J L Pepin
Affiliation: CHU de Grenoble
- Overdrive atrial pacing does not improve obstructive sleep apnoea syndromeJ L Pepin
Sleep Laboratory, Joseph Fourier University, Grenoble, France
Eur Respir J 25:343-7. 2005..Overdrive pacing changed none of the respiratory indices, or sleep fragmentation or sleep structure parameters. In conclusion, atrial overdrive pacing has no significant effect on obstructive sleep apnoea...
- Prevention and care of respiratory failure in obese patientsJean Louis Pepin
HP2 Laboratory, Inserm U1042, Grenoble Alpes University, Grenoble, France EFCR Laboratory, Thorax and Vessels Division, Grenoble Alpes University Hospital, Grenoble, France Electronic address
Lancet Respir Med 4:407-18. 2016..We also address other aspects of care of obese patients, including antibiotic dosing and catheter-related infections. ..
- Hypertension and sleep: overview of a tight relationshipJean Louis Pepin
HP2 Laboratory, Inserm U1042, Grenoble Alpes University, Grenoble, France Grenoble University Hospital, EFCR Laboratory, LOCOmotion, Rehabilitation and Physiology Department, Grenoble, France Electronic address
Sleep Med Rev 18:509-19. 2014..Combined sleep problems may have potential synergistic deleterious effects. ..
- Endothelial dysfunction and specific inflammation in obesity hypoventilation syndromeJean Christian Borel
INSERM ERI17, Laboratoire HP2, Universite Joseph Fourier, Faculte de Medecine, Grenoble, France
PLoS ONE 4:e6733. 2009..Obesity hypoventilation syndrome (OHS) is associated with increased cardiovascular morbidity. What moderate chronic hypoventilation adds to obesity on systemic inflammation and endothelial dysfunction remains unknown...
- Comorbidities and mortality in hypercapnic obese under domiciliary noninvasive ventilationJean Christian Borel
INSERM U 1042, HP2 Laboratory, Universite Joseph Fourier, Faculte de Medecine, Grenoble, France
PLoS ONE 8:e52006. 2013..The impacts of comorbidities, medications and NIV compliance on survival of these patients remain largely unexplored...
- Polysomnography in stable COPD under non-invasive ventilation to reduce patient-ventilator asynchrony and morning breathlessnessDan Adler
Division of Pulmonary Diseases, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, 1211, Geneva 14, Switzerland
Sleep Breath 16:1081-90. 2012..We hypothesised that in these patients, progressive hyperinflation, resulting from inappropriate ventilator settings, leads to patient-ventilator asynchrony (PVA) with a high rate of unrewarded inspiratory efforts and morning discomfort...
- A critical review of peripheral arterial tone and pulse transit time as indirect diagnostic methods for detecting sleep disordered breathing and characterizing sleep structureJean Louis Pepin
Rehabilitation and Physiology Department, Grenoble University Hospital, France
Curr Opin Pulm Med 15:550-8. 2009....
- The upper airway resistance syndromeJ L Pepin
Sleep Laboratory, EFCR, Grenoble University Hospital, Grenoble, France
Respiration 83:559-66. 2012..In this review, the authors attempt to describe the specific characteristics of UARS that are relevant for both clinicians and researchers...
- Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trialJean Christian Borel
Laboratoire EFCR, CHU de Grenoble, Grenoble Cedex 09, France
Chest 141:692-702. 2012....
- Pressure reduction during exhalation in sleep apnea patients treated by continuous positive airway pressureJean Louis Pepin
HP2 Laboratory, Institut National de la Sante et de la Recherche Medicale, Equipe Région INSERM 17, Grenoble University Hospital, Grenoble, France
Chest 136:490-7. 2009....
- Pulse transit time improves detection of sleep respiratory events and microarousals in childrenJean Louis Pepin
Department of Pediatrics and Respiratory Medicine, Intensive Care Unit and Sleep Laboratory, University Hospital, Grenoble, France
Chest 127:722-30. 2005..To evaluate the additional information provided by pulse transit time (PTT), a noninvasive tool, when using during polysomnography for the diagnosis of sleep breathing disorders in a pediatric population...
- Comparison of continuous positive airway pressure and valsartan in hypertensive patients with sleep apneaJean Louis Pepin
Rehabilitation and Physiology Department, Grenoble University Hospital, Grenoble, France
Am J Respir Crit Care Med 182:954-60. 2010..CPAP treatment has never been compared with antihypertensive medications in an RCT...
- Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre studyJ L Pepin
HP2 Laboratory Hypoxia Pathophysiology, INSERM ERI 0017, EA 3745 Joseph Fourier University, Grenoble, France
Eur Respir J 33:1062-7. 2009..As 230,000 obstructive sleep apnoea patients are currently treated in France by continuous positive airway pressure, more than 13,800 of them might suffer from residual excessive sleepiness...
- Sleep apnea diagnosis using an ECG Holter device including a nasal pressure (NP) recording: validation of visual and automatic analysis of nasal pressure versus full polysomnographyJean Louis Pepin
Cardiology Department, EFCR et Laboratoire du sommeil, Pôle Rééducation Physiologie, CHU de Grenoble, BP 217X 38043 Grenoble Cedex 09, France
Sleep Med 10:651-6. 2009..New simplified techniques for diagnosing sleep apnea should be specially tailored for easy use in cardiologic practice...
- [Influence of CPAP in inflammation and nasal obstruction]J L Pepin
Laboratoire du Sommeil, Laboratoire HP2, Inserm ESPRI 0017, Universite Joseph Fourier, 621, av Centrale, 38400 Saint Martin d Hères
Rev Mal Respir 23:7S137-7S139. 2006
- [Resistance syndrome of the upper airways: a separate entity of sleep apnea syndrome?]J L Pepin
EFCR, Laboratoire du Sommeil, Centre Hospitalier Universitaire, BP 217, 38043 Grenoble Cedex 9 Laboratoire HP2, INSERM ERI 0017
Rev Mal Respir 23:7S44-7S47. 2006
- [Periodic respiration and central sleep apnea syndrome in subjects with congestive heart disease]J L Pepin
Laboratoire du Sommeil et Département de Médecine Aiguë Spécialisée, CHU de Grenoble
Rev Mal Respir 21:S49-55. 2004
- [Tools available for the diagnosis of obstructive sleep apnea syndrome. Measurements for the evaluation of therapeutic efficacy]J L Pepin
Departement de Medecine, CHU de Grenoble, 38043 Grenoble
Rev Stomatol Chir Maxillofac 103:151-7. 2002..It should also include simplified methods or complete polysomnography to obtain a precise measurement of residual respiratory events and sleep pattern after treatment...
- [Pathophysiology of cardiovascular risk in sleep apnea syndrome (SAS)]J L Pepin
Département de Médecine aiguë spécialisée et Laboratoire de Neurophysiopathologie du sommeil et de l épilepsie Pr Lévy, CHU, Grenoble, France
Rev Neurol (Paris) 158:785-97. 2002..Very recently, epidemiological studies suggested that continuous positive pressure ventilation in SAS patients can reduce the cardiovascular risk...
- [Alveolar hypoventilation during sleep and domiciliary assisted ventilation]J L Pepin
Département de Médecine Aiguë Spécialisée, CHU, Grenoble, France
Rev Mal Respir 22:113-25. 2005..An alveolar hypoventilation physiologically occurs during sleep and more specifically during REM sleep...
- Differentiating obstructive and central sleep respiratory events through pulse transit timeJ Argod
Department of Respiratory Medicine and Sleep Laboratory, University Hospital, Grenoble, France
Am J Respir Crit Care Med 158:1778-83. 1998..8%). PTT has shown a high sensitivity and specificity in differentiating obstructive and central respiratory events, and may become the reference noninvasive tool for this purpose...
- 14 nights of intermittent hypoxia elevate daytime blood pressure and sympathetic activity in healthy humansR Tamisier
Sleep Laboratory and EFCR, Dept of Rehabilitation and Physiology, University Hospital, Grenoble, France
Eur Respir J 37:119-28. 2011..These mechanisms may reflect those underlying the blood pressure elevation associated with OSAS...
- [Surgery and obstructive sleep apnea syndrome: indications and precautions]G Bettega
Service de Chirurgie Maxillo faciale, CHU de Grenoble, B P 217, 38043 Grenoble
Rev Stomatol Chir Maxillofac 103:181-7. 2002..A considerable effort must be made in this domain...
