Alexis Elbaz

Summary

Country: France

Publications

  1. doi request reprint Prodromal symptoms of Parkinson's disease: Implications for epidemiological studies of disease etiology
    A Elbaz
    Université Paris Saclay, Universite Paris Sud, UVSQ, CESP, INSERM, Villejuif, France Electronic address
    Rev Neurol (Paris) 172:503-511. 2016
  2. doi request reprint Epidemiology of Parkinson's disease
    A Elbaz
    INSERM, Centre for research in Epidemiology and Population Health, U1018, Epidemiology of Ageing and Age Related Diseases, 94807 Villejuif, France University Paris Sud, UMRS 1018, 94807 Villejuif, France Département santé travail, institut de veille sanitaire InVS, 94415 Saint Maurice, France Electronic address
    Rev Neurol (Paris) 172:14-26. 2016
  3. pmc Trajectories of the Framingham general cardiovascular risk profile in midlife and poor motor function later in life: the Whitehall II study
    Alexis Elbaz
    INSERM, Centre for research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F 94807, Villejuif, France Department of Epidemiology and Public Health, University College London, UK Univ Versailles St Quentin, UMRS 1018, F 94807, Villejuif, France Electronic address
    Int J Cardiol 172:96-102. 2014
  4. pmc Motor function in the elderly: evidence for the reserve hypothesis
    Alexis Elbaz
    INSERM, Centre for research in Epidemiology and Population Health, U1018 Social and Occupational Determinants of Health, Villejuif, France
    Neurology 81:417-26. 2013
  5. doi request reprint Unhealthy behaviours and disability in older adults: three-City Dijon cohort study
    Fanny Artaud
    INSERM, Centre for research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F 94807 Villejuif, France
    BMJ 347:f4240. 2013
  6. pmc Association of walking speed in late midlife with mortality: results from the Whitehall II cohort study
    Alexis Elbaz
    INSERM, U708, Neuroepidemiology, 75013, Paris, France
    Age (Dordr) 35:943-52. 2013
  7. pmc Alcohol consumption and cognitive decline in early old age
    Severine Sabia
    From the Department of Epidemiology and Public Health S S, A B, S B, M S, M K, A S M, University College London, UK INSERM A E, A S M, U1018, Centre for research in Epidemiology and Population Health, Villejuif University Paris 11 A E, A S M, Villejuif University Versailles St Quentin A D, A S M, Boulogne Billancourt and Centre de Gérontologie A S M, Hôpital Ste Périne, AP HP, France
    Neurology 82:332-9. 2014
  8. pmc Predicting cognitive decline: a dementia risk score vs. the Framingham vascular risk scores
    Sara Kaffashian
    INSERM, U1018, Centre for research in Epidemiology and Population Health, Villejuif Université de Versailles St Quentin, France
    Neurology 80:1300-6. 2013
  9. doi request reprint Subjective cognitive complaints and mortality: does the type of complaint matter?
    Archana Singh-Manoux
    INSERM, U1018, Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, Bât 15 16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France Department of Epidemiology and Public Health, University College London, UK Centre de Gérontologie, Hôpital Ste Périne, AP HP, France Electronic address
    J Psychiatr Res 48:73-8. 2014
  10. pmc Obesity phenotypes in midlife and cognition in early old age: the Whitehall II cohort study
    Archana Singh-Manoux
    INSERM, U1018, Center for Research in Epidemiology and Population Health, Hopital Paul Brousse, Villejuif, France
    Neurology 79:755-62. 2012

Detail Information

Publications45

  1. doi request reprint Prodromal symptoms of Parkinson's disease: Implications for epidemiological studies of disease etiology
    A Elbaz
    Université Paris Saclay, Universite Paris Sud, UVSQ, CESP, INSERM, Villejuif, France Electronic address
    Rev Neurol (Paris) 172:503-511. 2016
    ..Well-designed epidemiological studies using innovative approaches will also be key in elucidating whether these intriguing associations are causal or a consequence of reverse causation...
