Bernard Begaud

Summary

Country: France

Publications

  1. ncbi request reprint An easy to use method to approximate Poisson confidence limits
    Bernard Begaud
    Department de Pharmacologie, Universite Victor Segalen, 33076 Bordeaux Cedex, France
    Eur J Epidemiol 20:213-6. 2005
  2. pmc Benchmarking clinical management of spinal and non-spinal disorders using quality of life: results from the EPI3-LASER survey in primary care
    Michel Rossignol
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 4820 Boulevard Saint Laurent, Montreal, QC H2T 1R5, Canada
    Eur Spine J 20:2210-6. 2011
  3. pmc Who seeks primary care for musculoskeletal disorders (MSDs) with physicians prescribing homeopathic and other complementary medicine? Results from the EPI3-LASER survey in France
    Michel Rossignol
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Canada and LA SER Centre for Risk Research, Montreal, Canada
    BMC Musculoskelet Disord 12:21. 2011
  4. pmc Did the US boycott of French products spread to include scientific output?
    Bernard Begaud
    EA 3676, IFR99 of Public Health, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    BMJ 329:1430-1. 2004
  5. pmc Drug reimbursement: indicators of inappropriate resource allocation
    Bernard Begaud
    Department de Pharmacologie, Universite Victor Segalen Bordeaux 2, Hopital Pellegrin, F33076 Bordeaux Cedex, France
    Br J Clin Pharmacol 54:528-34. 2002
  6. doi request reprint Concordance between prescriber- and patient-reported previous medical history and NSAID indication in the CADEUS cohort
    Annie Fourrier-Reglat
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux, France
    Pharmacoepidemiol Drug Saf 19:474-81. 2010
  7. ncbi request reprint A new method for assessing drug causation provided agreement with experts' judgment
    Yannick Arimone
    INSERM U657, 33076 Bordeaux Cedex, France
    J Clin Epidemiol 59:308-14. 2006
  8. ncbi request reprint Patterns and correlates of benzodiazepine use in the French general population
    Rajaa Lagnaoui
    Departement de Pharmacologie, EA 3676, IFR 99, Universite Victor Segalen, Bordeaux 2, 33076 Bordeaux, France
    Eur J Clin Pharmacol 60:523-9. 2004
  9. ncbi request reprint Effects of armagnac or vodka on platelet aggregation in healthy volunteers: a randomized controlled clinical trial
    Anwar Umar
    Departement de Pharmacologie, EA525 and EA3676, IFR99, Universite Victor Segalen, CHU Pellegrin Carreire BP36, 33076 Bordeaux, France
    Thromb Res 115:31-7. 2005
  10. doi request reprint Comparison of three methods (consensual expert judgement, algorithmic and probabilistic approaches) of causality assessment of adverse drug reactions: an assessment using reports made to a French pharmacovigilance centre
    Hélène Théophile
    Universite de Bordeaux, Departement de Pharmacologie, INSERM U657, Bordeaux, France
    Drug Saf 33:1045-54. 2010

