Thierry Fandeur

Summary

Country: France

Publications

  1. pmc Invasion of Africa by a single pfcrt allele of South East Asian type
    Frederic Ariey
    Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Malar J 5:34. 2006
  2. pmc Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure
    Wassim Daher
    INSERM U547, Institut Pasteur, 1 rue du Pr Calmette, BP 245, 59019 Lille, France
    Malar J 5:11. 2006
  3. pmc Countrywide survey shows very high prevalence of Plasmodium falciparum multilocus resistance genotypes in Cambodia
    Nimol Khim
    Faculte de Pharmacie, UFR Sciences Pharmaceutiques, UMR INRA Université d Immunologie Parasitaire et de Vaccinologie, 31, avenue Monge Parc Grandmont, 37200 Tours, France
    Antimicrob Agents Chemother 49:3147-52. 2005
  4. pmc Protection against lethal Neospora caninum infection in mice induced by heterologous vaccination with a mic1 mic3 knockout Toxoplasma gondii strain
    Diana Marcela Penarete-Vargas
    UMR Université INRA d Immunologie Parasitaire et Vaccinologie, Faculte de Pharmacie, 31 Avenue Monge, 37200 Tours, France
    Infect Immun 78:651-60. 2010
  5. pmc First case of emergence of atovaquone resistance in Plasmodium falciparum during second-line atovaquone-proguanil treatment in South America
    Eric Legrand
    Antimicrob Agents Chemother 51:2280-1. 2007
  6. ncbi Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border
    Alisa P Alker
    Department of Epidemiology, UNC School of Public Health, Chapel Hill, North Carolina 27599, USA
    Am J Trop Med Hyg 76:641-7. 2007
  7. ncbi Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia
    Mey Bouth Denis
    National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    Trop Med Int Health 11:1800-7. 2006
  8. ncbi Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6
    Ronan Jambou
    Unite d immunologie, Institut Pasteur de Dakar, BP 220, Dakar, Senegal
    Lancet 366:1960-3. 2005
  9. ncbi Mekong malaria. II. Update of malaria, multi-drug resistance and economic development in the Mekong region of Southeast Asia
    Doung Socheat
    Center for National Malaria Control CNM, Phnom Penh, Cambodia
    Southeast Asian J Trop Med Public Health 34:1-102. 2003
  10. ncbi Gene polymorphism of Plasmodium falciparum merozoite surface proteins 4 and 5
    Hannah E J Polson
    Laboratoire de Vaccinologie Parasitaire, CNRS URA 2581, Institut Pasteur, Paris, France
    Mol Biochem Parasitol 142:110-5. 2005

