H Chabriat

Summary

Country: France

Publications

  1. doi Predictors of Clinical Worsening in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: Prospective Cohort Study
    Hugues Chabriat
    From the Department of Neurology, GH Saint Louis Lariboisière, Assistance publique des Hôpitaux de Paris APHP, Université Paris Denis Diderot and DHU NeuroVasc Sorbonne Paris Cité, Paris, France H C, D H, O G, E J, N A, S R, A J INSERM UMR 1161, Paris, France H C, D H, E J Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany M D, C O, N Z, M D Department of Neuroradiology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, Paris, France J P G Bioclinica Inc, Lyon, France C P Unité de Recherche Clinique, GH Saint Louis Lariboisière, Assistance Publique des Hopitaux de Paris, Université Paris Denis Diderot, Paris, France E V and Munich Cluster for Systems Neurology SyNergy, Munich, Germany M D
    Stroke 47:4-11. 2016
  2. doi [Reference center for rare vascular diseases of the eye and brain]
    H Chabriat
    CERVCO, Service de Neurologie, Pôle Neurosensoriel, Hopital Lariboisiere et INSERM UMR740, 75010 Paris, France
    Rev Neurol (Paris) 169:S28-32. 2013
  3. doi Extensive white matter hyperintensities may increase brain volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Ming Yao
    University Paris Diderot, INSERM UMR 740, and Department of Neurology, Lariboisiere Hospital, 2 rue Ambroise Pare, 75010 Paris, France
    Stroke 43:3252-7. 2012
  4. doi Effects of gender on the phenotype of CADASIL
    Bence Gunda
    Department of Neurology, CHU Lariboisière, APHP and Université Paris VII, Paris, France
    Stroke 43:137-41. 2012
  5. pmc Three-dimensional MRI analysis of individual volume of Lacunes in CADASIL
    Dominique Herve
    Hopital Lariboisiere, 2 rue Ambroise Pare, 75010 Paris, France
    Stroke 40:124-8. 2009
  6. doi Cortical folding influences migraine aura symptoms in CADASIL
    Eric Jouvent
    Univ Paris Diderot, Sorbonne Paris Cité, UMR 740 INSERM, France
    J Neurol Neurosurg Psychiatry 83:213-6. 2012
  7. pmc Neuropsychiatric manifestations in CADASIL
    Hugues Chabriat
    Department of Neurology, Hopital Lariboisiere, Universite Paris VII, Denis Diderot, Paris, France
    Dialogues Clin Neurosci 9:199-208. 2007
  8. ncbi Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL
    A Viswanathan
    Departments of Neurology, Centre Hospitalier Universitaire Lariboisière, Assistance Publique des Hopitaux de Paris, France
    Neurology 69:172-9. 2007
  9. ncbi Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI
    H Chabriat
    Department of Neurology, CHU Lariboisière, Universite Paris VII, France
    Stroke 30:2637-43. 1999
  10. doi Apathy: a major symptom in CADASIL
    S Reyes
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, France
    Neurology 72:905-10. 2009

Collaborators

Detail Information

Publications65

  1. doi Predictors of Clinical Worsening in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: Prospective Cohort Study
    Hugues Chabriat
    From the Department of Neurology, GH Saint Louis Lariboisière, Assistance publique des Hôpitaux de Paris APHP, Université Paris Denis Diderot and DHU NeuroVasc Sorbonne Paris Cité, Paris, France H C, D H, O G, E J, N A, S R, A J INSERM UMR 1161, Paris, France H C, D H, E J Institute for Stroke and Dementia Research, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany M D, C O, N Z, M D Department of Neuroradiology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, Paris, France J P G Bioclinica Inc, Lyon, France C P Unité de Recherche Clinique, GH Saint Louis Lariboisière, Assistance Publique des Hopitaux de Paris, Université Paris Denis Diderot, Paris, France E V and Munich Cluster for Systems Neurology SyNergy, Munich, Germany M D
    Stroke 47:4-11. 2016
    ..This study aims to identify demographic, clinical, and magnetic resonance imaging predictors of incident strokes, incident dementia, clinical deterioration, and death in patients with this genetically proven disease...
