- Multicenter randomized trial of chewing gum for preventing oral mucositis in children receiving chemotherapyVirginie Gandemer
Department of Paediatrics, Teaching Hospitals 35203 Rennes Cedex, France
J Pediatr Hematol Oncol 29:86-94. 2007..72%, P=0.03). In the multivariate analysis, the risk of oral mucositis was related only to the type of chemotherapy regimen, suggesting that further strategies for preventing oral mucositis could be mainly based on these criteria...
- Impact of age, leukocyte count and day 21-bone marrow response to chemotherapy on the long-term outcome of children with philadelphia chromosome-positive acute lymphoblastic leukemia in the pre-imatinib era: results of the FRALLE 93 studyVirginie Gandemer
Department of Pediatric Hematology, University Hospital of Rennes, Rennes, France
BMC Cancer 9:14. 2009..Here we report the long-term results of the FRALLE 93 study conducted in the era before the use of tyrosine kinase inhibitors...
- Excellent prognosis of late relapses of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia: lessons from the FRALLE 93 protocolVirginie Gandemer
Department of Pediatric Hematology Oncology, University Hospital of Rennes, France
Haematologica 97:1743-50. 2012..We performed a long-term, follow-up retrospective study to address the outcome of patients with ETV6/RUNX1-positive leukemia relapses...
- Five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemiaVirginie Gandemer
CNRS UMR 6061 Laboratoire de Génétique et Développement, Equipe Régulation Transcriptionnelle et Oncogenèse, Universite de Rennes 1, Faculte de Medecine, IFR140 GFAS, 2 Av du Pr Leon Bernard, CS 34317, Rennes Cedex, France
BMC Genomics 8:385. 2007..We report an analysis of gene expression in 60 children with B-lineage ALL using Agilent whole genome oligo-chips (44K-G4112A) and/or real time RT-PCR...
- Influence of previous antimicrobial therapy on oral carriage of beta-lactamase producing Capnocytophaga isolatesAnne Jolivet-Gougeon
Equipe de Microbiologie, UPRES EA 1254, Universite de Rennes, Rennes, France
Acta Paediatr 97:964-7. 2008..The examined parameters included clinical observation of oropharyngeal mucosa, type of malignant disease and intake of chemotherapy and antimicrobial treatment...
- CD9 expression can be used to predict childhood TEL/AML1-positive acute lymphoblastic leukemia: proposal for an accelerated diagnostic flowchartVirginie Gandemer
Centre National de Recherche Scientifique, Unité Mixte de Recherche 6061 Laboratoire de Génétique et Développement, Equipe Régulation Transcriptionnelle et Oncogenèse, Universite de Rennes 1, Rennes Cedex, France
Leuk Res 34:430-7. 2010..Finally, we propose a faster procedure for optimizing the diagnosis of childhood BCP-ALL subgroups...
- CD9, a key actor in the dissemination of lymphoblastic leukemia, modulating CXCR4-mediated migration via RAC1 signalingMarie Pierre Arnaud
Centre National de la Recherche Scientifique CNRS Unités Mixtes de Recherche UMR 6290, Institut de Génétique et Développement de Rennes and Structure Fédérative de Recherche SFR en Biologie et Santé de Rennes Biosit, Unité Mixte de Service UMS CNRS 3480 US INSERM 018, Universite de Rennes 1, Rennes, France
Blood 126:1802-12. 2015..These findings demonstrate, for the first time, that CD9 plays a key role in the CXCR4-mediated migration and engraftment of B-ALL cells in the bone marrow or testis, through RAC1 activation. ..
- Clinical value of pre-transplant minimal residual disease in childhood lymphoblastic leukaemia: the results of the French minimal residual disease-guided protocolVirginie Gandemer
Department of Paediatric Haematology Oncology, University Hospital of Rennes, Rennes, France
Br J Haematol 165:392-401. 2014..Thus, pre-transplant MRD is still a major predictor of outcome for ALL. The MRD-guided strategy resulted in survival for 72·3% of patients with MRD<10(-3) and 40·4% of those with MRD ≥10(-3)...