  2. doi request reprint Epidemiology of Parkinson's disease
    A Elbaz
    INSERM, Centre for research in Epidemiology and Population Health, U1018, Epidemiology of Ageing and Age Related Diseases, 94807 Villejuif, France University Paris Sud, UMRS 1018, 94807 Villejuif, France Département santé travail, institut de veille sanitaire InVS, 94415 Saint Maurice, France Electronic address
    Rev Neurol (Paris) 172:14-26. 2016
    ..This review discusses some of the methodological challenges involved in assessing the descriptive, prognostic and etiological epidemiological studies of PD, and summarizes their main findings. ..
  3. pmc Trajectories of the Framingham general cardiovascular risk profile in midlife and poor motor function later in life: the Whitehall II study
    Alexis Elbaz
    INSERM, Centre for research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F 94807, Villejuif, France Department of Epidemiology and Public Health, University College London, UK Univ Versailles St Quentin, UMRS 1018, F 94807, Villejuif, France Electronic address
    Int J Cardiol 172:96-102. 2014
    ..We examined the association between trajectories of the Framingham general cardiovascular disease risk score (FRS) over midlife and motor function later in life...
  4. pmc Motor function in the elderly: evidence for the reserve hypothesis
    Alexis Elbaz
    INSERM, Centre for research in Epidemiology and Population Health, U1018 Social and Occupational Determinants of Health, Villejuif, France
    Neurology 81:417-26. 2013
    ..We also examined the cross-sectional and longitudinal association between education and WS...
  5. doi request reprint Unhealthy behaviours and disability in older adults: three-City Dijon cohort study
    Fanny Artaud
    INSERM, Centre for research in Epidemiology and Population Health, U1018, Social and occupational determinants of health, F 94807 Villejuif, France
    BMJ 347:f4240. 2013
    ....
  6. pmc Association of walking speed in late midlife with mortality: results from the Whitehall II cohort study
    Alexis Elbaz
    INSERM, U708, Neuroepidemiology, 75013, Paris, France
    Age (Dordr) 35:943-52. 2013
    ..39, 95% CI = 1.04-1.84). In conclusion, walking speed measured in late midlife seems to be an important marker of mortality risk; multiple factors, in particular inflammatory markers, partially explain this association...
  7. pmc Alcohol consumption and cognitive decline in early old age
    Severine Sabia
    From the Department of Epidemiology and Public Health S S, A B, S B, M S, M K, A S M, University College London, UK INSERM A E, A S M, U1018, Centre for research in Epidemiology and Population Health, Villejuif University Paris 11 A E, A S M, Villejuif University Versailles St Quentin A D, A S M, Boulogne Billancourt and Centre de Gérontologie A S M, Hôpital Ste Périne, AP HP, France
    Neurology 82:332-9. 2014
    ..To examine the association between alcohol consumption in midlife and subsequent cognitive decline...
  8. pmc Predicting cognitive decline: a dementia risk score vs. the Framingham vascular risk scores
    Sara Kaffashian
    INSERM, U1018, Centre for research in Epidemiology and Population Health, Villejuif Université de Versailles St Quentin, France
    Neurology 80:1300-6. 2013
    ..Our aim was to compare 2 Framingham vascular risk scores with a dementia risk score in relation to 10-year cognitive decline in late middle age...
  9. doi request reprint Subjective cognitive complaints and mortality: does the type of complaint matter?
    Archana Singh-Manoux
    INSERM, U1018, Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, Bât 15 16, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France Department of Epidemiology and Public Health, University College London, UK Centre de Gérontologie, Hôpital Ste Périne, AP HP, France Electronic address
    J Psychiatr Res 48:73-8. 2014
    ..18, 1.68) were significantly associated with mortality, while memory complaints did not carry increased risk (HR = 0.93, 95% CI: 0.79, 1.09). All SCCS were strongly associated with depression but not all carried excess risk of mortality...
