Patrice Cacoub

Summary

Country: France

Publications

  1. ncbi request reprint Treatment of hepatitis C in HIV/hepatitis C co-infected patients: what is the evidence?
    Patrice Cacoub
    Department of Internal Medicine, hôpital La Pitié Salpêtrière, 41 Boulevard de l hôpital, 75013 Paris, France
    Int J STD AIDS 16:1-4. 2005
  2. doi request reprint Rituximab plus Peg-interferon-alpha/ribavirin compared with Peg-interferon-alpha/ribavirin in hepatitis C-related mixed cryoglobulinemia
    David Saadoun
    Department of Internal Medicine, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Blood 116:326-34; quiz 504-5. 2010
  3. pmc Patient education improves adherence to peg-interferon and ribavirin in chronic genotype 2 or 3 hepatitis C virus infection: a prospective, real-life, observational study
    Patrice Cacoub
    Department of Internal Medicine, Pitie Salpetriere Hospital, 47 83 boulevard de l Hopital, Paris cedex 13 F 75651, France
    World J Gastroenterol 14:6195-203. 2008
  4. ncbi request reprint PEGylated interferon alfa-2b and ribavirin treatment in patients with hepatitis C virus-related systemic vasculitis
    Patrice Cacoub
    hôpital La Pitié Salpêtrière, Paris, France
    Arthritis Rheum 52:911-5. 2005
  5. doi request reprint Predictors of early relapse in patients with non-infectious mixed cryoglobulinemia vasculitis: results from the French nationwide CryoVas survey
    Benjamin Terrier
    Department of Internal Medicine, National Reference Center for Autoimmune Diseases, Hopital Cochin, Assistance Publique Hopitaux de Paris AP HP, Université Pierre Descartes, Paris 5, Paris, France
    Autoimmun Rev 13:630-4. 2014
  6. ncbi request reprint Antiviral therapy for hepatitis C virus--associated mixed cryoglobulinemia vasculitis: a long-term followup study
    David Saadoun
    hôpital La Pitié Salpêtrière, Paris, France
    Arthritis Rheum 54:3696-706. 2006
  7. doi request reprint Prognostic factors of survival in patients with non-infectious mixed cryoglobulinaemia vasculitis: data from 242 cases included in the CryoVas survey
    Benjamin Terrier
    Department of Internal Medicine, Cochin Hospital, Paris 75014, France
    Ann Rheum Dis 72:374-80. 2013
  8. ncbi request reprint Predominance of type 1 (Th1) cytokine production in the liver of patients with HCV-associated mixed cryoglobulinemia vasculitis
    David Saadoun
    Service de Medecine Interne, Hopital Pitie Salpetriere, 47 bd de l Hopital, 75013 Paris, France
    J Hepatol 41:1031-7. 2004
  9. doi request reprint Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis
    Benjamin Terrier
    Department of Internal Medicine, Universite Pierre et Marie Curie, Paris, France
    J Hepatol 55:756-61. 2011
  10. pmc Intraocular complications of IFN-alpha and ribavirin therapy in patients with chronic viral hepatitis C
    Damien Sene
    Department of Internal Medicine, Hopital Pitie Salpetriere, Paris, France
    World J Gastroenterol 13:3137-40. 2007

Detail Information

Publications98

  1. ncbi request reprint Treatment of hepatitis C in HIV/hepatitis C co-infected patients: what is the evidence?
    Patrice Cacoub
    Department of Internal Medicine, hôpital La Pitié Salpêtrière, 41 Boulevard de l hôpital, 75013 Paris, France
    Int J STD AIDS 16:1-4. 2005
    ..Furthermore, in about half the patients, treatments were not stopped during the first months of treatment because of side effects, but due to non-early virological response...
  2. doi request reprint Rituximab plus Peg-interferon-alpha/ribavirin compared with Peg-interferon-alpha/ribavirin in hepatitis C-related mixed cryoglobulinemia
    David Saadoun
    Department of Internal Medicine, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Blood 116:326-34; quiz 504-5. 2010
    ..Our findings indicate that rituximab combined with Peg-IFN-alpha/ribavirin is well tolerated and more effective than Peg-IFN-alpha/ribavirin in HCV-MC...
  3. pmc Patient education improves adherence to peg-interferon and ribavirin in chronic genotype 2 or 3 hepatitis C virus infection: a prospective, real-life, observational study
    Patrice Cacoub
    Department of Internal Medicine, Pitie Salpetriere Hospital, 47 83 boulevard de l Hopital, Paris cedex 13 F 75651, France
    World J Gastroenterol 14:6195-203. 2008
    ....
  4. ncbi request reprint PEGylated interferon alfa-2b and ribavirin treatment in patients with hepatitis C virus-related systemic vasculitis
    Patrice Cacoub
    hôpital La Pitié Salpêtrière, Paris, France
    Arthritis Rheum 52:911-5. 2005
    ..The present trial was established to investigate the efficacy of therapy with PEGylated interferon alfa-2b (PEG-IFN alfa-2b) plus ribavirin in patients with HCV-related MC vasculitis...
  5. doi request reprint Predictors of early relapse in patients with non-infectious mixed cryoglobulinemia vasculitis: results from the French nationwide CryoVas survey
    Benjamin Terrier
    Department of Internal Medicine, National Reference Center for Autoimmune Diseases, Hopital Cochin, Assistance Publique Hopitaux de Paris AP HP, Université Pierre Descartes, Paris 5, Paris, France
    Autoimmun Rev 13:630-4. 2014
    ..We aimed to identify predictors of early relapses occurring within the first 12months of treatment in such patients...
