Affiliation: CHU de Grenoble
- Sleep, sleep-disordered breathing and metabolic consequencesP Levy
INSERM ERI 17, HP2 Laboratory, Joseph Fourier University and Sleep Laboratory, EFCR, Pôle Rééducation et Physiologie, CHU Grenoble, Grenoble, France
Eur Respir J 34:243-60. 2009..Molecular and cellular mechanisms are currently being investigated...
- [Surviving sleep: when the heart and brain are damaged by apnea]Patrick Levy
Exploration fonctionnelle cardio respiratoire et Laboratoire du sommeil Pôl de locomotion rééducation et physiologie CHU de Grenoble 38043 Grenoble cédex
Bull Acad Natl Med 195:1611-28; discussion 1628-34. 2011..Continuous positive airway pressure (CPAP) has been the first-line treatment for the last 30 years, and partly prevents the excess cardiovascular morbidity and mortality...
- Sleep deprivation, sleep apnea and cardiovascular diseasesPatrick Levy
INSERM U 1042, Hypoxia PathoPhysiology Laboratory, Joseph Fourier University, Grenoble, France
Front Biosci (Elite Ed) 4:2007-21. 2012..Whether treating sleep apnea enables the reversal of chronic cardiovascular and metabolic consequences of OSA, remains to be studied in adequately designed studies, particularly in comparison with usual treatment strategies...
- Intermittent hypoxia and sleep-disordered breathing: current concepts and perspectivesP Levy
Pathophysiology Laboratory, Grenoble University, Grenoble, France
Eur Respir J 32:1082-95. 2008..Overall, chronic intermittent hypoxia appears to have specific genomic effects that differ notably from continuous hypoxia. Further research is required to fully elucidate the molecular and cellular mechanisms...
- Obstructive sleep apnea and atherosclerosisPatrick Levy
HP2 Laboratory, INSERM ERI17, Joseph Fourier University, Grenoble, France
Prog Cardiovasc Dis 51:400-10. 2009..Further studies are needed to identify at-risk subjects prone to develop vascular changes because OSA treatment may either be initiated earlier or combined with specific drug treatments...
- Should all sleep apnoea patients be treated? YesPatrick Levy
Department of Respiratory Medicine and Sleep Laboratory, PRETA Laboratory TIMC UMR CNRS 5525, University Hospital, Grenoble, France
Sleep Med Rev 6:17-26; discussion 27. 2002..Moreover, there is increasing evidence that the cardiovascular risk has to be taken into account when deciding on treatment, even in asymptomatic patients. All this evidence put together suggests early treatment in OSA...
- [Obstructive sleep apnea syndrome]Patrick Levy
Laboratoire du sommeil et d explorations fonctionnelles cardiorespiratoires, Pôle Rééducation et Physiologie, CHU Grenoble, 38043 Grenoble Cedex 09
Rev Prat 57:1569-80. 2007..Surgical treatment remains poorly efficient and is of limited use in OSA. Lastly, pharmacological developments are currently being evaluated regarding symptoms such as sleepiness or comorbidities...
- Cognitive executive dysfunction in patients with obstructive sleep apnea syndrome (OSAS) after CPAP treatmentB Naegele
CNRS GDR 978, Department of Clinical and Biological Neurosciences, CHU, Grenoble, France
Sleep 21:392-7. 1998..In conclusion, short-term memory impairment was persistent in OSAS patients despite CPAP treatment for 4-6 months...
- Prevalence of residual excessive sleepiness in CPAP-treated sleep apnoea patients: the French multicentre studyJ L Pepin
HP2 Laboratory Hypoxia Pathophysiology, INSERM ERI 0017, EA 3745 Joseph Fourier University, Grenoble, France
Eur Respir J 33:1062-7. 2009..As 230,000 obstructive sleep apnoea patients are currently treated in France by continuous positive airway pressure, more than 13,800 of them might suffer from residual excessive sleepiness...
- 14 nights of intermittent hypoxia elevate daytime blood pressure and sympathetic activity in healthy humansR Tamisier
Sleep Laboratory and EFCR, Dept of Rehabilitation and Physiology, University Hospital, Grenoble, France
Eur Respir J 37:119-28. 2011..These mechanisms may reflect those underlying the blood pressure elevation associated with OSAS...
- Sleep quality, sleep duration and physical activity in obese adolescents: effects of exercise trainingM Mendelson
University Grenoble Alpes, HP2, F 38000, Grenoble, France
Pediatr Obes 11:26-32. 2016..Decreased sleep duration and altered sleep quality are risk factors for obesity in youth. Structured exercise training has been shown to increase sleep duration and improve sleep quality...
- Differentiating obstructive and central sleep respiratory events through pulse transit timeJ Argod
Department of Respiratory Medicine and Sleep Laboratory, University Hospital, Grenoble, France
Am J Respir Crit Care Med 158:1778-83. 1998..8%). PTT has shown a high sensitivity and specificity in differentiating obstructive and central respiratory events, and may become the reference noninvasive tool for this purpose...
