Marie France Cesbron-Delauw

Summary

Country: France

Publications

  1. doi request reprint A highly conserved toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage
    Pierre Cavailles
    UMR 5163, Centre National de la Recherche Scientifique CNRS, Grenoble, France Université Grenoble 1, Grenoble, France
    PLoS Pathog 10:e1004005. 2014
  2. doi request reprint Apicomplexa in mammalian cells: trafficking to the parasitophorous vacuole
    Marie France Cesbron-Delauw
    Laboratoire Adaptation et Pathogenie des Microorganismes, CNRS UMR 5163, Universite Joseph Fourier Grenoble 1, BP 170, 38042 Grenoble Cedex 9, France
    Traffic 9:657-64. 2008
  3. doi request reprint Post-translational membrane sorting of the Toxoplasma gondii GRA6 protein into the parasite-containing vacuole is driven by its N-terminal domain
    Claire Gendrin
    Laboratoire Adaptation et Pathogénie des Micro Organismes, CNRS UMR 5163, Universite Joseph Fourier Grenoble 1, Institut Jean Roget, BP 170, 38042 Grenoble Cedex 9, France
    Int J Parasitol 40:1325-34. 2010
  4. ncbi request reprint The Toxoplasma surface protein SAG1 triggers efficient in vitro secretion of chemokine ligand 2 (CCL2) from human fibroblasts
    Marie Pierre Brenier-Pinchart
    Laboratoire Adaptation et Pathogenie des Microorganismes, CNRS UJF UMR 5163, Institut J Roget, Faculte de Medecine, Université J Fourier Grenoble, Domaine de la Merci, 38000 Grenoble, France
    Microbes Infect 8:254-61. 2006
  5. ncbi request reprint Functional domains of the Toxoplasma GRA2 protein in the formation of the membranous nanotubular network of the parasitophorous vacuole
    Laetitia Travier
    Laboratoire Adaptation et Pathogénie des Micro Organismes, Universite Joseph Fourier Grenoble 1, Centre National de la Recherche Scientifique UMR 5163, BP 170, Campus Sante, Domaine de la Merci, Grenoble Cedex 9, France
    Int J Parasitol 38:757-73. 2008
  6. ncbi request reprint The dense granule protein GRA2, a new marker for the serodiagnosis of acute Toxoplasma infection: comparison of sera collected in both France and Iran from pregnant women
    Majid Golkar
    CNRS UMR 5163, UFR de Biologie, Institut Jean Roget, Universite Joseph Fourier, Campus Sante, Domaine de la Merci, and Parasitology and Mycology Laboratory, Grenoble Teaching Hospital A Michallon, Grenoble Cedex 09, France
    Diagn Microbiol Infect Dis 58:419-26. 2007
  7. ncbi request reprint Toxoplasma gondii triggers secretion of interleukin-12 but low level of interleukin-10 from the THP-1 human monocytic cell line
    Delphine Aldebert
    Laboratoire Adaptation et Pathogenie des Microorganismes, UMR 5163 CNRS Université Joseph Fourier, Institut J Roget, BP 170, 38042 Grenoble Cedex 9, France
    Cytokine 37:206-11. 2007
  8. pmc Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors
    Cordelia Bisanz
    Laboratoire Adaptation et Pathogénie des Micro Organismes, UMR 5163, CNRS UJF, Grenoble, France
    Biochem J 394:197-205. 2006
  9. doi request reprint Toxoplasma gondii uses unusual sorting mechanisms to deliver transmembrane proteins into the host-cell vacuole
    Claire Gendrin
    Laboratoire Adaptation et Pathogénie des Micro Organismes, CNRS UMR 5163, Universite Joseph Fourier Grenoble 1, Institut Jean Roget, Grenoble Cedex 9, France
    Traffic 9:1665-80. 2008
  10. pmc Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cells
    Véronique Sergent
    CNRS UMR 5163, Institut Jean Roget, Universite Joseph Fourier, UFR de Biologie, Grenoble, France
    Infect Immun 73:6990-7. 2005

