P Froguel

Summary

Country: France

Publications

  1. ncbi Tracking down genes to cure diabetes: an achievable task for the 21st century?
    P Froguel
    Department of Human Genetics, CNRS EP 10, Institut Pasteur de Lille, France
    Diabetes Metab 23:8-13. 1997
  2. ncbi Genetics of type 1 insulin-dependent diabetes mellitus
    P Froguel
    CNRS EP 10, Pasteur Institute of Lille, France
    Horm Res 48:55-7. 1997
  3. ncbi Effect of common polymorphisms in the HNF4alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population
    M Vaxillaire
    CNRS 8090 Institut de Biologie, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019, Lille, France
    Diabetologia 48:440-4. 2005
  4. ncbi Indication for genetic linkage of the phosphoenolpyruvate carboxykinase (PCK1) gene region on chromosome 20q to non-insulin-dependent diabetes mellitus
    E H Hani
    CNRS EP 10, Institut Pasteur de Lille, France
    Diabetes Metab 22:451-4. 1996
  5. ncbi A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27
    S Francke
    Institute of Biology, CNRS UPRES A 8090, Pasteur Institute of Lille, 1, rue du Pr Calmette, B P 447, 59021 Lille Cedex, France
    Hum Mol Genet 10:2751-65. 2001
  6. ncbi Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families
    J Delplanque
    Institute of Biology CNRS 8090, Pasteur Institute of Lille, CHRU of Lille, Lille, France
    Diabetologia 43:1554-7. 2000
  7. ncbi Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians
    J Delplanque
    Institute of Biology, Centre National de la Recherche Scientifique 8090 and University Hospital, Pasteur Institute of Lille, F 59019 Lille, France
    J Clin Endocrinol Metab 87:867-9. 2002
  8. ncbi Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs
    N Vionnet
    Centre National Recherche Scientifique, Institut Pasteur de Lille, France
    Diabetes 46:1062-8. 1997
  9. ncbi Genetic study of the CD36 gene in a French diabetic population
    F Lepretre
    Institute of Biology CNRS 8090, Pasteur Institute of Lille, France
    Diabetes Metab 30:459-63. 2004
  10. ncbi Nuclear factors and type 2 diabetes
    P Froguel
    Department of Human Genetics, Pasteur Institute, Lille, France
    Schweiz Med Wochenschr 128:1936-9. 1998

