L Buee

Summary

Country: France

Publications

  1. ncbi Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
    L Buee
    INSERM U422, Place de Verdun, 59045 Cedex, Lille, France
    Brain Res Brain Res Rev 33:95-130. 2000
  2. ncbi [Tau story: from frontotemporal dementia to other tauopathies]
    Luc Buee
    INSERM U422, Place de Verdun, F 59045 Lille, France
    J Soc Biol 196:103-8. 2002
  3. doi Tau exon 2 responsive elements deregulated in myotonic dystrophy type I are proximal to exon 2 and synergistically regulated by MBNL1 and MBNL2
    C Carpentier
    Inserm UMR837 1 and Univ Lille Nord de France, Jean Pierre Aubert Research Center, Alzheimer and Tauopathies, F 59045 Lille, France Regional University Hospital of Lille, France
    Biochim Biophys Acta 1842:654-64. 2014
  4. ncbi Alzheimer-specific epitope of AT100 in transfected cell lines with tau: toward an efficient cell model of tau abnormal phosphorylation
    C Mailliot
    INSERM U422, Lille, France
    Neurosci Lett 255:13-6. 1998
  5. doi Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats
    C M Dhaenens
    INSERM, U837, Place de Verdun, 59045 Lille, France
    Exp Neurol 210:467-78. 2008
  6. doi Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology
    P Dourlen
    Institut Pasteur de Lille, Lille, France
    Mol Psychiatry . 2016
  7. ncbi Proteasome inhibition and Tau proteolysis: an unexpected regulation
    P Delobel
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, 59045, Lille, France
    FEBS Lett 579:1-5. 2005
  8. pmc Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation
    K Schindowski
    INSERM, U837, Place de Verdun, Lille Cedex, France
    Genes Brain Behav 7:92-100. 2008
  9. ncbi Brain microvascular changes in Alzheimer's disease and other dementias
    L Buee
    INSERM U422, Lille, France
    Ann N Y Acad Sci 826:7-24. 1997
  10. doi Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencing
    C M Dhaenens
    INSERM, U837 1, Alzheimer and Tauopathies, Place de Verdun, F 59045 Lille, France
    Biochim Biophys Acta 1812:732-42. 2011