  2. doi [Reference center for rare vascular diseases of the eye and brain]
    H Chabriat
    CERVCO, Service de Neurologie, Pôle Neurosensoriel, Hopital Lariboisiere et INSERM UMR740, 75010 Paris, France
    Rev Neurol (Paris) 169:S28-32. 2013
    ..The reference center now needs simplified assessment tools, the formal recognition of a network of medical 'experts', and adaptation of its technical and human resources to achieve its objectives...
  3. doi Extensive white matter hyperintensities may increase brain volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Ming Yao
    University Paris Diderot, INSERM UMR 740, and Department of Neurology, Lariboisiere Hospital, 2 rue Ambroise Pare, 75010 Paris, France
    Stroke 43:3252-7. 2012
    ..The association between WMH and brain volume was analyzed in a large population of patients with CADASIL...
  4. doi Effects of gender on the phenotype of CADASIL
    Bence Gunda
    Department of Neurology, CHU Lariboisière, APHP and Université Paris VII, Paris, France
    Stroke 43:137-41. 2012
    ..This study aims to evaluate the effect of gender on the main clinical and neuroimaging characteristics of CADASIL...
  5. pmc Three-dimensional MRI analysis of individual volume of Lacunes in CADASIL
    Dominique Herve
    Hopital Lariboisiere, 2 rue Ambroise Pare, 75010 Paris, France
    Stroke 40:124-8. 2009
    ..The purpose of this study was to study the impact of age, vascular risk factors, and MRI markers on the ILV in a large cohort of patients with CADASIL...
  6. doi Cortical folding influences migraine aura symptoms in CADASIL
    Eric Jouvent
    Univ Paris Diderot, Sorbonne Paris Cité, UMR 740 INSERM, France
    J Neurol Neurosurg Psychiatry 83:213-6. 2012
    ..The aim of this study was to determine whether specific morphology of the primary visual cortex is associated with the absence of visual symptoms during migraine aura in CADASIL...
  7. pmc Neuropsychiatric manifestations in CADASIL
    Hugues Chabriat
    Department of Neurology, Hopital Lariboisiere, Universite Paris VII, Denis Diderot, Paris, France
    Dialogues Clin Neurosci 9:199-208. 2007
    ..Further studies are needed to better understand the relationships between cerebral lesions and both cognitive and psychiatric symptoms in this small-vessel disease of the brain...
  8. ncbi Lacunar lesions are independently associated with disability and cognitive impairment in CADASIL
    A Viswanathan
    Departments of Neurology, Centre Hospitalier Universitaire Lariboisière, Assistance Publique des Hopitaux de Paris, France
    Neurology 69:172-9. 2007
    ..Our purpose was to examine the influence of the visible MRI markers in the disease, including the load of lacunar lesions on cognitive impairment and disability in CADASIL...
  9. ncbi Clinical severity in CADASIL related to ultrastructural damage in white matter: in vivo study with diffusion tensor MRI
    H Chabriat
    Department of Neurology, CHU Lariboisière, Universite Paris VII, France
    Stroke 30:2637-43. 1999
    ..The exact role played by MRI white-matter abnormalities, a hallmark of the disease, in the severity of the clinical phenotype remains poorly understood...
  10. doi Apathy: a major symptom in CADASIL
    S Reyes
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, France
    Neurology 72:905-10. 2009
    ....
  11. doi Verbal memory impairment in subcortical ischemic vascular disease: a descriptive analysis in CADASIL
    S Epelbaum
    Department of Neurology, CHU Lariboisière, APHP, France
    Neurobiol Aging 32:2172-82. 2011
    ....
  12. doi Apathy is related to cortex morphology in CADASIL. A sulcal-based morphometry study
    E Jouvent
    Service de Neurologie, Hopital Lariboisiere, 2 rue Ambroise Pare, Paris, France
    Neurology 76:1472-7. 2011
    ..The aim of this study was to evaluate the neuroanatomic correlates of apathy, using new MRI postprocessing methods based on the identification of cortical sulci, in a large cohort of patients with CADASIL...