Collaborators

Detail Information

Publications25

  1. doi request reprint A highly conserved toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage
    Pierre Cavailles
    UMR 5163, Centre National de la Recherche Scientifique CNRS, Grenoble, France Université Grenoble 1, Grenoble, France
    PLoS Pathog 10:e1004005. 2014
    ..These data represent new insights towards the identification of a major pathway of innate resistance to toxoplasmosis and the prediction of individual resistance. ..
  2. doi request reprint Apicomplexa in mammalian cells: trafficking to the parasitophorous vacuole
    Marie France Cesbron-Delauw
    Laboratoire Adaptation et Pathogenie des Microorganismes, CNRS UMR 5163, Universite Joseph Fourier Grenoble 1, BP 170, 38042 Grenoble Cedex 9, France
    Traffic 9:657-64. 2008
    ..We also discuss the existence of peculiar export mechanisms and/or sorting determinants that are potentially involved in the post-secretory targeting of parasite proteins to the PV subcompartments...
  3. doi request reprint Post-translational membrane sorting of the Toxoplasma gondii GRA6 protein into the parasite-containing vacuole is driven by its N-terminal domain
    Claire Gendrin
    Laboratoire Adaptation et Pathogénie des Micro Organismes, CNRS UMR 5163, Universite Joseph Fourier Grenoble 1, Institut Jean Roget, BP 170, 38042 Grenoble Cedex 9, France
    Int J Parasitol 40:1325-34. 2010
    ..These results support our emerging model: sorting of transmembrane GRA proteins to the host cell vacuole is mainly driven by the dual role of their N-terminal hydrophilic domain and is compartmentally regulated...
  4. ncbi request reprint The Toxoplasma surface protein SAG1 triggers efficient in vitro secretion of chemokine ligand 2 (CCL2) from human fibroblasts
    Marie Pierre Brenier-Pinchart
    Laboratoire Adaptation et Pathogenie des Microorganismes, CNRS UJF UMR 5163, Institut J Roget, Faculte de Medecine, Université J Fourier Grenoble, Domaine de la Merci, 38000 Grenoble, France
    Microbes Infect 8:254-61. 2006
    ..gondii infection. These results could explain the parasitic mechanisms leading to cell infiltrates detected only in the presence of tachyzoites, a phenomenon observed in toxoplasmic reactivation...
  5. ncbi request reprint Functional domains of the Toxoplasma GRA2 protein in the formation of the membranous nanotubular network of the parasitophorous vacuole
    Laetitia Travier
    Laboratoire Adaptation et Pathogénie des Micro Organismes, Universite Joseph Fourier Grenoble 1, Centre National de la Recherche Scientifique UMR 5163, BP 170, Campus Sante, Domaine de la Merci, Grenoble Cedex 9, France
    Int J Parasitol 38:757-73. 2008
    ....
  6. ncbi request reprint The dense granule protein GRA2, a new marker for the serodiagnosis of acute Toxoplasma infection: comparison of sera collected in both France and Iran from pregnant women
    Majid Golkar
    CNRS UMR 5163, UFR de Biologie, Institut Jean Roget, Universite Joseph Fourier, Campus Sante, Domaine de la Merci, and Parasitology and Mycology Laboratory, Grenoble Teaching Hospital A Michallon, Grenoble Cedex 09, France
    Diagn Microbiol Infect Dis 58:419-26. 2007
    ..4% (sera collected in Iran) for sera of chronic infection. The recombinant GRA2 could thus advantageously complement previously described T. gondii antigens for the serodiagnosis of acute Toxoplasma infection...
  7. ncbi request reprint Toxoplasma gondii triggers secretion of interleukin-12 but low level of interleukin-10 from the THP-1 human monocytic cell line
    Delphine Aldebert
    Laboratoire Adaptation et Pathogenie des Microorganismes, UMR 5163 CNRS Université Joseph Fourier, Institut J Roget, BP 170, 38042 Grenoble Cedex 9, France
    Cytokine 37:206-11. 2007
    ..We also showed that infection by live parasites is not mandatory since heat-killed parasites, crude tachyzoite lysate as well as excreted/secreted antigens induced significant, yet reduced production of IL-12...
  8. pmc Toxoplasma gondii acyl-lipid metabolism: de novo synthesis from apicoplast-generated fatty acids versus scavenging of host cell precursors
    Cordelia Bisanz
