Pierre Asfar

Summary

Affiliation: Centre Hospitalier Universitaire
Country: France

Publications

  1. ncbi request reprint Mean arterial pressure target in patients with septic shock
    François Beloncle
    Département de Réanimation Médicale et de Médecine Hyperbare, Centre Hospitalier Universitaire d Angers, Angers, France
    Minerva Anestesiol 82:777-84. 2016
  2. pmc Impact of early enteral versus parenteral nutrition on mortality in patients requiring mechanical ventilation and catecholamines: study protocol for a randomized controlled trial (NUTRIREA-2)
    Laurent Brisard
    UPRES EA 3826, Clinical and Experimental Therapies for Infections, University of Nantes, Nantes, France
    Trials 15:507. 2014
  3. pmc Residual rates of mortality in patients with severe sepsis: a fatality or a new challenge?
    Pierre Asfar
    Réanimation Médicale Polyvalente, Cochin University Hospital, AP HP, Paris, France
    Ann Intensive Care 3:27. 2013
  4. pmc Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?
    Florian Wagner
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik fur Anasthesiologie, Universitatsklinikum, Helmholtzstrasse 8 1, D 89081 Ulm, Germany
    Crit Care 16:112. 2012
  5. pmc Does vasopressor therapy have an indication in hemorrhagic shock?
    François Beloncle
    Laboratoire HIFIH, UPRES EA 3859, IFR 132, Universite d Angers, PRES LUNAM, Angers, France
    Ann Intensive Care 3:13. 2013
  6. doi request reprint The effects of vasopressin and its analogues on the liver and its disorders in the critically ill
    Pierre Asfar
    Laboratoire HIFIH, UPRES EA 3859, IFR 132, Universite d Angers, PRES UNAM, France
    Curr Opin Crit Care 16:148-52. 2010
  7. pmc Of mice and men (and sheep, swine etc.): the intriguing hemodynamic and metabolic effects of hydrogen sulfide (H2S)
    Katja Wagner
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik fur Anasthesiologie, Universitatsklinikum Ulm, Parkstrasse 11, D 89081 Ulm, Germany
    Crit Care 15:146. 2011
  8. pmc Bench-to-bedside review: circulating microparticles--a new player in sepsis?
    Ferhat Meziani
    Service de Reanimation Medicale, Nouvel Hopital Civil, Hopitaux Universitaires de Strasbourg, F 67091 Strasbourg, France
    Crit Care 14:236. 2010
  9. pmc Vasopressin in vasodilatory shock: is the heart in danger?
    Balázs Hauser
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
    Crit Care 12:132. 2008
  10. pmc Comparison of cardiac, hepatic, and renal effects of arginine vasopressin and noradrenaline during porcine fecal peritonitis: a randomized controlled trial
    Florian Simon
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik fur Anasthesiologie, Universitatsklinikum, Steinhovelstrasse 9, 89075 Ulm, Germany
    Crit Care 13:R113. 2009

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Mean arterial pressure target in patients with septic shock
    François Beloncle
    Département de Réanimation Médicale et de Médecine Hyperbare, Centre Hospitalier Universitaire d Angers, Angers, France
    Minerva Anestesiol 82:777-84. 2016
    ..The mortality was not different in the two groups. However in patients with chronic hypertension, there were significantly less renal failure in the high mean arterial pressure group than the low mean arterial pressure group. ..
  2. pmc Impact of early enteral versus parenteral nutrition on mortality in patients requiring mechanical ventilation and catecholamines: study protocol for a randomized controlled trial (NUTRIREA-2)
    Laurent Brisard
    UPRES EA 3826, Clinical and Experimental Therapies for Infections, University of Nantes, Nantes, France
    Trials 15:507. 2014
    ..The primary goal of this trial is to assess the hypothesis that early first-line EN, as compared to early first-line PN, decreases day 28 all-cause mortality in patients receiving IMV and vasoactive drugs for shock...
  3. pmc Residual rates of mortality in patients with severe sepsis: a fatality or a new challenge?
    Pierre Asfar
    Réanimation Médicale Polyvalente, Cochin University Hospital, AP HP, Paris, France
    Ann Intensive Care 3:27. 2013
    ..The new challenge to enhance the probability of decreasing mortality rates should include a more appropriate definition of sepsis based on more specific criteria involving biomarker use and accurate patient phenotypes. ..
  4. pmc Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?
    Florian Wagner
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik fur Anasthesiologie, Universitatsklinikum, Helmholtzstrasse 8 1, D 89081 Ulm, Germany
    Crit Care 16:112. 2012
    ..On the other hand, this paper adds to the ongoing discussion on the usefulness of ethyl pyruvate as a resuscitation fluid in the critically ill...