  13. ncbi Diffusion tensor imaging study of subcortical gray matter in cadasil
    N Molko
    , INSERM U334, Paris, France
    Stroke 32:2049-54. 2001
    ..The importance of this degenerative phenomenon in the pathophysiology of CADASIL requires further investigation...
  14. doi Paediatric moyamoya in mainland France: a comprehensive survey of academic neuropaediatric centres
    M Kossorotoff
    Paediatric Neurology Department, Hopital Necker Enfants Malades, APHP, Paris, France
    Cerebrovasc Dis 33:76-9. 2012
    ..Epidemiological data of paediatric moyamoya disease/syndrome (MMD/MMS) in non-Asian populations are scarce...
  15. doi Presymptomatic genetic testing in CADASIL
    S Reyes
    Department of Neurology and CERVCO, GH Saint Louis Lariboisière Fernand Widal, APHP et Université Paris, 7 Denis Diderot, Paris, France
    J Neurol 259:2131-6. 2012
    ..Our study also highlights that a multidisciplinary and multistep procedure in genetic counselling testing appears useful to obtain minimal harmful consequences of genetic testing...
  16. doi CADASIL
    D Herve
    Service de Neurologie, Centre de Référence des maladies Vasculaires rares du Cerveau et de l Oeil CERVCO, Hopital Lariboisiere, Paris, France
    J Geriatr Psychiatry Neurol 23:269-76. 2010
    ..The pathologic hallmark of CADASIL is the presence of electron-dense granules in the media of arterioles that can be identified by electron microscopic evaluation of skin biopsies...
  17. ncbi Cerebral hemodynamics in CADASIL before and after acetazolamide challenge assessed with MRI bolus tracking
    H Chabriat
    Department of Neurology, CHU Lariboisière, Universite Paris VII, France
    Stroke 31:1904-12. 2000
    ..Although chronic ischemia is presumed to cause the tissue lesions, the pattern of perfusion abnormalities and hemodynamic reserve in CADASIL, particularly within the white matter, remains unknown...
  18. ncbi Blood pressure and haemoglobin A1c are associated with microhaemorrhage in CADASIL: a two-centre cohort study
    Anand Viswanathan
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, Paris, France
    Brain 129:2375-83. 2006
    ..These lesions have a potential clinical impact in CADASIL. These findings further suggest that modulation of blood pressure and glucose levels might influence the course of the disease...
  19. ncbi Lower Magnetization Transfer Ratio in the Forceps Minor Is Associated with Poorer Gait Velocity in Older Adults
    S Seiler
    From the Department of Neurology S S, L P, E H, D P, F F, S R, R S and Institute of Medical Informatics, Statistics and Documentation E H, Medical University of Graz, Graz, Austria Institute for Stroke and Dementia Research B G, M D, Klinikum der Universitat Munchen, Ludwig Maximilians University, Munich, Germany Department of Neurology E J, H C, Institut National de la Sante et de la Recherche Medicale, UMR 740, Centre Hospitalo Universitaire Lariboisière, Paris, France and Neurospin J F M, Commissariat à l Énergie Atomique et aux Énergies Alternatives Saclay, Gif Yvette, France
    AJNR Am J Neuroradiol . 2016
    ..In this multimodal MR imaging study, we used 2 voxel-based analysis methods to assess the voxelwise relationship of magnetization transfer ratio and white matter hyperintensity location with gait velocity in older adults...
  20. doi Vascular risk factors and morphometric data in cervical artery dissection: a case-control study
    M Arnold
    Assistance Publique, Hopitaux de Paris, Department of Neurology, University Hospitals Lariboisière, Paris, France
    J Neurol Neurosurg Psychiatry 80:232-4. 2009
    ..Limited knowledge exists on vascular risk factors, body height and weight in patients with spontaneous cervical artery dissection (sCAD)...
