N Enjolras

Summary

Country: France

Publications

  1. ncbi Two novel mutations in EGF-like domains of human factor IX dramatically impair intracellular processing and secretion
    N Enjolras
    Laboratoire d Hémobiologie EA 1508, Faculté de médecine RTH Laennec, Lyon, France
    J Thromb Haemost 2:1143-54. 2004
  2. ncbi A factor VIII minigene comprising the truncated intron I of factor IX highly improves the in vitro production of factor VIII
    J L Plantier
    INSERM U331, , Lyon, France
    Thromb Haemost 86:596-603. 2001
  3. ncbi The P-selectin cytoplasmic domain directs the cellular storage of a recombinant chimeric factor IX
    J L Plantier
    INSERM U331, Laboratoire d Hémobiologie Faculté de Médecine RTH, Laennec, Lyon, France
    J Thromb Haemost 1:292-9. 2003
  4. doi Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiency
    J L Plantier
    Laboratoire d hémobiologie EA4174, Faculté RTH Laennec, Universite de Lyon, Universite Lyon 1, Lyon, France
    J Thromb Haemost 8:286-93. 2010
  5. ncbi Expression of coagulation factor IX in a haematopoietic cell line
    M H Rodriguez
    INSERM U331, Laboratoire d Hemobiologie Faculté de Médecine RTH Laennec, Lyon, France
    Thromb Haemost 87:366-73. 2002
  6. doi In vivo efficacy of human recombinant factor IX produced by the human hepatoma cell line HuH-7
    N Enjolras
    Unite Hemostase, Inflammation and Sepsis EA 4174, Faculte de Medecine Laennec, Université Lyon 1 Hospices Civils de Lyon, Lyon, France
    Haemophilia 21:e317-21. 2015

Collaborators

Detail Information

Publications6

  1. ncbi Two novel mutations in EGF-like domains of human factor IX dramatically impair intracellular processing and secretion
    N Enjolras
    Laboratoire d Hémobiologie EA 1508, Faculté de médecine RTH Laennec, Lyon, France
    J Thromb Haemost 2:1143-54. 2004
    ..These results strongly suggest that chaperone and lectin molecules act in concert to ensure both proper folding of FIXwt and the retention of mutant molecules...
  2. ncbi A factor VIII minigene comprising the truncated intron I of factor IX highly improves the in vitro production of factor VIII
    J L Plantier
    INSERM U331, , Lyon, France
    Thromb Haemost 86:596-603. 2001
    ..Therefore, the FVIII I1+13 minigene could represent a particular interest to produce recombinant FVIII in vitro as well as in the aim of gene therapy of haemophilia A...
  3. ncbi The P-selectin cytoplasmic domain directs the cellular storage of a recombinant chimeric factor IX
    J L Plantier
    INSERM U331, Laboratoire d Hémobiologie Faculté de Médecine RTH, Laennec, Lyon, France
    J Thromb Haemost 1:292-9. 2003
    ....
  4. doi Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiency
    J L Plantier
    Laboratoire d hémobiologie EA4174, Faculté RTH Laennec, Universite de Lyon, Universite Lyon 1, Lyon, France
    J Thromb Haemost 8:286-93. 2010
    ..Among the proteases that attack FVIII (activated factor X (FXa), activated protein C (APC) and plasmin), only APC cleaves within the FVIII A2 domain at R562 to fully abolish FVIII activity...
  5. ncbi Expression of coagulation factor IX in a haematopoietic cell line
    M H Rodriguez
    INSERM U331, Laboratoire d Hemobiologie Faculté de Médecine RTH Laennec, Lyon, France
    Thromb Haemost 87:366-73. 2002
    ..These data also demonstrate that hematopoietic cells may represent potential target cells in an approach to gene therapy of haemophilia B...
  6. doi In vivo efficacy of human recombinant factor IX produced by the human hepatoma cell line HuH-7
    N Enjolras
    Unite Hemostase, Inflammation and Sepsis EA 4174, Faculte de Medecine Laennec, Université Lyon 1 Hospices Civils de Lyon, Lyon, France
    Haemophilia 21:e317-21. 2015
    ..The aim of the study consisted to verify the improved post-translational modifications effect of HIX on in vivo recovery...