Affiliation: CHRU de Lille
- [Management and treatment of respiratory failure associated with amyotrophic lateral sclerosis]V Danel-Brunaud
Centre SLA, Clinique de Neurologie, Hopital Roger Salengro, EA 2683 CHRU, Lille
Rev Neurol (Paris) 161:480-5. 2005..Frequent testing of pulmonary function and regular evaluations are recommended since 1999 by the American Academy of Neurology in order to take appropriate treatment decisions...
- [Early nasal ventilation in amyotrophic latéral sclerosis: impact on survival and quality of life (the VNP-SLA study)]T Perez
Clinique des Maladies Respiratoires, Hopital Calmette, Lille, France
Rev Mal Respir 20:589-98. 2003
- Impact of gender on COPD expression in a real-life cohortNicolas Roche
Service de Pneumologie et Soins Intensifs Respiratoires, Groupe Hospitalier Cochin Broca Hôtel Dieu, AP HP and Université Paris Descartes, Sorbonne Paris Cité, Paris, France
Respir Res 15:20. 2014....
- [COPD and quality of life: impact of the disease in primary care in France]T Perez
Service de Pneumologie, Hopital Albert Calmette, CHRU de Lille, Boulevard Jules Leclercq, 59037 Lille Cedex, France
Rev Mal Respir 30:22-32. 2013..The impact of COPD on patients' daily activities is a key feature of the disease and it is essential that this is evaluated systematically and recognized as a target for management as much as other manifestations of the disease...
- [Recent advances in the assessment of respiratory muscle endurance: (1999-2004)]T Perez
Service d Explorations Fonctionnelles Respiratoires et Clinique des Maladies Respiratoires, Hopital Calmette, CHRU de Lille, Lille, France
Rev Mal Respir 22:338-42. 2005
- Airways involvement in rheumatoid arthritis: clinical, functional, and HRCT findingsT Perez
Department of Pneumology, University Hospital of Lille, France
Am J Respir Crit Care Med 157:1658-65. 1998..A high prevalence of airway abnormalities as assessed with HRCT and/or PFTs was observed in our RA population. HRCT appears to be more sensitive than PFTs for detecting small airways disease...
- [Neuromuscular disorders - assessment of the respiratory muscles]T Perez
Service d Explorations Fonctionnelles Respiratoires et Clinique des Maladies Respiratoires Hôpital Calmette, CHRU de Lille, Lille
Rev Neurol (Paris) 162:437-44. 2006..Criteria defining significant desaturations remain however controversial. Suspicion of obstructive sleep apnea syndrome on clinical grounds or oxymetry findings should be confirmed by a conventional polysomnography...
- [Evaluation and follow up of hyperinflation in COPD]T Perez
Service d Explorations Fonctionnelles Respiratoires et Clinique des Maladies Respiratoires, Hopital Calmette, CHRU de Lille, France
Rev Mal Respir 26:381-93; quiz 478, 482. 2009..Evaluation of hyperinflation is an important criterion in the phenotyping of COPD patients. However, its natural history remains at present poorly defined...
- [Clinical investigation of diaphragmatic function. Relationships with the biology of muscle]T Perez
Service de Pneumologie et Immuno Allergologie, Hopital Calmette, CHRU de Lille
Rev Mal Respir 17:591-6. 2000..Recent data in rats suggest that decreased IGF expression induced by corticosteroids might contribute to diaphragmatic changes...
- [First line assessment of respiratory muscle function]T Perez
Service d Explorations Fonctionnelles Respiratoires et Clinique des Maladies Respiratoires, Hopital Calmette, CHRU, Lille
Rev Mal Respir 22:2S37-46. 2005
- Validity, reliability, and responsiveness of a new short Visual Simplified Respiratory Questionnaire (VSRQ) for health-related quality of life assessment in chronic obstructive pulmonary diseaseT Perez
Centre Hospitalier Regional Universitaire CHRU, Lille, France
Int J Chron Obstruct Pulmon Dis 4:9-18. 2009..5. In conclusion, VSRQ brevity and satisfactory psychometric properties make it a good candidate for large studies to assess HRQoL in COPD patients. Further validation is needed to extend its use in clinical practice...
- High erythropoietin and low vascular endothelial growth factor levels in cerebrospinal fluid from hypoxemic ALS patients suggest an abnormal response to hypoxiaN Just
Department of Pneumology, A Calmette Hospital, Lille University Medical Centre, France
Neuromuscul Disord 17:169-73. 2007..The high EPO levels in hypoxemic ALS patients nevertheless suggest an intact common oxygen-sensor pathway...
- Elevated IL-6 and TNF-alpha levels in patients with ALS: inflammation or hypoxia?C Moreau
Department of Neurology, INSERM, Pasteur Institute of Lille, University Hospital, Lille, France
Neurology 65:1958-60. 2005..Elevated IL-6 levels in ALS could correspond to a normal response to hypoxemia...