Collaborators

Detail Information

Publications65

  1. ncbi request reprint An easy to use method to approximate Poisson confidence limits
    Bernard Begaud
    Department de Pharmacologie, Universite Victor Segalen, 33076 Bordeaux Cedex, France
    Eur J Epidemiol 20:213-6. 2005
    ..It allows computation of Poisson confidence limits both for count or rates and proportions...
  2. pmc Benchmarking clinical management of spinal and non-spinal disorders using quality of life: results from the EPI3-LASER survey in primary care
    Michel Rossignol
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 4820 Boulevard Saint Laurent, Montreal, QC H2T 1R5, Canada
    Eur Spine J 20:2210-6. 2011
    ..001). In conclusion, anxiety and depressive disorders were commonly reported by GPs among chronic MSD patients. Their prescriptions of psychotropic and analgesic drugs were consistent with patients' self-rated mental and physical health...
  3. pmc Who seeks primary care for musculoskeletal disorders (MSDs) with physicians prescribing homeopathic and other complementary medicine? Results from the EPI3-LASER survey in France
    Michel Rossignol
    Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Canada and LA SER Centre for Risk Research, Montreal, Canada
    BMC Musculoskelet Disord 12:21. 2011
    ....
  4. pmc Did the US boycott of French products spread to include scientific output?
    Bernard Begaud
    EA 3676, IFR99 of Public Health, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    BMJ 329:1430-1. 2004
  5. pmc Drug reimbursement: indicators of inappropriate resource allocation
    Bernard Begaud
    Department de Pharmacologie, Universite Victor Segalen Bordeaux 2, Hopital Pellegrin, F33076 Bordeaux Cedex, France
    Br J Clin Pharmacol 54:528-34. 2002
    ....
  6. doi request reprint Concordance between prescriber- and patient-reported previous medical history and NSAID indication in the CADEUS cohort
    Annie Fourrier-Reglat
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux, France
    Pharmacoepidemiol Drug Saf 19:474-81. 2010
    ..In the CADEUS study, both patients and their prescribers reported medical data allowing investigation of the concordance between these sources...
  7. ncbi request reprint A new method for assessing drug causation provided agreement with experts' judgment
    Yannick Arimone
    INSERM U657, 33076 Bordeaux Cedex, France
    J Clin Epidemiol 59:308-14. 2006
    ..The many methods proposed for causality assessment of adverse drug reaction (ADR) generally rely on algorithms. They have no clear relationship to probabilities, however, a situation we attempted to improve...
  8. ncbi request reprint Patterns and correlates of benzodiazepine use in the French general population
    Rajaa Lagnaoui
    Departement de Pharmacologie, EA 3676, IFR 99, Universite Victor Segalen, Bordeaux 2, 33076 Bordeaux, France
    Eur J Clin Pharmacol 60:523-9. 2004
    ..To investigate the prevalence of current use of benzodiazepines (BZDs) and related drugs in the French general population and factors associated with this use...
  9. ncbi request reprint Effects of armagnac or vodka on platelet aggregation in healthy volunteers: a randomized controlled clinical trial
    Anwar Umar
    Departement de Pharmacologie, EA525 and EA3676, IFR99, Universite Victor Segalen, CHU Pellegrin Carreire BP36, 33076 Bordeaux, France
    Thromb Res 115:31-7. 2005
    ..To test the possible relevance of these findings, we tested the effects of daily use of small quantities of armagnac against same alcohol strength, polyphenol-free vodka in healthy volunteers...
  10. doi request reprint Comparison of three methods (consensual expert judgement, algorithmic and probabilistic approaches) of causality assessment of adverse drug reactions: an assessment using reports made to a French pharmacovigilance centre
    Hélène Théophile
    Universite de Bordeaux, Departement de Pharmacologie, INSERM U657, Bordeaux, France
    Drug Saf 33:1045-54. 2010
    ..They approximately belong to three main categories: expert judgement, operational algorithms and probabilistic approaches...
  11. ncbi request reprint Interactions between aspirin and COX-2 inhibitors or NSAIDs in a rat thrombosis model
    Anwar Umar
    Department of Pharmacology, Universite Victor Segalen, 33076 Bordeaux, France
    Fundam Clin Pharmacol 18:559-63. 2004
    ..The interactions with aspirin do not seem to affect all NSAIDs to equal levels. The clinical impact of this needs to be confirmed in adequately powered clinical trials or pharmaco-epidemiological studies...
  12. doi request reprint Effect of date of drug marketing on disproportionality measures in pharmacovigilance: the example of suicide with SSRIs using data from the UK MHRA
    Antoine Pariente
    INSERM, U657, Bordeaux, France
    Drug Saf 32:441-7. 2009
    ....
  13. doi request reprint Risk of death related to psychotropic drug use in older people during the European 2003 heatwave: a population-based case-control study
    Clementine Nordon
    INSERM U657, Universite Victor Segalen Bordeaux 2, Bordeaux Cedex, France
    Am J Geriatr Psychiatry 17:1059-67. 2009
    ..The authors investigated the association between death of older people and use of psychotropic drugs before and during the Western European August 2003 heatwave...