Collaborators

Detail Information

Publications17

  1. ncbi Tracking down genes to cure diabetes: an achievable task for the 21st century?
    P Froguel
    Department of Human Genetics, CNRS EP 10, Institut Pasteur de Lille, France
    Diabetes Metab 23:8-13. 1997
    ..Tracking down diabetes genes will thus contribute to the development of novel predictive and therapeutic approaches for the coming century...
  2. ncbi Genetics of type 1 insulin-dependent diabetes mellitus
    P Froguel
    CNRS EP 10, Pasteur Institute of Lille, France
    Horm Res 48:55-7. 1997
    ..Understanding the genetic basis of IDDM will aid in the design of new strategies to prevent or cure the disease...
  3. ncbi Effect of common polymorphisms in the HNF4alpha promoter on susceptibility to type 2 diabetes in the French Caucasian population
    M Vaxillaire
    CNRS 8090 Institut de Biologie, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019, Lille, France
    Diabetologia 48:440-4. 2005
    ....
  4. ncbi Indication for genetic linkage of the phosphoenolpyruvate carboxykinase (PCK1) gene region on chromosome 20q to non-insulin-dependent diabetes mellitus
    E H Hani
    CNRS EP 10, Institut Pasteur de Lille, France
    Diabetes Metab 22:451-4. 1996
    ..0003, mean IBD = 0.66). These results suggest that the PCK1 gene or a nearby locus contributes to the development of NIDDM in the French population...
  5. ncbi A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27
    S Francke
    Institute of Biology, CNRS UPRES A 8090, Pasteur Institute of Lille, 1, rue du Pr Calmette, B P 447, 59021 Lille Cedex, France
    Hum Mol Genet 10:2751-65. 2001
    ..These results show the first evidence for susceptibility loci that predispose to CHD, T2DM and HBP in the context of the metabolic syndrome...
  6. ncbi Linkage and association studies between the proopiomelanocortin (POMC) gene and obesity in caucasian families
    J Delplanque
    Institute of Biology CNRS 8090, Pasteur Institute of Lille, CHRU of Lille, Lille, France
    Diabetologia 43:1554-7. 2000
    ..A polyhormone peptide, POMC is expressed in brain, gut, placenta and pancreas. The POMC mutations are responsible for rare cases of early-onset obesity. Thus we examined the contribution of the POMC locus to obesity in French families...
  7. ncbi Mutation screening of the urocortin gene: identification of new single nucleotide polymorphisms and association studies with obesity in French Caucasians
    J Delplanque
    Institute of Biology, Centre National de la Recherche Scientifique 8090 and University Hospital, Pasteur Institute of Lille, F 59019 Lille, France
    J Clin Endocrinol Metab 87:867-9. 2002
    ..Thus, our analyses of the genetic variations of the UCN gene suggest that, at least in French Caucasians, they do not represent a major cause of obesity...
  8. ncbi Genetics of NIDDM in France: studies with 19 candidate genes in affected sib pairs
    N Vionnet
    Centre National Recherche Scientifique, Institut Pasteur de Lille, France
    Diabetes 46:1062-8. 1997
    ..Analyses of six additional markers spanning 27 cM on chromosome 11p confirmed the suggestive linkage in this region. Whether an NIDDM susceptibility gene lies on chromosome 11p in our population must be determined by further analyses...
  9. ncbi Genetic study of the CD36 gene in a French diabetic population
    F Lepretre
    Institute of Biology CNRS 8090, Pasteur Institute of Lille, France
    Diabetes Metab 30:459-63. 2004
    ..In rodents, CD36 gene variations modulate glucose homeostasis and contribute to metabolic syndrome associated with type 2 diabetes but the effects in human are unknown...
  10. ncbi Nuclear factors and type 2 diabetes
    P Froguel
    Department of Human Genetics, Pasteur Institute, Lille, France
    Schweiz Med Wochenschr 128:1936-9. 1998
    ..Altogether, these data suggest that non-MODY monofactorial forms of late-onset NIDDM, due to islet transcription factor defects, exist...
  11. ncbi Genetics of human obesity
    P Boutin
    CNRS-Institute of Biology of Lille, Pasteur Institute of Lille, France
    Best Pract Res Clin Endocrinol Metab 15:391-404. 2001
    ..Approaches involving the candidate genes and the positional cloning of major obesity-linked regions (state-of-the-art future prospects) will be discussed...
  12. ncbi Genetics of pathways regulating body weight in the development of obesity in humans
    P Froguel
    Centre National de la Recherche Scientifique, Institute of Biology of Lille, Pasteur Institute of Lille, France
    Exp Biol Med (Maywood) 226:991-6. 2001
    ..e., they are "susceptibility" genes and work in combination with each other as well as with environmental factors such as nutrients, physical activity, and smoking)...
  13. ncbi Rapid SNP allele frequency determination in genomic DNA pools by pyrosequencing
    B Neve
    Genetics of Multifactorial Diseases, CNRS UPRES A 8090, Institut Biologie de Lille, Institut Pasteur de Lille, France
    Biotechniques 32:1138-42. 2002
    ..Furthermore, it allows the rapid determination of allelefrequency differences in case/control groups for association studies and susceptibility gene discovery in complex diseases...
  14. ncbi An uncoupling protein 3 gene polymorphism associated with a lower risk of developing Type II diabetes and with atherogenic lipid profile in a French cohort
    A Meirhaeghe
    Department of Epidemiology and Public Health, INSERM U 508, Pasteur Institute of Lille, Central Hospital and University of Lille, France
    Diabetologia 43:1424-8. 2000
    ..We also examined the association of this polymorphism with obesity and Type II (non-insulin-dependent) diabetes mellitus...
  15. ncbi Genetic determinants of type 2 diabetes
    P Froguel
    Institute of Biology-CNRS 8090, Institut Pasteur de Lille, France
    Recent Prog Horm Res 56:91-105. 2001
    ..The goal of this chapter is to summarize and discuss the significant results of recent literature on the genetics of both the monogenic and polygenic forms of T2DM...
  16. ncbi Mutation screening in 18 Caucasian families suggest the existence of other MODY genes
    J C Chevre
    Institut de Biologie de Lille, CNRS EP 10, France
    Diabetologia 41:1017-23. 1998
    ..Eleven families do not have mutations in the five known MODY genes suggesting that there is at least one additional locus that can cause MODY...
  17. ncbi A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q
    M Vaxillaire
    CNRS EP10, Institut Pasteur de Lille, France
    Nat Genet 9:418-23. 1995
    ..These MODY patients exhibit major hyperglycaemia with a severe insulin secretory defect, suggesting that the causal gene is implicated in pancreatic beta-cell function...