  21. doi Location of lacunar infarcts correlates with cognition in a sample of non-disabled subjects with age-related white-matter changes: the LADIS study
    S Benisty
    Department of Neurology, Lariboisiere Fernand Widal Hospital, APHP, Paris, France
    J Neurol Neurosurg Psychiatry 80:478-83. 2009
    ..The purpose of this study is to assess the topographic distribution of lacunes and determine whether it has an impact on cognitive functions in a sample of non-disabled patients with age-related white-matter changes...
  22. ncbi Skin biopsy immunostaining with a Notch3 monoclonal antibody for CADASIL diagnosis
    A Joutel
    INSERM EPI 99 21, Faculté de Médecine Lariboisiere, 10 Avenue de Verdun, 75010, Paris, France
    Lancet 358:2049-51. 2001
    ..Our immunostaining technique is highly sensitive (96%) and specific (100%) for diagnosis of CADASIL...
  23. doi Dilative arteriopathy and basilar artery dolichoectasia complicating late-onset Pompe disease
    P Laforet
    Institut de Myologie, Batiment Babinski, Groupe Hospitalier Pitie Salpetriere, 75651 Paris Cedex 13, France
    Neurology 70:2063-6. 2008
    ..Strokes related to intracranial aneurysm or arteriopathy have been reported in a few patients with late-onset Pompe disease. These reports suggested that cerebral vessel involvement could be an underrecognized complication of this disease...
  24. doi Inverse association between CSF Aβ 42 levels and years of education in mild form of Alzheimer's disease: the cognitive reserve theory
    Julien Dumurgier
    Centre Mémoire de Ressources et de Recherche CMRR Paris Nord Ile de France, Lariboisiere, Fernand Widal Hospital, APHP, University Paris 7 Denis Diderot, Paris, France
    Neurobiol Dis 40:456-9. 2010
    ..These results are consistent with the cognitive reserve theory, and suggest that cognitive reserve may be protective against amyloid related cognitive impairment at the onset of the clinical dementia...
  25. ncbi Dilation of Virchow-Robin spaces in CADASIL
    R Cumurciuc
    Department of Neurology, Lariboisiere Hospital, Paris, France
    Eur J Neurol 13:187-90. 2006
    ..In contrast, the relation with age suggests that either aging, progression of vascular wall alterations during the course of the disease, or both of these processes can favour the extension of VRS in CADASIL...
  26. doi Cadasil
    Hugues Chabriat
    Service de Neurologie, Groupe Hospitalier Lariboisière Fernand Widal, Assistance Publique Hopitaux de Paris, F 75010, Paris, France
    Lancet Neurol 8:643-53. 2009
    ..In this Review, we summarise the current understanding of CADASIL, a devastating disorder that also serves as a model for the more common forms of subcortical ischaemic strokes and pure vascular dementia...
  27. doi Cortical changes in cerebral small vessel diseases: a 3D MRI study of cortical morphology in CADASIL
    Eric Jouvent
    Department of Neurology, INSERM UMR 740 and Université Paris VII, France
    Brain 131:2201-8. 2008
    ..These results suggest that the examination of cortical morphology may be of high clinical relevance in SVDB...
  28. doi Decreased T1 contrast between gray matter and normal-appearing white matter in CADASIL
    F De Guio
    From University Paris Diderot, Sorbonne Paris Cité, Paris, France
    AJNR Am J Neuroradiol 35:72-6. 2014
    ..The aim of this study was to evaluate the contrast alterations between gray matter and normal-appearing white matter on T1-weighted images in patients with CADASIL compared with healthy subjects...
  29. doi MR imaging features of isolated cortical vein thrombosis: diagnosis and follow-up
    M Boukobza
    Department of Neuroradiology, Hopital Lariboisiere, AP HP, Paris, France
    AJNR Am J Neuroradiol 30:344-8. 2009
    ..To our knowledge, very few MR imaging data have been reported in isolated cortical venous thrombosis (ICoVT). The purpose of this study was to describe MR imaging features, including T2*gradient-echo (GE) sequence, in presumed ICoVT...