  14. pmc Hospitalizations for gastrointestinal and cardiovascular events in the CADEUS cohort of traditional or Coxib NSAID users
    David Laharie
    Universite Victor Segalen, Bordeaux, France
    Br J Clin Pharmacol 69:295-302. 2010
    ..To assess hospital admission rates for gastrointestinal (GI) or cardiovascular (CV) events in real-life use of nonsteroidal anti-inflammatory drugs (NSAIDs)...
  15. ncbi request reprint Psychotropic drugs use and risk of heat-related hospitalisation
    Karin Martin-Latry
    Universite Victor Segalen Bordeaux 2, France
    Eur Psychiatry 22:335-8. 2007
    ..To assess if use of psychotropic drugs is associated with an increased risk of admission for heat-related pathologies during a heat wave period...
  16. doi request reprint Comparison of three methods (an updated logistic probabilistic method, the Naranjo and Liverpool algorithms) for the evaluation of routine pharmacovigilance case reports using consensual expert judgement as reference
    Hélène Théophile
    Univ de Bordeaux, U657, 33000, Bordeaux, France
    Drug Saf 36:1033-44. 2013
    ..An updated probabilistic causality assessment method and the Liverpool algorithm presented as an improved version of the Naranjo algorithm, one of the most used and accepted causality assessment methods, have recently been proposed...
  17. ncbi request reprint [Celecoxib prescription: data from the "Sécurité Sociale" database of the Aquitaine Region, South-Western, France]
    Annie Fourrier-Reglat
    Departement de Pharmacologie, INSERM U657, Universite Victor Segalen Bordeaux, Bordeaux, France
    Therapie 60:25-9. 2005
    ..The objective of this study was to describe the characteristics of subjects beginning celecoxib treatment and the evolution of treatment over a 6-month period...
  18. doi request reprint Pilot evaluation of an automated method to decrease false-positive signals induced by co-prescriptions in spontaneous reporting databases
    Paul Avillach
    Universite de Bordeaux, Bordeaux, France
    Pharmacoepidemiol Drug Saf 23:186-94. 2014
    ..To test an automated method to decrease the number of false-positive (FP) signals of disproportionate reportings (SDRs) generated by co-prescription...
  19. doi request reprint Use of health insurance claim patterns to identify patients using nonsteroidal anti-inflammatory drugs for rheumatoid arthritis
    Marie Agnes Bernard
    INSERM, U657, F 33000, Bordeaux, France
    Pharmacoepidemiol Drug Saf 21:573-83. 2012
    ..To determine healthcare claim patterns associated using nonsteroidal anti-inflammatory drugs (NSAIDs) for rheumatoid arthritis (RA)...
  20. ncbi request reprint [Antidepressant adverse effects in the elderly: analysis of spontaneous reports in France]
    Mathilde Daurel-Receveur
    Centre de Pharmacovigilance, Departement de Pharmacologie, Universite Victor Segalen, CHU, Bordeaux, France
    Therapie 60:61-5. 2005
    ..However, the consequences of adverse effects such as hyponatraemia are far from negligible in the elderly...
  21. doi request reprint Effect of competition bias in safety signal generation: analysis of a research database of spontaneous reports in France
    Antoine Pariente
    Departement de Pharmacologie, INSERM U657, Université Bordeaux Segalen, Bordeaux, France
    Drug Saf 35:855-64. 2012
    ..It can theoretically be influenced by a competition bias for signal detection owing to the presence of reports related to well-established drug-event associations...
  22. doi request reprint How reimbursement databases can be used to support drug utilisation studies: example using the main French national health insurance system database
    Philippe Latry
    Echelon régional du service médical de l assurance maladie d Aquitaine, 80 avenue de la Jallère, 33000, Bordeaux, France
    Eur J Clin Pharmacol 66:743-8. 2010
    ..For the latter, we think that two are important: the presence of the drug in the database and the capacity to capture real-life use, both of which are influenced by the marketing status (e.g., OTC) and whether reimbursement is possible...
  23. doi request reprint Trends in incident use of benzodiazepines and Z-drugs in France from 2006 to 2012: a population-based study
    Anne Bénard-Laribière
    Univ Bordeaux, U1219, Bordeaux, France
    Pharmacoepidemiol Drug Saf . 2016
    ..To study trends in incident use of benzodiazepines in France between 2006 and 2012...
  24. ncbi request reprint Effect of age of Armagnac extract and duration of treatment on antithrombotic effects in a rat thrombosis model
    Anwar Umar
    Department of Pharmacology, Universite Victor Segalen, CHU Pellegrin Carreire BP36, 33076, Bordeaux, France
    Thromb Res 111:185-9. 2003
    ..The effect disappeared within 3 days after stopping a 7-day treatment. We confirm the dose-, age- and duration-dependent inhibition of arteriovenous shunt thrombosis in vivo by Armagnac extracts in rats...
  25. ncbi request reprint Trends in spontaneous adverse drug reaction reports to the French pharmacovigilance system (1986-2001)
    Frantz Thiessard
    EA3676, IFR99, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Drug Saf 28:731-40. 2005
    ..The objective of this study is to describe the characteristics of the reports and the reporting trends in the French pharmacovigilance spontaneous reporting database from 1986 to 2001...