    Laboratoire Adaptation et Pathogénie des Micro Organismes, UMR 5163, CNRS UJF, Grenoble, France
    Biochem J 394:197-205. 2006
    ....
  9. doi request reprint Toxoplasma gondii uses unusual sorting mechanisms to deliver transmembrane proteins into the host-cell vacuole
    Claire Gendrin
    Laboratoire Adaptation et Pathogénie des Micro Organismes, CNRS UMR 5163, Universite Joseph Fourier Grenoble 1, Institut Jean Roget, Grenoble Cedex 9, France
    Traffic 9:1665-80. 2008
    ..They also highlight the diversity of sorting mechanisms that leads to the specialization of secretory processes uniquely adapted to intracellular parasitism...
  10. pmc Innate refractoriness of the Lewis rat to toxoplasmosis is a dominant trait that is intrinsic to bone marrow-derived cells
    Véronique Sergent
    CNRS UMR 5163, Institut Jean Roget, Universite Joseph Fourier, UFR de Biologie, Grenoble, France
    Infect Immun 73:6990-7. 2005
    ..This model is therefore an attractive and powerful tool to dissect host genetic factors involved in susceptibility to toxoplasmosis...
  11. ncbi request reprint GRA9, a new Toxoplasma gondii dense granule protein associated with the intravacuolar network of tubular membranes
    Koku D Z Adjogble
    Institute for Medical Microbiology and Virology, Universitätstr 1, D 40225 Dusseldorf, Germany
    Int J Parasitol 34:1255-64. 2004
    ..The dual properties of GRA9 are not only ascribed by the presence of amphipathic and hydrophobic alpha-helices but also by the fact that the protein is mainly hydrophilic...
  12. ncbi request reprint Purification of Toxoplasma dense granule proteins reveals that they are in complexes throughout the secretory pathway
    Laurence Braun
    UMR 5163 CNRS Université Joseph Fourier, Domaine de la Merci, 38700 Grenoble, France
    Mol Biochem Parasitol 157:13-21. 2008
    ..Insertion into the PV membranes correlates with the decrease of the GRA partners number...
  13. pmc Biogenesis of nanotubular network in Toxoplasma parasitophorous vacuole induced by parasite proteins
    Corinne Mercier
    Centre National de la Recherche Scientifique FRE 2383, Bâtiment CERMO, Universite Joseph Fourier, Grenoble, France 38041
    Mol Biol Cell 13:2397-409. 2002
    ..The induction of nanotubues by the parasite protein GRA2 may be a conserved feature of amphipathic alpha-helical regions, which have also been implicated in the organization of Golgi nanotubules and endocytic vesicles in mammalian cells...
  14. doi request reprint Serodiagnosis of recently acquired Toxoplasma gondii infection in pregnant women using enzyme-linked immunosorbent assays with a recombinant dense granule GRA6 protein
    Majid Golkar
    Molecular Parasitology Laboratory, Parasitology Department, Pasteur Institute of Iran, Tehran 1316943551, Iran
    Diagn Microbiol Infect Dis 61:31-9. 2008
    ..2%) (Euroimmun, Lübeck, Germany) for detection of recent infection. These results demonstrate that IgG and IgM ELISA with rGRA6 are useful to identify and discriminate recent from past Toxoplasma infection in pregnant women...
  15. doi request reprint Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii
    Cyrille Botté
    Unité Mixte de Recherche 5168, Centre National de la Recherche Scientifique Commissariat à l Energie, Institut de Recherches en Technologies et Sciences pour le Vivant, 38058 Grenoble, France
    J Lipid Res 49:746-62. 2008
    ..DGLE was detected in other Apicomplexa (i.e., Neospora, Plasmodium, Babesia, and Cryptosporidium)...
  16. doi request reprint Serotyping of Toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America
    Stéphane Morisset
    Laboratoire de Biométrie et Biologie Évolutive UMR 5558, CNRS, Universite de Lyon 1, Villeurbanne, France
    Microbes Infect 10:742-7. 2008
    ..We conclude that GRA5-GRA6 serotyping is an interesting tool to study serotype prevalence in populations but it is not an accurate marker of pathogenicity of Toxoplasma infection in humans...
  17. ncbi request reprint Evaluation of protective effect of recombinant dense granule antigens GRA2 and GRA6 formulated in monophosphoryl lipid A (MPL) adjuvant against Toxoplasma chronic infection in mice
    Majid Golkar
