences University, Paris, France
    Thromb Haemost 104:823-30. 2010
    ..These effects were unaffected by either rFVIIa dose. rFVIIa accelerated thrombin generation but had no effect on platelet aggregation in citrated platelet-rich plasma. rFVIIa did not modify HS blood loss associated with cAPA in rabbits...
  35. doi request reprint Circulating endothelial cells: a new candidate biomarker of irreversible pulmonary hypertension secondary to congenital heart disease
    David M Smadja
    Paris Descartes University, Faculty of Pharmacy, INSERM U765, Paris, France
    Circulation 119:374-81. 2009
    ..The objective of the present study was to identify noninvasive biomarkers of endothelial turnover that could be used to identify congenital heart disease patients at risk of irreversible PAH...
  36. ncbi request reprint Development of a novel immunoassay for the assessment of plasma Gas6 concentrations and their variation with hormonal status
    Sylvain Clauser
    Assistance Publique Hopitaux de Paris, Hopital Europeen Georges Pompidou, Service d Hématologie Biologique A, Paris, France
    Clin Chem 53:1808-13. 2007
    ..We report the development and validation of an ELISA for Gas6, and the variation of plasma Gas6 with hormonal status in a study designed to evaluate the effect of oral contraception on plasma markers...
  37. doi request reprint Association rate constants rationalise the pharmacodynamics of apixaban and rivaroxaban
    Georges Jourdi
    Bernard Le Bonniec, PhD, UMR_S1140, Faculte de Pharmacie, 4 avenue de l Observatoire, 75006 Paris, France, Tel 33 1 53 73 98 28, Fax 33 1 44 07 17 72, E mail
    Thromb Haemost 114:78-86. 2015
    ..Analogous differences in TGA and PT were obtained irrespective of the drug amount added. We concluded that kon values for FXa of apixaban and rivaroxaban rationalise the unexpected lower sensitivity of PT and TGA to the former. ..
  38. doi request reprint Distinct patterns of circulating endothelial cells in pulmonary hypertension
    D M Smadja
    Université Paris Descartes Paris, France
    Eur Respir J 36:1284-93. 2010
    ....
  39. doi request reprint Arterial and venous thrombosis is associated with different angiogenic cytokine patterns in patients with antiphospholipid syndrome
    Dm Smadja
    Universite Paris Descartes, Faculte de Pharmacie, Paris, France
    Lupus 19:837-43. 2010
    ..Together, these results suggest that APS is associated with an angiogenic process, but that the angiogenic signal differs between patients with arterial and venous thrombosis. Lupus (2010) 19, 837-843...
  40. doi request reprint Thromboxane Antagonism with terutroban in Peripheral Arterial Disease: the TAIPAD study
    J N Fiessinger
    centre d investigation clinique, Hopital Europeen Georges Pompidou, Université Descartes, Paris, France
    J Thromb Haemost 8:2369-76. 2010
    ..Terutroban is a selective prostaglandin endoperoxide (TP) receptor antagonist with antithrombotic, antivasoconstrictive and antiatherosclerotic properties and is currently in development for long-term cardiovascular secondary prevention...
  41. doi request reprint Bone-marrow-derived very small embryonic-like stem cells in patients with critical leg ischaemia: evidence of vasculogenic potential
    Coralie L Guerin
    Prof David Smadja, European Georges Pompidou Hospital, Hematology Department, 20 rue Leblanc, 75015 Paris, France, Tel 31 56093933, Fax 31 56093393, E mail
    Thromb Haemost 113:1084-94. 2015
    ..In conclusion, VSELs are a potential new source of therapeutic cells that may give rise to cells of the endothelial lineage in humans...
  42. pmc Cooperation between human fibrocytes and endothelial colony-forming cells increases angiogenesis via the CXCR4 pathway
    David M Smadja
    Prof David Smadja, Paris Descartes University, INSERM UMR S 1140, Hematology Department, European Georges Pompidou Hospital, 20 rue Leblanc, 75015 Paris, France, Tel 33 1 56093933, Fax 33 1 56093393, E mail
    Thromb Haemost 112:1002-13. 2014
    ..In conclusion, circulating fibrocytes might contribute to the intense remodelling of the pulmonary vasculature in patients with idiopathic pulmonary fibrosis. ..