- Management of simple snoring, upper airway resistance syndrome, and moderate sleep apnea syndromeP Levy
Sleep and Respiration Unit, Grenoble University Hospital, France
Sleep 19:S101-10. 1996..However, these conditions are likely to be particularly appropriate for randomized trials comparing different modalities of treatment that may be the only way to validate these treatment strategies...
- Critical analysis of the results of surgery in the treatment of snoring, upper airway resistance syndrome (UARS), and obstructive sleep apnea (OSA)J L Pepin
Department of Respiratory Medicine, University Hospital, Grenoble, France
Sleep 19:S90-100. 1996....
- Cognitive executive dysfunction in patients with obstructive sleep apnea syndrome (OSAS) after CPAP treatmentB Naegele
CNRS GDR 978, Department of Clinical and Biological Neurosciences, CHU, Grenoble, France
Sleep 21:392-7. 1998..In conclusion, short-term memory impairment was persistent in OSAS patients despite CPAP treatment for 4-6 months...
- [Management of central sleep apnea]I Boutin
Laboratoire du sommeil et EFCR, Pôle Rééducation et Physiologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
Rev Pneumol Clin 65:261-72. 2009..Ventilatory supports used for treating central sleep apnea are non-invasive ventilation and servo-assisted ventilation in hypercapnic and hypocapnic patients respectively...
- Leukotriene B4: early mediator of atherosclerosis in obstructive sleep apnoea?B Lefebvre
INSERM, ERI7, Centre Hospitalier Universitaire, Hopital A Michallon, BP 217, 38043 Grenoble Cedex 9, France
Eur Respir J 32:113-20. 2008..Leukotriene B(4) production is increased in obstructive sleep apnoea in relation to oxygen desaturation. Leukotriene B(4) could promote early vascular remodelling in moderate-to-severe hypoxic obstructive sleep apnoea patients...
- Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectivesP Levy
Pathophysiology Laboratory, Grenoble University, Grenoble, France
Eur Respir J 32:1082-95. 2008..Overall, chronic intermittent hypoxia appears to have specific genomic effects that differ notably from continuous hypoxia. Further research is required to fully elucidate the molecular and cellular mechanisms...
- Sleep quality, sleep duration and physical activity in obese adolescents: effects of exercise trainingM Mendelson
University Grenoble Alpes, HP2, F 38000, Grenoble, France
Pediatr Obes 11:26-32. 2016..Decreased sleep duration and altered sleep quality are risk factors for obesity in youth. Structured exercise training has been shown to increase sleep duration and improve sleep quality...
- Driving ability in sleep apnoea patients before and after CPAP treatment: evaluation on a road safety platformS Mazza
HP2 laboratory hypoxia, pathophysiology INSERM ERI 0017, Joseph Fourier University, Grenoble, France
Eur Respir J 28:1020-8. 2006..This stresses the importance of evaluating attentional parameters in apnoeic patients and of offering continuous positive airway pressure treatment even to non-sleepy subjects...
- [Lateral cephalometric radiography of the upper airways for evaluation of surgical treatment of obstructive sleep apnea syndrome]J Teitelbaum
Service de chirurgie maxillofaciale, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
Rev Stomatol Chir Maxillofac 108:13-20. 2007..We studied the prognostic value of this exploration in terms of therapeutic outcome in surgically treated patients...
- The impact of obstructive sleep apnea on homocysteine and carotid remodeling in metabolic syndromeD Monneret
Inserm U1042 HP2 Laboratory Hypoxia and Pathophysiology, Joseph Fourier University, Grenoble, France
Respir Physiol Neurobiol 180:298-304. 2012..We conclude that homocysteine level was higher in MetS when associated with OSA and proportional to OSA severity. In this context, vascular remodeling appeared more severe and mediated by oxidative stress...
- Left ventricular diastolic dysfunction is linked to severity of obstructive sleep apnoeaJ P Baguet
Dept of Cardiology, Functional Explorations Unit, University Hospital, France
Eur Respir J 36:1323-9. 2010..91) were associated with left ventricular diastolic dysfunction. Our findings demonstrate that left ventricular diastolic dysfunction frequently occurs in patients with OSA and that it is related to the severity of oxygen desaturation...