  5. pmc Does vasopressor therapy have an indication in hemorrhagic shock?
    François Beloncle
    Laboratoire HIFIH, UPRES EA 3859, IFR 132, Universite d Angers, PRES LUNAM, Angers, France
    Ann Intensive Care 3:13. 2013
    ..Therefore, based on current information, further clinical trials comparing early vasopressor support plus fluid resuscitation versus fluid resuscitation alone are warranted. ..
  6. doi request reprint The effects of vasopressin and its analogues on the liver and its disorders in the critically ill
    Pierre Asfar
    Laboratoire HIFIH, UPRES EA 3859, IFR 132, Universite d Angers, PRES UNAM, France
    Curr Opin Crit Care 16:148-52. 2010
    ..In this review, we summarize the effects of these drugs on splanchnic hemodynamics and organ function...
  7. pmc Of mice and men (and sheep, swine etc.): the intriguing hemodynamic and metabolic effects of hydrogen sulfide (H2S)
    Katja Wagner
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik fur Anasthesiologie, Universitatsklinikum Ulm, Parkstrasse 11, D 89081 Ulm, Germany
    Crit Care 15:146. 2011
    ..Since the highest H2S concentration caused toxic side effects (possibly due to an inhibition of mitochondrial respiration), the therapeutic use of inhaled H2S should be cautioned...
  8. pmc Bench-to-bedside review: circulating microparticles--a new player in sepsis?
    Ferhat Meziani
    Service de Reanimation Medicale, Nouvel Hopital Civil, Hopitaux Universitaires de Strasbourg, F 67091 Strasbourg, France
    Crit Care 14:236. 2010
    ..Microparticles' abilities are of increasing interest in deciphering the mechanisms underlying the multiple organ dysfunction of septic shock...
  9. pmc Vasopressin in vasodilatory shock: is the heart in danger?
    Balázs Hauser
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
    Crit Care 12:132. 2008
    ....
  10. pmc Comparison of cardiac, hepatic, and renal effects of arginine vasopressin and noradrenaline during porcine fecal peritonitis: a randomized controlled trial
    Florian Simon
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik fur Anasthesiologie, Universitatsklinikum, Steinhovelstrasse 9, 89075 Ulm, Germany
    Crit Care 13:R113. 2009
    ..Therefore, we tested the hypothesis whether low-dose AVP is safe with respect to liver, kidney, and heart function and organ injury during resuscitated septic shock...
  11. pmc Bench-to-bedside review: Hydrogen sulfide--the third gaseous transmitter: applications for critical care
    Florian Wagner
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Klinik für Anästehsiologie, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
    Crit Care 13:213. 2009
    ....
  12. pmc Vasopressin and ischaemic heart disease: more than coronary vasoconstriction?
    Pierre Asfar
    Laboratoire HIFIH UPRES EA 3859, IFR 132, Universite d Angers, Département de Réanimation Médicale et Médecine Hyperbare, Centre Hospitalier Universitaire, 49933 Angers cedex 09, France
    Crit Care 13:169. 2009
    ..Consequently, the authors conclude that the use of AVP should be cautioned in patients with underlying cardiac disease...
  13. ncbi request reprint Impact of vasopressin analogues on the gut mucosal microcirculation
    Pierre Asfar
    Laboratoire HIFIH, UPRES EA 3859, IFR 132, Universite d Angers, France
    Best Pract Res Clin Anaesthesiol 22:351-8. 2008
    ..Thus, the absence of clinically harmful effect does not exclude covert splanchnic ischaemia, which may counterbalance the beneficial systemic effects...
  14. pmc Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats
    Frédérique Ganster
    Laboratoire HIFIH, UPRES EA 3859, IFR 132, Universite d Angers, Rue Haute de Reculee, Angers, F 49035 France
    Crit Care 14:R165. 2010
    ....
  15. doi request reprint Interleukin-10 controls the protective effects of circulating microparticles from patients with septic shock on tissue-engineered vascular media
    Hadj Ahmed Mostefai
    LUNAM Université, INSERM UMR U1063, Universite d Angers, Angers, France
    Clin Sci (Lond) 125:77-85. 2013
    ..These findings show an association between the capacity of MPs from patients with sepsis to restore vascular hyporeactivity induced by LPS and their ability to increase IL-10 in the tissue-engineered blood vessel model...
  16. doi request reprint Detrimental hemodynamic and inflammatory effects of microparticles originating from septic rats
    Satar Mortaza
    Laboratoire HIFIH UPRES EA 3859, Universite d Angers, Angers, France
    Crit Care Med 37:2045-50. 2009
    ..This study was designed to assess the effects of MPs from septic origin on the systemic hemodynamics as well as on the inflammatory, oxidative, and nitrosative stresses...