  30. pmc Cognitive profile in CADASIL
    F Buffon
    Department of Neurology, Hopital Lariboisiere, 2 rue Ambroise Pare, 75010, Paris, France
    J Neurol Neurosurg Psychiatry 77:175-80. 2006
    ..The spectrum of cognitive alterations associated with CADASIL, a model of pure vascular dementia, has not been thoroughly evaluated...
  31. doi Frequency and location of dilated Virchow-Robin spaces in elderly people: a population-based 3D MR imaging study
    Y C Zhu
    From INSERM U708, Paris, France
    AJNR Am J Neuroradiol 32:709-13. 2011
    ..dVRS have been previously associated with aging and cerebrovascular diseases. However, little is known about their prevalence and topographic distribution in the general elderly population...
  32. ncbi Vascular dementia: potential of antiplatelet agents in prevention
    H Chabriat
    Department of Neurology, Hopital Lariboisiere, Paris, France
    Eur Neurol 55:61-9. 2006
    ....
  33. ncbi Brain atrophy is related to lacunar lesions and tissue microstructural changes in CADASIL
    Eric Jouvent
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, and Université Paris VII, Paris, France
    Stroke 38:1786-90. 2007
    ..The contribution of subcortical cerebral lesions in this process remains undetermined. The aim of this study was to investigate the relationships between cerebral volume and different types of subcortical MRI lesions in CADASIL...
  34. ncbi Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Anna Maria Basile
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy, and Department of Neurology, Hopital Lariboisiere, Paris, France
    Cerebrovasc Dis 21:315-22. 2006
    ..We sought whether such a trend existed in the association of vascular risk factors or comorbidities with the severity of ARWMC aiming particularly at further elucidating the relative roles of hypertension and stroke in this regard...
  35. doi Confluent thalamic hyperintensities in CADASIL
    Mathilde Jacqmin
    Service de Neurologie, Centre de Référence pour les maladies rares des Vaisseaux du Cerveau et de l Oeil CERVCO, INSERM U740, CHU Lariboisière, APHP, Paris, France
    Cerebrovasc Dis 30:308-13. 2010
    ..These lesions are often associated with focal lesions in the basal ganglia such as lacunar infarctions. The prevalence and significance of diffuse or confluent thalamic hyperintensities (CTH) remain unknown...
  36. pmc Distinct phenotypic and functional features of CADASIL mutations in the Notch3 ligand binding domain
    Marie Monet-Leprêtre
    INSERM U740, Faculté de Médecine Paris 7, Site Villemin, 10 Avenue de Verdun, Paris, France
    Brain 132:1601-12. 2009
    ....
  37. ncbi Electrocardiogram in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy patients without any clinical evidence of coronary artery disease: a case-control study
    Rodica Cumurciuc
    Department of Neurology, AP HP, Lariboisiere Hospital, Université Diderot, Paris, France
    Stroke 37:1100-2. 2006
    ..Thus, we conducted a case control study to determine the frequency of electrical abnormalities on a 12-lead resting ECG in CADASIL patients without classical atherosclerotic risk factors...
  38. ncbi Monitoring disease progression in CADASIL with diffusion magnetic resonance imaging: a study with whole brain histogram analysis
    Nicolas Molko
    INSERM U562, Orsay, Department of Neurology, CHU Lariboisière, Paris, France
    Stroke 33:2902-8. 2002
    ..The aim of the present study was to assess the sensitivity of diffusion tensor imaging for monitoring the progression of cerebral tissue damage during the course of CADASIL...
  39. ncbi Diffusion-weighted imaging of intravascular clots in cerebral venous thrombosis
    Pascal Favrole
    Department of Neurology, CHU Lariboisiere St Louis, Paris, France
    Stroke 35:99-103. 2004
    ..The frequency of these signal changes according to late venous recanalization was not determined yet...