- Late ovarian relapse of TEL/AML1 positive ALL confirming that TEL deletion is a secondary event in leukemogenesisBeatrice Ly-Sunnaram
Laboratoire d ématologie et d mmunologie CHU Université de Rennes1, avenue du professeur Leon Bernard, Rennes, France
Leuk Res 29:1089-94. 2005..To our knowledge, it is the first complete description of extramedullary ALL relapse combining all methodologies...
- Central neurotoxicity of cyclosporine in two children with nephrotic syndromeSophie Taque
Departement de medecine de l Enfant et de l Adolescent, CHU Rennes, Hopital Sud, 16 Boulevard de Bulgarie, 35056 Rennes, France
Pediatr Nephrol 19:276-80. 2004..We present two patients with central neurotoxicity both of whom have elevated cholesterol levels...
- Invasive Fungal Infections in Pediatric Acute Myelogenous LeukemiaStéphane Ducassou
From the Unité d Oncologie Hématologie Pédiatrique, Hopital des Enfants, Groupe Hospitalier, Pellegrin, CHU de Bordeaux, Bordeaux Cedex, France Service d Onco Hématologie Pédiatrique, Hopital Armand Trousseau, Paris Cedex, France Institut d Hématologie Oncologie Pédiatrique, CHU Lyon, Lyon Cedex, France and Unité d Hémato Oncologie Pédiatrique, CHU Hopital Sud, Rennes Cedex, France
Pediatr Infect Dis J 34:1262-4. 2015..The most frequent localization of IFIs was in the lungs. It was found that after a median of 34 months, 2 deaths were attributable to IFI without any difference in survival between the groups with and without IFI. ..
- Single- vs double-unit cord blood transplantation for children and young adults with acute leukemia or myelodysplastic syndromeGerard Michel
Department of Pediatric Hematology Oncology, Assistance Publique Hopitaux de Marseille, La Timone Hospital, Aix Marseille University, Marseille, France Department of Public Health, Laboratoire de Santé Publique EA 3279 Research Unit, Marseille University Hospital, Aix Marseille University, Marseille, France
Blood 127:3450-7. 2016..Double-unit transplantation should be reserved for patients who lack such units. This trial was registered at www.clinicaltrials.gov as #NCT01067300. ..
- Hearing loss during osteosarcoma chemotherapy: when acute ifosfamide toxicity revealed unnoticed methotrexate encephalopathyGuillaume Robert
Departments of Pediatric Oncology Radiology, CHU Rennes CNRS IGDR UMR 6290, Institut Génétique et Développement de Rennes Université Rennes 1, UEB, IFR 140, Medical University, Rennes, France
J Pediatr Hematol Oncol 36:e100-2. 2014..This is the second reported case of acute deafness, possibly associated with ifosfamide, whereas MRI data revealed unnoticed chronic methotrexate toxicity. Systematic MRI screening and hearing evaluation may be useful in such cases. ..
- Prevalence of oropharyngeal beta-lactamase-producing Capnocytophaga spp. in pediatric oncology patients over a ten-year periodAnne Jolivet-Gougeon
Equipe de Microbiologie, UPRES EA 1254, Faculte des Sciences Pharmaceutiques et Biologiques, Universite de Rennes 1, 2 Avenue du Professeur Leon Bernard, 35043 Rennes, France
BMC Infect Dis 5:32. 2005....
- Particular cutaneous side effects with etoposide-containing courses: is VP16 or etoposide phosphate responsible?Katel Marigny
Department of Pharmacy, CHU Hopital Sud, bd de Bulgarie, 35000, Rennes, France
Cancer Chemother Pharmacol 55:244-50. 2005....
- Cohort Profile: the French childhood cancer survivor study for leukaemia (LEA Cohort)Julie Berbis
EA3279, Self perceived Health Assessment Research Unit, School of Medicine, Aix Marseilles University, Marseilles 13385, France, Department of Paediatric Onco haematology, APHM, La Timone Hospital, Marseilles, France, Department of Paediatric Onco haematology, APHP, Saint Louis Hospital, Paris, France, Department of Paediatric Onco haematology, APHP, Robert Debre Hospital, Paris, France, Department of Paediatric Onco haematology, HCL, Lyon, France, Department of Paediatric Onco haematology, University Hospital of Nancy, Nancy, France, CHU Clermont Ferrand, Department of Paediatric Onco haematology, CIC Inserm 501, Clermont Ferrand, France, Department of Paediatric Onco haematology, APHP, GHUEP, Armand Trousseau Hospital, Paris 75012, France, Department of Paediatric Onco haematology, University Hospital of Grenoble, Grenoble, France, Department of Paediatric Onco haematology
Int J Epidemiol 44:49-57. 2015..The cohort has already included 2385 survivors, with rate of exhaustiveness of almost 80%. Data access can be requested from principal coordinators and must be approved by the steering committee. ..
