Affiliation: CHRU de Lille
- Advances and perspectives in the genetics of inflammatory bowel diseasesMathias Chamaillard
INSERM 0114, Hôpital Swynghedauw, Rue A Verhaeghe, F 59037 Lille, France
Clin Gastroenterol Hepatol 4:143-51. 2006..This is a prerequisite for rational clinical management of IBD. Genetic, functional, serologic testing and development of therapeutics in IBD are discussed...
- NODs in defence: from vulnerable antimicrobial peptides to chronic inflammationLaurent Peyrin-Biroulet
INSERM U795, University of Lille 2, Huriez Hospital, Digestive Tract Diseases and Nutrition Department, F 59037 Lille, France
Trends Microbiol 14:432-8. 2006..Further work is required to clarify how gastrointestinal CAPs are regulated and to assess their role in maintaining epithelial homeostasis and triggering adaptive immunity...
- Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colonLaurent Peyrin-Biroulet
Institut National de la Sante et de la Recherche Medicale, U795, F 59037 Lille, France
Proc Natl Acad Sci U S A 107:8772-7. 2010..These findings support the development of PPARgamma-targeting therapeutic and/or nutritional approaches to prevent colonic inflammation by restoring antimicrobial immunity in CD...
- CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel diseaseSuzanne Lesage
Fondation Jean Dausset CEPH, 27 rue Juliette Dodu, 75010 Paris, France
Am J Hum Genet 70:845-57. 2002..These findings provide tools for a DNA-based test of susceptibility and for genetic counseling in inflammatory bowel disease...
- Detection of antisynthetic mannoside antibodies (ASigmaMA) reveals heterogeneity in the ASCA response of Crohn's disease patients and contributes to differential diagnosis, stratification, and predictionPeggy Vandewalle-El Khoury
INSERM, U799, Lille, France
Am J Gastroenterol 103:949-57. 2008....
- IBD serological panels: facts and perspectivesLaurent Peyrin-Biroulet
INSERM, U795, Lille, F 59037, France
Inflamm Bowel Dis 13:1561-6. 2007..Better understanding of the serological response in IBD might also provide new insights into their epidemiology and pathophysiology...
- NOD2 and defensins: translating innate to adaptive immunity in Crohn's diseaseLaurent Peyrin-Biroulet
INSERM, U795, Lille, France
J Endotoxin Res 13:135-9. 2007....
- How NOD2 mutations predispose to Crohn's disease?Cecile Vignal
INSERM, U 795, Lille, F 59037 France
Microbes Infect 9:658-63. 2007..Further work should now focus on restoring abnormal NOD2 function by modulating antimicrobial function and regulatory mechanisms of the adaptive immune system...
- Vascular and cellular stress in inflammatory bowel disease: revisiting the role of homocysteineLaurent Peyrin-Biroulet
INSERM, U724, Laboratory of Cellular and Molecular Pathology in Nutrition, Faculty of Medicine, Nancy Universitè Vandoeuvre les Nancy, F 54511, France
Am J Gastroenterol 102:1108-15. 2007....
- Mesenteric fat in Crohn's disease: a pathogenetic hallmark or an innocent bystander?Laurent Peyrin-Biroulet
INSERM U795, F 59037 Lille Cedex, France
Gut 56:577-83. 2007
- Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detectionStephen E Girardin
Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris Cedex 15, France
J Biol Chem 278:8869-72. 2003..Additionally, the characterization of Nod2 as the first pathogen-recognition molecule that detects MDP will help to unravel the well known biological activities of this immunomodulatory compound...
- Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseasesMathias Chamaillard
Fondation Jean Dausset, Centre d Etude du Polymorphisme Humain, 27 rue Juliette Dodu, 75010 Paris, France
Proc Natl Acad Sci U S A 100:3455-60. 2003....
- Nod2-dependent regulation of innate and adaptive immunity in the intestinal tractKoichi S Kobayashi
Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Science 307:731-4. 2005..The Nod2 protein is thus a critical regulator of bacterial immunity within the intestine, providing a possible mechanism for Nod2 mutations in CD...
- [Regulatory role of Nod2 in intestinal immunity]Mathias Chamaillard
University of Michigan Medical School, Ann Arbor 48109, USA
Gastroenterol Clin Biol 28:1189-91. 2004
- Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognitionTsuyoshi Tanabe
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA
EMBO J 23:1587-97. 2004..These results provide new insights into the molecular function and regulation of NOD2 and related NOD family proteins...
- An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acidMathias Chamaillard
Department of Pathology, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nat Immunol 4:702-7. 2003..Thus, NOD1 mediates selective recognition of bacteria through detection of iE-DAP-containing peptidoglycan...
- Clustering of Crohn's disease within affected sibshipsJean Pierre Hugot
Fondation Jean Dausset CEPH, Paris, France
Eur J Hum Genet 11:179-84. 2003..More generally, the CAST statistics may be widely applicable to estimate the involvement of environmental factors in the aetiology of other binary traits which may be observed in multiple members of the same sibship...