  40. ncbi Longitudinal diffusion changes in cerebral hemispheres after MCA infarcts
    Frederique Buffon
    Department of Neurology, CHU Lariboisière, Universite Paris VII, Paris, France
    J Cereb Blood Flow Metab 25:641-50. 2005
    ..These results suggest that micro- and macrostructural tissue modifications can be detected with diffusion tensor imaging in regions remote from the ischemic area in both hemispheres...
  41. ncbi Shape and volume of lacunar infarcts: a 3D MRI study in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Dominique Herve
    Department of Neurology, CHU Lariboisière, Paris, France
    Stroke 36:2384-8. 2005
    ..The shape and size of lacunar infarcts was investigated using these techniques in 10 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients...
  42. doi Diagnostic criteria of vascular dementia in CADASIL
    Sarah Benisty
    Department of Geriatric Medicine, University Paris 7, 2 rue Ambroise Pare, 75010 Paris, France
    Stroke 39:838-44. 2008
    ..Application of these criteria in CADASIL, a genetic model of SIVD, may help to better assess their significance. The aim of this study was to compare different sets of diagnostic criteria of VaD in a population of CADASIL patients...
  43. doi Intracortical infarcts in small vessel disease: a combined 7-T postmortem MRI and neuropathological case study in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Eric Jouvent
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, France
    Stroke 42:e27-30. 2011
    ....
  44. ncbi A gene for familial hemiplegic migraine maps to chromosome 19
    A Joutel
    Laboratoire de Pathologie de l Immunité, Faculte de Medecine Necker, Paris, France
    Nat Genet 5:40-5. 1993
    ..Multilocus linkage analysis suggested that the loci responsible for the two diseases reside within an interval of about 30 cM on chromosome 19...
  45. ncbi Vertebrobasilar occlusive disorders presenting as sudden sensorineural hearing loss
    E Sauvaget
    Department of Otorhinolaryngology, Assistance Publique des Hopitaux de Paris, Hopital Lariboisiere, Universite Paris VII, Paris, France
    Laryngoscope 114:327-32. 2004
    ..This is an important issue for both neurologists and otolaryngologists, since the management and prognosis of this type of hearing loss widely differs from that of hearing loss from other causes...
  46. ncbi Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia
    A Joutel
    INSERM U25, Faculte de Medecine Necker Enfants Malades, Paris, France
    Nature 383:707-10. 1996
    ..We have identified mutations in CADASIL patients that cause serious disruption of this gene, indicating that Notch3 could be the defective protein in CADASIL patients...
  47. doi Silent brain infarcts: a review of MRI diagnostic criteria
    Yi cheng Zhu
    Department of Neurology, Peking Union Medical College Hospital, Beijing, China
    Stroke 42:1140-5. 2011
    ..In this study, we aimed to evaluate the different MRI parameters and criteria used for their evaluation in the literature to better understand the variation across studies and related limitations...
  48. ncbi A novel hereditary small vessel disease of the brain
    Steve Verreault
    Service de Neurologie, Laboratoire de Genetique, Hopital Lariboisiere, Assistance Publique des Hopitaux de Paris, France
    Ann Neurol 59:353-7. 2006
    ..Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most frequent of them. Herein, we report a family affected by a SVDB distinct from CADASIL...
  49. ncbi Clinical course and MRI changes of basilar artery dolichoectasia: three case reports
    Ahmed Idbaih
    Service de Neurologie, CHU Lariboisière, Paris, France
    Cerebrovasc Dis 17:262-4. 2004
  50. ncbi Cerebral microhemorrhage
    Anand Viswanathan
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, France
    Stroke 37:550-5. 2006
    ..This review summarizes the pathophysiology, differential diagnosis, epidemiology, and clinical significance of cerebral microhemorrhages...
  51. ncbi Characteristic features of in vivo skin microvascular reactivity in CADASIL
    Claire Gobron
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, Paris, France
    J Cereb Blood Flow Metab 27:250-7. 2007
    ..This characteristic pattern may be related to the specific ultrastructural modifications related to Notch3 gene mutations involving smooth muscle cells in the microvasculature...