  10. pmc Obesity phenotypes in midlife and cognition in early old age: the Whitehall II cohort study
    Archana Singh-Manoux
    INSERM, U1018, Center for Research in Epidemiology and Population Health, Hopital Paul Brousse, Villejuif, France
    Neurology 79:755-62. 2012
    ..To examine the association of body mass index (BMI) and metabolic status with cognitive function and decline...
  11. doi request reprint Prediction model of Parkinson's disease based on antiparkinsonian drug claims
    Frédéric Moisan
    Unité Neuroepidemiology, INSERM, Paris, France
    Am J Epidemiol 174:354-63. 2011
    ..Similar approaches could be developed for other conditions...
  12. pmc Association of lung function with physical, mental and cognitive function in early old age
    Archana Singh-Manoux
    Inserm U1018, Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, 16 Avenue Paul Vaillant Couturier, Villejuif Cedex, France
    Age (Dordr) 33:385-92. 2011
    ..Our results suggest that lung function is a good 'summary' measure of overall functioning in early old age...
  13. doi request reprint Professional exposure to pesticides and Parkinson disease
    Alexis Elbaz
    INSERM, U, Paris, France
    Ann Neurol 66:494-504. 2009
    ..Our objective was to investigate the role of specific pesticide families and to perform dose-effect analyses...
  14. pmc Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study
    Julien Dumurgier
    INSERM, U708, F 75013, Paris, France
    BMJ 339:b4460. 2009
    ..To study the relation between low walking speed and the risk of death in older people, both overall and with regard to the main causes of death...
  15. pmc The relation between type of farming and prevalence of Parkinson's disease among agricultural workers in five French districts
    Frédéric Moisan
    INSERM, Paris, France
    Mov Disord 26:271-9. 2011
    ..Our findings are consistent with studies reporting an association between PD and insecticide use and show that workers in farms specialized in fruits or permanent crops may be an occupational group at higher PD risk...
  16. pmc Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife
    Archana Singh-Manoux
    From INSERM A S M, A D, A E, U1018, Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, Villejuif Cedex, France Department of Epidemiology and Public Health A S M, E B, M Kumari, M S, A E, M Kivimaki, University College London, UK Centre de Gérontologie A S M, Hôpital Ste Périne, AP HP and University Versailles St Quentin en Yvelines A D, France
    Neurology 83:486-93. 2014
    ..In order to assess their etiologic role, we examined whether interleukin-6 (IL-6) and C-reactive protein (CRP) measured in midlife predict concurrently assessed cognition and subsequent cognitive decline...
  17. pmc Increased risk of coronary heart disease among individuals reporting adverse impact of stress on their health: the Whitehall II prospective cohort study
    Hermann Nabi
    Unit 1018, Epidemiology of occupational and social determinants of health team, INSERM, Centre for research in Epidemiology and Population Health, F 94807 Villejuif, France
    Eur Heart J 34:2697-705. 2013
    ..We examined whether individuals who report that stress adversely affects their health are at increased risk of coronary heart disease (CHD) compared with those who report that stress has no adverse health impact...
  18. pmc Timing of onset of cognitive decline: results from Whitehall II prospective cohort study
    Archana Singh-Manoux
    Institut National de la Sante et de la Recherche Medicale, U1018, Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, 94807 Villejuif Cedex, France
    BMJ 344:d7622. 2012
    ..To estimate 10 year decline in cognitive function from longitudinal data in a middle aged cohort and to examine whether age cohorts can be compared with cross sectional data to infer the effect of age on cognitive decline...
  19. pmc Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
    Alexis Elbaz
    INSERM, U708, Neuroepidemiology, F 75013, Paris, France
    Ann Neurol 69:778-92. 2011
    ....
