Pierre Chambon

Summary

Country: France

Publications

  1. ncbi request reprint The nuclear receptor superfamily: a personal retrospect on the first two decades
    Pierre Chambon
    Institut Clinique de la Souris, College de France, BP 10142, 67404 Illkirch Cedex, France
    Mol Endocrinol 19:1418-28. 2005
  2. pmc Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland
    Sonia Mallepell
    National Center of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, 155 Chemin des Boveresses, CH 1066 Epalinges s Lausanne, Switzerland
    Proc Natl Acad Sci U S A 103:2196-201. 2006
  3. ncbi request reprint How I became one of the fathers of a superfamily
    Pierre Chambon
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, College de France, Strasbourg
    Nat Med 10:1027-31. 2004
  4. ncbi request reprint Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells
    Nicolas Matt
    Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC Collège de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 132:4789-800. 2005
  5. pmc Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation
    Florence Cammas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP10142, 67404 Illkirch, France
    Genes Dev 18:2147-60. 2004
  6. ncbi request reprint The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 130:2525-34. 2003
  7. ncbi request reprint TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids
    Konstantin Khetchoumian
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP Collège de France and Institut Clinique de la Souris, BP 10142, 67 404 Illkirch Cedex, France
    J Biol Chem 279:48329-41. 2004
  8. pmc Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells
    Nadège Vernet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U596, 1 rue Laurent Fries, Illkirch F 67404, France
    EMBO J 25:5816-25. 2006
  9. ncbi request reprint Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice
    Merce Martin
    INSERM, U682, Strasbourg, France
    Dev Biol 284:399-411. 2005
  10. ncbi request reprint Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation
    Arup Kumar Indra
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Strasbourg, France
    Development 132:4533-44. 2005

Detail Information

Publications103 found, 100 shown here

  1. ncbi request reprint The nuclear receptor superfamily: a personal retrospect on the first two decades
    Pierre Chambon
    Institut Clinique de la Souris, College de France, BP 10142, 67404 Illkirch Cedex, France
    Mol Endocrinol 19:1418-28. 2005
  2. pmc Paracrine signaling through the epithelial estrogen receptor alpha is required for proliferation and morphogenesis in the mammary gland
    Sonia Mallepell
    National Center of Competence in Research Molecular Oncology, Swiss Institute for Experimental Cancer Research, 155 Chemin des Boveresses, CH 1066 Epalinges s Lausanne, Switzerland
    Proc Natl Acad Sci U S A 103:2196-201. 2006
    ....
  3. ncbi request reprint How I became one of the fathers of a superfamily
    Pierre Chambon
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS, INSERM, ULP, College de France, Strasbourg
    Nat Med 10:1027-31. 2004
  4. ncbi request reprint Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells
    Nicolas Matt
    Institut de Génétique et de Biologie Moléculaire et Cellulaire IGBMC Collège de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 132:4789-800. 2005
    ..We additionally show that RALDH1 and RALDH3 are the only enzymes that are required for RA synthesis in the eye region from E10.5 to E13.5, and that patterning of the dorsoventral axis of the retina does not require RA...
  5. pmc Association of the transcriptional corepressor TIF1beta with heterochromatin protein 1 (HP1): an essential role for progression through differentiation
    Florence Cammas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP10142, 67404 Illkirch, France
    Genes Dev 18:2147-60. 2004
    ..Collectively, these data demonstrate that the interaction between TIF1beta and HP1 proteins is essential for progression through differentiation by regulating the expression of endoderm differentiation master players...
  6. ncbi request reprint The regional pattern of retinoic acid synthesis by RALDH2 is essential for the development of posterior pharyngeal arches and the enteric nervous system
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 130:2525-34. 2003
    ..Thus, RALDH2 plays a crucial role in producing RA required for pharyngeal development, and RA is one of the diffusible mesodermal signals that pattern the pharyngeal endoderm...
  7. ncbi request reprint TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids
    Konstantin Khetchoumian
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP Collège de France and Institut Clinique de la Souris, BP 10142, 67 404 Illkirch Cedex, France
    J Biol Chem 279:48329-41. 2004
    ..Collectively, these data are consistent with specific, nonredundant functions for the TIF1 family members in vivo and suggest a role for TIF1delta in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis...
  8. pmc Prepubertal testis development relies on retinoic acid but not rexinoid receptors in Sertoli cells
    Nadège Vernet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U596, 1 rue Laurent Fries, Illkirch F 67404, France
    EMBO J 25:5816-25. 2006
    ....
  9. ncbi request reprint Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice
    Merce Martin
    INSERM, U682, Strasbourg, France
    Dev Biol 284:399-411. 2005
    ..We conclude that RA synthesized in the mesenchyme is specifically required for the normal development of the dorsal pancreatic endoderm at a stage preceding Pdx 1 function...