  52. ncbi Multiple simultaneous cerebral infarctions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Claire Gobron
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, Paris, France
    Cerebrovasc Dis 22:445-6. 2006
  53. doi Cerebral atrophy in cerebrovascular disorders
    Eric Jouvent
    Department of Neurology, Hopital Lariboisiere, Assistance Pulique Hôpitaux de Paris and Université Paris VII, Paris, France
    J Neuroimaging 20:213-8. 2010
    ..Studies of the effects of different cerebrovascular magnetic resonance imaging (MRI) markers and of the effects of various vascular risk factors on the cerebral volume have been analyzed...
  54. ncbi Apoptosis in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Francoise Gray
    Department of Pathology, APHP Hôpital Lariboisière, Universite Paris VII, 2 rue Ambroise Pare, 75475 Paris, France
    J Neuropathol Exp Neurol 66:597-607. 2007
    ..This supports the view that neuronal apoptosis may contribute to cortical atrophy and cognitive impairment in patients with CADASIL and that it may, at least partly, result from axonal damage in the underlying white matter...
  55. doi Impact of MRI markers in subcortical vascular dementia: a multi-modal analysis in CADASIL
    Anand Viswanathan
    Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, Paris, France
    Neurobiol Aging 31:1629-36. 2010
    ..The results suggest that the clinical impact of cerebral tissue loss plays a principal role in this genetic model of subcortical ischemic vascular dementia...
  56. ncbi Cortical neuronal apoptosis in CADASIL
    Anand Viswanathan
    Department of Neurology, Assistance Publique Hôpitaux de Paris AP HP Hôpital Lariboisière Université Paris VII, Paris, France
    Stroke 37:2690-5. 2006
    ..Cortical atrophy has been reported to be associated with cognitive decline in the disease, although the underlying mechanism is unknown. We postulated that apoptosis may be involved in this process...
  57. doi Activating NOTCH3 mutation in a patient with small-vessel-disease of the brain
    Charles Fouillade
    INSERM, U740, Paris, F 75010, France
    Hum Mutat 29:452. 2008
    ..L1515P mutation falls in a novel mechanistic class of NOTCH3 mutations and that NOTCH3 activating mutations should be further considered for molecular analysis of patients with cerebral small-vessel-disease...
  58. doi Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
    ..We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development...
  59. ncbi Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 54:1095-101. 2006
    ..To determine whether leukoaraiosis severity is independently associated with differences in global functioning in nondisabled elderly patients...
  60. doi On the etiology of incident brain lacunes: longitudinal observations from the LADIS study
    Alida A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 39:3083-5. 2008
    ..We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period...
  61. ncbi Diffusion histograms in CADASIL
    Hugues Chabriat
    Stroke 36:2526. 2005
  62. doi Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Cerebrovasc Dis 25:247-53. 2008
    ..However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression...
  63. pmc Differential impact of cerebral white matter changes, diabetes, hypertension and stroke on cognitive performance among non-disabled elderly. The LADIS study
    Ana Verdelho
    Neurology Department, Centro de Estudos Egas Moniz, Santa Maria Hospital, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 78:1325-30. 2007
    ..Our aim was to study the influence of vascular risk factors and ARWMC on the neuropsychological performance of an independent elderly population, to see if vascular risk factors impair cognition in addition to the effects of ARWMC...
  64. ncbi Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Intern Med 167:81-8. 2007
    ..The LADIS (LeukoAraiosis and DISability) Study primarily aims to assess ARWMCs as a determinant of global functional decline in the elderly population...
  65. pmc Tissue microstructural changes are independently associated with cognitive impairment in cerebral amyloid angiopathy
    Anand Viswanathan
    Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Stroke Research Center, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
    Stroke 39:1988-92. 2008
    ..We hypothesized that higher global mean apparent diffusion coefficient (mean ADC), reflecting a higher amount of chronic tissue disruption caused by CAA, would be independently associated with CAA-related cognitive impairment...