  20. pmc Trajectories of Unhealthy Behaviors in Midlife and Risk of Disability at Older Ages in the Whitehall II Cohort Study
    Fanny Artaud
    INSERM, U1018, Centre for research in Epidemiology and Population Health, Villejuif, France
    J Gerontol A Biol Sci Med Sci 71:1500-1506. 2016
    ....
  21. doi request reprint Body mass index trajectories and functional decline in older adults: Three-City Dijon cohort study
    Fanny Artaud
    U1018, CESP Centre for research in Epidemiology and Population Health, Epidemiology of Aging and Age Related Diseases, INSERM, 94807, Villejuif, France
    Eur J Epidemiol 31:73-83. 2016
    ..Our results underline the interest of repeated BMI and motor assessments to identify those at higher risk of disability...
  22. doi request reprint MRI atrophy of the caudate nucleus and slower walking speed in the elderly
    Julien Dumurgier
    INSERM, U708, Neuroepidemiology, F 75005, Paris, France
    Neuroimage 60:871-8. 2012
    ..001). These results underline the role of gray matter subcortical structures, in particular of the caudate nucleus, in the age-related decline of motor performances among community-dwelling elderly subjects...
  23. doi request reprint Association between Parkinson's disease and the HLA-DRB1 locus
    Ismail Ahmed
    INSERM, U708, Neuroepidemiology, Paris, France
    Mov Disord 27:1104-10. 2012
    ..The highly polymorphic HLA-DRB1 locus contains rs660895, which represents a more legitimate candidate than previous ones. Our finding is in agreement with the hypothesis of an immune component in PD pathophysiology...
  24. pmc Hypertension and lower walking speed in the elderly: the Three-City study
    Julien Dumurgier
    INSERM, U708, Hopital de la Salpetriere, Paris, France
    J Hypertens 28:1506-14. 2010
    ..The brain is one of the main targets of hypertension. However, little is known about the relation between hypertension and motor performances. We studied the association between hypertension and walking speed in a cohort of elderly people...
  25. doi request reprint Decline in Fast Gait Speed as a Predictor of Disability in Older Adults
    Fanny Artaud
    INSERM, Centre for research in Epidemiology and Population Health, U1018, Epidemiology of Ageing and Age Related Diseases, Villejuif, France
    J Am Geriatr Soc 63:1129-36. 2015
    ..To determine whether fast gait speed at study baseline and change in gait speed had independent associations with disability onset...
  26. pmc No evidence of a longitudinal association between diurnal cortisol patterns and cognition
    Archana Singh-Manoux
    INSERM, U1018, Centre for research in Epidemiology and Population Health, Hôpital Paul Brousse Villejuif Cedex, France Department of Epidemiology and Public Health, University College London, London, UK Centre de Gérontologie, Hôpital Ste Périne, AP HP, Paris, France Electronic address
    Neurobiol Aging 35:2239-45. 2014
    ..These results, based on a large sample of community-dwelling adults suggest that variability in hypothalamic-pituitary-adrenal function is not a strong contributor to cognitive aging...
  27. pmc Association of body mass index and waist circumference with successful aging
    Archana Singh-Manoux
    INSERM U1018 Centre for Research in Epidemiology and Population Health, Hopital Paul Brousse, 94807, Villejuif Cedex, France Department of Epidemiology and Public Health, University College, London, UK Centre de Gérontologie, Hôpital Ste Périne, AP HP, France
    Obesity (Silver Spring) 22:1172-8. 2014
    ..The prediction of successful aging by midlife body mass index (BMI) and waist circumference (WC) was examined...
  28. pmc Midlife type 2 diabetes and poor glycaemic control as risk factors for cognitive decline in early old age: a post-hoc analysis of the Whitehall II cohort study
    Richard H Tuligenga
    Inserm U1018, Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, Villejuif, France Université Paris Sud 11, Paris, France
    Lancet Diabetes Endocrinol 2:228-35. 2014
    ..We investigated whether duration of diabetes in late midlife and poor glycaemic control were associated with accelerated cognitive decline...
