Annick Clement

Summary

Country: France

Publications

  1. pmc Idiopathic eosinophilic pneumonia in children: the French experience
    Lisa Giovannini-Chami
    Pediatric Pulmonology and Allergy Department, Hôpitaux pédiatriques de Nice CHU Lenval, Nice F 06200, France
    Orphanet J Rare Dis 9:28. 2014
  2. pmc Flagellin concentrations in expectorations from cystic fibrosis patients
    Viviane Balloy
    Unité de Défense Innée et Inflammation, Institut Pasteur, Paris, France
    BMC Pulm Med 14:100. 2014
  3. pmc Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis
    Harriet Corvol
    Universite Pierre et Marie Curie PARIS6, Paris, 75571 France
    Respir Res 8:88. 2007
  4. pmc Impaired cortical processing of inspiratory loads in children with chronic respiratory defects
    Brigitte Fauroux
    AP HP, Hopital Armand Trousseau, Pediatric Pulmonary Department, Paris, 75571 France
    Respir Res 8:61. 2007
  5. pmc Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury
    Karmene Ahamed
    INSERM U719, Hospital Saint Antoine, 75012 Paris, France
    Respir Res 6:31. 2005
  6. pmc Interstitial lung diseases in children
    Annick Clement
    Pediatric Pulmonary Department, Reference Center for Rare Lung Diseases, AP HP, Hopital Trousseau, INSERM UMR S 938, Universite Pierre et Marie Curie Paris 6, Paris, F 75012 France
    Orphanet J Rare Dis 5:22. 2010
  7. pmc Loss-of-function mutations in RSPH1 cause primary ciliary dyskinesia with central-complex and radial-spoke defects
    Esther Kott
    INSERM UMR S933, Universite Pierre et Marie Curie Paris 6, Paris, France
    Am J Hum Genet 93:561-70. 2013
  8. pmc Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesia
    Esther Kott
    INSERM UMR_S933, Universite Pierre et Marie Curie Paris 6, Paris, France
    Am J Hum Genet 91:958-64. 2012
  9. ncbi request reprint Changes in pulmonary mechanics with increasing disease severity in children and young adults with cystic fibrosis
    Nicholas Hart
    Pediatric Pulmonary Department, Armand Trousseau Hospital AP HP INSERM E 0213, Paris
    Am J Respir Crit Care Med 166:61-6. 2002
  10. pmc AGER -429T/C is associated with an increased lung disease severity in cystic fibrosis
    Julie Beucher
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Inserm U938, Paris, France
    PLoS ONE 7:e41913. 2012

