Affiliation: CHU de Bordeaux
- Factors predictive of medication nonadherence after renal transplantation: a French observational studyLionel Couzi
CHU de Bordeaux, Hopital Pellegrin, Service de Nephrologie et Transplantation Renale, Bordeaux, France
Transplantation 95:326-32. 2013..The objective of this study was to prospectively evaluate the rate of and risk factors for NA in a French cohort of KTRs...
- Preemptive therapy versus valgancyclovir prophylaxis in cytomegalovirus-positive kidney transplant recipients receiving antithymocyte globulin inductionL Couzi
Service de Néphrologie Transplantation, Centre Hospitalier Universitaire, Hopital Pellegrin, Bordeaux, France
Transplant Proc 44:2809-13. 2012..In light of this study, preemptive therapy and universal prophylaxis were almost equally effective to prevent CMV infection among R+ KTR receiving ATG induction...
- High incidence of anticytomegalovirus drug resistance among D+R- kidney transplant recipients receiving preemptive therapyL Couzi
Centre Hospitalier Universitaire de Bordeaux, Hopital Pellegrin, 33076 Bordeaux, France
Am J Transplant 12:202-9. 2012..02). In summary, preemptive therapy in D+R- KTR with high CMV loads and antiviral treatment failure was associated with a high incidence of anti-CMV drug resistance...
- Interpretation of positive flow cytometric crossmatch in the era of the single-antigen bead assayLionel Couzi
CHU Bordeaux, Hopital Pellegrin, Nephrology, Place Amelie Raba Leon, Bordeaux, France
Transplantation 91:527-35. 2011..Prognosis of renal transplants with positive flow cytometric crossmatch (FCXM) remains controversial...
- An unusual endocarditis-induced crescentic glomerulonephritis treated by plasmapheresisL Couzi
Departement de Nephrologie, Hopital Pellegrin, France
Clin Nephrol 62:461-4. 2004..In very few cases, plasmapheresis was successfully used for the treatment of infective endocarditis-induced crescentic glomerulonephritis. The pathophysiology and the potential efficiency of plasmapheresis are discussed...
- The immunosuppressor mycophenolic acid kills activated lymphocytes by inducing a nonclassical actin-dependent necrotic signalBenjamin Chaigne-Delalande
Universite de Bordeaux 2, Bordeaux, France
J Immunol 181:7630-8. 2008..In addition to its medical interest, this study sheds light on a novel and atypical molecular mechanism leading to necrotic cell death...
- Common features of gammadelta T cells and CD8(+) alphabeta T cells responding to human cytomegalovirus infection in kidney transplant recipientsLionel Couzi
Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
J Infect Dis 200:1415-24. 2009..The anti-CMV function of these cells was previously demonstrated by their ability to kill CMV-infected cells in vitro...
- Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa)Lionel Couzi
Universite de Bordeaux, Bordeaux, France
Blood 119:1418-27. 2012..Taken together, these data identify a new antiviral function for γδ T cells through cooperation with anti-HCMV IgG that could contribute to surveillance of HCMV reactivation in transplant recipients...
- Therapeutic management of de novo urological malignancy in renal transplant recipients: the experience of the French Department of Urology and Kidney Transplantation from BordeauxHicham Elkentaoui
Department of Urology, Centre Hospitalo Universitaire Pellegrin Tripode, 33000, Bordeaux, France
Urology 75:126-32. 2010..To determine and analyze the incidence, prognosis, and therapeutic strategy of de novo urological malignancies in a series of renal transplant recipients (RTRs)...
- Cytomegalovirus-responsive γδ T cells: novel effector cells in antibody-mediated kidney allograft microcirculation lesionsThomas Bachelet
University of Bordeaux, Mixte Research Unit 5164, Bordeaux, France National Center for Scientific Research CNRS, Bordeaux, France and Department of Nephrology, Transplantation, and Dialysis
J Am Soc Nephrol 25:2471-82. 2014..Moreover, these findings offer a new physiopathologic link between cytomegalovirus infection and allograft dysfunction in recipients with donor-specific antibodies. ..
- Clinical impact of preformed donor-specific denatured class I HLA antibodies after kidney transplantationJonathan Visentin
Laboratoire d Immunologie et Immunogénétique, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, France UMR CNRS 5164, Universite de Bordeaux, Bordeaux, France
Clin Transplant 29:393-402. 2015..Therefore, both anti-dHLA DSA and SAFB+/iBeads- DSA appear irrelevant, which could explain the good outcome observed in some patients with preformed class I DSA...