  6. ncbi request reprint Antiviral therapy for hepatitis C virus--associated mixed cryoglobulinemia vasculitis: a long-term followup study
    David Saadoun
    hôpital La Pitié Salpêtrière, Paris, France
    Arthritis Rheum 54:3696-706. 2006
    ..To evaluate the long-term efficacy of anti-hepatitis C virus (HCV) therapy in patients with HCV-associated mixed cryoglobulinemia (HCV-MC) vasculitis and to assess the factors associated with clinical remission of MC...
  7. doi request reprint Prognostic factors of survival in patients with non-infectious mixed cryoglobulinaemia vasculitis: data from 242 cases included in the CryoVas survey
    Benjamin Terrier
    Department of Internal Medicine, Cochin Hospital, Paris 75014, France
    Ann Rheum Dis 72:374-80. 2013
    ..Data on the prognosis of non-infectious mixed cryoglobulinaemia vasculitis (CryoVas) in the era of hepatitis C virus screening are lacking...
  8. ncbi request reprint Predominance of type 1 (Th1) cytokine production in the liver of patients with HCV-associated mixed cryoglobulinemia vasculitis
    David Saadoun
    Service de Medecine Interne, Hopital Pitie Salpetriere, 47 bd de l Hopital, 75013 Paris, France
    J Hepatol 41:1031-7. 2004
    ..To compare the cytokine profile of liver-infiltrating T cells in HCV-infected patients with or without MC vasculitis...
  9. doi request reprint Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis
    Benjamin Terrier
    Department of Internal Medicine, Universite Pierre et Marie Curie, Paris, France
    J Hepatol 55:756-61. 2011
    ..Data are lacking in HIV-HCV coinfected patients...
  10. pmc Intraocular complications of IFN-alpha and ribavirin therapy in patients with chronic viral hepatitis C
    Damien Sene
    Department of Internal Medicine, Hopital Pitie Salpetriere, Paris, France
    World J Gastroenterol 13:3137-40. 2007
    ..Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-alpha treatment with ophthalmological monitoring if any ocular manifestation occurs...
  11. doi request reprint Prognostic factors in patients with hepatitis C virus infection and systemic vasculitis
    Benjamin Terrier
    Department of Internal Medicine, CNRS, UMR 7211, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, and Université Pierre et Marie Curie Paris 6, Paris, France
    Arthritis Rheum 63:1748-57. 2011
    ....
  12. doi request reprint Cryofibrinogenemia: new insights into clinical and pathogenic features
    David Saadoun
    Pierre et Marie Curie Paris 6 University, Department of Internal Medicine, Hopital Pitie Salpetriere, Paris, France
    Am J Med 122:1128-35. 2009
    ..Cryofibrinogenemia is an under-recognized cryoprotein that can be life-threatening when untreated. Our aim was to describe the prevalence and clinical findings of patients with cryofibrinogenemia and to clarify the mechanisms involved...
  13. doi request reprint Efficacy and tolerability of rituximab with or without PEGylated interferon alfa-2b plus ribavirin in severe hepatitis C virus-related vasculitis: a long-term followup study of thirty-two patients
    Benjamin Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris AP HP, CNRS UMR 7211, and Université Pierre et Marie Curie Paris 6, Paris, France
    Arthritis Rheum 60:2531-40. 2009
    ..To report on the long-term followup of a cohort of patients with hepatitis C virus (HCV)-related vasculitis treated with rituximab with or without PEGylated interferon alfa-2b (PEG-IFN alfa-2b) plus ribavirin...
  14. doi request reprint Long-term outcome of arterial lesions in Behçet disease: a series of 101 patients
    David Saadoun
    Department of Internal Medicine, UMR CNRS 7211, INSERM U959, France
    Medicine (Baltimore) 91:18-24. 2012
    ..0001). In conclusion, the long-term outcome of arterial lesions in BD is poor, especially in the case of occlusive lesions and associated venous involvement. The use of immunosuppressants improved the prognosis...
  15. pmc Peg-IFNα/ribavirin/protease inhibitor combination in hepatitis C virus associated mixed cryoglobulinemia vasculitis: results at week 24
    David Saadoun
    Department of Internal Medicine, Service de Medecine Interne, AP HP, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Ann Rheum Dis 73:831-7. 2014
    ..About 30-40% of patients are non-responders or relapsers to such combination...
  16. ncbi request reprint Cryoglobulinaemia vasculitis in patients coinfected with HIV and hepatitis C virus
    David Saadoun
    Service de Medecine Interne, hôpital La Pitié Salpêtrière, Paris, France
    AIDS 20:871-7. 2006
    ..To describe mixed cryoglobulinaemia (MC) vasculitis in patients coinfected with hepatitis C virus (HCV) and HIV...
  17. doi request reprint Presentation and prognosis of cardiac involvement in hepatitis C virus-related vasculitis
    Benjamin Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Am J Cardiol 111:265-72. 2013
    ..Cardiac involvement is associated with B-cell lymphoma and life-threatening manifestations. Despite favorable early outcomes, patients with cardiac damage had poorer survival than those without...
  18. doi request reprint Low 25-hydroxyvitamin D serum levels correlate with the presence of extra-hepatic manifestations in chronic hepatitis C virus infection
    Benjamin Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    Rheumatology (Oxford) 51:2083-90. 2012
    ..Recent studies have suggested an immunomodulatory role for vitamin D during HCV infection. We investigated the association between serum vitamin D status and the presence of HCV extra-hepatic manifestations...