- The upper airway resistance syndromeJ L Pepin
Sleep Laboratory, EFCR, Grenoble University Hospital, Grenoble, France
Respiration 83:559-66. 2012..In this review, the authors attempt to describe the specific characteristics of UARS that are relevant for both clinicians and researchers...
- Glucose tolerance and cardiovascular risk biomarkers in non-diabetic non-obese obstructive sleep apnea patients: Effects of long-term continuous positive airway pressureD Monneret
HP2 Laboratory, Inserm U1042, Grenoble Alpes University, Grenoble, France Department of Biochemistry Toxicology and Pharmacology, Biology and Pathology Institute, Grenoble University Hospital, Grenoble, France Electronic address
Respir Med 112:119-25. 2016..The effects of a long-term continuous positive airway pressure (LT-CPAP) treatment on such mechanisms still remain conflicting...
- Exhaled nitric oxide in single and repetitive prolonged exerciseS Verges
HP2 Laboratory, Department of Medicine, Joseph Fourier University, La Tronche, France
J Sports Sci 24:1157-63. 2006..However, repetitive exercises (at least every 24 h) allow complete NO recovery from one session to another. The implication of such a decrease in NO availability within the lung remains to be clarified...
- The impact of obstructive sleep apnea on homocysteine and carotid remodeling in metabolic syndromeD Monneret
Inserm U1042 HP2 Laboratory Hypoxia and Pathophysiology, Joseph Fourier University, Grenoble, France
Respir Physiol Neurobiol 180:298-304. 2012..We conclude that homocysteine level was higher in MetS when associated with OSA and proportional to OSA severity. In this context, vascular remodeling appeared more severe and mediated by oxidative stress...
- A new model of chronic intermittent hypoxia in humans: effect on ventilation, sleep, and blood pressureR Tamisier
Laboratoire du sommeil et EFCR, Pôle Rééducation et Physiologie, CHU A Michallon, Grenoble, B P 217, 38043 Grenoble Cedex 9, France
J Appl Physiol (1985) 107:17-24. 2009..3 to 74 +/- 1.7 mmHg). We propose this model as a new technique to study the cardiovascular and metabolic consequences of CIH in human volunteers...
- [Management of central sleep apnea]I Boutin
Laboratoire du sommeil et EFCR, Pôle Rééducation et Physiologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
Rev Pneumol Clin 65:261-72. 2009..Ventilatory supports used for treating central sleep apnea are non-invasive ventilation and servo-assisted ventilation in hypercapnic and hypocapnic patients respectively...
- Impact of exercise training without caloric restriction on inflammation, insulin resistance and visceral fat mass in obese adolescentsM Mendelson
Univ Grenoble Alpes, HP2 F 38000, Grenoble, France
Pediatr Obes 10:311-9. 2015..Exercise training has been shown to improve cardiometabolic health in obese adolescents...
- Deficits of cognitive executive functions in patients with sleep apnea syndromeB Naegele
Department of Clinical and Biological Neurosciences, CHU, Grenoble, France
Sleep 18:43-52. 1995....
- Driving ability in sleep apnoea patients before and after CPAP treatment: evaluation on a road safety platformS Mazza
HP2 laboratory hypoxia, pathophysiology INSERM ERI 0017, Joseph Fourier University, Grenoble, France
Eur Respir J 28:1020-8. 2006..This stresses the importance of evaluating attentional parameters in apnoeic patients and of offering continuous positive airway pressure treatment even to non-sleepy subjects...
- Non-arteritic anterior ischaemic optic neuropathy is nearly systematically associated with obstructive sleep apnoeaK Palombi
Department of Ophthalmology, University Hospital, Grenoble, France
Br J Ophthalmol 90:879-82. 2006..To evaluate newly diagnosed non-arteritic anterior ischaemic optic neuropathy (NAION) patients for the existence of an associated sleep apnoea syndrome...
- Time-dependent effect of acute hypoxia on corticospinal excitability in healthy humansT Rupp
HP2 Laboratory, Joseph Fourier University and CHU Grenoble, Grenoble, France
J Neurophysiol 108:1270-7. 2012..The impact of these cortical changes on physical or psychomotor performances needs to be elucidated to better understand the cerebral effects of hypoxemia...
- Critical analysis of the results of surgery in the treatment of snoring, upper airway resistance syndrome (UARS), and obstructive sleep apnea (OSA)J L Pepin
Department of Respiratory Medicine, University Hospital, Grenoble, France
Sleep 19:S90-100. 1996....
- Can crossover and maximal fat oxidation rate points be used equally for ergocycling and walking/running on a track?M Mendelson
Joseph Fourier University, Hypoxia Physiopathology laboratory, 38000 Grenoble, France
Diabetes Metab 38:264-70. 2012....
- [Obstructive sleep-apnoea syndrome in adult and its perioperative management]J F Payen
Pôle d Anesthésie Réanimation, Hopital Michallon, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
Ann Fr Anesth Reanim 29:787-92. 2010..Alternatives to opioids should be promoted for postoperative pain control...