  10. ncbi request reprint Temporally controlled targeted somatic mutagenesis in embryonic surface ectoderm and fetal epidermal keratinocytes unveils two distinct developmental functions of BRG1 in limb morphogenesis and skin barrier formation
    Arup Kumar Indra
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Strasbourg, France
    Development 132:4533-44. 2005
    ..Finally, we demonstrate that cell-specific targeted somatic mutations can be created at various times during the development of mouse embryos cell-specifically expressing the tamoxifen-activatable Cre-ER(T2) recombinase...
  11. ncbi request reprint Conditional (loxP-flanked) allele for the gene encoding the retinoic acid-synthesizing enzyme retinaldehyde dehydrogenase 2 (RALDH2)
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104 du CNRS, U 596 de l INSERM, Universite Louis Pasteur, CU de Strasbourg, France
    Genesis 44:155-8. 2006
    ..The conditional allele described herein is a genetic tool for studying tissue-specific, RALDH2-dependent functions of retinoic acid during development and in adult life...
  12. pmc Arterial calcifications and increased expression of vitamin D receptor targets in mice lacking TIF1alpha
    Mihaela Ignat
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, BP 10142, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 105:2598-603. 2008
    ....
  13. pmc Ligand-dependent contribution of RXRbeta to cholesterol homeostasis in Sertoli cells
    Bénédicte Mascrez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut Clinique de la Souris, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    EMBO Rep 5:285-90. 2004
    ..Our results also indicate that RXRbeta may be activated by a ligand distinct from 9-cis retinoic acid...
  14. pmc Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis
    Mathilde Raverdeau
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Institut National de la Santé et de la Recherche Médicale Unité 964, Universite de Strasbourg, Illkirch, France
    Proc Natl Acad Sci U S A 109:16582-7. 2012
    ....
  15. pmc Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis
    Mei Li
    Institut de Génétique et de Biologie Moléculaire et Cellulaire and Institut Clinique de la Souris, BP10142, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 103:11736-41. 2006
    ..We propose molecular mechanisms through which vitamin D3 and retinoic acid signalings could be involved in the pathogenesis of atopic diseases...
  16. ncbi request reprint Retinoic acid controls the bilateral symmetry of somite formation in the mouse embryo
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, Strasbourg, France
    Science 308:563-6. 2005
    ..These data implicate retinoic acid as an endogenous signal that maintains the bilateral synchrony of mesoderm segmentation, and therefore controls bilateral symmetry, in vertebrate embryos...
  17. ncbi request reprint Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development
    Nicolas Matt
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut Clinique de la Souris ICS, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Dev Dyn 233:167-76. 2005
    ..Therefore, CRBP1 is required in prenatal life to maintain normal amounts of ROL and to ensure its efficient storage but seems of secondary importance for RA synthesis, at least under conditions of maternal vitamin A sufficiency...
  18. ncbi request reprint Retinoic acid-induced developmental defects are mediated by RARbeta/RXR heterodimers in the pharyngeal endoderm
    Nicolas Matt
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 130:2083-93. 2003
    ..Additionally, we provide the first in vivo evidence that the synthetic RARbeta agonist BMS453 exhibits an antagonistic activity on the two other RAR isotypes...
  19. ncbi request reprint Targeted conditional somatic mutagenesis in the mouse: temporally-controlled knock out of retinoid receptors in epidermal keratinocytes
    Daniel Metzger
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 10142, 67404 Illkirch, France
    Methods Enzymol 364:379-408. 2003
  20. pmc Temporally controlled ablation of PTEN in adult mouse prostate epithelium generates a model of invasive prostatic adenocarcinoma
    Chandrahas Koumar Ratnacaram
    Department of Functional Genomics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, F 67400 Illkirch, France
    Proc Natl Acad Sci U S A 105:2521-6. 2008
    ..However, no progression to adenocarcinoma was observed. Because PTEN expression was undetectable in epithelial cells from these PINs, loss of PTEN function appears to act as a permissive event for uncontrolled cell proliferation...
  21. pmc Genetic and pharmacological evidence that a retinoic acid cannot be the RXR-activating ligand in mouse epidermis keratinocytes
    Cécile Calléja
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut Clinique de la Souris ICS, CNRS INSERM ULP, College de France, 67404 Illkirch Cedex, CU de Strasbourg, France
    Genes Dev 20:1525-38. 2006
    ....
  22. pmc Retinal dystrophy resulting from ablation of RXR alpha in the mouse retinal pigment epithelium
    Mikiro Mori
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, College de France, Strasbourg, France
    Am J Pathol 164:701-10. 2004
    ....
  23. doi request reprint Temporally controlled targeted somatic mutagenesis in mouse eye pigment epithelium
    Mikiro Mori
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS UMR7104 INSERM U964, College de France, Universite de Strasbourg, Illkirch Cedex, France
    Genesis 50:828-32. 2012
    ..Importantly, no excision was detected in any cells in the absence of tamoxifen treatment. Thus, the TRP1-Cre-ER(T2) mouse line provides a powerful tool to study in vivo gene functions in the mouse eye pigment epithelium...
