Genomes and Genes
- Interaction between the ADH1C polymorphism and maternal alcohol intake in the risk of nonsyndromic oral clefts: an evaluation of the contribution of child and maternal genotypesCécile Chevrier
Institut National de la Santé et de la Recherche Médicale INSERM U625, Rennes, France
Birth Defects Res A Clin Mol Teratol 73:114-22. 2005..We focused on a polymorphism of the ADH1C gene (third gene of the class I alcohol dehydrogenase family), involved in the metabolism of ethanol and other alcohols...
- Environmental exposure assessment in European birth cohorts: results from the ENRIECO projectUlrike Gehring
Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
Environ Health 12:8. 2013....
- Urinary biomarkers of prenatal atrazine exposure and adverse birth outcomes in the PELAGIE birth cohortCécile Chevrier
INSERM, U625, Rennes, France
Environ Health Perspect 119:1034-41. 2011..Despite evidence of atrazine toxicity in developing organisms from experimental studies, few studies--and fewer epidemiologic investigations--have examined the potential effects of prenatal exposure...
- Occupational exposure to organic solvent mixtures during pregnancy and the risk of non-syndromic oral cleftsC Chevrier
Inserm U625, Rennes, France
Occup Environ Med 63:617-23. 2006..To examine the association between maternal occupational exposure to mixtures of organic solvents during pregnancy and the risk of non-syndromic oral clefts...
- Fetal and maternal MTHFR C677T genotype, maternal folate intake and the risk of nonsyndromic oral cleftsCécile Chevrier
Inserm U625, GERHM, Campus de Beaulieu, Univ Rennes I, Rennes, France
Am J Med Genet A 143:248-57. 2007..The modest sample size limits this study, which nonetheless provides new estimate of the possible impact of dietary folate intake and MTHFR polymorphism on oral clefts...
- Fetal and maternal CYP2E1 genotypes and the risk of nonsyndromic oral cleftsCécile Chevrier
INSERM, U625 Univ Rennes I, GERHM, IFR140, Rennes, France
Am J Med Genet A 143:1382-5. 2007
- Genetic susceptibilities in the association between maternal exposure to tobacco smoke and the risk of nonsyndromic oral cleftCécile Chevrier
Inserm U625, Universite de Rennes I, GERHM, Rennes, France
Am J Med Genet A 146:2396-406. 2008..We did not confirm the maternal smoking-infant GSTT1 null interaction previously reported by other investigators...
- Qualitative assessment of visuospatial errors in mercury-exposed Amazonian childrenCécile Chevrier
INSERM, U625, University of Rennes I, GERHM, IFR140, F 35000 Rennes, France
Neurotoxicology 30:37-46. 2009....
- Environmental determinants of the urinary concentrations of herbicides during pregnancy: the PELAGIE mother-child cohort (France)Cécile Chevrier
INSERM National Institute of Health and Medical Research U1085 IRSET, Rennes, France University of Rennes I, Rennes, France Electronic address
Environ Int 63:11-8. 2014..48, 1.09-1.99). This study reinforces previous results that suggest that environmental contamination resulting from agricultural activities may contribute to the general population's exposure to herbicides. ..
- Impact on fetal growth of prenatal exposure to pesticides due to agricultural activities: a prospective cohort study in Brittany, FranceClaire Petit
Inserm U625, GERHM, IFR140, Campus de Beaulieu, Rennes, France
Environ Health 9:71. 2010..Our purpose was to investigate the effect on intrauterine growth of such exposure due to agricultural activities in the residential municipality...
- Organophosphate Insecticide Metabolites in Prenatal and Childhood Urine Samples and Intelligence Scores at 6 Years of Age: Results from the Mother-Child PELAGIE Cohort (France)Chloé Cartier
INSERM U1085 IRSET, Universite Rennes I, Rennes, France
Environ Health Perspect 124:674-80. 2016..Several studies suggest that exposure to organophosphate insecticides (OP) during pregnancy impairs neurodevelopment in children...
- Pyrethroid insecticide exposure and cognitive developmental disabilities in children: The PELAGIE mother-child cohortJean François Viel
INSERM IRSET n 1085, Epidemiological Research on Environment, Reproduction and Development, University of Rennes 1, Rennes, France Department of Epidemiology and Public Health, University Hospital, Rennes, France Electronic address
Environ Int 82:69-75. 2015..Potential causes that can be prevented are of paramount public health importance. ..
- Urinary glycol ether metabolites in women and time to pregnancy: the PELAGIE cohortRonan Garlantezec
INSERM Institut National de la Santé et de la Recherche Médicale, U1085 IRSET Institut de Recherche en Santé, Environnement et Travail, Rennes, France
Environ Health Perspect 121:1167-73. 2013..Glycol ethers are present in a wide range of occupational and domestic products. Animal studies have suggested that some of them may affect ovarian function...
- Organochlorine pesticides, polychlorinated biphenyls, seafood consumption, and time-to-pregnancyCécile Chevrier
INSERM, U1085 Irset, University of Rennes I, Rennes, France
Epidemiology 24:251-60. 2013..We explored whether serum levels of these pollutants and seafood consumption were associated with the fertility of couples enrolled in a French birth cohort (PELAGIE)...