Collaborators

Detail Information

Publications31

  1. pmc Idiopathic eosinophilic pneumonia in children: the French experience
    Lisa Giovannini-Chami
    Pediatric Pulmonology and Allergy Department, Hôpitaux pédiatriques de Nice CHU Lenval, Nice F 06200, France
    Orphanet J Rare Dis 9:28. 2014
    ..Idiopathic eosinophilic pneumonia is extremely rare in children and adults. We present herein the first series describing the specificities of idiopathic chronic (ICEP) and acute (IAEP) eosinophilic pneumonia in children...
  2. pmc Flagellin concentrations in expectorations from cystic fibrosis patients
    Viviane Balloy
    Unité de Défense Innée et Inflammation, Institut Pasteur, Paris, France
    BMC Pulm Med 14:100. 2014
    ..The aim was to measure flagellin concentrations in the expectorations of CF patients and to examine whether there are correlations with the level of respiratory insufficiency and inflammation...
  3. pmc Glucocorticoid receptor gene polymorphisms associated with progression of lung disease in young patients with cystic fibrosis
    Harriet Corvol
    Universite Pierre et Marie Curie PARIS6, Paris, 75571 France
    Respir Res 8:88. 2007
    ....
  4. pmc Impaired cortical processing of inspiratory loads in children with chronic respiratory defects
    Brigitte Fauroux
    AP HP, Hopital Armand Trousseau, Pediatric Pulmonary Department, Paris, 75571 France
    Respir Res 8:61. 2007
    ..The aim of the present study was to compare the presence, the latencies and the amplitudes of the P1, N1, P2, and N2 components of the RREPs in children with chronic lung or neuromuscular disease...
  5. pmc Deficiency in type 1 insulin-like growth factor receptor in mice protects against oxygen-induced lung injury
    Karmene Ahamed
    INSERM U719, Hospital Saint Antoine, 75012 Paris, France
    Respir Res 6:31. 2005
    ..This led us to suspect that reduction of IGF-1R levels in lung tissue could prevent deleterious effects of oxygen exposure...
  6. pmc Interstitial lung diseases in children
    Annick Clement
    Pediatric Pulmonary Department, Reference Center for Rare Lung Diseases, AP HP, Hopital Trousseau, INSERM UMR S 938, Universite Pierre et Marie Curie Paris 6, Paris, F 75012 France
    Orphanet J Rare Dis 5:22. 2010
    ..An overall favorable response to corticosteroid therapy is observed in around 50% of cases, often associated with sequelae such as limited exercise tolerance or the need for long-term oxygen therapy...
  7. pmc Loss-of-function mutations in RSPH1 cause primary ciliary dyskinesia with central-complex and radial-spoke defects
    Esther Kott
    INSERM UMR S933, Universite Pierre et Marie Curie Paris 6, Paris, France
    Am J Hum Genet 93:561-70. 2013
    ..RSPH1 mutations thus appear as a major etiology for this PCD phenotype, which in fact includes RS defects, thereby unveiling the importance of RSPH1 in the proper building of CCs and RSs in humans. ..
  8. pmc Loss-of-function mutations in LRRC6, a gene essential for proper axonemal assembly of inner and outer dynein arms, cause primary ciliary dyskinesia
    Esther Kott
    INSERM UMR_S933, Universite Pierre et Marie Curie Paris 6, Paris, France
    Am J Hum Genet 91:958-64. 2012
    ..The evolutionarily conserved LRRC6, therefore, emerges as an additional player in DA assembly, a process that is essential for proper axoneme building and that appears to be much more complex than was previously thought...
  9. ncbi request reprint Changes in pulmonary mechanics with increasing disease severity in children and young adults with cystic fibrosis
    Nicholas Hart
    Pediatric Pulmonary Department, Armand Trousseau Hospital AP HP INSERM E 0213, Paris
    Am J Respir Crit Care Med 166:61-6. 2002
    ..1). As FEV(1) declines in children and young adults with CF, there is an increase in the elastic load and work of breathing, resulting in a rapid shallow breathing pattern, that is associated with further impairment of gas exchange...
  10. pmc AGER -429T/C is associated with an increased lung disease severity in cystic fibrosis
    Julie Beucher
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Inserm U938, Paris, France
    PLoS ONE 7:e41913. 2012
    ..The functional promoter AGER -429C variant is associated with an increased RAGE expression that can lead to an increased lung inflammation and a more severe lung disease...
  11. doi request reprint Chronic eosinophilic pneumonia in a 13-year-old child
    Nadia Nathan
    Pediatric Pulmonary Department, AP HP, Hopital Armand Trousseau, Universite Pierre et Marie Curie Paris 6, 28 avenue du Docteur Arnold Netter, Paris, 75012, France
    Eur J Pediatr 167:1203-7. 2008