  24. pmc A newborn lethal defect due to inactivation of retinaldehyde dehydrogenase type 3 is prevented by maternal retinoic acid treatment
    Valérie Dupé
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Universite Louis Pasteur, College de France, BP10142, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    Proc Natl Acad Sci U S A 100:14036-41. 2003
    ..This malformation, which is similar to isolated congenital CA in humans and may result from impaired RA-controlled down-regulation of Fgf8 expression in nasal fins, can be prevented by a simple maternal treatment with RA...
  25. ncbi request reprint Temporally controlled site-specific mutagenesis in the germ cell lineage of the mouse testis
    Philipp Weber
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Universite Louis Pasteur, College de France, B P 163, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    Biol Reprod 68:553-9. 2003
    ..The established PrP-Cre-ER(T) line should provide a valuable tool for studying functions of germ cell-expressed genes involved in spermatogenesis...
  26. pmc Thymic stromal lymphopoietin overproduced by keratinocytes in mouse skin aggravates experimental asthma
    Zhikun Zhang
    Department of Functional Genomics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 106:1536-41. 2009
    ..Our study, which provides a mouse model to study human "atopic march," indicates that keratinocyte-produced TSLP may represent an important factor in the link of atopic dermatitis to asthma...
  27. ncbi request reprint Retinaldehyde dehydrogenase 2 and Hoxc8 are required in the murine brachial spinal cord for the specification of Lim1+ motoneurons and the correct distribution of Islet1+ motoneurons
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP 10142, 67404 Illkirch Cedex, C U de Strasbourg, France
    Development 132:1611-21. 2005
    ..Thus, interdependent RA signaling and Hox gene functions are required for the specification of brachial motoneurons in the mouse...
  28. pmc Decreased embryonic retinoic acid synthesis results in a DiGeorge syndrome phenotype in newborn mice
    Julien Vermot
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche, Médicale Université Louis Pasteur, College de France, BP 10142, 67404 Illkirch Cedex, France
    Proc Natl Acad Sci U S A 100:1763-8. 2003
    ....
  29. pmc A transcriptionally silent RXRalpha supports early embryonic morphogenesis and heart development
    Bénédicte Mascrez
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Institut National de la Santé et de la Recherche Médicale U964, University Louis Pasteur de Strasbourg, France
    Proc Natl Acad Sci U S A 106:4272-7. 2009
    ....
  30. ncbi request reprint Molecular cloning, genomic structure, and expression analysis of the mouse transcriptional intermediary factor 1 gamma gene
    Kai Ping Yan
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, CNRS INSERM ULP College de France, BP 10142, 67 404 Illkirch Cedex, France
    Gene 334:3-13. 2004
    ..Taken together, these results indicate-and serve as a basis for investigating-a possible involvement of Tif1gamma in the control of embryonic development and spermatogenesis...
  31. ncbi request reprint Temporally controlled targeted somatic mutagenesis in skeletal muscles of the mouse
    Michael Schuler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, College de France, Illkirch Cedex, France
    Genesis 41:165-70. 2005
    ..HSA-Cre-ER(T2) mice should be of great value to analyze gene function in skeletal muscles, and to establish animal models of human skeletal muscle disorders...
  32. ncbi request reprint Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha
    Konstantin Khetchoumian
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Department of Functional Genomics, Centre National de la Recherche Scientifique UMR7104, Universite Louis Pasteur, College de France, Illkirch, France
    Nat Genet 39:1500-6. 2007
    ..Our results not only provide genetic evidence that Trim24 and Rara co-regulate hepatocarcinogenesis in an antagonistic manner but also suggest that aberrant activation of Rara is deleterious to liver homeostasis...
  33. pmc Tripartite motif 24 (Trim24/Tif1α) tumor suppressor protein is a novel negative regulator of interferon (IFN)/signal transducers and activators of transcription (STAT) signaling pathway acting through retinoic acid receptor α (Rarα) inhibition
    Johan Tisserand
    Department of Functional Genomics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP 10142, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    J Biol Chem 286:33369-79. 2011
    ..Altogether, these results identify Trim24 as a novel negative regulator of the IFN/STAT pathway and suggest that this repression through Rara inhibition may prevent liver cancer...
  34. ncbi request reprint The retinoic acid receptors RARalpha and RARgamma are required for inner ear development
    Raymond Romand
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, College de France, B P 10142, 67404 Illkirch Cedex, France
    Mech Dev 119:213-23. 2002
    ..Altogether, these results demonstrate that RARalpha and RARgamma play an essential role in the initial differentiation of otic placode derivatives, whereas RARbeta plays a minimal role in this process...
  35. pmc Selective interaction between the chromatin-remodeling factor BRG1 and the heterochromatin-associated protein HP1alpha
    Anders Lade Nielsen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP10142, 67404 Illkirch Cedex, France
    EMBO J 21:5797-806. 2002
    ..Taken together, these results demonstrate that mammalian HP1 proteins are biochemically distinct and suggest an entirely novel function for BRG1 in modulating HP1alpha-containing heterochromatic structures...