  29. pmc Why does lung function predict mortality? Results from the Whitehall II Cohort Study
    Severine Sabia
    INSERM, U1018, Centre for research in Epidemiology and Population Health, Hopital Paul Brousse, 16 Avenue Paul Vaillant Couturier, Bâtiment 15 16, F 94807, Villejuif, France
    Am J Epidemiol 172:1415-23. 2010
    ..5% reduction). Taken together, these factors explained 32.5% of the association. Multiple pathways link lung function to mortality; these results show inflammatory markers to be particularly important...
  30. doi request reprint Abdominal obesity and lower gray matter volume: a Mendelian randomization study
    Stephanie Debette
    INSERM, Neuroepidemiology U708, Paris and Bordeaux, France Department of Epidemiology, University of Versailles Saint Quentin en Yvelines, Garches, France Department of Neurology, Boston University School of Medicine, Boston, MA, USA Department of Neurology, Lariboisiere Hospital, Paris 7 University, Paris, France Electronic address
    Neurobiol Aging 35:378-86. 2014
    ..015). Age and BMI-adjusted effect estimates from the MR analysis confirmed the inverse association between GMV and WHR and are in favor of a causal association...
  31. pmc Parkinson disease male-to-female ratios increase with age: French nationwide study and meta-analysis
    Frédéric Moisan
    Département Santé Travail, institut de veille sanitaire InVS, Saint Maurice, France
    J Neurol Neurosurg Psychiatry 87:952-7. 2016
    ..Whether age modifies this ratio is unclear. We examined whether male-to-female (M-F) ratios change with age through a French nationwide prevalence/incidence study (2010) and a meta-analysis of incidence studies...
  32. doi request reprint Antidepressant medication use and trajectories of fasting plasma glucose, glycated haemoglobin, β-cell function and insulin sensitivity: a 9-year longitudinal study of the D.E.S.I.R. cohort
    Marine Azevedo Da Silva
    INSERM, U1018, Centre for research in Epidemiology and Population Health, F 94807, Villejuif, France, University Paris Sud 11, UMRS 1018, F 94807 Villejuif, France
    Int J Epidemiol 44:1927-40. 2015
    ..We examined whether antidepressant use was associated with change in fasting plasma glucose, glycated haemoglobin (HbA1c), β-cell function (HOMA2-%B) and insulin sensitivity (HOMA2-%S) over time...
  33. pmc Physical activity and adiposity markers at older ages: accelerometer vs questionnaire data
    Severine Sabia
    Department of Epidemiology and Public Health, University College London, London, United Kingdom University Versailles St Quentin, Boulogne Billancourt, France Electronic address
    J Am Med Dir Assoc 16:438.e7-13. 2015
    ..We assessed the associations of questionnaire-assessed and accelerometer-assessed physical activity with adiposity markers in older adults...
  34. doi request reprint Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
    Julien Chapuis
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Hum Mol Genet 17:2863-7. 2008
    ..In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD...
  35. doi request reprint Improving survival in a large French ALS center cohort
    Paul H Gordon
    INSERM, Unité U708, F 75013, Neuroépidémiologie, Hopital de la Pitie Salpetriere, 47 Boulevard de l Hopital, 75651, Paris Cedex 13, France
    J Neurol 259:1788-92. 2012
    ..At this large ALS center, survival improved after 2006. Because more aggressive use of NIV was the principal therapeutic adaptation, our data suggest that better survival resulted from improved respiratory care...