Collaborators

Detail Information

Publications22

  1. pmc Invasion of Africa by a single pfcrt allele of South East Asian type
    Frederic Ariey
    Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Malar J 5:34. 2006
    ..Many questions remain about the actual selection and spreading process of CQR parasites, and about the evolution of the ancestral mutant gene(s) during spreading...
  2. pmc Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure
    Wassim Daher
    INSERM U547, Institut Pasteur, 1 rue du Pr Calmette, BP 245, 59019 Lille, France
    Malar J 5:11. 2006
    ..FQ is also curative on rodent malaria parasites. As FQ will be tested in patients, the potential for resistance to this drug was evaluated...
  3. pmc Countrywide survey shows very high prevalence of Plasmodium falciparum multilocus resistance genotypes in Cambodia
    Nimol Khim
    Faculte de Pharmacie, UFR Sciences Pharmaceutiques, UMR INRA Université d Immunologie Parasitaire et de Vaccinologie, 31, avenue Monge Parc Grandmont, 37200 Tours, France
    Antimicrob Agents Chemother 49:3147-52. 2005
    ..Our findings show an alarming rate of multilocus resistance genotypes in Cambodia, requiring diligent surveillance and imposing limitations on possible future drug combinations...
  4. pmc Protection against lethal Neospora caninum infection in mice induced by heterologous vaccination with a mic1 mic3 knockout Toxoplasma gondii strain
    Diana Marcela Penarete-Vargas
    UMR Université INRA d Immunologie Parasitaire et Vaccinologie, Faculte de Pharmacie, 31 Avenue Monge, 37200 Tours, France
    Infect Immun 78:651-60. 2010
    ..We report here the acquisition of heterologous protective immunity against N. caninum following immunization with a live attenuated mic1-3KO strain of T. gondii...
  5. pmc First case of emergence of atovaquone resistance in Plasmodium falciparum during second-line atovaquone-proguanil treatment in South America
    Eric Legrand
    Antimicrob Agents Chemother 51:2280-1. 2007
  6. ncbi Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border
    Alisa P Alker
    Department of Epidemiology, UNC School of Public Health, Chapel Hill, North Carolina 27599, USA
    Am J Trop Med Hyg 76:641-7. 2007
    ..040). pfmdr1 copy number should be evaluated further as a surveillance tool for artesunate-mefloquine resistance in Cambodia...
  7. ncbi Efficacy of artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in northwest Cambodia
    Mey Bouth Denis
    National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
    Trop Med Int Health 11:1800-7. 2006
    ..To determine the efficacy of artemether-lumefantrine malaria treatment, as an alternative to artesunate + mefloquine, which is becoming ineffective in some areas of the Thai-Cambodian border...
  8. ncbi Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6
    Ronan Jambou
    Unite d immunologie, Institut Pasteur de Dakar, BP 220, Dakar, Senegal
    Lancet 366:1960-3. 2005
    ..0001, Mann-Whitney). All resistant isolates came from areas with uncontrolled use of artemisinin derivatives. This rise in resistance indicates the need for increased vigilance and a coordinated and rapid deployment of drug combinations...
  9. ncbi Mekong malaria. II. Update of malaria, multi-drug resistance and economic development in the Mekong region of Southeast Asia
    Doung Socheat
    Center for National Malaria Control CNM, Phnom Penh, Cambodia
    Southeast Asian J Trop Med Public Health 34:1-102. 2003
    ....
  10. ncbi Gene polymorphism of Plasmodium falciparum merozoite surface proteins 4 and 5
    Hannah E J Polson
    Laboratoire de Vaccinologie Parasitaire, CNRS URA 2581, Institut Pasteur, Paris, France
    Mol Biochem Parasitol 142:110-5. 2005
  11. ncbi In vitro monitoring of Plasmodium falciparum susceptibility to artesunate, mefloquine, quinine and chloroquine in Cambodia: 2001-2002
    Pharath Lim
    Laboratoire d Epidemiologie Moleculaire, Institut Pasteur du Cambodge, 5 Bd Monivong, P O Box 983, Phnom Penh, Cambodia
    Acta Trop 93:31-40. 2005
    ....
  12. ncbi Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro
    Valérie Durrand
    Laboratoire d Epidemiologie Moleculaire, Institut Pasteur du Cambodge, 5 Bd Monivong, P O Box 983, Phnom Penh, Cambodia
    Mol Biochem Parasitol 136:273-85. 2004
    ..These results are discussed in light of recent finding suggesting the possible involvement of other transporters in CQ-resistance...
  13. ncbi Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria
    Mey Bouth Denis
    European Commission, Cambodia Malaria Control Programme, and National Malaria Centre, Phnom Penh, Cambodia
    Clin Infect Dis 35:1469-76. 2002
    ..Although Artekin is a promising and inexpensive option for antimalarial therapy, further efficacy and pharmacokinetic studies are needed, especially for its use in children...
  14. pmc pfcrt polymorphism and chloroquine resistance in Plasmodium falciparum strains isolated in Cambodia
    Pharath Lim
    Laboratoire d Epidemiologie Moleculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Antimicrob Agents Chemother 47:87-94. 2003
    ..This indicates that in vitro resistance to chloroquine was associated with accumulation of point mutations in pfcrt...
  15. ncbi Large sequence heterogeneity of the small subunit ribosomal RNA gene of Plasmodium ovale in cambodia
    Sandra Incardona
    Laboratoire d Epidemiologie Moleculaire, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Am J Trop Med Hyg 72:719-24. 2005
    ..ovale variants from each sample. Our data indicate that P. ovale was overlooked in Cambodia until now, and call for the implementation of larger prevalence surveys and accurate diagnosis methods in this country...
  16. pmc Sequence analysis of Plasmodium falciparum cytochrome b in multiple geographic sites
    Marie Therese Ekala
    Immunologie Moléculaire des Parasites, CNRS URA 2581, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, Paris, France
    Malar J 6:164. 2007
    ..To this end, a large molecular survey was conducted in several malaria endemic areas where atovaquone was not yet in regular use...
  17. pmc World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility
    David J Bacon
    Parasitology Program, Naval Medical Research Center Detachment, Lima, Peru
    Malar J 6:120. 2007
    ..Such a network would facilitate the rapid detection of strains with novel antimalarial resistance profiles and investigate suitable alternative treatments with retained efficacy...
  18. pmc Large-scale malaria survey in Cambodia: novel insights on species distribution and risk factors
    Sandra Incardona
    Laboratory of Molecular Epidemiology, Institut Pasteur du Cambodge, Phnom Penh, Cambodia
    Malar J 6:37. 2007
    ..A global estimate of the current malaria situation and associated risk factors is, therefore, still lacking...
  19. ncbi Antimalarial activity of artemisinins: identification of a novel target?
    Odile Mercereau-Puijalon
    Unité d Immunologie Moléculaire des Parasites, CNRS URA 2581, Institut Pasteur, 75724 Paris Cedex 15, France
    Lancet 362:2035-6. 2003
  20. ncbi Design and synthesis of hydroxyferroquine derivatives with antimalarial and antiviral activities
    Christophe Biot
    Unite de Catalyse et Chimie du Solide UMR CNRS 8181, ENSCL, Batiment C7, USTL, B P 90108, 59652 Villeneuve d Ascq cedex, France
    J Med Chem 49:2845-9. 2006
    ..These new drugs may offer an interesting alternative for Asia where SARS originated and malaria has remained endemic...
  21. ncbi Importance of protection of antimalarial combination therapies
    Socheat Duong
    Lancet 364:1754-5. 2004
  22. ncbi A sero-epidemiological study of malaria in human and monkey populations in French Guiana
    Beatrice Volney
    Laboratoire de Parasitologie Moleculaire, Institut Pasteur de Guyane, 97306 Cedex, Cayenne, French Guiana
    Acta Trop 82:11-23. 2002
    ..malariae, and possibly of other malaria species, in isolated areas of the Amazonian rainforest...