    ..Dyspnoea and cough disappeared within one week and chest CT scan showed regression of the lung infiltrates within one month. No relapse occurred during the following nine months...
  12. ncbi request reprint Respiratory muscle testing: a valuable tool for children with neuromuscular disorders
    Frederic Nicot
    AP HP, Hopital Armand Trousseau, Pediatric Pulmonary Department, Research Unit INSERM U 719, Universite Pierre et Marie Curie Paris 6, Paris, France
    Am J Respir Crit Care Med 174:67-74. 2006
    ..Data on respiratory muscle performance in children with neuromuscular disorders are limited...
  13. doi request reprint Which tests may predict the need for noninvasive ventilation in children with neuromuscular disease?
    Brigitte Fauroux
    AP HP, Hopital Armand Trousseau, Pediatric Pulmonary Department, Paris, France
    Respir Med 103:574-81. 2009
    ..Forced vital capacity (FVC) and maximal inspiratory pressure correlate with nocturnal hypoventilation in adults with neuromuscular disease, but children may not be able to perform these volitional tests...
  14. doi request reprint Interstitial lung disease: physiopathology in the context of lung growth
    Nadia Nathan
    INSERM, UMR S U938, Paris, F 75012 France
    Paediatr Respir Rev 12:216-22. 2011
    ..This article reviews recent advances in the understanding of the mechanisms involved in the pathogenesis of ILDs, and provides information on their adaptation in the context of lung growth...
  15. doi request reprint Lung sarcoidosis in children: update on disease expression and management
    Nadia Nathan
    Pediatric Pulmonary Department, AP HP, Hopital Trousseau, Paris, France Université Pierre et Marie Curie Paris6, Paris, France UMR S U933, INSERM, Paris, France
    Thorax 70:537-42. 2015
    ..Sarcoidosis is a rare lung disease in children. The aim of the present study was to provide update information on disease presentation and progression, patient management and prognosis factors in a cohort of children with lung sarcoidosis...
  16. doi request reprint Ancestral haplotype 8.1 and lung disease severity in European cystic fibrosis patients
    Harriet Corvol
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Inserm U938, Paris, France
    J Cyst Fibros 11:63-7. 2012
    ..As inflammation is a key component inducing CF lung damage, we investigated whether the 8.1AH represents a lung function modifier in CF...
  17. pmc New insights into pediatric idiopathic pulmonary hemosiderosis: the French RespiRare(®) cohort
    Jessica Taytard
    Pediatric Pulmonary Department, AP HP, Hopital Trousseau, Universite Pierre et Marie Curie PARIS6, Inserm U938, 26, avenue du Docteur Arnold Netter, 75012 Paris, France
    Orphanet J Rare Dis 8:161. 2013
    ..We present the French pediatric cohort of IPH collected through the French Reference Center for Rare Lung Diseases (RespiRare®, http://www.respirare.fr)...
  18. ncbi request reprint Noninvasive positive pressure ventilation in infants with upper airway obstruction: comparison of continuous and bilevel positive pressure
    Sandrine Essouri
    Pediatric Intensive Care Unit, Kremlin Bicetre Hospital, AP HP, Paris, France
    Intensive Care Med 31:574-80. 2005
    ..This study evaluated the efficacy of noninvasive continuous positive pressure (CPAP) ventilation in infants with severe upper airway obstruction and compared CPAP to bilevel positive airway pressure (BIPAP) ventilation...
  19. pmc Reference percentiles for FEV(1) and BMI in European children and adults with cystic fibrosis
    Pierre Yves Boelle
    AP HP, Hôpital Trousseau Pediatric Pulmonary Department, Hopital St Antoine Public Health Department, Paris, France
    Orphanet J Rare Dis 7:64. 2012
    ..Here, we used a large database of European CF patients to compute CF specific reference equations for FEV(1) and BMI, derived CF-specific percentile charts and compared these European data to their nearest international equivalents...
  20. doi request reprint Therapeutic strategies for idiopathic chylothorax
    Ralph Epaud
    Hopital Armand Trousseau, Universite Pierre et Marie Curie Paris 6, Paris, France
    J Pediatr Surg 43:461-5. 2008
    ..The objectives of the study were to present our institutional experience of idiopathic chylothorax in children and to propose therapeutic strategies...
  21. ncbi request reprint Physiologic benefits of mechanical insufflation-exsufflation in children with neuromuscular diseases
    Brigitte Fauroux
    Assistance Publique Hopitaux de Paris, Hopital Armand Trousseau, Pediatric Pulmonary Department, Research Unit INSERM UMR S 719, Universite Pierre et Marie Curie Paris 6, 28 Ave du Docteur Arnold Netter, Paris, F 75012 France