- The Borg dyspnoea score: a relevant clinical marker of inspiratory muscle weakness in amyotrophic lateral sclerosisN Just
Service de Pneumologie, Hôpital Victor Provo, 11 17 Bd Lacordaire, F 59100 Roubaix Cedex, France
Eur Respir J 35:353-60. 2010..7+/-7 versus 39.2+/-5 mmHg; p = 0.05). The Borg dyspnoea scale is a valuable noninvasive test for the prediction of inspiratory muscle weakness in ALS patients...
- [Daily physical activity in adult patients with cystic fibrosis]A Prevotat
Centre de Ressources et de Compétences pour la Mucoviscidose, Universite de Lille 2, Clinique des Maladies Respiratoires, Hopital Calmette, 59037 Lille, France
Rev Pneumol Clin 69:3-9. 2013..423, P=0.02). This questionnaire is relevant for estimating DPA and DEE in patients with cystic fibrosis and is an interesting test to be used to evaluate changes in patients after pulmonary rehabilitation...
- [COPD and inflammation: statement from a French expert group. Phenotypes related to inflammation]T Perez
Service de Pneumologie et Immuno Allergologie, Hopital Calmette, CHRU de Lille, Boulevard du Professeur J Leclercq, Lille, France
Rev Mal Respir 28:192-215. 2011..The objective of the present article is to review available data on possible links between phenotypes and inflammatory profiles in patients with chronic obstructive pulmonary disease (COPD)...
- [The distal airways in systemic disease]I Tillie-Leblond
Service de Pneumologie et d Immuno Allergologie, Hopital Calmette, Institut Pasteur de Lille, université de Lille II et CHRU, France
Rev Mal Respir 29:1254-63. 2012..In these cases, lung transplantation should be considered in young patients...
- Update on the roles of distal airways in COPDP R Burgel
Service de Pneumologie, Hopital Cochin, 27 rue du Faubourg St Jacques, Universite Paris Descartes, Paris, France
Eur Respir Rev 20:7-22. 2011..g. dyspnoea and reduced health-related quality of life) and with the natural history of the disease, as reflected by lung function decline and mortality. These data provide a clear rationale for targeting distal airways in COPD...
- [Tolerance and efficacy of ceftazidime in combination with aztreonam for exacerbations of cystic fibrosis]A Prevotat
CRCM adultes, Service de Pneumologie et Immuno Allergologie, Hopital Calmette, CHRU de Lille, Boulevard du Professeur Leclercq, 59037 Lille, France
Rev Mal Respir 27:449-56. 2010..aeruginosa...
- [Measurement of daily physical activity in patients with cystic fibrosis]C Fournier
Centre de Ressources et Compétences pour la Mucoviscidose, Clinique des Maladies Respiratoires, Hopital Calmette, CHRU, Lille, France
Rev Mal Respir 22:63-9. 2005..The aim of this prospective study was to measure physical daily activity (PDA) in CF-patients and compare it with rest pulmonary functions and exercise tolerance...
- [Cystic fibrosis diabetes in adult]M C Vantyghem
Service d endocrinologie et métabolismes, 6, rue du Pr Laguesse Centre Hospitalo Universitaire, 59037 Lille Cedex
Ann Endocrinol (Paris) 66:347-54. 2005..In conclusion, the aim of treatment of cystic fibrosis is to prevent the lung function decline by controlling inflammation and infection, to implement endo- and exo-crine pancreas insufficiency, and to improve nutritional status...
- Effect of tiotropium on health-related quality of life as a primary efficacy endpoint in COPDA B Tonnel
Centre Hospitalier Régional Universitaire CHRU de Lille, Service de Pneumologie et Immuno Allergologie, Lille Cedex, France
Int J Chron Obstruct Pulmon Dis 3:301-10. 2008..01 +/- 0.02 L; between-group difference: 0.10 +/- 0.03 L, p = 0.0001) and reduced exacerbations vs placebo. Maintenance treatment with tiotropium provided significant and clinically relevant improvements in HRQoL, as measured by the SGRQ...
- [Respiratory failure due to acid maltase deficiency]T Perez
Centre de compétence des maladies pulmonaires rares, Clinique des Maladies Respiratoires, hôpital A Calmette, CHRU de Lille, Boulevard J Leclercq, 59037 Lille Cedex, France
Rev Mal Respir 29:74-8. 2012..Our observations suggest that non invasive ventilation together with enzyme supplementation (Myozyme®) is effective in correcting alveolar hypoventilation...
- [Inspiratory muscle myopathy and antisynthetase syndrome]A Dejardin Botelho
Service de Pneumologie et Immunoallergologie, hôpital A Calmette, CHRU de Lille, 59037 Lille Cedex, France
Rev Med Interne 29:325-7. 2008..Inflammatory myopathy of the antisynthetases syndrome could be limited or mainly expressed to respiratory muscles. Unexplained dyspnoea should call in mind a muscular respiratory myositis...
