E Oger

Summary

Affiliation: Brest University Hospital
Country: France

Publications

  1. ncbi Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study: a hospital-based case-control study
    E Oger
    GETBO EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    J Thromb Haemost 4:793-9. 2006
  2. ncbi Estrogen receptor alpha polymorphism and venous thromboembolism in male and female: data from the EDITH study
    Emmanuel Oger
    EPI PHARM GETBO and GETBO EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, France
    Thromb Res 119:433-9. 2007
  3. ncbi Interrelation of hyperhomocysteinemia and inherited risk factors for venous thromboembolism. Results from the E.D.I.TH. study: a hospital-based case-control study
    Emmanuel Oger
    G E T B O EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Brest University Hospital, 29609 Brest Cedex, France
    Thromb Res 120:207-14. 2007
  4. ncbi Antiplatelet drug use preceding the onset of intracerebral hemorrhage is associated with increased mortality
    Karine Lacut
    Department of Internal Medicine and Chest Diseases, G E T B O Groupe d Etude de la Thrombose de Bretagne Occidentale, Brest Cedex, France
    Fundam Clin Pharmacol 21:327-33. 2007
  5. ncbi [Incidence and risk factors for venous thromboembolism]
    Emmanuel Oger
    Universite de Bretagne Occidentale, GETBO EA 3878, Hopital de la Cavale Blanche, 29609 Brest
    Rev Prat 57:711-3, 716, 719-20. 2007
  6. ncbi High plasma concentration of factor VIII coagulant is also a risk factor for venous thromboembolism in the elderly
    Emmanuel Oger
    Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Haematologica 88:465-9. 2003
  7. ncbi [Deep venous thrombosis: epidemiology, acquired risk factors]
    E Oger
    département de médecine interne et pneumologie, Hopital de la Cavale Blanche, 29609 Brest Cedex, France
    Ann Cardiol Angeiol (Paris) 51:124-8. 2002
  8. ncbi High prevalence of asymptomatic deep vein thrombosis on admission in a medical unit among elderly patients
    Emmanuel Oger
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medecine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Thromb Haemost 88:592-7. 2002
  9. ncbi Is APC resistance a risk factor for venous thromboembolism in patients over 70 years?
    Emmanuel Oger
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Thromb Haemost 88:587-91. 2002
  10. ncbi Methylenetetrahydrofolate reductase C677T genotype and venous thromboembolic disease
    F Couturaud
    département de médecine interne et pneumologie, CHU de la Cavale Blanche, CHU Morvan, Brest, France
    Respiration 67:657-61. 2000

Collaborators

Detail Information

Publications49

  1. ncbi Hyperhomocysteinemia and low B vitamin levels are independently associated with venous thromboembolism: results from the EDITH study: a hospital-based case-control study
    E Oger
    GETBO EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    J Thromb Haemost 4:793-9. 2006
    ..Moderate hyperhomocysteinemia and B vitamins deficiency are thought to be risk factors for venous thromboembolism (VTE). The causality and independence of those associations are still questioned...
  2. ncbi Estrogen receptor alpha polymorphism and venous thromboembolism in male and female: data from the EDITH study
    Emmanuel Oger
    EPI PHARM GETBO and GETBO EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, France
    Thromb Res 119:433-9. 2007
    ..454-397 T>C and venous thromboembolism (VTE) has been reported in postmenopausal women. Comprehensive data are lacking. We herein evaluated the risk for VTE related to c.454-397 T>C ER alpha gene polymorphism in both men and women...
  3. ncbi Interrelation of hyperhomocysteinemia and inherited risk factors for venous thromboembolism. Results from the E.D.I.TH. study: a hospital-based case-control study
    Emmanuel Oger
    G E T B O EA 3878 Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Brest University Hospital, 29609 Brest Cedex, France
    Thromb Res 120:207-14. 2007
    ..The hypothesis of an interaction between those risks has been raised and conflicting results were reported...
  4. ncbi Antiplatelet drug use preceding the onset of intracerebral hemorrhage is associated with increased mortality
    Karine Lacut
    Department of Internal Medicine and Chest Diseases, G E T B O Groupe d Etude de la Thrombose de Bretagne Occidentale, Brest Cedex, France
    Fundam Clin Pharmacol 21:327-33. 2007
    ..Current antiplatelet drug use preceding the onset of ICH is associated with increased short-term ICH mortality, independently of age...