  19. ncbi request reprint Hepatitis C virus infection and mixed cryoglobulinaemia vasculitis: a review of neurological complications
    Patrice Cacoub
    Department of Internal Medicine, hôpital La Pitié Salpêtrière, Paris, France
    AIDS 19:S128-34. 2005
    ..Central nervous system (CNS) involvement is more rarely reported. In this review, peripheral and CNS involvement associated with chronic HCV infection are described. The underlying mechanisms and treatment possibilities are discussed...
  20. doi request reprint Systemic vasculitis in patients with hepatitis C virus infection with and without detectable mixed cryoglobulinemia
    Benjamin Terrier
    Department of Internal Medicine, APHP Groupe Hospitalier Pitié Salpétrière, 47 Boulevard de l Hopital, 75013 Paris, France
    J Rheumatol 38:104-10. 2011
    ..to describe hepatitis C virus (HCV)-related systemic vasculitis in patients without detectable mixed cryoglobulinemia (MC) and to compare them to typical cases of HCV-MC vasculitis...
  21. ncbi request reprint Interferon-alpha and ribavirin treatment in patients with hepatitis C virus-related systemic vasculitis
    Patrice Cacoub
    Department of Internal Medicine, hôpital La Pitié Salpêtrière, Paris, France
    Arthritis Rheum 46:3317-26. 2002
    ..Therefore, we retrospectively analyzed the response to treatment in patients with chronic hepatitis C complicated by systemic vasculitis who had received antiviral therapy with interferon-alpha (IFNalpha) and ribavirin...
  22. ncbi request reprint Biological markers of liver fibrosis and activity as non-invasive alternatives to liver biopsy in patients with chronic hepatitis C and associated mixed cryoglobulinemia vasculitis
    Damien Sene
    Department of Internal Medicine, La Pitie Salpetriere Hospital, France
    Clin Biochem 39:715-21. 2006
    ..We assessed the reliability of non-invasive biological scoring indexes (Fibrotest-Actitest [FT-AT], Forns, APRI, age-platelet, platelet, hyaluronic acid) as non-invasive alternatives to liver biopsy (LB) in 138 HCV-infected patients...
  23. doi request reprint Prevalence and clinical significance of cryofibrinogenaemia in patients with renal disorders
    Benjamin Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Nephrol Dial Transplant 26:3577-81. 2011
    ..In patients with end-stage renal disease, thromboses are common. However, the implication of CryoFg was never assessed. The aim of this study is to describe the prevalence and the significance of CryoFg in patients with renal disorders...
  24. ncbi request reprint Longterm course of mixed cryoglobulinemia in patients infected with hepatitis C virus
    Damien Sene
    Department of Internal Medicine, hôpital La Pitié Salpêtrière, Paris, France
    J Rheumatol 31:2199-206. 2004
    ..To describe epidemiological, clinical, and immunological characteristics and the longterm course of persistent mixed cryoglobulinemia (MC) in patients infected with hepatitis C virus (HCV)...
  25. ncbi request reprint Interferon-alpha2a and Vogt-Koyanagi-Harada disease: a double-edged sword?
    Valerie Touitou
    Department of Ophthalmology, Pitie Salpetriere Hospital, University of Paris VI, 47 83 boulevard de l Hopital, 75013 Paris, France
    Int Ophthalmol 27:211-5. 2007
    ..We report a small case series of two patients with refractory Vogt-Koyanagi-Harada disease, treated with interferon-alpha and discuss the potential benefits or detrimental role of interferon therapy in these patients...
  26. doi request reprint Myocardial perfusion imaging in Takayasu arteritis
    Cloé Comarmond
    From the Assistance Publique Hôpitaux de Paris AP HP, Groupe Hospitalier Pitie Salpetriere, Department of Internal Medicine, Université Pierre et Marie Curie AP HP, Groupe hospitalier Saint Antoine, Department of Nuclear Medicine, Université Pierre et Marie Curie AP HP, Hopital Saint Louis, Department of Biostatistics, Université Denis Diderot AP HP, Groupe Hospitalier Pitie Salpetriere, Department of Cardiology, Université Pierre et Marie Curie AP HP, Groupe Hospitalier Pitie Salpetriere, Department of Vascular Surgery, Universite Pierre et Marie Curie, Paris, France
    J Rheumatol 40:2052-60. 2013
    ..The aim of our study was to evaluate coronary microcirculation in TA using thallium-201 (201Tl) myocardial scintigraphy and dipyridamole (DPM) as vasodilator agent...
  27. doi request reprint Cannabis-associated arterial disease
    Anne Claire Desbois
    Department of Internal Medicine, AP HP Goupe hospitalier Pitié Salpêtrière, F 75013, Paris, France
    Ann Vasc Surg 27:996-1005. 2013
    ..The aim of this study was to describe the different arterial complications reported in cannabis smokers...
  28. doi request reprint Approaches to immunosuppression in Behçet's disease
    Cloé Comarmond
    Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, Service de médecine interne 2, Universite Pierre et Marie Curie Paris VI, 83 Boulevard de l hopital, 75013 Paris, France
    Immunotherapy 5:743-54. 2013
    ..Novel targeted immunosuppressive therapies might be used in the future for BD. ..
  29. ncbi request reprint Clonal B cell populations in the blood and liver of patients with chronic hepatitis C virus infection
    Laurent Vallat
    Department of Hematology, Assistance Publique Hopitaux, hôpital La Pitié Salpêtrière, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    Arthritis Rheum 50:3668-78. 2004
    ..The objective of this study was to determine the frequency of circulating and liver-infiltrating monoclonal B cells in patients with HCV infection...