Collaborators

Detail Information

Publications20

  1. ncbi Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
    L Buee
    INSERM U422, Place de Verdun, 59045 Cedex, Lille, France
    Brain Res Brain Res Rev 33:95-130. 2000
    ....
  2. ncbi [Tau story: from frontotemporal dementia to other tauopathies]
    Luc Buee
    INSERM U422, Place de Verdun, F 59045 Lille, France
    J Soc Biol 196:103-8. 2002
    ..Conversely, recent data in myotonic dystrophy has demonstrated that indirect effect (CTG repeat expansion) leading to variations in tau alternative splicing also produce neurofibrillary degeneration...
  3. doi Tau exon 2 responsive elements deregulated in myotonic dystrophy type I are proximal to exon 2 and synergistically regulated by MBNL1 and MBNL2
    C Carpentier
    Inserm UMR837 1 and Univ Lille Nord de France, Jean Pierre Aubert Research Center, Alzheimer and Tauopathies, F 59045 Lille, France Regional University Hospital of Lille, France
    Biochim Biophys Acta 1842:654-64. 2014
    ..In conclusion, both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both...
  4. ncbi Alzheimer-specific epitope of AT100 in transfected cell lines with tau: toward an efficient cell model of tau abnormal phosphorylation
    C Mailliot
    INSERM U422, Lille, France
    Neurosci Lett 255:13-6. 1998
    ..This represents a useful model to study abnormal tau phosphorylation in situ...
  5. doi Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats
    C M Dhaenens
    INSERM, U837, Place de Verdun, 59045 Lille, France
    Exp Neurol 210:467-78. 2008
    ..The modified splicing of Tau thus results from a possibly CUG-mediated loss of function of MBNL1, but not from changes in the MBNL1 expression pattern...
  6. doi Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology
    P Dourlen
    Institut Pasteur de Lille, Lille, France
    Mol Psychiatry . 2016
    ..These data indicate that PTK2B acts as an early marker and in vivo modulator of Tau toxicity.Molecular Psychiatry advance online publication, 26 April 2016; doi:10.1038/mp.2016.59...
  7. ncbi Proteasome inhibition and Tau proteolysis: an unexpected regulation
    P Delobel
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, 59045, Lille, France
    FEBS Lett 579:1-5. 2005
    ..Surprisingly, we showed that the inhibition of the proteasome led to a bidirectional degradation of Tau. Following this result, the cellular mechanisms that may degrade Tau were investigated...
  8. pmc Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation
    K Schindowski
    INSERM, U837, Place de Verdun, Lille Cedex, France
    Genes Brain Behav 7:92-100. 2008
    ..Altogether, these data suggest that cell cycle events in THY-Tau22 are resulting from neurogenesis in young animals and cell death in older ones. It suggests that neuronal cell death in such models is much more complex than believed...
  9. ncbi Brain microvascular changes in Alzheimer's disease and other dementias
    L Buee
    INSERM U422, Lille, France
    Ann N Y Acad Sci 826:7-24. 1997
    ..This aspect of pathology is particularly interesting in view of its accessibility to therapeutic interventions...
  10. doi Mis-splicing of Tau exon 10 in myotonic dystrophy type 1 is reproduced by overexpression of CELF2 but not by MBNL1 silencing
    C M Dhaenens
    INSERM, U837 1, Alzheimer and Tauopathies, Place de Verdun, F 59045 Lille, France
    Biochim Biophys Acta 1812:732-42. 2011
    ....
  11. ncbi Tau pathology: a marker of neurodegenerative disorders
    A Delacourte
    Unit Inserm 422, 59045 Lille Cedex, France
    Curr Opin Neurol 13:371-6. 2000
    ....
  12. pmc Neurotrophic factors in Alzheimer's disease: role of axonal transport
    K Schindowski
    Institut National de la Santé et de la Research Médicale U837, Universite Lille 2, Lille Cedex, France
    Genes Brain Behav 7:43-56. 2008
    ....
  13. ncbi Loss of medial septum cholinergic neurons in THY-Tau22 mouse model: what links with tau pathology?
    K Belarbi
    Universite Lille Nord de France, Lille, France
    Curr Alzheimer Res 8:633-8. 2011
    ..Finally, our data strongly support that tau pathology could be instrumental in the cholinergic neuronal loss observed in AD...
  14. ncbi Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal degeneration, FTDP-17 and Pick's disease
    L Buee
    INSERM U422, F 59045 Lille, France
    Brain Pathol 9:681-93. 1999
    ..Thus, tau mutations and polymorphisms may also be instrumental in many neurodegenerative disorders...
  15. ncbi Modelling Alzheimer-specific abnormal Tau phosphorylation independently of GSK3beta and PKA kinase activities
    P Delobel
    INSERM U422, IMPRT, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, 59045, Lille, France
    FEBS Lett 516:151-5. 2002
    ..Our results demonstrate that a non-modified physiological process in a cell model can generate the most specific Alzheimer epitope of Tau pathology...
  16. doi [The testicular microtubule-associated protein Tau: Where, when during spermatogenesis?]
    J Sigala
    Institut de biologie de la reproduction spermiologie, CECOS, Hopital Jeanne de Flandre, Centre Hospitalier Regional Universitaire de Lille, avenue Eugene Avinee, 59037 Lille Cedex, France EA 4308 gamètogenèse et qualité du gamète, France Inserm UMR S 1172 Alzheimer et tauopathies, Place de Verdun, 59045 Lille Cedex, France
    Morphologie 99:141-8. 2015
    ..The localization and the potential roles of the Tau protein during the spermatogenesis are discussed by emphasizing the link with the microtubular structures of seminiferous tubules. ..
  17. doi Sstr2A: a relevant target for the delivery of genes into human glioblastoma cells using fiber-modified adenoviral vectors
    K Lécolle
    INSERM, UMR837, rue Polonovski, Lille, France
    Gene Ther 20:283-97. 2013
    ..Adenoviral vectors targeting SRIF receptors might thus represent a promising therapeutic approach to brain tumors...
  18. ncbi The peptidyl prolyl cis/trans isomerase Pin1 downregulates the Inhibitor of Apoptosis Protein Survivin
    P Dourlen
    INSERM, U837, Place de Verdun, 59045 Lille Cedex, France
    Biochim Biophys Acta 1773:1428-37. 2007
    ..The characterization of this functional relationship between Pin1 and Survivin might help to better understand mitosis control and cancer mechanisms...
  19. pmc Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology
    J Chapuis
    1 INSERM U744, Universite Lille Nord de France, Institut Pasteur de Lille, Lille, France 2 Université Lille Nord de France, Institut Pasteur de Lille, Lille, France 3 Université Lille Nord de France, Institut Pasteur de Lille, Lille, France
    Mol Psychiatry 18:1225-34. 2013
    ..Finally, the 3 bp insertion was associated with Tau but not Amyloid loads in AD brains. We propose that BIN1 mediates AD risk by modulating Tau pathology. ..
  20. ncbi Evidence for induction of the ornithine transcarbamylase expression in Alzheimer's disease
    F Bensemain
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Mol Psychiatry 14:106-16. 2009
    ..In conclusion, our results suggest the involvement of a new pathway in AD brains involving the urea cycle...