  5. ncbi [Incidence and risk factors for venous thromboembolism]
    Emmanuel Oger
    Universite de Bretagne Occidentale, GETBO EA 3878, Hopital de la Cavale Blanche, 29609 Brest
    Rev Prat 57:711-3, 716, 719-20. 2007
    ..Those latter frequent inherited factors interact with environmental risk factors such as oral contraceptives, pregnancy, hormone therapy...
  6. ncbi High plasma concentration of factor VIII coagulant is also a risk factor for venous thromboembolism in the elderly
    Emmanuel Oger
    Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Haematologica 88:465-9. 2003
    ..This study aimed to test the hypothesis that an association also exists in the elderly...
  7. ncbi [Deep venous thrombosis: epidemiology, acquired risk factors]
    E Oger
    département de médecine interne et pneumologie, Hopital de la Cavale Blanche, 29609 Brest Cedex, France
    Ann Cardiol Angeiol (Paris) 51:124-8. 2002
    ..Venous thrombosis is a multifactorial disease and analysis of the interactions between acquired and inherited risk factors is an extremely interesting field of investigation...
  8. ncbi High prevalence of asymptomatic deep vein thrombosis on admission in a medical unit among elderly patients
    Emmanuel Oger
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medecine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Thromb Haemost 88:592-7. 2002
    ..5 to 32.6%) and 6.0 per 1,000 person-days (95% confidence interval, 0.0 to 12.7) among patients over 80 years. A high prevalence of asymptomatic deep vein thrombosis on admission was suggested particularly among elderly medical patients...
  9. ncbi Is APC resistance a risk factor for venous thromboembolism in patients over 70 years?
    Emmanuel Oger
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, F 29609 Brest Cedex, France
    Thromb Haemost 88:587-91. 2002
    ..8, 95% CI, 0.4 to 1.7). Age appeared as an effect-measure modifier with a significant interaction (p = 0.005). Our data suggest that APC resistance is not a risk factor for VTE in elderly...
  10. ncbi Methylenetetrahydrofolate reductase C677T genotype and venous thromboembolic disease
    F Couturaud
    département de médecine interne et pneumologie, CHU de la Cavale Blanche, CHU Morvan, Brest, France
    Respiration 67:657-61. 2000
    ..Many studies have suggested an increased risk of venous thromboembolism (VTE) in patients with mild hyperhomocysteinemia. The C677T mutation in the MTHFR gene has recently been described as a cause of mild hyperhomocysteinemia...
  11. ncbi Vitamin K epoxide reductase genetic polymorphism is associated with venous thromboembolism: results from the EDITH Study
    K Lacut
    EA3878, Universite de Brest, Brest, France
    J Thromb Haemost 5:2020-4. 2007
    ..The aim of this study was to evaluate the association between the VKORC1 1173C > T polymorphism and venous thromboembolism (VTE)...
  12. ncbi High frequency of factor V Leiden in surgical patients with symptomatic venous thromboembolism despite prophylaxis
    Mohamed Baba-Ahmed
    Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    Thromb Haemost 97:171-5. 2007
    ..4; 95% CI, 2.4 to 29). This study shows a close association between the presence of factorV Leiden mutation in symptomatic VTE occurring after surgery despite prophylaxis...
  13. ncbi Prevalence of 20210 A allele of the prothrombin gene in venous thromboembolism patients
    C Leroyer
    Department of Internal Medicine and Chest Diseases, CHRU de la Cavale Blanche, Brest, France
    Thromb Haemost 80:49-51. 1998
    ..The 20210 A allele variation in the 3' -untranslated region of the prothrombin gene was recently identified as a risk factor as regards deep venous thrombosis...
  14. ncbi Early versus delayed introduction of oral vitamin K antagonists in combination with low-molecular-weight heparin in the treatment of deep vein thrombosis. a randomized clinical trial. The ANTENOX Study Group
    C Leroyer
    Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, Brest, France
    Haemostasis 28:70-7. 1998
    ..To compare oral anticoagulant treatment (fluindione) started on either the 1st or the 10th day of a low-molecular-weight heparin (enoxaparin) treatment for deep vein thrombosis confirmed by venography...
  15. ncbi Diagnostic accuracy of compression ultrasonography for the detection of asymptomatic deep venous thrombosis in medical patients--the TADEUS project
    L Bressollette
    Department of Internal Medicine and Chest Diseases, Hĵpital de la Cavale Blanche, Brest, France
    Thromb Haemost 86:529-33. 2001
    ..88 and 0.56. We concluded that venous compression ultrasonography, performed as described, fulfils requirements of a screening test that could be available for prophylactic clinical trials or epidemiological researches...