  36. pmc Physiological and retinoid-induced proliferations of epidermis basal keratinocytes are differently controlled
    Benoit Chapellier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    EMBO J 21:3402-13. 2002
    ....
  37. ncbi request reprint Transgenic mice for conditional gene manipulation in astroglial cells
    Michal Slezak
    Department of Neurotransmission Neuroendocrine Secretion, Institute of Cellular and Integrative Neuroscience INCI, UMR 7168 LC2 CNRS Université Louis Pasteur, Strasbourg, France
    Glia 55:1565-76. 2007
    ..These new mouse lines should help to further explore the relevance of astrocytes for brain function, as well as their contribution to pathological conditions because of aging, disease or injury...
  38. pmc Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin
    Mei Li
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut Clinique de la Souris ICS, College de France, BP10142, 1 rue Laurent Fries, Illkirch 67404, CU de Strasbourg, France
    Proc Natl Acad Sci U S A 102:14795-800. 2005
    ..Finally, we demonstrate that thymic stromal lymphopoietin, whose expression is rapidly and strongly induced in RXRalphabeta-ablated keratinocytes, plays a key role in initiating the skin and systemic AD-like pathologies...
  39. doi request reprint STRA8-deficient spermatocytes initiate, but fail to complete, meiosis and undergo premature chromosome condensation
    Manuel Mark
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, INSERM U596, CNRS UMR7104, Illkirch, France
    J Cell Sci 121:3233-42. 2008
    ..From these latter observations and from the wild-type pattern of Stra8 expression, we propose that, in preleptotene spermatocytes, STRA8 is involved in the process that leads to stable commitment to the meiotic cell cycle...
  40. doi request reprint Corneodesmosin gene ablation induces lethal skin-barrier disruption and hair-follicle degeneration related to desmosome dysfunction
    Emilie A Leclerc
    UMR 5165 Différenciation Epidermique et Autoimmunité Rhumatoïde UDEAR, CNRS Université Toulouse III, IFR150, INSERM, CHU Purpan, Place du Dr Baylac, TSA 40031, F 31059 Toulouse, Cedex 9, France
    J Cell Sci 122:2699-709. 2009
    ..The strong adhesive function that the protein confers on corneodesmosomes also seems necessary for maintaining the architecture of the hair follicle...
  41. pmc The transcriptional coregulators TIF2 and SRC-1 regulate energy homeostasis by modulating mitochondrial respiration in skeletal muscles
    Delphine Duteil
    Department of Physiological Genetics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Cell Metab 12:496-508. 2010
    ..Thus, modulation of the expression and/or activity of these coregulators represents an attractive way to prevent or treat metabolic disorders...
  42. ncbi request reprint Function of retinoid nuclear receptors: lessons from genetic and pharmacological dissections of the retinoic acid signaling pathway during mouse embryogenesis
    Manuel Mark
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut Clinique de la Souris, Centre National de la Recherche Scientifique INSERM, Universite Louis Pasteur de Strasbourg, College de France, 67404 Illkirch Cedex, CU de Strasbourg, France
    Annu Rev Pharmacol Toxicol 46:451-80. 2006
    ..Additional cell type-restricted and temporally controlled somatic mutagenesis is required to determine the functions of RARs and RXRs during postnatal life...
  43. pmc Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche ScientifiqueInstitut National de la Santé et de la Recherche MédicaleUniversité Louis PasteurCollège de France, Strasbourg, France
    Proc Natl Acad Sci U S A 99:16111-6. 2002
    ....
  44. ncbi request reprint Retinoic acid signalling in the development of branchial arches
    Manuel Mark
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut Clinique de la Souris ICS, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Curr Opin Genet Dev 14:591-8. 2004
    ..In all vertebrate species, dramatic malformations generated by experimental blocks or activations of retinoic acid signalling highlight key roles for this molecule in the endoderm for branchial arch formation and morphogenesis...
  45. pmc Phosphorylation by p38MAPK and recruitment of SUG-1 are required for RA-induced RAR gamma degradation and transactivation
    Maurizio Gianni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 163, 67404 Illkirch Cedex, France
    EMBO J 21:3760-9. 2002
    ..Blocking RAR gamma 2 degradation through inhibition of either the p38MAPK pathway or the 26S proteasome function impairs its RA-induced transactivation activity. Thus, the turnover of RAR gamma 2 is linked to transactivation...
  46. ncbi request reprint Retinoic acid metabolism and signaling pathways in the adult and developing mouse testis
    Nadège Vernet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Université Louis Pasteur de Strasbourg ULP Collège de France, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    Endocrinology 147:96-110. 2006
    ..Our data also suggest that the involvement of RA in testis development starts when primary spermatogonia first appear...