    Chest 133:161-8. 2008
    ..To analyze the physiologic effects and tolerance of mechanical insufflation-exsufflation (MI-E) by means of mechanical cough assistance (Cough Assist; JH Emerson Company; Cambridge, MA) for children with neuromuscular disease...
  22. ncbi request reprint Practice of noninvasive ventilation for cystic fibrosis: a nationwide survey in France
    Brigitte Fauroux
    Pediatric Pulmonary Department, Hopital Armand Trousseau, Centre de Ressources et de Compe tences pour la Mucoviscidose, Universite Pierre et Marie Curie Paris 6, Paris, France
    Respir Care 53:1482-9. 2008
    ..No guidelines are available for noninvasive ventilation (NIV) for cystic fibrosis (CF)...
  23. ncbi request reprint Lung disease in Niemann-Pick disease
    Nathalie Guillemot
    AP HP, Hopital Armand Trousseau, Pediatric Pulmonary Department, Paris, France
    Pediatr Pulmonol 42:1207-14. 2007
    ..Lung involvement in children with Niemann-Pick disease has rarely been studied systematically...
  24. doi request reprint Lung disease modifier genes in cystic fibrosis
    Loic Guillot
    INSERM, UMR_S 938, CDR Saint Antonie, Paris, France Sorbonne Universités, UPMC Univ Paris 06, UMR_S 938, CDR Saint Antonie, Paris, France Electronic address
    Int J Biochem Cell Biol 52:83-93. 2014
    ..e. the candidate gene approach; (2) a "without a priori" approach, analyzing the whole genome by linkage and genome-wide association studies (GWAS), or the whole exome by exome sequencing...
  25. doi request reprint HRCT and MRI of the lung in children with cystic fibrosis: comparison of different scoring systems
    Chiara Sileo
    AP HP, Hopital Trousseau, Pediatric Radiology Department, Paris, France Université Pierre et Marie Curie Paris 6, Paris, France
    J Cyst Fibros 13:198-204. 2014
    ....
  26. pmc A national internet-linked based database for pediatric interstitial lung diseases: the French network
    Nadia Nathan
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Paris, France
    Orphanet J Rare Dis 7:40. 2012
    ..After the launch of the French Reference Centre for Rare Lung Diseases (RespiRare®), we created a national network and a web-linked database to collect data on pediatric ILD...
  27. doi request reprint Delineation of CCDC39/CCDC40 mutation spectrum and associated phenotypes in primary ciliary dyskinesia
    Sylvain Blanchon
    Institut National de la Santé et de la Recherche Médicale UMR_S933, Universite Pierre et Marie Curie Paris 6, and Assistance Publique Hopitaux de Paris, Hopital Armand Trousseau, Service de génétique et d embryologie médicales, Paris, France
    J Med Genet 49:410-6. 2012
    ..Aiming to delineate the CCDC39/CCDC40 mutation spectrum and associated phenotypes, this study screened a large cohort of patients with IDA defects, in whom clinical and ciliary phenotypes were accurately described...
  28. ncbi request reprint Long-term noninvasive ventilation in patients with cystic fibrosis
    Brigitte Fauroux
    Pediatric Pulmonary Department, Hopital Armand Trousseau, Assistance Publique Hopitaux de Paris, INSERM UMR S 719, Universite Pierre et Marie Curie Paris 6, Paris, France
    Respiration 76:168-74. 2008
    ..The benefits of long-termnoninvasive positive pressure ventilation (NPPV) have not yet been evaluated in patients with cystic fibrosis (CF)...
  29. doi request reprint Management of primary ciliary dyskinesia: the lower airways
    Brigitte Fauroux
    AP HP, Hopital Armand Trousseau, Pediatric Pulmonary Department, Universite Pierre et Marie Curie, Research unit INSERM UMR S 893 Equipe 12, 28 avenue du Docteur Arnold Netter, Paris F 75012, France
    Paediatr Respir Rev 10:55-7. 2009
    ..Treatment of the lower airways should always be in conjunction with that of the upper airways. Importantly in PCD, respiratory disease may be controlled with the use of early, adequate and aggressive management...
  30. pmc Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis
    Ralph Epaud
    Inserm UMRS 938, Hopital Saint Antoine, Paris, France
    PLoS ONE 7:e48071. 2012
    ..Lethal respiratory failure in neonatal IGF-1R knockout mice suggested a particular role for this receptor in pulmonary development, and we therefore investigated the consequences of IGF-1R inactivation in lung tissue...
  31. doi request reprint Genetic variations in inflammatory mediators influence lung disease progression in cystic fibrosis
    Harriet Corvol
    AP HP, Hopital Trousseau, Pediatric Pulmonary Department, Paris, France
    Pediatr Pulmonol 43:1224-32. 2008
    ..These findings support the concept that TGFB1 gene variants appear to be important genetic modifiers of lung disease progression in CF...