  16. ncbi Association between antipsychotic drugs, antidepressant drugs and venous thromboembolism: results from the EDITH case-control study
    K Lacut
    EPI PHARM G E T B O, Equipe d accueil 3878, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, 29609 Brest Cedex, France
    Fundam Clin Pharmacol 21:643-50. 2007
    ..More studies are needed in order to further elucidate this adverse effect, and to determine the possible predisposing factors and the biological mechanisms involved...
  17. doi Association of common genetic variations and idiopathic venous thromboembolism. Results from EDITh, a hospital-based case-control study
    Aurelien Delluc
    Université Européeenne de Bretagne, Universite de Brest, Brest, France
    Thromb Haemost 103:1161-9. 2010
    ..In this hospital-based case-control study, two polymorphisms located on the factor XI gene were significantly associated with VTE. Other newly investigated polymorphisms with potentially false negatives may warrant further analyses...
  18. ncbi Incidence of venous thromboembolism: a community-based study in Western France. EPI-GETBP Study Group. Groupe d'Etude de la Thrombose de Bretagne Occidentale
    E Oger
    Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, Brest, France
    Thromb Haemost 83:657-60. 2000
    ..Of these, sixteen percent had been previously hospitalised within three months. These results raise concerns on identification of medical patients at high risk and effective prophylaxis...
  19. ncbi [Hormone therapy and risk for venous thromboembolism in postmenopausal women]
    Karine Lacut
    Groupe d Etude de la Thrombose de Bretagne Occidentale, GETBO EA 3878, département de médecine interne et pneumologie, Hopital de la Cavale Blanche, 29609 Brest Cedex
    Rev Prat 55:389-92. 2005
    ..Whether addition of progestin plays a significant role is undetermined so far...
  20. ncbi Prevention of venous thrombosis in patients with acute intracerebral hemorrhage
    K Lacut
    Groupe d Etude de la Thrombose de Bretagne Occidentale, Equipe d accueil 3878, Cavale Blanche Hospital, Brest, France
    Neurology 65:865-9. 2005
    ..To assess intermittent pneumatic compression (IPC) in the prevention of venous thromboembolism (VTE)...
  21. ncbi [Current status of anticoagulants]
    E Oger
    département de médecine interne et pneumologie, Hopital de la Cavale Blanche, Brest
    Presse Med 29:1079-82. 2000
    ..LMWH: Low-molecular weight heparins are not yet authorized in France for the treatment of pulmonary embolism. However, deep venous thrombosis can be securely treated with one daily fixed dose of nadroparin or tinzaparin...
  22. ncbi [Vertical transmission of human coronavirus. Prospective pilot study]
    A Gagneur
    Departement de Pediatrie, Inserm CIC 0502, CHU de Brest, Brest, France
    Pathol Biol (Paris) 55:525-30. 2007
    ..This prospective pilot monocentric pilot study investigates the possibility of maternofetal transmission of HCoV responsible for cases of neonatal infection observed within the first 24 hours of life...
  23. doi Materno-fetal transmission of human coronaviruses: a prospective pilot study
    A Gagneur
    Department of Pediatrics, CHU Morvan, 2 avenue Foch, Brest Cedex, France
    Eur J Clin Microbiol Infect Dis 27:863-6. 2008
    ..For case 6, only MV and NG tested positive. In case 7, only MV was positive. Possible vertical transmission of HCoV was hypothesized in this pilot study and requires further investigation on a larger scale...
  24. ncbi Incidence of venous thromboembolism in first-degree relatives of patients with venous thromboembolism who have factor V Leiden
    Francis Couturaud
    GETBO, EA 3878, Department of Internal Medicine and Chest Diseases, University Hospital Centre La Cavale Blanche, 29609 Brest, Cedex, France
    Thromb Haemost 96:744-9. 2006
    ..FVL is associated with a two- to threefold increase in VTE in first-degree relatives of patients with VTE. No subgroup of relatives was identified who require more than routine prophylaxis because of a particularly high risk of VTE...
  25. ncbi Fibrinogen Aalpha-Thr312Ala and factor XIII-A Val34Leu polymorphisms in idiopathic venous thromboembolism
    Gregoire Le Gal
    EA 3878, Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    Thromb Res 121:333-8. 2007
    ..However, clinical studies have yielded conflicting results on their possible association with venous thromboembolism (VTE)...