- The complement interference phenomenon as a cause for sharp fluctuations of serum anti-HLA antibody strength in kidney transplant patientsGwendaline Guidicelli
Laboratoire d Immunologie et Immunogénétique, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, France Electronic address
Transpl Immunol 29:17-21. 2013..A prospective pre-transplant crossmatch still remains an ultimate safeguard...
- Immunological monitoring of calcineurin inhibitors for predicting cytomegalovirus infection in kidney transplant recipientsLionel Couzi
Service de Nephrologie, CHU Bordeaux, Hopital Pellegrin, CNRS UMR 5164, 146 rue Leo Saignat, Universite Bordeaux 2, INSERM U897, 146, rue Leo Saignat, Bordeaux, France
Transplantation 86:1060-7. 2008..Measurement of the biological effects of CNI could provide clues to identify overimmunosuppressed kidney transplant recipients (KTR) who would subsequently develop CMV infection...
- Reassessment of T Lymphocytes Crossmatches Results Prediction With Luminex Class I Single Antigen Flow Beads AssayJonathan Visentin
1 Laboratoire d Immunologie et Immunogénétique, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, France 2 UMR 5164 CNRS, Université Bordeaux Segalen, Bordeaux, France 3 One Lambda, Inc, Canoga Park, CA 4 Service de Néphrologie, Transplantation, Dialyse, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, France
Transplantation . 2016....
- Evaluation of the iBeads assay as a tool for identifying class I HLA antibodiesJonathan Visentin
Laboratoire d Immunologie et Immunogénétique, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, France UMR CNRS 5164, Universite de Bordeaux, Bordeaux, France
Hum Immunol 76:651-6. 2015..6% negative predictive value and 0.08 negative likelihood ratio. The iBeads assay still has limitations, but might represent an invaluable alternative to SAFB for virtual crossmatch strategies in organ transplant allocation programs. ..
- Intravenous immunoglobulins and rituximab therapy for severe transplant glomerulopathy in chronic antibody-mediated rejection: a pilot studyThomas Bachelet
Unite de Transplantation, Service de Nephrologie, Transplantation, Dialyse, CHU de Bordeaux, Bordeaux, France UMR 5164, CNRS, Bordeaux, France Université de Bordeaux, Bordeaux, France
Clin Transplant 29:439-46. 2015..03). Taken together, IVIG/RTX treatment for severe TG during chronic antibody-mediated rejection does not seem to change the natural history of TG and is associated with a high incidence of adverse events...
- Variability and recombination of clinical human cytomegalovirus strains from transplantation recipientsMuriel Faure-Della Corte
PRES Université de Bordeaux, Laboratoire de Virologie EA2968 and IFR66, 33076 Bordeaux, France
J Clin Virol 47:161-9. 2010..Human cytomegalovirus (HCMV) is the first cause of viral infection in immunocompromised transplanted patients...
- Long-term expansion of effector/memory Vdelta2-gammadelta T cells is a specific blood signature of CMV infectionVincent Pitard
Universite Bordeaux 2, Bordeaux, France
Blood 112:1317-24. 2008..In conclusion, the increased level of effector-memory Vdelta2- gammadelta T cells in the peripheral blood is a specific signature of an adaptive immune response to CMV infection of both immunocompetent and immunosuppressed patients...
- Cytomegalovirus-induced gammadelta T cells associate with reduced cancer risk after kidney transplantationLionel Couzi
Centre National de la Recherche Scientifique Unite Mixte de Recherche 5164, Universite Victor Segalen Bordeaux 2, Bordeaux, France
J Am Soc Nephrol 21:181-8. 2010..In summary, these results suggest a protective role of CMV exposure against cancer in kidney transplant recipients...
- Deciphering IgM interference in IgG anti-HLA antibody detection with flow beads assaysJonathan Visentin
CHU de Bordeaux, Laboratoire d Immunologie et Immunogénétique, Hopital Pellegrin, Bordeaux, France Université de Bordeaux, UMR CNRS, 5164 Talence, France
Hum Immunol 77:1048-1054. 2016..Therefore, three mechanisms can explain the IgM interference for IgG anti-HLA antibodies in flow beads assays: direct competition for antigen, steric hindrance and complement activation...
- Non-Complement-Binding De Novo Donor-Specific Anti-HLA Antibodies and Kidney Allograft SurvivalGwendaline Guidicelli
Departments of Immunology, Bordeaux University, Bordeaux, France National Center for Scientific Research CNRS, UMR 5164, Bordeaux, France
J Am Soc Nephrol 27:615-25. 2016..In conclusion, C1q-binding de novo DSA are associated with graft loss occurring quickly after their appearance. However, the long-term persistence of C1q-nonbinding de novo DSA could lead to lower graft survival. ..