  47. ncbi request reprint Expression of Sox9 in granulosa cells lacking the estrogen receptors, ERalpha and ERbeta
    Sonia Dupont
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Illkirch Cedex, France
    Dev Dyn 226:103-6. 2003
    ..These findings suggest that functional Sertoli cells can transdifferentiate from mature granulosa cells devoid of estrogen receptors as a result of Sox9 expression...
  48. ncbi request reprint Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes
    Arup Kumar Indra
    Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS UMR7104 INSERM U596 ULP, College de France, Illkirch, Strasbourg, France
    J Invest Dermatol 127:1250-60. 2007
    ....
  49. ncbi request reprint Cell differentiation induces TIF1beta association with centromeric heterochromatin via an HP1 interaction
    Florence Cammas
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP163, 67404 Illkirch Cedex, France
    J Cell Sci 115:3439-48. 2002
    ..Collectively, these data provide compelling evidence for a dynamic nuclear compartmentalization of TIF1beta that is regulated during cell differentiation through a mechanism that requires HP1 interaction...
  50. pmc Myocytic androgen receptor controls the strength but not the mass of limb muscles
    Céline Chambon
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7104, Institut National de la Santé et de la Recherche Médicale U964, Universite de Strasbourg, College de France, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 107:14327-32. 2010
    ..These distinct androgen signaling pathways in perineal and limb muscles may allow the design of screens to identify selective androgen modulators of muscle strength...
  51. pmc Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant
    Maria Cristina Antal
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, College de France, Universite Louis Pasteur de Strasbourg, Illkirch, France
    Proc Natl Acad Sci U S A 105:2433-8. 2008
    ....
  52. pmc Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure
    Nassim Dali-Youcef
    Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, Universite Louis Pasteur, 1 rue Laurent Fries, BP 10142, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 104:10703-8. 2007
    ....
  53. pmc Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse
    Takeshi Imai
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale, Universite Louis Pasteur, BP10142, 1 rue Laurent Fries, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 101:4543-7. 2004
    ..Our data suggest that potent PPARgamma antagonists could be used to acutely reduce obesity...
  54. ncbi request reprint The phosphorylation site located in the A region of retinoic X receptor alpha is required for the antiproliferative effect of retinoic acid (RA) and the activation of RA target genes in F9 cells
    Julie Bastien
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 163, 67404 Illkirch Cedex, France
    J Biol Chem 277:28683-9. 2002
    ..Ser(22) is also indispensable for the antiproliferative effect of RA and necessary for the RA-induced down-regulation of p21(CIP) and p27(KIP) CKIs proteins that are known to be involved in the control of cell cycle progression...
  55. ncbi request reprint SRC-1 and TIF2 control energy balance between white and brown adipose tissues
    Frederic Picard
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 111:931-41. 2002
    ..Interestingly, a high-fat diet increases the TIF2/SRC-1 expression ratio, which may contribute to weight gain. These results reveal that the relative level of TIF2/SRC-1 can modulate energy metabolism...
  56. ncbi request reprint Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP 10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 129:3563-74. 2002
    ..We suggest that RA signaling cooperates with a posteriorly restricted factor such as dHand, to generate a functional zone of polarizing activity (ZPA)...
  57. pmc Glucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex
    Guoqiang Hua
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS UMR7104, INSERM U964, Illkirch 67404, France
    Proc Natl Acad Sci U S A 113:E635-43. 2016
    ....
  58. ncbi request reprint A directional strategy for monitoring Cre-mediated recombination at the cellular level in the mouse
    Frank Schnütgen
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Ce dex, CU de Strasbourg, France
    Nat Biotechnol 21:562-5. 2003
    ..We discuss how this strategy can be used to generate genetic modifications in a conditional manner...
  59. ncbi request reprint Mouse phenogenomics: the fast track to "systems metabolism"
    Carmen A Argmann
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique Institut Nationale de la Sante et de la Recherche Medicale Universite Louis Pasteur, 67404 Illkirch, France
    Cell Metab 2:349-60. 2005
    ..The ultimate goal of such strategies will be to mimic human metabolism with the click of a mouse...
  60. doi request reprint Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor
    Milan Surjit
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS UMR7104, INSERM U964, Universite de Strasbourg, College de France, Illkirch, 67404, France
    Cell 145:224-41. 2011
    ..This mechanism suits GR signaling remarkably well, given that adrenal secretion of GC fluctuates in a circadian and stress-related fashion...
  61. pmc Working memory deficits in retinoid X receptor gamma-deficient mice
    Marta Wietrzych
    Institut de Gaénétique et de Biologie Moléculaire et Cellulaire IGBMC, Institut Clinique de la Souris ICS, CNRS INSERM ULP, College de France, BP10142, 67404 Illkirch Cedex, CU de Strasbourg, France
    Learn Mem 12:318-26. 2005
    ..The mechanism of this modulation is potentially related to functions of RXRgamma in frontal and perirhinal cortex, structures in which we detected RXRgamma expression and which are functionally implicated in working memory processes...