  26. ncbi Differential associations between lipid-lowering drugs, statins and fibrates, and venous thromboembolism: role of drug induced homocysteinemia?
    Karine Lacut
    Brest University, GETBO EA 3878, EPI PHARM, Brest, F 29609, France
    Thromb Res 122:314-9. 2008
    ..This report aims to test the hypothesis that part of these contrasting associations is related to total homocysteine level (tHcy)...
  27. ncbi Effects of the route of oestrogen administration on IGF-1 and IGFBP-3 in healthy postmenopausal women: results from a randomized placebo-controlled study
    Emmanuel Sonnet
    Service Endocrinologie, CHU de Brest, Hôpital Cavale Blanche, Brest, France
    Clin Endocrinol (Oxf) 66:626-31. 2007
    ..This secondary analysis, based on a large randomized trial, aimed to estimate the effect of the route of administration of 17beta-oestradiol in combined hormone replacement therapy with progesterone on IGF-1 and IGFBP-3 levels...
  28. ncbi Diagnostic value of a negative single complete compression ultrasound of the lower limbs to exclude the diagnosis of deep venous thrombosis in pregnant or postpartum women: a retrospective hospital-based study
    Gregoire Le Gal
    EA 3878 and Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest, France
    Thromb Res 118:691-7. 2006
    ....
  29. ncbi Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein
    Karine Lacut
    Departement de Medecine Interne, Hopital de la Cavale Blanche, Brest, France
    Thromb Haemost 90:124-31. 2003
    ..The clinical relevance of these effects remains to be determined...
  30. ncbi Statins but not fibrates are associated with a reduced risk of venous thromboembolism: a hospital-based case-control study
    Karine Lacut
    Groupe d Etude de la Thrombose de Bretagne Occidentale GETBO, Department of Internal Medicine and Chest Diseases, Hopital de la Cavale Blanche, 29609 Brest Cedex, France
    Fundam Clin Pharmacol 18:477-82. 2004
    ..This possible protective effect of statins warrants further investigations...
  31. ncbi Differential effects of oral and transdermal estrogen/progesterone regimens on sensitivity to activated protein C among postmenopausal women: a randomized trial
    Emmanuel Oger
    Departement de Medecine Interne, Hopital de la Cavale Blanche, Brest, France
    Arterioscler Thromb Vasc Biol 23:1671-6. 2003
    ..Oral estrogen replacement therapy (ERT) has been reported to induce APC resistance. Little is known about the effect of transdermal estrogen...
  32. ncbi Influence of the humidification device during acute respiratory distress syndrome
    Gwenael Prat
    Reanimation et Urgences Medicales, CHU de la Cavale Blanche, Boulevard Tanguy Prigent, 29609, Brest Cedex, France
    Intensive Care Med 29:2211-5. 2003
    ..To evaluate the effects of the humidification device on respiratory, hemodynamic and gas exchange parameters in acute respiratory distress syndrome (ARDS) patients...
  33. ncbi Effects of oral and transdermal 17 beta-estradiol combined with progesterone on homocysteine metabolism in postmenopausal women: a randomised placebo-controlled trial
    Karine Lacut
    Department of Internal Medicine and Chest Diseases, Brest University Hospital, Brest Cedex, France
    Atherosclerosis 174:173-80. 2004
    ..This finding does not support a role for transdermal estrogen in the prevention of ischaemic heart disease in postmenopausal women...
  34. ncbi Education and self-management: a one-year randomized trial in stable adult asthmatic patients
    F Couturaud
    Department of Internal Medicine and Chest Diseases, CHRU de la Cavale Blanche, Brest, France
    J Asthma 39:493-500. 2002
    ..to assess the effects of an educational program in asthmatic patients, following treatment readjustment...
  35. ncbi Clinical, physiologic, and biologic impact of environmental and behavioral interventions in neonates during a routine nursing procedure
    Céline Catelin
    Neonatal Intensive Care Unit, Department of Pediatrics, University Hospital, Brest, France
    J Pain 6:791-7. 2005
    ..For groups A and B, a trend of increased TOI was observed with EBI. We concluded that EBI during a nursing procedure provides a decrease in pain scores in preterm and term neonates with changes in heart rate...
  36. ncbi Effect of the 1998 Soccer World Cup tournament on rescue requests
    C Savry
    Service d Aide Médicale Urgente 29, CHU Cavale Blanche, Brest, France
    Intensive Care Med 27:1224-6. 2001
    ..We studied whether the Soccer World Cup Tournament in 1998 had an impact on the number of distress calls received by an emergency service...