- School performance of childhood cancer survivors: mind the teenagers!Jacinthe Bonneau
Department of Pediatric Hematology, University Hospital, Rennes, France
J Pediatr 158:135-41. 2011..To assess school performance in an unselected group of childhood cancer survivors and study risk factors for impairment...
- Prognostic signature of ALL blasts at diagnosis: what can we really find?Virginie Gandemer
Leuk Res 31:1317-9. 2007
- Economic evaluation of recombinant human granulocyte colony-stimulating factor in very high-risk childhood acute lymphoblastic leukemiaJean Delorme
Department of Pharmacy, Research Unit INSERM No 379, France
J Pediatr Hematol Oncol 25:441-7. 2003..The aim of the current study was to perform an economic evaluation in the same cohort...
- Outcome in children with relapsed acute myeloid leukemia after initial treatment with the French Leucemie Aique Myeloide Enfant (LAME) 89/91 protocol of the French Society of Pediatric Hematology and ImmunologyNathalie Aladjidi
Unité d Onco Hématologie, Departement de Pediatrie, Hopital des Enfants, Groupe Hospitalier Pellegrin, Place Amelie Raba Leon, 33076 Bordeaux, France
J Clin Oncol 21:4377-85. 2003..The goals of this retrospective study were to determine whether these children could be treated successfully with a salvage regimen and to establish the optimal therapeutic strategy...
- High-dose chemotherapy followed by locoregional irradiation improves the outcome of patients with international neuroblastoma staging system Stage II and III neuroblastoma with MYCN amplificationAnne Laprie
Département d Hémato Oncologie, Hopital des Enfants, Toulouse, France
Cancer 101:1081-9. 2004..The objective of this study was to determine whether systemic and regional, intensified treatment can improve the outcome of children who present with a localized neuroblastoma (NB) with MYCN amplification (MNA)...
- Familial history of cancer and childhood acute leukemia: a French population-based case-control studyMahaut Ripert
INSERM, U754, IFR69, Villejuif, France
Eur J Cancer Prev 16:466-70. 2007..7 [1.3-86], respectively). This study supports the hypothesis that a familial history of cancer may play a role in the etiology of childhood acute leukemia. It also evidences some specific associations that require further investigation...
- Results of a phase II trial testing interferon-alpha 2b and cytarabine in children and adolescents with chronic myelogenous leukemiaFrederic Millot
Oncology Hematology, University Hospital, Poitiers, France
Pediatr Blood Cancer 47:555-9. 2006....
- Prognostic factors for leukemic induction failure in children with acute lymphoblastic leukemia and outcome after salvage therapy: the FRALLE 93 studyCaroline Oudot
Service d hématologie et oncologie pédiatrique, Hopital Mere Enfant, Limoges, France
J Clin Oncol 26:1496-503. 2008..To identify prognostic factors and to evaluate the outcome of children with acute lymphoblastic leukemia (ALL) failure after induction therapy...
- Impact of addition of maintenance therapy to intensive induction and consolidation chemotherapy for childhood acute myeloblastic leukemia: results of a prospective randomized trial, LAME 89/91. Leucámie Aiqüe Myéloïde EnfantYves Perel
Unité d Onco Hématologie, Departement de Pediatrie, Hopital des Enfants, Groupe Hospitalier Pellegrin, Centres Hospitalo Universitaires de Bordeaux, France
J Clin Oncol 20:2774-82. 2002..To determine whether the use of maintenance therapy (MT) delivered after intensive induction and consolidation therapy confers any advantage in childhood acute myeloid leukemia (AML)...