- Long-term outcome on renal replacement therapy in patients who previously received a keto acid-supplemented very-low-protein dietPhilippe Chauveau
Department of Nephrology, Centre Hospitalier Universitaire and University Bordeaux II, Bordeaux, France
Am J Clin Nutr 90:969-74. 2009..The consequences of a supplemented very-low-protein diet remain a matter of debate with regard to patient outcome before or after the onset of renal replacement therapy...
- IgE Inhibits Toll-like Receptor 7- and Toll-like Receptor 9-Mediated Expression of Interferon-α by Plasmacytoid Dendritic Cells in Patients With Systemic Lupus ErythematosusLiliane Khoryati
Université de Bordeaux and Immuno ConcEpT, CNRS UMR 5164, Bordeaux, France
Arthritis Rheumatol 68:2221-31. 2016..These receptors use the γ-chain of high-affinity Fc receptor (FcR) for IgE, FcɛRI. We undertook this study to test our hypothesis that IgE engagement of FcɛRI on PDCs may impact IFNα production in SLE patients...
- Deleterious Impact of Donor-Specific Anti-HLA Antibodies Toward HLA-Cw and HLA-DP in Kidney TransplantationThomas Bachelet
1 Service de Néphrologie, Transplantation, Dialyse, CHU Bordeaux, Bordeaux, France 2 UMR CNRS 5164, CNRS, Bordeaux, France 3 Department of Nephrology and Organ Transplantation CHU Rangueil, Toulouse, France 4 Laboratoire d Immunologie et Immunogénétique, CHU Bordeaux, France 5 Laboratoire d Anatomie Pathologique, CHU Bordeaux, France 6 Department of Immunology, CHU Rangueil, Toulouse, France 7 INSERM U1043, IFR BMT, Toulouse, France
Transplantation 100:159-66. 2016..However, in many transplant programs, preformed anti-HLA-Cw and anti-HLA-DP DSA are not considered in organ allocation policies because their clinical relevance is still uncertain...
- Denatured class I human leukocyte antigen antibodies in sensitized kidney recipients: prevalence, relevance, and impact on organ allocationJonathan Visentin
1 Laboratoire d Immunologie et Immunogénétique, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, France 2 UMR CNRS 5164, Universite de Bordeaux, Bordeaux, France 3 Agence de la Biomédecine, Saint Denis La Plaine, France 4 One Lambda, Inc, Canoga Park, CA 5 Laboratoire d histocompatibilité, Etablissement Français du Sang, Lyon, France 6 Service de Néphrologie, Transplantation, Dialyse, Hopital Pellegrin, CHU de Bordeaux, Bordeaux, France 7 Address correspondence to Jean Luc Taupin, Pharm D, Ph D, Laboratoire d Immunologie et Immunogénétique, Hopital Pellegrin, CHU de Bordeaux, Place Amelie Raba Leon, 33076 Bordeaux Cedex, France
Transplantation 98:738-44. 2014..Single antigen flow beads assays may overestimate sensitization because of the detection of supposedly irrelevant antibodies recognizing denatured class I human leukocyte antigens (HLAs)...
- Laparoscopic radical prostatectomy in renal transplant recipientsGregoire Robert
Department of Urology, Bordeaux University Hospital, Bordeaux, France
Urology 74:683-7. 2009..Retropubic radical prostatectomy has widely been described in RTR, whereas LRP has rarely been studied...
- Variability of UL18, UL40, UL111a and US3 immunomodulatory genes among human cytomegalovirus clinical isolates from renal transplant recipientsIsabelle Garrigue
Universite Bordeaux 2, Laboratoire de Virologie EA2968 and IFR66, 146 rue Leo Saignat, 33 076, Bordeaux Cedex, France
J Clin Virol 40:120-8. 2007..Variability of human cytomegalovirus (HCMV) genes counteracting immune responses is poorly investigated in non-cultured clinical strains...
- Prediction of cytomegalovirus (CMV) plasma load from evaluation of CMV whole-blood load in samples from renal transplant recipientsIsabelle Garrigue
Universite Victor Segalen Bordeaux 2, Laboratoire de Virologie EA2968, 146 rue Leo Saignat, 33 076 Bordeaux Cedex, France
J Clin Microbiol 46:493-8. 2008..WB seems to be an appropriate candidate for routine CMV monitoring of transplant recipients by using a single assay...
- [Analysis of hemodialysis and graft representations in patients with chronic renal failure: an anthropological approach]Aurélie Desseix
EA2963, laboratoire d ethnologie Anthropologie des traditions orales et du temps, Universite Victor Segalen Bordeaux 2, 3, ter Place de la Victoire, 33076 Bordeaux Cedex, France
Nephrol Ther 6:111-20. 2010....