  17. pmc Clinical review: influence of vasoactive and other therapies on intestinal and hepatic circulations in patients with septic shock
    Pierre Asfar
    Département de Réanimation Médicale, Centre Hospitalier Universitaire, Angers, France
    Crit Care 8:170-9. 2004
    ....
  18. ncbi request reprint Catecholamines and vasopressin during critical illness
    Pierre Asfar
    Département de Réanimation Médicale, Centre Hospitalier Universitaire, 4 rue Larry, 49993 Angers Cedex 9, France
    Crit Care Clin 22:131-49, vii-viii. 2006
    ..Although the evidence supporting the use of low doses of vasopressin or its analogs in vasodilatory shock is increasing, lack of data regarding mortality and morbidity prevent their implementation in critical care protocols...
  19. doi request reprint Circulating microparticles from septic shock patients exert differential tissue expression of enzymes related to inflammation and oxidative stress
    Maria Letizia Mastronardi
    INSERM, U694, Universite d Angers, Angers, France
    Crit Care Med 39:1739-48. 2011
    ..Here, we have investigated the effects of in vivo injection of microparticles from nonseptic or septic subjects on protein expression in mouse tissues...
  20. ncbi request reprint Percutaneous radiologic gastrostomy versus nasogastric tube in critically ill patients
    Pierre Marie Roy
    Emergency Department, Angers University Hospital, 4 rue Larrey, Angers 49033, France
    Clin Nutr 24:321-5. 2005
    ..To examine the feasibility of percutaneous radiologic gastrostomy in critically ill patients and to assess the rates of complications, esophagitis and gastroesophageal reflux when compared with nasogastric tube...
  21. ncbi request reprint Low-dose terlipressin improves systemic and splanchnic hemodynamics in fluid-challenged endotoxic rats
    Pierre Asfar
    Laboratoire HIFIH, Universite d Angers, France
    Crit Care Med 31:215-20. 2003
    ..We tested the effects of a low-dose vasopressin analogue, terlipressin (6 microg/kg), on systemic and splanchnic hemodynamics in fluid-challenged endotoxic rats (lipopolysaccharide, 30 mg/kg in 1 hr)...
  22. pmc Enriched Air Nitrox Breathing Reduces Venous Gas Bubbles after Simulated SCUBA Diving: A Double-Blind Cross-Over Randomized Trial
    Vincent Souday
    Department of Medical Intensive Care and Hyperbaric Medicine, University Hospital, Angers, France
    PLoS ONE 11:e0154761. 2016
    ..To test the hypothesis whether enriched air nitrox (EAN) breathing during simulated diving reduces decompression stress when compared to compressed air breathing as assessed by intravascular bubble formation after decompression...
  23. ncbi request reprint [Infection and variceal bleeding in cirrhosis]
    Jérôme Boursier
    Laboratoire HIFIH, UPRES EA 3859, IFR 132, Universite, Angers
    Gastroenterol Clin Biol 31:27-38. 2007
    ..In patients with cirrhosis and variceal bleeding, antibiotic-prophylaxis decreases bacterial infection and the incidence of early rebleeding, and, more important, significantly decreases the death rate in these patients...
  24. ncbi request reprint Different Impact of the Number of Organ Failures and Graft-Versus-Host Disease on the Outcome of Allogeneic Stem Cell Transplantation Recipients Requiring Intensive Care
    Corentin Orvain
    1 Maladies du Sang, CHU d Angers, Angers, France 2 Réanimation Médicale, CHU d Angers, Angers, France 3 Centre de Recherche Clinique, CHU d Angers, Angers, France 4 Plateforme SNP, Transcriptome et Epigénomique, CHU d Angers, Angers, France 5 INSERM U892 CNRS 6295, Universite d Angers, Angers, France
    Transplantation . 2016
    ..Admission of allogeneic stem cell transplantation (SCT) recipients to the intensive care unit (ICU) remains controversial, especially when graft-versus-host disease (GVHD) is present...
  25. pmc From theory to bench confirmation or from bench to theory
    Julien Demiselle
    Département de Réanimation Médicale et de Médecine Hyperbare, Centre Hospitalier Universitaire, Angers, Cedex 9, 49933, France
    Intensive Care Med Exp 4:39. 2016
    ..Indeed, how can already published data and theoretical likelihood of failure be reconciled?..