  30. pmc The spectrum of type I cryoglobulinemia vasculitis: new insights based on 64 cases
    Benjamin Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique Hopitaux de Paris, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Medicine (Baltimore) 92:61-8. 2013
    ..Besides alkylating agents, the use of regimens based on rituximab, thalidomide or lenalinomide, and bortezomib are interesting alternative options, although the exact role of each strategy remains to be defined...
  31. doi request reprint Interleukin 21 correlates with T cell and B cell subset alterations in systemic lupus erythematosus
    Benjamin Terrier
    UPMC Université Paris, CNRS, UMR 7211, INSERM, UMRS959, and Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, 47 Boulevard de l Hopital, 75013 Paris, France
    J Rheumatol 39:1819-28. 2012
    ..Interleukin 21 (IL-21) plays a critical role in T cell and B cell homeostasis. Our objective was to determine the implication of IL-21 and IL-21-producing CD4+ T cells in the pathogenesis of SLE...
  32. ncbi request reprint Increased risks of lymphoma and death among patients with non-hepatitis C virus-related mixed cryoglobulinemia
    David Saadoun
    Department of Internal Medicine, Centre National de la Recherche Scientific Unité Mixte de Recherche 7087, Paris, France
    Arch Intern Med 166:2101-8. 2006
    ..Our objective was to describe the spectrum of MC in the era of HCV infection...
  33. doi request reprint Presentation and outcome of gastrointestinal involvement in hepatitis C virus-related systemic vasculitis: a case-control study from a single-centre cohort of 163 patients
    Benjamin Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Universite Pierre et Marie Curie, 75013 Paris, France
    Gut 59:1709-15. 2010
    ..The significance of GI involvement during hepatitis C virus (HCV)-related systemic vasculitis has never been evaluated...
  34. ncbi request reprint Hepatitis B virus genotypes and extrahepatic manifestations
    Patrice Cacoub
    Department of Internal Medicine, hôpital La Pitié Salpêtrière, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    J Hepatol 43:764-70. 2005
    ..This study aimed at correlating the presence of extrahepatic manifestations with hepatitis B virus (HBV) genotypes in patients with chronic HBV infection...
  35. ncbi request reprint Hepatitis C virus-associated extrahepatic manifestations: a review
    Damien Sene
    Department of Internal Medicine, Boulevard de l Hopital, Paris, France
    Metab Brain Dis 19:357-81. 2004
    ..Howerver, even in cases of tight association, the mechanisms through which HCV may promote or induce extrahepatic manifestations remain unclear and merit further investigations...
  36. doi request reprint [Kidney involvement in mixed cryoglobulinemia: which treatment?]
    Patrice Cacoub
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, 75013 Paris, France
    Presse Med 41:254-9. 2012
    ..1/100 patient-years), particularly in patients over 70 years, with a renal insufficiency and previously treated with high dose steroids...
  37. doi request reprint Dermatological side effects of hepatitis C and its treatment: patient management in the era of direct-acting antivirals
    Patrice Cacoub
    Department of Internal Medicine, Assistance Publique Hopitaux de Paris, Groupe Hospitalier Pitie Salpetriere, and Universite Pierre et Marie Curie, Paris, France
    J Hepatol 56:455-63. 2012
    ..In case of suspicion or confirmed diagnosis of SCAR, all study medication must be discontinued...
  38. doi request reprint Renal involvement in HCV-related vasculitis
    Benjamin Terrier
    Department of Internal Medicine, centre de référence pour vascularites et sclérodermies, Hopital Cochin, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
    Clin Res Hepatol Gastroenterol 37:334-9. 2013
    ..In the present review, we have focused on renal involvement in HCV-related vasculitis...
  39. doi request reprint Use of first-generation HCV protease inhibitors in patients coinfected by HIV and HCV genotype 1
    Dominique Salmon-Ceron
    Paris Descartes University, Paris, France APHP, Department of Internal Medicine, Infectious Diseases Unit, Cochin Hospital, Paris, France
    Liver Int 34:869-89. 2014
    ..However, complex drug-to-drug interactions and tolerability issues remain a concern...
  40. ncbi request reprint Tumor antigen markers for the detection of solid cancers in inflammatory myopathies
    Zahir Amoura
    Service de Medecine Interne, Hopital Pitie Salpetriere, 47 83 Bd de l Hopital, 75013 Paris, France
    Cancer Epidemiol Biomarkers Prev 14:1279-82. 2005
    ....
  41. doi request reprint Management of noninfectious mixed cryoglobulinemia vasculitis: data from 242 cases included in the CryoVas survey
    Benjamin Terrier
    Department of Internal Medicine, Groupe Hospitalier Pitie Salpetriere, Assistance Publique des Hopitaux de Paris, Universite Pierre et Marie Curie, 47 83 boulevard de l Hopital, Paris, France
    Blood 119:5996-6004. 2012
    ..The role of each of these strategies remains to be defined in well-designed randomized controlled trials...
  42. doi request reprint Screening of unrecognized peripheral arterial disease (PAD) using ankle-brachial index in high cardiovascular risk patients free from symptomatic PAD
    Jean Jacques Mourad
    Department of Internal Medicine, Avicenne University Hospital AP HP and Paris 13 University, Bobigny, France
    J Vasc Surg 50:572-80. 2009
    ..Although PAD is a consistent predictor of cardiovascular morbidity and mortality, it is often under-diagnosed and under-treated...
  43. ncbi request reprint Impact of treatment on extra hepatic manifestations in patients with chronic hepatitis C
    Patrice Cacoub
    Department of Internal Medicine, hôpital La Pitié Salpêtrière, 83 Boulevard de l hopital, 75651 Paris Cedex 13, France
    J Hepatol 36:812-8. 2002
    ..The aim was to assess the prevalence of these symptoms prior to any treatment, and on prolonged follow-up in treated and untreated patients...