- UL40 human cytomegalovirus variability evolution patterns over time in renal transplant recipientsIsabelle Garrigue
Universite Bordeaux 2, Laboratoire de Virologie EA2968 and IFR66, F 33 076 Bordeaux, France
Transplantation 86:826-35. 2008..One of HCMV immunomodulatory genes, UL40, confers HCMV-infected cells' protection from natural killer-mediated lysis through its encoded nonapeptide presented in the context of human leukocyte antigen-E...
- New molecular assays to predict occurrence of cytomegalovirus disease in renal transplant recipientsI Pellegrin
Laboratoire de Virologie, Centre Hospitalier Régional Hôpital Pellegrin, Place Amelie Raba Leon, 33 076 Bordeaux Cedex, France
J Infect Dis 182:36-42. 2000..PBL assays appear to be more appropriate than plasma assays when pre-emptive therapy is required to prevent the rapid progression from the first detection of the virus to CMV disease...
- TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillanceFlorent Guerville
Bordeaux University CIRID Bordeaux, France CNRS, UMR 5164, Bordeaux, France Nephrology and Renal Transplantation Department Bordeaux University Hospital Bordeaux, France
Oncoimmunology 4:e1003011. 2015....
- Inherited deficiency of membrane cofactor protein expression and varying manifestations of recurrent atypical hemolytic uremic syndrome in a sibling pairLionel Couzi
CHU Bordeaux, Hopital Pellegrin, Bordeaux, France
Am J Kidney Dis 52:e5-9. 2008..In conclusion, we describe for the first time a disease-free individual with complete CD46 deficiency, confirming the extremely variable penetrance and genetic complexity of aHUS...
- Predominance of CD8+ T lymphocytes among periglomerular infiltrating cells and link to the prognosis of class III and class IV lupus nephritisLionel Couzi
CHU, and UMR CNRS 5164, Universite Victor Segalen Bordeaux 2, Bordeaux, France
Arthritis Rheum 56:2362-70. 2007..The aim of the present study was to analyze the localization of CD8+ cells in the kidneys of patients with class III and class IV lupus nephritis and to establish correlations with histologic, biologic, and clinical features of SLE...
- An atypical necrotic signal induced by immunosuppressive and anti-viral agentsBenjamin Chaigne-Delalande
Universite de Bordeaux 2, CNRS UMR 5164 and IFR66, 146 rue Leo Saignat, Bordeaux, France
Autophagy 5:425-7. 2009....
- [Immunomonitoring for cytomegalovirus infection in kidney transplantation: Development and prospects]Hannah Kaminski
Service de Néphrologie Transplantation Dialyse, Hopital Pellegrin, CHU de Bordeaux, Place Amelie Raba Leon, 33076 Bordeaux, France
Nephrol Ther 11:465-73. 2015....
- Analysis of the effectiveness and safety of rituximab in patients with refractory lupus nephritis: a chart reviewAnne Contis
Service de médecine interne et immunologie clinique, Hôpital Saint André, 1 rue Jean Burguet, 33075, Bordeaux, France
Clin Rheumatol 35:517-22. 2016..Rituximab therapy resulted in a significant improvement in proteinuria and steroid dose tapering in all patients. Rituximab should be considered as a treatment option for refractory lupus glomerulonephritis...
- Whole blood real-time quantitative PCR for cytomegalovirus infection follow-up in transplant recipientsIsabelle Garrigue
Département de Virologie et d Immunologie Biologique and Laboratoire EA 2968, Centre Hospitalo Universitaire de Bordeaux, 33076 Bordeaux, France
J Clin Virol 36:72-5. 2006..However, correlations are lacking between results of pp65Ag and quantitative PCR assays and there is no consensus yet as to the more appropriate blood compartment (whole blood (WB), leukocytes, plasma) to be tested with PCR assays...
- Verapamil and mild hyperkalemia in hemodialysis patients: a potentially hazardous associationEmmanuel Letavernier
Service de Néphrologie et d Hémodialyse, CHU Pellegrin, Bordeaux, France
Hemodial Int 10:170-2. 2006..The medical history of these patients revealed no intrinsic cause of atrioventricular conduction disturbance. We report herein the 3 cases and draw attention to the risks of atrioventricular block in this particular context...
- Quantitative elastography of renal transplants using supersonic shear imaging: a pilot studyNicolas Grenier
Service d Imagerie Diagnostique et Interventionnelle de l Adulte, Centre Hospitalier Universitaire de Bordeaux, Université Bordeaux Segalen, 33076, Bordeaux, France
Eur Radiol 22:2138-46. 2012..To evaluate the reliability of quantitative ultrasonic measurement of renal allograft elasticity using supersonic shear imaging (SSI) and its relationship with parenchymal pathological changes...