- Intermittent hypoxia induces early functional cardiovascular remodeling in miceMaurice Dematteis
Laboratoire HP2, Institut Jean Roget, Faculte de Medecine de Grenoble, 38042 Grenoble Cedex 09, France
Am J Respir Crit Care Med 177:227-35. 2008..Intermittent hypoxia, a hallmark of sleep apnea, is a major factor for hypertension and impaired vasoreactivity...
- Cardiovascular consequences of sleep-disordered breathing: contribution of animal models to understanding the human diseaseMaurice Dematteis
HP2 Laboratory, INSERM ERI17, Universite Joseph Fourier, Grenoble, France
ILAR J 50:262-81. 2009..By combining clinical and experimental research, these models will contribute to the understanding of differential patient susceptibility and to the elaboration of prevention strategies and tailored treatments for sleep apnea patients...
- A simple procedure for measuring pharyngeal sensitivity: a contribution to the diagnosis of sleep apnoeaM Dematteis
Laboratoire HP2 INSERM ESPRI EA3745, Centre Hospitalier Universitaire, Grenoble Cedex, France
Thorax 60:418-26. 2005..The accuracy of a simple new procedure to measure pharyngeal sensitivity and to diagnose sleep disordered breathing (SDB) was investigated...
- Sleep deprivation, sleep apnea and cardiovascular diseasesPatrick Levy
INSERM U 1042, Hypoxia PathoPhysiology Laboratory, Joseph Fourier University, Grenoble, France
Front Biosci (Elite Ed) 4:2007-21. 2012..Whether treating sleep apnea enables the reversal of chronic cardiovascular and metabolic consequences of OSA, remains to be studied in adequately designed studies, particularly in comparison with usual treatment strategies...
- The inflammatory preatherosclerotic remodeling induced by intermittent hypoxia is attenuated by RANTES/CCL5 inhibitionClaire Arnaud
Inserm U1042, Grenoble, France
Am J Respir Crit Care Med 184:724-31. 2011....
- Obstructive sleep apnea and atherosclerosisPatrick Levy
HP2 Laboratory, INSERM ERI17, Joseph Fourier University, Grenoble, France
Prog Cardiovasc Dis 51:400-10. 2009..Further studies are needed to identify at-risk subjects prone to develop vascular changes because OSA treatment may either be initiated earlier or combined with specific drug treatments...
- Inflammation contributes to the atherogenic role of intermittent hypoxia in apolipoprotein-E knock out miceClaire Arnaud
Inserm U1042, Grenoble, F 38042, France
Atherosclerosis 219:425-31. 2011..Our study aimed at examining their respective contribution to the proatherogenic role of IH in atherosclerosis-prone mice...
- Obstructive sleep apnea, immuno-inflammation, and atherosclerosisClaire Arnaud
INSERM ERI17, Grenoble, 38043, France
Semin Immunopathol 31:113-25. 2009....
- Toll-like receptor-4 mediated inflammation is involved in the cardiometabolic alterations induced by intermittent hypoxiaLaureline Poulain
Université Grenoble Alpes, Laboratoire HP2, 38042 Grenoble, France Inserm U1042, 38042 Grenoble, France
Mediators Inflamm 2015:620258. 2015..As the latter results from inflammation involving toll-like receptor-4 (TLR4) signaling, we assessed this pathway in the cardiometabolic consequences of IH...
- Visceral white fat remodelling contributes to intermittent hypoxia-induced atherogenesisLaureline Poulain
HP2 Laboratory, Grenoble
Eur Respir J 43:513-22. 2014..Our results confirmed that the dyslipidaemic and proatherogenic effects of intermittent hypoxia are partly mediated through morphological, functional and inflammatory remodelling of visceral white fat, regardless of obesity...
- Chronic Intermittent Hypoxia Induces Chronic Low-Grade Neuroinflammation in the Dorsal Hippocampus of MiceEmilie Sapin
Université Grenoble Alpes, Grenoble, F 38042, France
Sleep 38:1537-46. 2015....
- Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectivesP Levy
Pathophysiology Laboratory, Grenoble University, Grenoble, France
Eur Respir J 32:1082-95. 2008..Overall, chronic intermittent hypoxia appears to have specific genomic effects that differ notably from continuous hypoxia. Further research is required to fully elucidate the molecular and cellular mechanisms...
- Charcot-Marie-Tooth disease and sleep apnoea syndrome: a family studyM Dematteis
, University Hospital, Grenoble, France
Lancet 357:267-72. 2001..Upper airway dysfunction, previously described in the CMT2C subtype, might be a clinical expression of the CMT1A subtype, to which familial susceptibility could predispose...
- An adaptive detector of genioglossus EMG reflex using Berkner transform for time latency measurement in OSA pathophysiological studiesPierre Yves Gumery
Laboratoire Techniques de l Imagerie, de la Modélisation et de la Cognition, UMR CNRS 5525, Joseph Fourier University, 38706 Grenoble, France
IEEE Trans Biomed Eng 52:1382-9. 2005..These physiological findings may partly explain why the upper airway protective reflex occurring when a negative pressure is applied to the upper airway is ineffective in OSA patients, leading to pharyngeal collapse...