  44. doi request reprint Effects of adherence to guidelines for the control of major cardiovascular risk factors on outcomes in the REduction of Atherothrombosis for Continued Health (REACH) Registry Europe
    Patrice P Cacoub
    AP HP Service de Médecine Interne, Groupe Hospitalier La Pitié Salpêtrière, 47 83, Boulevard de l Hopital, 75013 Paris, France
    Heart 97:660-7. 2011
    ..To examine the impact of cardiovascular risk factor control on 3-year cardiovascular event rates in patients with stable symptomatic atherothrombotic disease in Europe...
  45. doi request reprint Progression of fibrosis in HIV and hepatitis C virus-coinfected patients treated with interferon plus ribavirin-based therapy: analysis of risk factors
    Firouzé Bani-Sadr
    Groupe Hospitalier Universitaire Est, Universite Paris 6, INSERM U707, France
    Clin Infect Dis 46:768-74. 2008
    ..We determined the prevalence and determinants of worsening fibrosis in patients coinfected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) who were receiving anti-HCV therapy...
  46. doi request reprint Kidney diseases in HIV/HCV-co-infected patients
    Hassane Izzedine
    Departments of Nephrology, Pitie Salpetriere Hospital, Paris, France
    AIDS 23:1219-26. 2009
    ..Hepatitis C virus (HCV) co-infection occurs in 25% of HIV-infected persons. The impact of HIV/HCV coinfection on renal and patient outcomes is unclear...
  47. ncbi request reprint Circulating monocyte chemoattractant protein-1 in heart transplant recipients with cardiac allograft vasculopathy
    Jean Louis Beaudeux
    Service de Biochimie C, Groupe Hospitalier Pitie Salpetriere, 83 Boulevard de l hopital, 75013, Paris, France
    Clin Biochem 35:77-9. 2002
    ..To evaluate serum Monocyte Chemoattractant Protein-1 (MCP-1) as a biologic marker of cardiac allograft vasculopathy (CAV) in heart transplant recipients (HTR)...
  48. ncbi request reprint Prevalence of monoclonal gammopathy in patients presenting with acquired angioedema type 2
    Veronique Fremeaux-Bacchi
    Departement d Immunologie, Hopital Europeen Georges Pompidou, Paris, France
    Am J Med 113:194-9. 2002
    ..We studied the clinical features, complement profiles, and associated diseases in 19 new patients with diagnosed acquired angioedema type 2...
  49. ncbi request reprint Castleman's disease and lymphoma: report of eight cases in HIV-negative patients and literature review
    Claire Larroche
    Department of Internal Medicine and Laboratory of Hematology, Hopital Avicenne, Bobigny, France
    Am J Hematol 69:119-26. 2002
    ..The association of CD and lymphoma seems to be more than coincidental, and its pathogenesis is discussed...
  50. ncbi request reprint Thrombotic thrombocytopenic purpura with severe ADAMTS-13 deficiency in two patients with primary antiphospholipid syndrome
    Zahir Amoura
    Centre Hospitalier Universitaire Pitie Salpetriere, Paris, France
    Arthritis Rheum 50:3260-4. 2004
    ..Our findings suggest that primary APS must be added to the list of autoimmune disorders that can be complicated by TTP...
  51. ncbi request reprint Cardiovascular involvement, an overlooked feature of Erdheim-Chester disease: report of 6 new cases and a literature review
    Julien Haroche
    Service de Medecine Interne, Hopital Pitie Salpetriere, Paris, France
    Medicine (Baltimore) 83:371-92. 2004
    ..Data concerning follow-up were available for 58 (80.6%) patients. Of these, 35 (60.3%) patients died, confirming the severe prognosis of ECD. Cardiovascular complications were responsible for the death of 11 of the 35 patients (31.4%)...
  52. ncbi request reprint Risk factors for symptomatic mitochondrial toxicity in HIV/hepatitis C virus-coinfected patients during interferon plus ribavirin-based therapy
    Firouzé Bani-Sadr
    Groupe Hospitalier Universitaire Est, Universite Paris 6, INSERM U444, France
    J Acquir Immune Defic Syndr 40:47-52. 2005
    ..To evaluate the incidence, clinical features, and risk factors for symptomatic mitochondrial toxicity in HIV/hepatitis C virus (HCV)-coinfected patients receiving anti-HCV therapy...
  53. ncbi request reprint Descending thoracic and thoracoabdominal aortic aneurysm in patients with Takayasu's disease
    Edouard Kieffer
    Department of Vascular Surgery, Internal Medicine, and Cardiology, Pitié Salpêtrière University Hospital Center, Assitance Publique Hopitaux de Paris AP HP, Paris, France
    Ann Vasc Surg 18:505-13. 2004
    ....
  54. ncbi request reprint Hepatic steatosis in HIV-HCV coinfected patients: analysis of risk factors
    Firouzé Bani-Sadr
    Groupe Hospitalier Universitaire Est, Universite Paris 6, INSERM V707, Paris, France
    AIDS 20:525-31. 2006
    ..To evaluate the prevalence and severity of steatosis and possible interactions between steatosis, host factors, viral factors, and treatment for HIV infection in HIV-hepatitis C virus (HCV) coinfected patients...
  55. ncbi request reprint Spontaneous hepatic decompensation in patients coinfected with HIV and hepatitis C virus during interferon-ribavirin combination treatment
    Firouzé Bani-Sadr
    INSERM U707, Faculte de Medecine Hopital Saint Antoine, Paris, France
    Clin Infect Dis 41:1806-9. 2005
    ..02), and elevated total bilirubin level (OR, 7.9; 95% CI, 1.08-93.3; P<.03). Didanosine should thus not be given to patients with cirrhosis, particularly when treatments for HCV and HIV infections have to be administered concomitantly...
