- Multiple sclerosis retrovirus particles and recombinant envelope trigger an abnormal immune response in vitro, by inducing polyclonal Vbeta16 T-lymphocyte activationH Perron
bioMérieux Pierre Fabre, R and D, Chemin de l orme, Marcy l Etoile, 69280, France
Virology 287:321-32. 2001..Molecular analysis of Vbeta CDR3 showed that Vbeta16 expansions are polyclonal. Our results thus provide evidence that MSRV envelope protein can trigger an abnormal immune response with similar characteristics to that of superantigens...
- Human endogenous retrovirus (HERV)-W ENV and GAG proteins: physiological expression in human brain and pathophysiological modulation in multiple sclerosis lesionsHervé Perron
bioMerieux, R and D, Chemin de l orme, 69280 Marcy l Etoile, France
J Neurovirol 11:23-33. 2005..This is compatible with a pathophysiological role in MS, but also illustrates the ambivalence of such HERV antigens, which can be expressed in cell-specific patterns, under physiological or pathological conditions...