  62. ncbi request reprint TRIM involvement in transcriptional regulation
    Florence Cammas
    Department of Functional Genomics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, Illkirch, France
    Adv Exp Med Biol 770:59-76. 2012
    ..In this chapter, we will consider the molecular interactions made by these TRIM proteins and will attempt to clarify some of the molecular mechanisms underlying their regulatory effect on transcription...
  63. pmc ADA3-containing complexes associate with estrogen receptor alpha
    Arndt Benecke
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, BP163, 67404 Illkirch Cedex, France
    Nucleic Acids Res 30:2508-14. 2002
    ..However, the ADA3-containing TBP-free-TAF-containing complex (TFTC) can interact with ERalpha in a ligand-independent manner, indicating that other subunits of the complex are sufficient to mediate interaction with NRs...
  64. pmc The function of TIF2/GRIP1 in mouse reproduction is distinct from those of SRC-1 and p/CIP
    Martine Gehin
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, 67404 Illkirch Cedex, France
    Mol Cell Biol 22:5923-37. 2002
    ..Thus, even though the three p160 coactivators exhibit strong sequence homology and similar activity in assays in vitro, they play distinct physiological roles in vivo, as their genetic eliminations result in distinct pathologies...
  65. pmc Function of retinoic acid receptors during embryonic development
    Manuel Mark
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Département de Biologie Cellulaire and Développement, Strasbourg, France
    Nucl Recept Signal 7:e002. 2009
    ..Spatio-temporally-controlled somatic mutations generated in given cell types/tissues and at chosen times during postnatal life, will be required to reveal all the functions of RAR and RXR throughout the lifetime of the mouse...
  66. ncbi request reprint Seeing is believing
    Pierre Oudet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centre National de la Recherche Scientifique, College de France, Universite Louis Pasteur, BP10143, 67404 Illkirch Cedex, Communaute Urbaine de Strasbourg, France
    Cell 116:S79-80, 1 p following S80. 2004
  67. ncbi request reprint International Union of Pharmacology. LX. Retinoic acid receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:712-25. 2006
    ..This review summarizes the considerable amount of knowledge generated on these receptors...
  68. ncbi request reprint International Union of Pharmacology. LXIII. Retinoid X receptors
    Pierre Germain
    Centre National de la Recherche Scientifique Institut National de la Santé et de la Recherche Médicale Université Louis Pasteur, Illkirch, Communaute Urbaine de Strasbourg, France
    Pharmacol Rev 58:760-72. 2006
    ..Indeed, multiple questions about the actual biological role of RXRs and the existence of an endogenous ligand have still to be answered...
  69. ncbi request reprint Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, B P 163, 67404 Illkirch Cedex, C U de Strasbourg, France
    Mech Dev 110:165-71. 2002
    ..Only Raldh1 expression is seen after birth in specific brain structures. These data indicate a requirement for regulated RA synthesis in various differentiating organs...
  70. pmc The nuclear hormone receptor PPARγ counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells
    Estelle Woldt
    CNRS, UMR 7213, University of Strasbourg, 67401 Illkirch, France
    Nat Commun 3:1077. 2012
    ..Targeting this signalling pathway may have clinical implications in the context of common complications of atherosclerosis, including coronary artery calcification and valvular sclerosis...
  71. ncbi request reprint Mouse functional genomics requires standardization of mouse handling and housing conditions
    Marie France Champy
    Institut Clinique de la Souris, BP10142, 67404, Illkirch Cedex, France
    Mamm Genome 15:768-83. 2004
    ..Our results, which show that minor changes in procedures can profoundly affect biological variables, underscore the importance of establishing uniform and validated animal procedures to improve reproducibility of mouse phenotypic data...
  72. doi request reprint Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice
    Marta Wietrzych-Schindler
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Centres National de Recherche Scientifique Institut National de Santé et de Recherche Médicale Université de Strasbourg Collège de France, Strasbourg, France
    Biol Psychiatry 69:788-94. 2011
    ..The mechanisms of such activities are still elusive and may involve retinoid X receptors (RXRs), transcription factors known to bind DHA in vitro...
  73. ncbi request reprint Site-specific somatic mutagenesis in the retinal pigment epithelium
    Mikiro Mori
    Institute of Genetics and Molecular and Cellular Biology IGBMC, CNRS INSERM ULP College de France, BP 163, 67404 Illkirch Cedex, CU de Strasbourg, France
    Invest Ophthalmol Vis Sci 43:1384-8. 2002
    ..Generate site-specific somatic mutations selectively in the retinal pigment epithelium (RPE) in mice...
  74. ncbi request reprint Down-regulation of the phosphatidylinositol 3-kinase/Akt pathway is involved in retinoic acid-induced phosphorylation, degradation, and transcriptional activity of retinoic acid receptor gamma 2
    Maurizio Gianni
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Université Louis Pasteur Collège de France, BP 163, 67404 Illkirch Cedex, France
    J Biol Chem 277:24859-62. 2002
    ..Altogether these data indicate that the PI3K/Akt pathway plays an important role in retinoic acid signaling...