  56. doi request reprint Application in general practice of treatment guidelines for patients with dyslipidaemia: the RESPECT study
    Patrice Cacoub
    Service Medecine Interne, Groupe Hospitalier La Pitié Salpêtrière, Universite Pierre et Marie Curie Paris VI, AP HP, 47, Boulevard de l Hopital, 75013 Paris, France
    Arch Cardiovasc Dis 101:715-21. 2008
    ..The impact on general practitioners (GP) of the 2005 French guidelines for hypercholesterolaemia has not been evaluated...
  57. doi request reprint Is thromboangiitis obliterans presentation influenced by cannabis addiction?
    Guillaume Martin-Blondel
    Department of Internal Medicine, Assistance Publique des Hopitaux de Paris, Hopital Pitie Salpetriere, Paris, France
    Ann Vasc Surg 25:469-73. 2011
    ..Cannabis implication in the pathophysiology of distal arteritis remains controversial. The aim is to assess whether cannabis co-exposure influences presentation and outcome of thromboangiitis obliterans (TAO) in tobacco smokers...
  58. ncbi request reprint Hyperhomocysteinaemia, thrombosis and pernicious anaemia
    Nicolas Limal
    Department of Internal Medicine, hôpital La Pitié Salpêtrière, Paris, France
    Thromb Haemost 96:233-5. 2006
  59. doi request reprint The DRESS syndrome: a literature review
    Patrice Cacoub
    Department of Internal Medicine, Pitie Salpetriere Hospital, Assistance Publique Hopitaux de Paris, France
    Am J Med 124:588-97. 2011
    ..The outcome was death in 9 cases. However, no predictive factors for serious cases were found. This better knowledge of DRESS may contribute to improve the diagnosis and management of this syndrome in clinical practice...
  60. doi request reprint Antiphospholipid syndrome: from pathogenesis to novel immunomodulatory therapies
    Cloé Comarmond
    Assistance Publique Hopitaux de Paris AP HP, Groupe Hospitalier Pitie Salpetriere, Department of Internal Medicine, Universite Pierre et Marie Curie, Paris 6, Paris, France
    Autoimmun Rev 12:752-7. 2013
    ..In contrast to non-specific anticoagulation, the emergence of immunomodulatory drugs provides the possibility of interfering with specific pathogenic pathways. Novel therapies might be used in the future for APS...
  61. ncbi request reprint Cryoglobulinemia vasculitis
    Patrice Cacoub
    Service de Medecine Interne, hôpital La Pitié Salpêtrière, Paris, France
    Curr Opin Rheumatol 14:29-35. 2002
    ....
  62. ncbi request reprint High ferritin and low glycosylated ferritin may also be a marker of excessive macrophage activation
    Olivier Lambotte
    Department of Internal Medicine, Groupe Hospitalier Pitié, Paris, France
    J Rheumatol 30:1027-8. 2003
    ..However, high ferritin levels are found during hemophagocytosis syndrome (HS). We investigated the ferritin level and the percentage of glycosylation in a HS series of various causes...
  63. ncbi request reprint Mortality due to hepatitis C-related liver disease in HIV-infected patients in France (Mortavic 2001 study)
    Eric Rosenthal
    Service d Hematologie Clinique, Hopital Archet, Nice, France
    AIDS 17:1803-9. 2003
    ....
  64. ncbi request reprint Epidemiology, diagnosis and treatment of chronic hepatitis B in HIV-infected patients (EPIB 2005 STUDY)
    Lionel Piroth
    Service de Maladies Infectieuses et Tropicales, CHU Dijon, 10 boulevard du Maréchal de Lattre de Tassigny, 21079 Dijon Cedex, France
    AIDS 21:1323-31. 2007
    ..To describe the characteristics of hepatitis B (HBV) infection in HIV-infected patients and the impact of anti-HBV treatments...
  65. ncbi request reprint Pegylated interferon alfa-2b vs standard interferon alfa-2b, plus ribavirin, for chronic hepatitis C in HIV-infected patients: a randomized controlled trial
    Fabrice Carrat
    Groupe Hospitalier Universitaire Est, Universite Paris 6, INSERM U444, Paris, France
    JAMA 292:2839-48. 2004
    ..Most data on the virologic efficacy and safety of the combination of peginterferon alfa-2b and ribavirin in coinfected patients come from uncontrolled studies...
  66. doi request reprint Comparison of non-invasive liver fibrosis biomarkers in HIV/HCV co-infected patients: the fibrovic study--ANRS HC02
    Patrice Cacoub
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Paris, France
    J Hepatol 48:765-73. 2008
    ..To compare non-invasive biological liver fibrosis scores, as alternatives to liver biopsy, in HIV/HCV co-infected patients...
  67. ncbi request reprint Vascular cell adhesion molecule-1 (VCAM-1) plays a central role in the pathogenesis of severe forms of vasculitis due to hepatitis C-associated mixed cryoglobulinemia
    Gilles Kaplanski
    INSERM U387, Hopital Sainte Marguerite, 270 boulevard Sainte Marguerite, 13009 Marseille, France
    J Hepatol 42:334-40. 2005
    ..To better characterize the molecules involved in leukocyte tissue infiltration during hepatitis C-mixed cryoglobulinemia (HCV-MC)-associated vasculitis...