- [Prognostic value of clinical exercise testing in adult patients with cystic fibrosis]S Nguyen
Service de Pneumologie et Immunoallergologie, centre de ressources et de compétence pour la mucoviscidose adulte, Clinique des Maladies Respiratoires, Hopital Albert Calmette, CHRU de Lille, 59037 Lille Cedex, France
Rev Mal Respir 27:219-25. 2010..The aim of this study was to determine the prognostic value of cardiopulmonary exercise testing (CPET) in adult CF patients...
- Bronchial interleukin-5 and eotaxin expression in nasal polyposis. Relationship with (a)symptomatic bronchial hyperresponsivenessC Lamblin
Clinique des Maladies Respiratoires, , CHRU, Lille, France
Am J Respir Crit Care Med 163:1226-32. 2001..Our study provides evidence of IL-5 involvement in bronchial eosinophilia and in the pathogenesis of asymptomatic BHR associated with NP, whereas both IL-5 and eotaxin are involved in asthma associated with NP...
- Prevalence and reversibility of lung hyperinflation in adult asthmatics with poorly controlled disease or significant dyspneaT Perez
Service de Pneumologie et des EFR, CHU Lille, et INSERM U1019, Université Lille, Lille, France
Allergy 71:108-14. 2016..In asthma, inflammation affects both the proximal and distal airways and may induce significant hyperinflation (HI). This study sought to evaluate the prevalence of HI in asthmatic patients with poorly controlled disease and/or dyspnea...
- [Amyotrophic lateral sclerosis (ALS): evaluation of respiratory function]T Perez
Service d Explorations Fonctionnelles Respiratoire et Clinique des Maladies Respiratoires, Hopital Calmette, CHRU de Lille, 59037 Lille Cedex
Rev Neurol (Paris) 162:4S188-4S194. 2006..Criteria defining significant desaturations remain however controversial. Suspicion of obstructive sleep apnea syndrome on clinical grounds or oxymetry findings should be confirmed by a conventional polysomnography...
- Clinical COPD phenotypes: a novel approach using principal component and cluster analysesP R Burgel
Service de Pneumologie, Hopital Cochin, Assistance Publique Hopitaux de Paris, 27 rue du Faubourg St Jacques, 75679 Paris Cedex 14, France
Eur Respir J 36:531-9. 2010..These analyses underscore the need for novel multidimensional COPD classification for improving patient care and quality of clinical trials...
- [Depression, anxiety and coping strategies in adult patients with cystic fibrosis]E Wargnies
Centre de Soins Mucoviscidose Adulte, Hopital Calmette, Lille
Rev Mal Respir 19:39-43. 2002....
- [Bronchodilatators and exercise in COPD: effects, evaluation and strategy of use]T Perez
Service de Pneumologie, Hopital Calmette, 59037 Lille, France
Rev Pneumol Clin 58:2S11-7. 2002
- Low levels of the vascular endothelial growth factor in CSF from early ALS patientsD Devos
Department of Neurology, R Salengro Hospital, Lille, France
Neurology 62:2127-9. 2004..This finding early in ALS patients suggests a possible role for VEGF gene regulation in the pathogenesis of ALS...
- [Recurrent edema of the face and neck in a chronically hemodialyzed patient]F Radenne
Service de Pneumologie et Immuno-Allergologie, Clinique des Maladies Respiratoires, , CHRU, Lille
Rev Mal Respir 18:553-6. 2001..Superior vena cava syndrome related to a central catheter and hypersensitivity reactions should always be considered as possible causes of recurrent face and neck edema in patients on long-term hemodialysis...
- Airway neutrophil inflammation in nonasthmatic patients with food allergyBenoit Wallaert
Clinique des Maladies Respiratoires, Service de Pneumologie et Immuno Allergologie, hôpital A Calmette, CHRU Lille, 59037 Lille Cedex, France
Allergy 57:405-10. 2002..In order to explain this observation, we sought to examine the presence of a bronchial inflammation in induced sputum of nonasthmatic patients with FA...
- Impact of chronic airflow obstruction in a working populationN Roche
Rene Descartes University of Paris, Respiratory and Intensive Care Medicine, Hotel Dieu Hospital, France
Eur Respir J 31:1227-33. 2008..In conclusion, even mild-to-moderate airflow obstruction is associated with an impaired health status, which represents an additional argument in favour of early detection in chronic obstructive pulmonary disease...
- Physiologic correlates of dyspnea in patients with morbid obesityF Collet
Lung Function Department, Calmette Hospital, Lille University, France
Int J Obes (Lond) 31:700-6. 2007..This study was undertaken to determine the relationships between dyspnea and pulmonary function including inspiratory muscle endurance (IME) in morbidly obese patients before bariatric surgery...
- [Homogeneising the respiratory care of ALS patients in France]J Gonzalez-Bermejo
Rev Mal Respir 22:156-8. 2005
- [Measurement of pulmonary inflammation in cystic fibrosis]M Fayon
CHU de Bordeaux, France
Rev Mal Respir 25:705-24. 2008..The interpretation of all these determinations in children and adults is also discussed...