- Childhood exposure to polybrominated diphenyl ethers and neurodevelopment at six years of ageCécile Chevrier
U1085 Irset Research Institute of Health Environment and Work, INSERM, Rennes, France University of Rennes 1, Rennes, France Electronic address
Neurotoxicology 54:81-8. 2016..Several countries are in the process of banning the use of PBDE mixtures as flame-retardants. However, these compounds are likely to remain present in the environment for a long time to come. ..
- Association between prenatal exposure to traffic-related air pollution and preterm birth in the PELAGIE mother-child cohort, Brittany, France. Does the urban-rural context matter?Mélanie Bertin
INSERM U1085 IRSET, Avenue Professeur Léon Bernard, 35043 Rennes, France University of Rennes 1, Rennes, France EHESP School of Public Health, Sorbonne Paris Cité, Rennes, France
Environ Res 142:17-24. 2015..Conversely, this relation has barely been investigated in rural areas where individual characteristics (demographic, socioeconomic, and psychosocial factors) and environmental co-exposures may differ...
- Potential input from metabolomics for exploring and understanding the links between environment and healthNathalie Bonvallot
a INSERM UMR1085 IRSET, Rennes, France
J Toxicol Environ Health B Crit Rev 17:21-44. 2014..Nevertheless, the validity of biomarkers and relevancy of animal-to-human extrapolation remain key challenges that need to be properly explored. ..
- Maternal residence near municipal waste incinerators and the risk of urinary tract birth defectsSylvaine Cordier
Inserm U625, Universite Rennes I, Campus de Beaulieu, Rennes Cedex, France
Occup Environ Med 67:493-9. 2010..The objective of the present study was to specifically test this association...
- Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort StudyRémi Béranger
INSERM U1085 IRSET, University Rennes 1, Rennes, France
Environ Health Perspect . 2016..Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children...
- Prenatal pesticide exposure and otitis media during early childhood in the PELAGIE mother-child cohortCamille Buscail
INSERM IRSET n 1085, Epidemiological Research on Environment, Reproduction and Development, University of Rennes I, Rennes, France
Occup Environ Med 72:837-44. 2015..We aimed to determine whether prenatal environmental exposure to these current-use pesticides was associated with otitis media (OM) during the first 2 years of life among children from the PELAGIE mother-child cohort...
- Sex-specific differences in fetal growth in newborns exposed prenatally to traffic-related air pollution in the PELAGIE mother-child cohort (Brittany, France)Mélanie Bertin
INSERM U1085 IRSET, France University of Rennes 1, Rennes, France EHESP School of Public Health, Sorbone Paris Cité, Rennes, France
Environ Res 142:680-7. 2015..Residence-based factors can also influence fetal growth by enhancing susceptibility to the toxic effects of air pollution and must also be considered in these relations...
- Does ozonation of drinking water reduce the risk of bladder cancer?Cécile Chevrier
National Institute of Health and Medical Research, Inserm U625, Rennes, France
Epidemiology 15:605-14. 2004..Because drinking water has been ozonated in France for decades, we were able to assess the carcinogenic risk of the disinfection byproducts generated by both ozonation and chlorination...
- Socioeconomic Disparities in Adverse Birth Outcomes in Urban and Rural Contexts: a French Mother-Child CohortMélanie Bertin
IRSET Inserm UMR 1085, University of Rennes 1, Rennes, France
Paediatr Perinat Epidemiol 29:426-35. 2015....
- Metabolomics tools for describing complex pesticide exposure in pregnant women in Brittany (France)Nathalie Bonvallot
National Institute of Health and Medical Research INSERM UMR 1085 IRSET Research Institute for Environmental and Occupational Health, Rennes, France
PLoS ONE 8:e64433. 2013..In early-life, such exposures could be responsible for adverse developmental effects. However, human health risks associated with exposure to complex mixtures are currently under-explored...
- Exposure during pregnancy to glycol ethers and chlorinated solvents and the risk of congenital malformationsSylvaine Cordier
IRSET Inserm U1085 Univ Rennes I IFR 140, Rennes, France sylvaine
Epidemiology 23:806-12. 2012..Exposure to solvents during pregnancy has long been suspected of increasing the risk of congenital malformations, but the lack of prospective assessment of specific solvent exposures has prevented definitive conclusions...
- Correcting for the influence of sampling conditions on biomarkers of exposure to phenols and phthalates: a 2-step standardization method based on regression residualsMarion Mortamais
Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, INSERM, Institut Albert Bonniot U823, Grenoble, France
Environ Health 11:29. 2012....
- Combined effect of prenatal solvent exposure and GSTT1 or GSTM1 polymorphisms in the risk of birth defectsRonan Garlantezec
INSERM U, University of Rennes, France
Birth Defects Res A Clin Mol Teratol 94:481-5. 2012..Replication and additional investigations are necessary to confirm and elucidate these findings...
- Can a deprivation index be used legitimately over both urban and rural areas?Mélanie Bertin
INSERM IRSET n 1085, Epidemiological Research on Environment, Reproduction and Development, University of Rennes 1, Rennes, France
Int J Health Geogr 13:22. 2014..There is, therefore, a need to determine to what extent available deprivation indices can be used legitimately over both urban and rural areas...