  68. ncbi request reprint Central nervous system involvement in hepatitis C virus cryoglobulinemia vasculitis: a multicenter case-control study using magnetic resonance imaging and neuropsychological tests
    Milvia Casato
    Department of Clinical Medicine, First School of Medicine, University of Rome La Sapienza, Rome, Italy
    J Rheumatol 32:484-8. 2005
    ..The mechanism by which brain lesions are produced is unclear. We investigated these phenomena by clinical evaluation (neuropsychological tests) and cerebral magnetic resonance imaging (MRI) studies in patients with HCV-MC vasculitis...
  69. ncbi request reprint Treatment with Peg-interferon alfa-2b and ribavirin of hepatitis C virus-associated mixed cryoglobulinemia
    David Saadoun
    J Hepatol 43:737; author reply 738. 2005
  70. ncbi request reprint Splenic lymphoma with villous lymphocytes, associated with type II cryoglobulinemia and HCV infection: a new entity?
    David Saadoun
    Department of Hematology, Hopital Necker, Paris, France
    Blood 105:74-6. 2005
    ..This study underscores the role of HCV in the lymphomagenesis and the benefit of antiviral treatment for patients presenting with HCV-driven lymphoproliferations...
  71. ncbi request reprint [The diagnostic tools of hepatitis C virus infections]
    Philippe Halfon
    Departement de Virologie, Laboratoire Alphabio, Marseille
    Presse Med 33:538-41. 2004
    ..The latter is useful in selecting the right therapy and duration of treatment, because the response depends on the genotype (better response rate for the genotypes 2 and 3)...
  72. ncbi request reprint Care of patients with hepatitis C and HIV co-infection
    Vincent Soriano
    AIDS 18:1-12. 2004
  73. ncbi request reprint Influence of antiviral therapy in hepatitis C virus-associated cryoglobulinemic MPGN
    Laurent Alric
    Service de Medecine Interne, Pavillon Dieulafoy, CHU Purpan, Toulouse, France
    Am J Kidney Dis 43:617-23. 2004
    ..The influence of hepatitis C virus (HCV) treatment on the course of HCV cryoglobulinemic membranoproliferative glomerulonephritis (MPGN) is controversial...
  74. ncbi request reprint CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis
    Olivier Boyer
    Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, CNRS UPMC, UMR 707 and Service de Médecine Interne, Hopital Pitie Salpetriere, Paris, France
    Blood 103:3428-30. 2004
    ....
  75. ncbi request reprint Hepatitis C virus infection in systemic lupus erythematosus: a case-control study
    Gabriel Perlemuter
    Service d hépatologie et de gastroentérologie, Hopital de Bicetre, Kremlin Bicetre, Paris, France
    J Rheumatol 30:1473-8. 2003
    ..Reports on the association between SLE and HCV infection are scarce. We investigated the association of HCV infection and SLE...
  76. ncbi request reprint Long-term impact of renal transplantation on liver fibrosis during hepatitis C virus infection
    Laurent Alric
    Service de Medecine Interne, Pavillon Dieulafoy, CHU Purpan, Toulouse, France
    Gastroenterology 123:1494-9. 2002
    ....
  77. ncbi request reprint [Treatment of extrahepatic manifestations associated with hepatitis C virus infection]
    Patrice Cacoub
    Service de Medecine Interne, hôpital La Pitié Salpêtrière, Paris
    Gastroenterol Clin Biol 26:B210-9. 2002
  78. ncbi request reprint Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection
    Olivier Hermine
    Department of Hematology and Centre National de la Recherche Scientifique Unité Mixte de Recherche 8603, Hopital Necker, Paris, France
    N Engl J Med 347:89-94. 2002
    ..We undertook this study after a patient with splenic lymphoma with villous lymphocytes had a hematologic response after antiviral treatment of HCV infection...
  79. pmc French women from multiplex abdominal aortic aneurysm families should be screened
    Claire Le Hello
    Service de chirurgie thoracique et cardio vasculaire, CHU de Caen, Caen, France
    Ann Surg 242:739-44. 2005
    ..Multiplex abdominal aortic aneurysm families (MAAAFs) (> or =1 subject plus the proband) represent 1% to 34% of abdominal aortic aneurysm (AAA), but the percentage in France is unknown...
  80. ncbi request reprint Vogt-Koyanagi-Harada disease in patients with chronic hepatitis C
    Valerie Touitou
    Department of Ophthalmology, Pitie Salpetriere Hospital, Paris, France
    Am J Ophthalmol 140:949-52. 2005
    ..To report the cases of four patients with hepatitis C virus infection who experienced clinical features that are virtually identical to Vogt-Koyanagi-Harada disease (VKH)...
  81. ncbi request reprint Cryoglobulinemia is associated with steatosis and fibrosis in chronic hepatitis C
    David Saadoun
    Service de Médecine Interne and CNRS UMR 7087, Hopital Pitie Salpetriere, Paris, France
    Hepatology 43:1337-45. 2006
    ..001), and steatosis higher than 10% (P = .04). In conclusion, our study shows an independent association between cryoglobulin and steatosis as well as advanced fibrosis...
  82. pmc Occult hepatitis C virus infection revisited with ultrasensitive real-time PCR assay
    Philippe Halfon
    Laboratoire Alphabio, 23 Rue de Friedland, Hopital Ambroise Pare, 13006 Marseille, France
    J Clin Microbiol 46:2106-8. 2008
    ..The significance of such occult infection must be elucidated...
  83. doi request reprint How to measure the diagnostic accuracy of noninvasive liver fibrosis indices: the area under the ROC curve revisited
    Jerome Lambert
    Université Pierre et Marie Curie Paris INSERM, UMR S 707 unité de santé publique, Assistance Publique Hopitaux de Paris, Hopital Saint Antoine, Paris, France
    Clin Chem 54:1372-8. 2008
    ..We explored other fibrosis staging accuracy measures designed for ordinal gold standards, the C-statistic and the Obuchowski measure...