- A new model of chronic intermittent hypoxia in humans: effect on ventilation, sleep, and blood pressureR Tamisier
Laboratoire du sommeil et EFCR, Pôle Rééducation et Physiologie, CHU A Michallon, Grenoble, B P 217, 38043 Grenoble Cedex 9, France
J Appl Physiol (1985) 107:17-24. 2009..3 to 74 +/- 1.7 mmHg). We propose this model as a new technique to study the cardiovascular and metabolic consequences of CIH in human volunteers...
- Glucose tolerance and cardiovascular risk biomarkers in non-diabetic non-obese obstructive sleep apnea patients: Effects of long-term continuous positive airway pressureD Monneret
HP2 Laboratory, Inserm U1042, Grenoble Alpes University, Grenoble, France Department of Biochemistry Toxicology and Pharmacology, Biology and Pathology Institute, Grenoble University Hospital, Grenoble, France Electronic address
Respir Med 112:119-25. 2016..The effects of a long-term continuous positive airway pressure (LT-CPAP) treatment on such mechanisms still remain conflicting...
- Is sleep apnea syndrome in the elderly a specific entity?P Levy
Secteur Sommeil et Respiration, Service de Pneumologie, Grenoble, France
Sleep 19:S29-38. 1996..Further studies are needed to determine whether or not the associated morbidity is different in the elderly; these studies could lead to different diagnosis strategies and therapeutic approaches...
- A simple procedure for measuring pharyngeal sensitivity: a contribution to the diagnosis of sleep apnoeaM Dematteis
Laboratoire HP2 INSERM ESPRI EA3745, Centre Hospitalier Universitaire, Grenoble Cedex, France
Thorax 60:418-26. 2005..The accuracy of a simple new procedure to measure pharyngeal sensitivity and to diagnose sleep disordered breathing (SDB) was investigated...
- [Cardiovascular consequences of obstructive sleep apnea syndrome]J P Baguet
Service de Cardiologie et hypertension artérielle, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
Rev Med Interne 24:530-7. 2003..This article is an update of past and current data on the relationship between obstructive sleep apnea syndrome and cardiovascular diseases...
- Hypertension and obstructive sleep apnoea syndrome: current perspectivesJ P Baguet
Department of Cardiology, University Hospital, Grenoble, France
J Hum Hypertens 23:431-43. 2009..Optimal treatment for HT associated with OSAS has not been evidenced. Antihypertensive drugs do not change the respiratory parameters during OSAS...
- Increased lipid peroxidation in patients with pulmonary hypertensionJ L Cracowski
Laboratoire de Pharmacologie, and Département de Médecine Aiguë Spécialisée, Grenoble University Hospital, Grenoble, France
Am J Respir Crit Care Med 164:1038-42. 2001..Furthermore, iPF(2alpha)-III levels inversely correlate to pulmonary vasoreactivity. These observations are consistent with the hypothesis that free radical generation is involved in PHT pathogenesis...
- Non-arteritic anterior ischaemic optic neuropathy is nearly systematically associated with obstructive sleep apnoeaK Palombi
Department of Ophthalmology, University Hospital, Grenoble, France
Br J Ophthalmol 90:879-82. 2006..To evaluate newly diagnosed non-arteritic anterior ischaemic optic neuropathy (NAION) patients for the existence of an associated sleep apnoea syndrome...
- [Obstructive sleep apnea syndrome]N Chouri-Pontarollo
Laboratoire du sommeil et EFCR, Département de Médecine Aiguë Spécialisée, CHU de Grenoble
Presse Med 34:1533-40. 2005..Prosthetic management is an alternative to CPAP in cases of moderate sleep apnea with or without retrognathism in normal-weight patients. The effectiveness of surgery has not been proven, and it is indicated only in exceptional cases...
- [Nyctohemeral variations in intraocular pressure]J P Romanet
Service d Ophtalmologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
J Fr Ophtalmol 27:2S19-2S26. 2004..Lowering IOP is still the only option that is available for treating patients with glaucoma. Variations encountered in the individual's nyctohemeral IOP pattern must be taken into consideration to provide the most effective treatment...
- [Clinical protocols for therapy of obstructive sleep apnea syndrome: the role of the stomatologist]G Bettega
Service de Chirurgie Maxillo faciale, CHU de Grenoble, BP 217, 38043 Grenoble
Rev Stomatol Chir Maxillofac 103:188-9. 2002
- Respiratory muscle endurance training in obese patientsJ C Villiot-Danger
HP2 Laboratory, INSERM ERI17, Joseph Fourier University, Grenoble, France
Int J Obes (Lond) 35:692-9. 2011..We evaluated the effect of respiratory muscle endurance training (RMET) on respiratory muscle capacities, symptoms and exercise capacity in obese patients...