  26. doi request reprint Recombinant human activated protein C improves endotoxemia-induced endothelial dysfunction: a blood-free model in isolated mouse arteries
    Nacira Sennoun
    Institut National de la Santé et de la Recherche Médicale INSERM Unité Mixte de Recherche UMR 771, Centre National de la Recherche Scientifique CNRS UMR 6214, Universite d Angers, Angers, France
    Am J Physiol Heart Circ Physiol 297:H277-82. 2009
    ..This finding provides important insights into the mechanism underlying rhAPC-induced improvements on arterial dysfunction during septic shock...
  27. ncbi request reprint Adenosine triphosphate-magnesium chloride: relevance for intensive care
    Marek Nalos
    Sektion Anästhesiologische Pathophysiologieund Verahrensentwicklung, Universitätsklinik für Anästhesiologie, Ulm, Germany
    Intensive Care Med 29:10-8. 2003
    ..The administration of ATP-MgCl(2) as a supportive measure has been investigated in various animal models of ischemia/reperfusion injury and hemorrhagic, endotoxic, and septic shock...
  28. ncbi request reprint Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia
    Antje Pittner
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
    Intensive Care Med 29:312-6. 2003
    ..To determine the mechanisms of improved gut mucosal acidosis associated with selective inducible nitric oxide synthase (iNOS) inhibition...
  29. ncbi request reprint Terlipressin in chronic hyperdynamic endotoxic shock: is it safe?
    Pierre Asfar
    Intensive Care Med 29:154-5. 2003
  30. ncbi request reprint Discrepancies between perceptions by physicians and nursing staff of intensive care unit end-of-life decisions
    Edouard Ferrand
    Unité de Réanimation Chirurgicale et Traumatologique, Service d Anesthesie Reanimation, Hopital Henri Mondor, AP HP, 51 rue du Mal de Lattre de Tassigny, 94010 Creteil Cedex, France
    Am J Respir Crit Care Med 167:1310-5. 2003
    ..Recommendations and legislation may help to build consensus and avoid conflicts among caregivers at each step of the decision-making process...
  31. ncbi request reprint Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia
    Zsolt Iványi
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung Universitatsklinikum, Ulm, Germany
    Shock 19:415-21. 2003
    ..Incomplete PARP inhibition because of dilutional effects and/or an only partial efficacy when used in post-treatment approaches may account for this finding...
  32. ncbi request reprint Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial
    Jean Chastre
    Service de Reanimation Medicale, Hopital Pitie Salpetriere, AP HP, Paris, France
    JAMA 290:2588-98. 2003
    ..The optimal duration of antimicrobial treatment for ventilator-associated pneumonia (VAP) is unknown. Shortening the length of treatment may help to contain the emergence of multiresistant bacteria in the intensive care unit (ICU)...
  33. ncbi request reprint Low-dose terlipressin during long-term hyperdynamic porcine endotoxemia: effects on hepatosplanchnic perfusion, oxygen exchange, and metabolism
    Pierre Asfar
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Ulm, Germany
    Crit Care Med 33:373-80. 2005
    ..To investigate whether the vasopressin analog terlipressin might induce hepatosplanchnic ischemia during long-term, hyperdynamic, volume-resuscitated porcine endotoxemia...
  34. ncbi request reprint Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia
    Balázs Hauser
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Ulm, Germany
    Crit Care Med 33:2034-42. 2005
    ..To investigate the systemic, pulmonary, and hepatosplanchnic hemodynamic and metabolic effects of delayed treatment with ethyl pyruvate in a long-term porcine model of hyperdynamic endotoxemia...
  35. ncbi request reprint Time out for vasopressors in increased microvascular permeability?
    Pierre Asfar
    Intensive Care Med 33:2045-7. 2007
  36. pmc Vasopressin in vasodilatory shock: hemodynamic stabilization at the cost of the liver and the kidney?
    Hendrik Bracht
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Parkstrasse 11, 89073 Ulm, Germany
    Crit Care 11:178. 2007
    ..Nevertheless, the findings reported by Krejci and colleagues need to be discussed in the context of the model design, the timing and dosing of AVP as well as the complex interaction between visceral organ perfusion and function...
  37. ncbi request reprint Adenosine triphosphate-magnesium dichloride during hyperdynamic porcine endotoxemia: effects on hepatosplanchnic oxygen exchange and metabolism
    Pierre Asfar
    Sektion Anasthesiologische Pathophysiologie und Verfahrensentwicklung, Universitatsklinikum, Ulm, Germany
    Crit Care Med 30:1826-33. 2002
    ..To assess the effects of adenosine triphosphate-magnesium dichloride (ATP-MgCl2) on systemic and hepatosplanchnic hemodynamics, oxygen exchange, and energy metabolism over 24 hrs of hyperdynamic normotensive porcine endotoxemia...