  84. doi request reprint Risk factors for bacterial infections in HIV/hepatitis C virus-coinfected patients treated with interferon plus ribavirin
    Firouzé Bani-Sadr
    AIDS 22:1385-7. 2008
  85. doi request reprint Cryofibrinogen in patients with hepatitis C virus infection
    Aurelien Delluc
    Service de Medecine Interne, Universite Pierre et Marie Curie, Paris 6, France
    Am J Med 121:624-31. 2008
    ..The objective was to study the prevalence and the clinical and therapeutic impacts of cryofibrinogen in HCV-infected patients...
  86. doi request reprint Serum alpha-fetoprotein predicts virologic response to hepatitis C treatment in HIV coinfected patients
    Fabrice Carrat
    UPMC Paris6, UMR S707, INSERM, UMR S707, Saint Antoine Hospital, Assistance Publique Hopitaux de Paris, France
    AIDS 22:1513-5. 2008
    ..83; 95% confidence interval 1.05-3.20). Serum alpha-fetoprotein measurement should be integrated in the pretreatment assessment of prognostic factors of a virologic response...
  87. doi request reprint Treatment of hepatitis C-associated mixed cryoglobulinemia vasculitis
    David Saadoun
    Université Pierre et Marie Curie Paris, Paris, France and Hôpital Pitié Salpêtrière, Service de Medecine Interne, Paris, France
    Curr Opin Rheumatol 20:23-8. 2008
    ..This review focuses on recent advances in our understanding of the treatment of hepatitis C virus-mixed cryoglobulinemia vasculitis...
  88. doi request reprint Relapse of hepatitis C virus-associated mixed cryoglobulinemia vasculitis in patients with sustained viral response
    Dan Avi Landau
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Assistance Publique Hopitaux de Paris, Hopital Pitie Salpetriere, Paris, France
    Arthritis Rheum 58:604-11. 2008
    ....
  89. doi request reprint Hepatitis C virus infection induced vasculitis
    Patrice Cacoub
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Paris, France
    Clin Rev Allergy Immunol 35:30-9. 2008
    ..For future prospects and projects, new therapeutic strategies include a combination of best antiviral treatment with Peg-Interferon plus Ribavirin and Rituximab. Multicenter controlled trials are mandatory...
  90. ncbi request reprint [Management of HCV-HIV and HBV-HIV coinfected patients]
    Patrice Cacoub
    Universite Pierre et Marie Curie, Paris 6, CNRS, UMR 7087, Paris, France
    Gastroenterol Clin Biol 31:887-94. 2007
  91. ncbi request reprint [Management of HCV-HIV patients]
    Stanislas Pol
    Unité d Hépatologie, Hopital Cochin, 27 rue du Faubourg Saint Jacques, 75014 Paris
    Gastroenterol Clin Biol 31:4S7-12. 2007
    ..The harmful impact of HIV underlines the need for improving:..
  92. ncbi request reprint Treatment of hepatitis C virus in human immunodeficiency virus infected patients in "real life": modifications in two large surveys between 2004 and 2006
    Patrice Cacoub
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Paris, France
    J Hepatol 48:35-42. 2008
    ..To analyze the barriers to HCV treatment in HIV-HCV co-infected patients and their evolution between 2004 and 2006...
  93. ncbi request reprint The pathophysiology of HCV induced B-cell clonal disorders
    Dan Avi Landau
    Universite Pierre et Marie Curie Paris 6, CNRS, UMR 7087, Paris, F 75013 France
    Autoimmun Rev 6:581-7. 2007
    ..Finally, genetic events such as bcl-2 rearrangement may also be involved in clonal expansion. In this review, evidence linking HCV with MC and NHL, as well as known events in the pathophysiological process are described...
  94. ncbi request reprint High hepatitis C virus viral load in HIV/hepatitis C virus-co-infected patients: a different influence of protease inhibitor and non-protease inhibitor-based HAART?
    Firouzé Bani-Sadr
    Groupe Hospitalier Universitaire Est, Universite Paris 6, INSERM U707, Paris, France
    AIDS 21:1645-8. 2007
    ..Antiretroviral therapy in general was independently associated with lower HCV viral load. This suggests that HCV viral load kinetics could differ according to the choice of HAART regimen...
  95. ncbi request reprint Early virologic failure in HIV-coinfected hepatitis C patients treated with the peginterferon-ribavirin combination: does abacavir play a role?
    Firouzé Bani-Sadr
    J Acquir Immune Defic Syndr 45:123-5. 2007
  96. pmc Rapid and early virological response to chronic hepatitis C treatment with IFN alpha2b or PEG-IFN alpha2b plus ribavirin in HIV/HCV co-infected patients
    Christopher Payan
    Départment de Microbiologie EA3882, CHU Hôpital Morvan, Brest, France
    Gut 56:1111-6. 2007
    ....
  97. ncbi request reprint Intrahepatic virus-specific IL-10-producing CD8 T cells prevent liver damage during chronic hepatitis C virus infection
    Michal Abel
    INSERM, U561 Equipe AVENIR, Paris, France
    Hepatology 44:1607-16. 2006
    ..Therapeutic modulation of the intrahepatic balance between specific and bystander CD8 T cells might be beneficial in patients with chronic hepatitis C...
  98. ncbi request reprint Care of patients with chronic hepatitis C and HIV co-infection: recommendations from the HIV-HCV International Panel
    Vincent Soriano
    AIDS 16:813-28. 2002