- [Obstructive sleep-apnoea syndrome in adult and its perioperative management]J F Payen
Pôle d Anesthésie Réanimation, Hopital Michallon, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
Ann Fr Anesth Reanim 29:787-92. 2010..Alternatives to opioids should be promoted for postoperative pain control...
- [Imaging in obstructive sleep apnea syndrome]G Ferretti
Service Central de Radiologie et Imagerie Médicale Centre Hospitalier Universitaire, Grenoble BP 217 F 38043 Grenoble, France
Rev Neurol (Paris) 157:S78-81. 2001....
- Fixed-pressure CPAP versus auto-adjusting CPAP: comparison of efficacy on blood pressure in obstructive sleep apnoea, a randomised clinical trialJ L Pepin
University of Grenoble Alpes, HP2 INSERM, U1042, Grenoble, France CHU de Grenoble, Laboratoire EFCR, Pôle thorax et vaisseaux, Grenoble, France
Thorax 71:726-33. 2016..However, evidence is scarce concerning the impact of different CPAP modalities on BP evolution...
- Impact of exercise training without caloric restriction on inflammation, insulin resistance and visceral fat mass in obese adolescentsM Mendelson
Univ Grenoble Alpes, HP2 F 38000, Grenoble, France
Pediatr Obes 10:311-9. 2015..Exercise training has been shown to improve cardiometabolic health in obese adolescents...
- [Cardiovascular morbidity associated with obstructive sleep apnea syndrome]M Destors
Laboratoire HP2, Université Grenoble Alpes, 38000 Grenoble, France Laboratoire Inserm U1042, 38000 Grenoble, France Clinique de pneumologie, CHU de Grenoble, 38000 Grenoble, France Electronic address
Rev Mal Respir 31:375-85. 2014..The obstructive sleep apnoea syndrome (OSAS) had become a major public health concern in modern society due to its high prevalence but, above all, to its associated morbidity, especially cardiovascular...
- Deficits of cognitive executive functions in patients with sleep apnea syndromeB Naegele
Department of Clinical and Biological Neurosciences, CHU, Grenoble, France
Sleep 18:43-52. 1995....
- [Can mandibular advancement prosthesis be used in the treatment of sleep apnea syndrome? Arguments against]J L Pepin
Service d Explorations Fonctionnelles Respiratoires, CHU de Grenoble, La Tronche, France
Rev Mal Respir 21:213-4. 2004
- Identification of quality of life concerns of patients with obstructive sleep apnoea at the time of initiation of continuous positive airway pressure: a discourse analysisD Veale
Sleep Laboratory, CHU Grenoble, Centre Pneumologie, Henri Bazire, France
Qual Life Res 11:389-99. 2002..Thus many worries and concerns of patients remain hidden. Treatment by nasal continuous positive airway pressure (CPAP) can be imposing for the individual. An analysis of the freely expressed concerns of such patients is required...
- 8C.08: CONTINUOUS POSITIVE AIRWAY PRESSURE IS EFFICIENT TO DECREASE BLOOD PRESSURE IN PATIENTS WITH RESISTANT HYPERTENSION. RESULTS FROM THE RHOOSAS STUDYJ P Baguet
1Mutualist Hospital Group, Grenoble, FRANCE 2University Hospital, Poitiers, FRANCE 3University Hospital, Lille, FRANCE 4University Hospital, Grenoble, France
J Hypertens 33:e112. 2015..Most of patients suffering from resistant hypertension (HTN) have obstructive sleep apnea (OSA). Little data are available to confirm or not the efficacy of continuous positive airway pressure (CPAP) on blood pressure (BP) in resistant HTN...
- Effect of autonomic blockade on heart rate and blood pressure in sleep apnea syndromeB Januel
Laboratoire du Sommeil, INSERM CJF 89 09, Hopital A Beclere, Clamart, France
Blood Press 4:226-31. 1995..9 +/- 1.9 bpm) and at RB (75.9 +/- 1.9 vs 81.6 +/- 1.8). With A, the rise in HR at end-apnea (P3) suggests a vagal hyperactivity during this phase which is blunted at resumption when HR is unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)..