  75. ncbi request reprint A conditional floxed (loxP-flanked) allele for the retinoic acid receptor alpha (RARalpha) gene
    Benoit Chapellier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Strasbourg, France
    Genesis 32:87-90. 2002
  76. ncbi request reprint A conditional floxed (loxP-flanked) allele for the retinoic acid receptor beta (RARbeta) gene
    Benoit Chapellier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Strasbourg, France
    Genesis 32:91-4. 2002
  77. ncbi request reprint A conditional floxed (loxP-flanked) allele for the retinoic acid receptor gamma (RARgamma) gene
    Benoit Chapellier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, College de France, Strasbourg, France
    Genesis 32:95-8. 2002
  78. ncbi request reprint Germ cell expression of the transcriptional co-repressor TIF1beta is required for the maintenance of spermatogenesis in the mouse
    Philipp Weber
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France, BP163, 67404 Illkirch Cedex, France
    Development 129:2329-37. 2002
    ....
  79. ncbi request reprint Developing with lethal RA levels: genetic ablation of Rarg can restore the viability of mice lacking Cyp26a1
    Suzan Abu-Abed
    Cancer Research Labs, Queen s University, Kingston, ON K7L 3N6, Canada
    Development 130:1449-59. 2003
    ....
  80. pmc NSD1 is essential for early post-implantation development and has a catalytically active SET domain
    Geetha Vani Rayasam
    Laboratory of Receptor Biology and Gene Expression, National Institutes of Health, Bethesda, MD 20892, USA
    EMBO J 22:3153-63. 2003
    ..We have also examined the enzymatic potential of NSD1 and found that its SET domain possesses intrinsic histone methyltransferase activity with specificity for Lys36 of histone H3 (H3-K36) and Lys20 of histone H4 (H4-K20)...
  81. pmc Modular patterning of structure and function of the striatum by retinoid receptor signaling
    Wen Lin Liao
    Institute of Neuroscience, Center of Neuroscience, Department of Life Sciences, National Yang Ming University, Taipei, Taiwan 112, Republic of China
    Proc Natl Acad Sci U S A 105:6765-70. 2008
    ..RARbeta signaling thus plays a crucial role in setting up striatal compartments that may engage in neural circuits of psychomotor control...
  82. pmc In vivo activation of PPAR target genes by RXR homodimers
    Annemieke IJpenberg
    Center for Integrative Genomics, NCCR Frontiers in Genetics, University of Lausanne, Lausanne, Switzerland
    EMBO J 23:2083-91. 2004
    ..These observations have important pharmacological implications for the development of new rexinoid-based treatments...
  83. pmc Retinoids regulate the anterior expression boundaries of 5' Hoxb genes in posterior hindbrain
    Tony Oosterveen
    Hubrecht Laboratory, The Netherlands Institute of Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    EMBO J 22:262-9. 2003
    ..The RARE and surrounding sequences are found at homologous positions in the human, mouse and zebrafish genome, which supports an evolutionarily conserved regulatory function...
  84. pmc RARgamma is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation
    Louise E Purton
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    J Exp Med 203:1283-93. 2006
    ..We conclude that the RARs have distinct roles in hematopoiesis and that RARgamma is a critical physiological and pharmacological regulator of the balance between HSC self-renewal and differentiation...
  85. ncbi request reprint Genetic evidence that oxidative derivatives of retinoic acid are not involved in retinoid signaling during mouse development
    Karen Niederreither
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP College de France
    Nat Genet 31:84-8. 2002
    ..We provide genetic evidence that ALDH1A2 and CYP26A1 activities concurrently establish local embryonic retinoic acid levels that must be finely tuned to allow posterior organ development and to prevent spina bifida...
  86. ncbi request reprint Interdigital apoptosis and downregulation of BAG-1 expression in mouse autopods
    Alexander Crocoll
    Forschungszentrum Karlsruhe, Institute of Toxicology and Genetics, P O Box 3640, 76021, Karlsruhe, Germany
    Mech Dev 111:149-52. 2002
    ..On the contrary, the expression of BAG-1 remains unaltered in autopods of RARbeta(-/-)/RARgamma(-/-) mice which show severe interdigital webbing due to a marked decrease in interdigital apoptosis...
  87. ncbi request reprint Estrogen receptor alpha, but not beta, is required for optimal dendritic cell differentiation and [corrected] CD40-induced cytokine production
    Victorine Douin-Echinard
    Institut National de la Sante et de la Recherche Medicale U563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    J Immunol 180:3661-9. 2008
    ..Taken together, these results provide the first genetic evidence that ERalpha is the main receptor regulating estrogen-dependent DC differentiation in vitro and acquisition of their effector functions...
  88. ncbi request reprint Identification and characterization of retinoic acid receptor beta2 target genes in F9 teratocarcinoma cells
    Yong Zhuang
    Pharmacology Department, Weill Medical College of Cornell University, New York, NY, USA
    Mol Cancer Res 1:619-30. 2003
    ..Because the lack of RARbeta(2) alters both the control of proliferation and differentiation in F9 cells, the genes that we have characterized may mediate key effects of RA, via RARbeta(2), on these processes...