    CNRS UMR 5163 Université Joseph Fourier, UFR de Biologie, Institut Jean Roget, Campus Sante, Domaine de la Merci BP 170, 38042 Grenoble Cedex 09, France
    Vaccine 25:4301-11. 2007
    ..This study shows the protective efficacy of recombinant GRA2 against chronic infection by T. gondii and confirms the utility of MPL adjuvant in enabling a vaccine candidate to induce a protective Th1 immune response...
  18. ncbi request reprint [The rat Toxo1 locus controls the outcome of the toxoplasmic infection according to a mendelian mode]
    Pierre Cavailles
    Med Sci (Paris) 22:679-80. 2006
  19. ncbi request reprint Serotyping of Toxoplasma gondii in chronically infected pregnant women: predominance of type II in Europe and types I and III in Colombia (South America)
    Francois Peyron
    Laboratoire de Parasitologie, Mycologie Medicale et Pathologie Exotique, Equipe d Accueil E A 3732, Faculté de médecine de Lyon, 8 avenue Rockefeller, 69373 Lyon, France
    Microbes Infect 8:2333-40. 2006
    ..We demonstrated that, despite some limitation due to antigen and/or antibody specificity, serotyping is a promising assay to investigate the relationship between type of strain and severity of the disease...
  20. pmc The rat Toxo1 locus directs toxoplasmosis outcome and controls parasite proliferation and spreading by macrophage-dependent mechanisms
    Pierre Cavailles
    Institut National de la Sante et de la Recherche Medicale, Département de génétique, INSERM U 563, Toulouse F 31300 France
    Proc Natl Acad Sci U S A 103:744-9. 2006
    ..This forward genetics approach should ultimately unravel a major pathway of innate resistance to toxoplasmosis and possibly to other apicomplexan parasitic diseases...
  21. ncbi request reprint T cell mediated immune responses to Toxoplasma gondii in pregnant women with primary toxoplasmosis
    Ignazia Prigione
    Laboratory of Oncology, Department of Experimental and Laboratory Medicine, G Gaslini Scientific Institute, Largo G Gaslini 5, 16148 Genoa, Italy
    Microbes Infect 8:552-60. 2006
    ..In conclusion, pregnant women with primary toxoplasmosis mounted in vitro Tg-specific Th1/Th0 responses whose impact on neonatal infection warrants further investigation...
  22. pmc Histone-modifying complexes regulate gene expression pertinent to the differentiation of the protozoan parasite Toxoplasma gondii
    Nehme Saksouk
    ATIP UMR5163 CNRS, Jean Roget Institute, Domaine de la Merci, 38700 Grenoble, France
    Mol Cell Biol 25:10301-14. 2005
    ..This may lead to new approaches for therapy against protozoal diseases and highlights Toxoplasma as an informative model to study the evolution of epigenetics in eukaryotic cells...
  23. pmc Limited value of assays using detection of immunoglobulin G antibodies to the two recombinant dense granule antigens, GRA1 and GRA6 Nt of Toxoplasma gondii, for distinguishing between acute and chronic infections in pregnant women
    Josette Ferrandiz
    Laboratoire de Parasitologie, Mycologie Medicale et Pathologie Exotique, Equipe d Accueil E A 3732, Faculté de médecine de Lyon, Lyon, France
    Clin Diagn Lab Immunol 11:1016-21. 2004
    ..Taken together, these results suggest that neither GRA1 nor GRA6 Nt is sensitive enough to be used routinely to differentiate between acute and chronic toxoplasmic infections...
  24. ncbi request reprint Evidence for de novo sphingolipid biosynthesis in Toxoplasma gondii
    Nahid Azzouz
    Medizinisches Zentrum für Hygiene und Medizinische Mikrobiologie, Philipps Universitat Marburg, Robert Koch Strasse 17, 35037, Marburg, Germany
    Int J Parasitol 32:677-84. 2002
    ..Taken together, we provide evidence for the first time that T. gondii is capable of synthesising glycosphingolipids de novo...
  25. pmc Toxoplasma gondii-infected human myeloid dendritic cells induce T-lymphocyte dysfunction and contact-dependent apoptosis
    Shuang Wei
    Baylor Institute for Immunology Research, Dallas, Texas 75205, USA
    Infect Immun 70:1750-60. 2002
    ..Thus, regulation of host cell and bystander cell apoptosis by viable T. gondii may be significant components of a strategy to evade immunity and enhance intracellular parasite survival...