  36. pmc Postmenopausal Hormone Therapy and Risk of Stroke: Impact of the Route of Estrogen Administration and Type of Progestogen
    Marianne Canonico
    From the Université Paris Saclay, Univ Paris Sud, UVSQ, Centre de Recheche en Epidémiologie et Santé des Populations, Inserm UMRS1018, Villejuif, France M C, E O, A S M, A E, P Y S Institut de veille sanitaire InVS, Département des Maladies Chroniques et des, Traumatismes, F 94415 Saint Maurice, France L C APHP, Hôpitaux Paris Centre, Unité de gynécologie endocrinienne, Paris, 75014, France et Université Paris Descartes G P B Université Paris Saclay, Univ Paris Sud, UVSQ, Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases, INSERM UMRS1181, Villejuif, France P T B and Institut Pasteur, Paris, France P T B
    Stroke 47:1734-41. 2016
    ..However, the differential association of oral and transdermal estrogens with stroke remains poorly investigated. Furthermore, there are no data regarding the impact of progestogens...
  37. pmc Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study
    Alexis Elbaz
    INSERM, Unit 708, Paris, France
    Lancet Neurol 5:917-23. 2006
    ..Small-scale replication studies were largely non-confirmatory, but a meta-analysis that included data from the original study could not exclude all SNP associations, leaving relevance of several markers uncertain...
  38. ncbi request reprint Interaction between genes and environment in neurodegenerative diseases
    Alexis Elbaz
    INSERM, U708 Neuroépidémiologie and université Pierre et Marie Curie Paris 6, Groupe Hospitalier Pitie Salpetriere, 75651 Paris Cedex 13, France
    C R Biol 330:318-28. 2007
    ..A few interactions between the epsilon polymorphism and possible risk factors for AD have been described. However, these interactions had no biological plausibility and were likely due to chance...
  39. ncbi request reprint Epidemiologic studies of environmental exposures in Parkinson's disease
    Alexis Elbaz
    INSERM, U708, Neuroepidemiology, Hopital de la Salpetriere, Paris, France
    J Neurol Sci 262:37-44. 2007
    ..Understanding the mechanisms underlying these epidemiological associations is an essential step for the understanding of the etiology of this neurodegenerative condition and, ideally, to develop neuroprotective drugs...
  40. ncbi request reprint [Parkinson's disease and rural environment]
    Alexis Elbaz
    INSERM, U 708, Paris, F 75013, France
    Rev Prat 57:37-9. 2007
    ..However, some questions remain to be answered, particularly the role of low-dose exposure, the gene-environment interactions and the implied biological mechanisms...
  41. doi request reprint Update in the epidemiology of Parkinson's disease
    Alexis Elbaz
    INSERM, U708, Paris, F 75013, France
    Curr Opin Neurol 21:454-60. 2008
    ....
  42. ncbi request reprint Common carotid artery intima-media thickness, carotid plaques, and walking speed
    Alexis Elbaz
    INSERM, Unit 708, Paris, France
    Stroke 36:2198-202. 2005
    ..We studied the association between carotid ultrasound parameters and measures of gait and balance in subjects 65 to 85 years of age who participated in the baseline phase of the Three-City Study in the Dijon center...
  43. doi request reprint Changing mortality for motor neuron disease in France (1968-2007): an age-period-cohort analysis
    Paul H Gordon
    INSERM, Unité U708, Neuroépidémiologie, Hopital de la Pitie Salpetriere, 47 Boulevard de l Hopital, 75651 Paris Cedex 13, France
    Eur J Epidemiol 26:729-37. 2011
    ..Changing environmental exposures may be a possible explanation and these findings warrant the continued search for environmental risk factors for MND...
  44. pmc Traffic-related air pollution in relation to cognitive function in older adults
    Cathryn Tonne
    aSocial and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, United Kingdom bMRC PHE Centre for Environment and Health, King s College London, London, United Kingdom cINSERM, U1018, Centre for research in Epidemiology and Population Health, Villejuif, France and dDepartment of Epidemiology and Public Health, University College London, London, United Kingdom
    Epidemiology 25:674-81. 2014
    ..We investigated whether exposure to particulate air pollution, characterized by size and source, was associated with cognitive function and decline in cognitive function...