  37. ncbi A prospective survey of early 12-h prone positioning effects in patients with the acute respiratory distress syndrome
    Erwan L'Her
    Reanimation et Urgences Medicales, CHU de la Cavale Blanche, Bvd Tanguy Prigent, 29609 Brest Cedex, France
    Intensive Care Med 28:570-5. 2002
    ..To evaluate of the oxygenation effects of 12-h prone positioning (PP) in ARDS patients and to assess the safety of such a procedure...
  38. ncbi [Pilot study of early breastfeeding difficulties of term newborns: incidence and risk factors]
    M P Michel
    Departement de Pediatrie, CHU Morvan, 5, avenue Foch, 29609 Brest Cedex, France
    Arch Pediatr 14:454-60. 2007
    ....
  39. doi Family history as a risk factor for venous thromboembolism
    Soledad Noboa
    Faculté de Médecine et des Sciences de la Santé de Brest, Université de Bretagne, Occidentale UBO, Brest, France
    Thromb Res 122:624-9. 2008
    ..There are very few data assessing a family history of venous thromboembolism (VTE) as a risk factor for VTE. This question is nonetheless of interest as inherited risk factors are involved but at least partly unknown...
  40. doi Antiplatelet drugs and risk of venous thromboembolism: results from the EDITH case-control study
    Karine Lacut
    Haematologica 93:1117-8. 2008
  41. ncbi Differential association of oral and transdermal oestrogen-replacement therapy with venous thromboembolism risk
    Pierre Yves Scarabin
    INSERM Cardiovascular Epidemiology Unit U258, Villejuif, France
    Lancet 362:428-32. 2003
    ..Transdermal ERT has little effect on haemostasis, but data assessing its effect on thrombotic process are scarce. We aimed to examine the effect of the route of oestrogen administration on VTE risk...
  42. ncbi Factors associated with liver steatosis and fibrosis in chronic hepatitis C patients
    Franck Cholet
    Service d Hepato Gastroenterologie, CHU La Cavale Blanche 29609 Brest Cedex
    Gastroenterol Clin Biol 28:272-8. 2004
    ..Host and viral factors have been associated with steatosis, but their relative contributions have not been clearly addressed. It has been suggested that steatosis plays a role in the progression of liver fibrosis...
  43. ncbi Phenotypic but not allelic ABO blood group association with risk of venous thrombosis
    Bernard Mercier
    Thromb Haemost 93:388-9. 2005
  44. ncbi Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study
    Marianne Canonico
    INSERM Unit 780, Cardiovascular Epidemiology Section, 16 Avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Circulation 115:840-5. 2007
    ..Transdermal estrogen may be safer. However, currently available data have limited the ability to investigate the wide variety of types of progestogen...
  45. ncbi Prothrombotic mutations, hormone therapy, and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration
    Celine Straczek
    INSERM, Cardiovascular Epidemiology Unit, Villejuif, France
    Circulation 112:3495-500. 2005
    ..Transdermal estrogen may be safe with respect to VTE. We investigated the impact of the route of estrogen administration on the association between a prothrombotic mutation (factor V Leiden or prothrombin G20210A mutation) and VTE risk...
  46. ncbi Postmenopausal hormone therapy and cardiovascular disease: an overview of main findings
    Marianne Canonico
    INSERM Unit U780, Cardiovascular Section 16, avenue Paul Vaillant Couturier, 94807 Villejuif Cedex, France
    Maturitas 54:372-9. 2006
    ..Clinical research should be continued to assist patients and clinicians in making treatment decisions on the basis of an individual's benefits and risks...
  47. ncbi Recurrent venous thromboembolism under anticoagulant therapy: a high risk in adenocarcinoma?
    Renaud Descourt
    Thromb Haemost 95:912-3. 2006
  48. ncbi Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality
    Alexander T Cohen
    Vascular Medicine, Department of Surgery, King s College Hospital, London, SE5 9RS, UK
    Thromb Haemost 98:756-64. 2007
    ..Given the availability of effective VTE prophylaxis, many of these events and deaths could have been prevented. These results have important implications for the allocation of healthcare resources...
  49. ncbi Estrogen plus progestin and risk of venous thrombosis
    Pierre Yves Scarabin
    JAMA 293:1322; author reply 1322-3. 2005