  43. pmc Impact of aspirin and clopidogrel interruption on platelet function in patients undergoing major vascular surgery
    Yannick Le Manach
    Departments of Anesthesia and Clinical Epidemiology and Biostatistics, Michael deGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada Population Health Research Institute, David Braley Cardiac, Vascular and Stroke Research Institute, Perioperative Medicine and Surgical Research Unit, Hamilton, Ontario, Canada AP HP, Hopital Pitie Salpetriere, Department of Anesthesiology and Critical Care, Paris, France
    PLoS ONE 9:e104491. 2014
    ..To investigate functional platelet recovery after preoperative withdrawal of aspirin and clopidogrel and platelet function 5 days after treatment resumption...
  44. doi request reprint [Thrombopathy induced by selective serotonin reuptake inhibitors: a case report]
    Mehdi Ben Said
    AP HP, Service d Hematologie Biologique, Hopital Europeen Georges Pompidou, Paris, France
    Ann Biol Clin (Paris) 72:607-11. 2014
    ....
  45. doi request reprint Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome)
    David Genevieve
    Département de génétique, Unité INSERM U781, Universite Paris Descartes, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, 149, rue de Sevres, 75015 Paris, France
    Nat Genet 40:284-6. 2008
    ..We also found that TXAS and TXA(2) modulated expression of TNFSF11 and TNFRSF11B (encoding RANKL and osteoprotegerin (OPG), respectively) in primary cultured osteoblasts...
  46. pmc Impaired platelet activation and cAMP homeostasis in MRP4-deficient mice
    Benoit Decouture
    INSERM Unité Mixte de Recherche S1140, Faculte de Pharmacie, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, France
    Blood 126:1823-30. 2015
    ..These data suggest that MRP4 promotes platelet aggregation by modulating the cAMP-protein kinase A signaling pathway, suggesting that MRP4 might serve as a target for novel antiplatelet agents. ..
  47. doi request reprint Targeting VEGFR1 on endothelial progenitors modulates their differentiation potential
    Clément d'Audigier
    Sorbonne Paris Cité, Universite Paris Descartes, Paris, France
    Angiogenesis 17:603-16. 2014
    ....
  48. doi request reprint Biphasic myosin II light chain activation during clot retraction
    Marion Egot
    Dr Christilla Bachelot Loza, INSERM UMR_S U765, Universite Paris Descartes, Faculte de Pharmacie, 4 avenue de l Observatoire, 75006 Paris, France, Tel 33 153739619, E mail
    Thromb Haemost 110:1215-22. 2013
    ..Only Rac-1 and actin polymerisation, controlled by outside-in signalling, were crucial to the second MLC phosphorylation peak. ..
  49. ncbi request reprint Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy
    Simon M G Smith
    Cardiovascular Research Unit, University of Sheffield, Division of Clinical Sciences North, Northern General Hospital, Sheffield, UK
    Platelets 17:250-8. 2006
    ..In conclusion, common sequence variations within the P2Y12 and CYP3A5 genes do not contribute any major effect to the inter-patient variability in clopidogrel efficacy...
  50. doi request reprint No clear link between VKORC1 genetic polymorphism and the risk of venous thrombosis or peripheral arterial disease
    David M Smadja
    Thromb Haemost 99:970-2. 2008
  51. ncbi request reprint Physiological plasma Gas6 levels do not influence platelet aggregation
    Sylvain Clauser
    Arterioscler Thromb Vasc Biol 26:e22. 2006
  52. ncbi request reprint A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosis
    Beatrice Saposnik
    INSERM U 428, 4 avenue de l Observatoire, 75006 Paris, France
    Blood 103:1311-8. 2004
    ..8; P =.004). Thus, the A3 haplotype, which is associated with elevated plasma sEPCR levels, is a candidate risk factor for venous thrombosis...