  89. ncbi request reprint CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse
    Masayuki Uehara
    Developmental Genetics Group, Graduate School of Frontier Biosciences, Osaka University, Osaka 565 0871, Japan
    Dev Biol 302:399-411. 2007
    ....
  90. ncbi request reprint Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis
    Tushar J Desai
    Pulmonary Center, Boston University School of Medicine, 80 East Concord Street R 304, Boston, MA 02118, USA
    Dev Biol 291:12-24. 2006
    ..Our data support the idea that balanced activation of RAR alpha and beta is critical for proper lung bud initiation and endodermal differentiation...
  91. ncbi request reprint Retinoic acid signaling affects cortical synchrony during sleep
    Stephanie Maret
    Center for Integrative Genomics, University of Lausanne, Genopode, 1015 Lausanne Dorigny, Switzerland
    Science 310:111-3. 2005
    ..Thus, retinoic acid signaling, which is involved in the patterning of the brain and dopaminergic pathways, regulates cortical synchrony in the adult...
  92. ncbi request reprint PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator
    Rushad Pavri
    Department of Biochemistry, Howard Hughes Medical Institute, University of Medicine and Dentistry of New Jersey, 683 Hoes Lane, Piscataway, New Jersey 08854, USA
    Mol Cell 18:83-96. 2005
    ..PARP-1 appears to function as a specificity factor regulating the RA-induced switch of Mediator from the inactive (Cdk8+) to the active (Cdk8-) state in RAR-dependent transcription...
  93. ncbi request reprint Insidious adrenocortical insufficiency underlies neuroendocrine dysregulation in TIF-2 deficient mice
    Alexandre V Patchev
    Institute of Experimental Endocrinology, Charite School of Medicine, Humboldt University, Schumannstr 20 21, Berlin 10117, Germany
    FASEB J 21:231-8. 2007
    ..Thus, hyperactivity of the hypothalamo-pituitary unit is ascribed to insidious adrenal insufficiency and impaired glucocorticoid feedback...
  94. ncbi request reprint TGF-beta superfamily signaling is essential for tooth and hair morphogenesis and differentiation
    Borut Klopcic
    I Medical Department, Section Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Eur J Cell Biol 86:781-99. 2007
    ..This study shows that TGF-beta superfamily signaling is essential for development of hair, tooth and T-cells as well as differentiation and proliferation control in adult tissues...
  95. ncbi request reprint Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation
    Patricia Serpente
    Medical Research Council, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK
    Development 132:503-13. 2005
    ..We propose that the function of this circuit is to align the initially incongruent expression of multiple RA-induced genes at a single segment boundary...
  96. pmc A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency
    Carl R Walkley
    Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, 3002, Australia
    Cell 129:1097-110. 2007
    ..These data show that loss of RARgamma results in a nonhematopoietic cell-intrinsic MPS, revealing the capability of the microenvironment to be the sole cause of hematopoietic disorders...
  97. ncbi request reprint Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts
    Takashi Nakamura
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Cell 130:811-23. 2007
    ..Our results support a model in which estrogen regulates the life span of mature osteoclasts via the induction of the Fas/FasL system, thereby providing an explanation for the osteoprotective function of estrogen as well as SERMs...
  98. ncbi request reprint Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver
    Yuzhi Jia
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Illinois 60611 3008, USA
    J Biol Chem 279:24427-34. 2004
    ..In essence, the absence of PBP in hepatocytes in vivo appears to mimic the absence of PPARalpha, indicating that coactivator PBP is essential for PPARalpha-regulated gene expression in liver parenchymal cells...
  99. ncbi request reprint Epithelial Bmpr1a regulates differentiation and proliferation in postnatal hair follicles and is essential for tooth development
    Thomas Andl
    Department of Dermatology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Development 131:2257-68. 2004
    ..These results provide definitive genetic evidence that epithelial Bmpr1a is required for completion of tooth morphogenesis, and regulates terminal differentiation and proliferation in postnatal hair follicles...
  100. ncbi request reprint Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage
    Alberto Ruiz
    Jules Stein Eye Institute, University of California, Los Angeles 90095 7002, USA
    Invest Ophthalmol Vis Sci 48:5377-87. 2007
    ..To evaluate the effects on the synthesis of retinyl esters and on the expression of other proteins involved in the continuation of the visual cycle...
  101. ncbi request reprint Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation
    Carl R Walkley
    Division of Research, Peter MacCallum Cancer Centre, St Andrew s Place, East Melbourne, Victoria, 3002, Australia
    Blood 103:1286-95. 2004
    ..Moreover, these data demonstrate selectivity among the RARs for cell cycle arrest pathways and provide a direct mechanism to link differentiation induction and regulation of the Myc antagonist Mad1...