- [Cardiovascular consequences of obstructive sleep apnea syndrome]J P Baguet
Service de Cardiologie et hypertension artérielle, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 09, France
Rev Med Interne 24:530-7. 2003..This article is an update of past and current data on the relationship between obstructive sleep apnea syndrome and cardiovascular diseases...
- [Influence of CPAP in inflammation and nasal obstruction]J L Pepin
Laboratoire du Sommeil, Laboratoire HP2, Inserm ESPRI 0017, Universite Joseph Fourier, 621, av Centrale, 38400 Saint Martin d Hères
Rev Mal Respir 23:7S137-7S139. 2006
- [Imaging in obstructive sleep apnea syndrome]G Ferretti
Service Central de Radiologie et Imagerie Médicale Centre Hospitalier Universitaire, Grenoble BP 217 F 38043 Grenoble, France
Rev Neurol (Paris) 157:S78-81. 2001....
- [Tools available for the diagnosis of obstructive sleep apnea syndrome. Measurements for the evaluation of therapeutic efficacy]J L Pepin
Departement de Medecine, CHU de Grenoble, 38043 Grenoble
Rev Stomatol Chir Maxillofac 103:151-7. 2002..It should also include simplified methods or complete polysomnography to obtain a precise measurement of residual respiratory events and sleep pattern after treatment...
- [Resistance syndrome of the upper airways: a separate entity of sleep apnea syndrome?]J L Pepin
EFCR, Laboratoire du Sommeil, Centre Hospitalier Universitaire, BP 217, 38043 Grenoble Cedex 9 Laboratoire HP2, INSERM ERI 0017
Rev Mal Respir 23:7S44-7S47. 2006
- Fixed-pressure CPAP versus auto-adjusting CPAP: comparison of efficacy on blood pressure in obstructive sleep apnoea, a randomised clinical trialJ L Pepin
University of Grenoble Alpes, HP2 INSERM, U1042, Grenoble, France CHU de Grenoble, Laboratoire EFCR, Pôle thorax et vaisseaux, Grenoble, France
Thorax 71:726-33. 2016..However, evidence is scarce concerning the impact of different CPAP modalities on BP evolution...
- Overdrive atrial pacing does not improve obstructive sleep apnoea syndromeJ L Pepin
Sleep Laboratory, Joseph Fourier University, Grenoble, France
Eur Respir J 25:343-7. 2005..Overdrive pacing changed none of the respiratory indices, or sleep fragmentation or sleep structure parameters. In conclusion, atrial overdrive pacing has no significant effect on obstructive sleep apnoea...
- Is sleep apnea syndrome in the elderly a specific entity?P Levy
Secteur Sommeil et Respiration, Service de Pneumologie, Grenoble, France
Sleep 19:S29-38. 1996..Further studies are needed to determine whether or not the associated morbidity is different in the elderly; these studies could lead to different diagnosis strategies and therapeutic approaches...
- [Pathophysiology of cardiovascular risk in sleep apnea syndrome (SAS)]J L Pepin
Département de Médecine aiguë spécialisée et Laboratoire de Neurophysiopathologie du sommeil et de l épilepsie Pr Lévy, CHU, Grenoble, France
Rev Neurol (Paris) 158:785-97. 2002..Very recently, epidemiological studies suggested that continuous positive pressure ventilation in SAS patients can reduce the cardiovascular risk...
- Left ventricular diastolic dysfunction is linked to severity of obstructive sleep apnoeaJ P Baguet
Dept of Cardiology, Functional Explorations Unit, University Hospital, France
Eur Respir J 36:1323-9. 2010..91) were associated with left ventricular diastolic dysfunction. Our findings demonstrate that left ventricular diastolic dysfunction frequently occurs in patients with OSA and that it is related to the severity of oxygen desaturation...
- Impact of salbutamol on muscle metabolism assessed by ³¹P NMR spectroscopyN Decorte
HP2 Laboratory, Grenoble Alpes University, Grenoble, France
Scand J Med Sci Sports 25:e267-73. 2015..Other mechanisms than changes in muscle metabolism may be responsible for the ergogenic effect of salbutamol administration. ..
- [Alveolar hypoventilation during sleep and domiciliary assisted ventilation]J L Pepin
Département de Médecine Aiguë Spécialisée, CHU, Grenoble, France
Rev Mal Respir 22:113-25. 2005..An alveolar hypoventilation physiologically occurs during sleep and more specifically during REM sleep...
- Identification of quality of life concerns of patients with obstructive sleep apnoea at the time of initiation of continuous positive airway pressure: a discourse analysisD Veale
Sleep Laboratory, CHU Grenoble, Centre Pneumologie, Henri Bazire, France
Qual Life Res 11:389-99. 2002..Thus many worries and concerns of patients remain hidden. Treatment by nasal continuous positive airway pressure (CPAP) can be imposing for the individual. An analysis of the freely expressed concerns of such patients is required...