  26. pmc Inter-expert agreement of seven criteria in causality assessment of adverse drug reactions
    Yannick Arimone
    INSERM U 657, Departement de Pharmacologie, Universite Victor Segalen, Bordeaux 2, France
    Br J Clin Pharmacol 64:482-8. 2007
    ..To evaluate agreement between five senior experts when assessing seven causality criteria and the probability of drug causation...
  27. ncbi request reprint Less use of NSAIDs in long-term than in recent chondroitin sulphate users in osteoarthritis: a pharmacy-based observational study in France
    Rajaa Lagnaoui
    Universite Victor Segalen, Departement de Pharmacologie, INSERM U657, Bordeaux, France
    Therapie 61:341-6. 2006
    ..Compared to recent users, long-term users of CS400 had a significantly lower current (44.4 versus 52.5%, p < 0.05) and long-term use of NSAIDs (11.8% versus 18.5%, p < 0.05), and of analgesics (70.3 versus 79.3%, p < 0.01)...
  28. pmc Adherence with statins in a real-life setting is better when associated cardiovascular risk factors increase: a cohort study
    Philippe Latry
    Univ de Bordeaux, Bordeaux, France
    BMC Cardiovasc Disord 11:46. 2011
    ..While the factors for poor adherence for treatment with statins have been highlighted, the impact of their combination on adherence is not clear...
  29. pmc A signal of increased risk of hypoglycaemia with angiotensin receptor blockers caused by confounding
    Fleur Gregoire
    CHU de Bordeaux, Bordeaux, France
    Br J Clin Pharmacol 66:142-5. 2008
    ..To study reporting of hypoglycaemia in angiotensin receptor blocker (ARB) users, and to investigate the possibility of confounding...
  30. ncbi request reprint Life-threatening adverse drug reactions at admission to medical intensive care: a prospective study in a teaching hospital
    Marieke Grenouillet-Delacre
    Universite Victor Segalen Bordeaux 2, INSERM U657, 146 rue Leo Saignat, 33075 Bordeaux cedex, France
    Intensive Care Med 33:2150-7. 2007
    ..To assess the characteristics of life-threatening adverse drug reactions in patients admitted to medical intensive care unit and to define those that could facilitate early identification...
  31. pmc Differences between clinical trials and postmarketing use
    Karin Martin
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux 2, Bordeaux, France
    Br J Clin Pharmacol 57:86-92. 2004
    ....
  32. ncbi request reprint [Pharmacoepidemiology of psychotropic medication: utilisation and impact in real-life conditions]
    Helene Verdoux
    Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Therapie 61:17-22. 2006
    ..Only findings obtained by such studies may allow risk management and elaboration of guidelines based upon factual data...
  33. doi request reprint Medicines submitted to narcotics regulations in France, 1992-2007
    Marie Baumevieille
    Centre d Evaluation et d Information sur la Pharmacodependance, CHU, Bordeaux, France
    Fundam Clin Pharmacol 23:345-9. 2009
    ..These results show the adaptation of French narcotics regulations, with the development of medicines indicated in acute or chronic pain treatment or opioid maintenance treatment...
  34. doi request reprint Impact of prescriber nonresponse on patient representativeness
    Annie Fourrier-Reglat
    INSERM, Unité 657, IFR 99, Bordeaux, France
    Epidemiology 19:186-90. 2008
    ..Our objective was to compare the characteristics of patients whose prescriber did or did not respond...
  35. ncbi request reprint NSAID use profiles derived from reimbursement data in France
    Nicholas Moore
    Departement de Pharmacologie, EA3676, IFR99, Universite Victor Segalen Bordeaux 2, Bordeaux, France France
    Therapie 59:541-6. 2004
    ....
  36. doi request reprint Comorbidities and concurrent medications increasing the risk of adverse drug reactions: prevalence in French benzodiazepine users
    Anne Bénard-Laribière
    University of Bordeaux, U1219, F 33000, Bordeaux, France
    Eur J Clin Pharmacol 72:869-76. 2016
    ..To estimate benzodiazepine prevalence of use and to quantify, in benzodiazepine users, the prevalence of comorbidities and concurrent medications increasing the risk of adverse drug reactions (ADRs)...
  37. doi request reprint Choice of the denominator in case population studies: event rates for registration for liver transplantation after exposure to NSAIDs in the SALT study in France
    Nicholas Moore
    Univ Bordeaux Segalen, Bordeaux, France
    Pharmacoepidemiol Drug Saf 22:160-7. 2013
    ..The effect of denominator options on event rates was tested on the French part of the Study of Acute Liver Transplant (SALT)...
  38. ncbi request reprint [Medical and socio-economical impact of drug-induced adverse reactions]
    Edwige Apretna
    Centre de Pharmacovigilance, EA3676 MPSS, Universite Victor Segalen Bordeaux 2, CHU de Bordeaux 33076, France
    Presse Med 34:271-6. 2005
    ..To analyse the nature of adverse drug reactions, their frequency, the drugs incriminated, their outcome, the different ways to treat them and their cost...
  39. ncbi request reprint Benzodiazepine utilization patterns in Alzheimer's disease patients
    Rajaa Lagnaoui
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux, France
    Pharmacoepidemiol Drug Saf 12:511-5. 2003
    ..Benzodiazepines (BZD) are commonly prescribed in the elderly. Persons with dementia may be at a greater risk of adverse reactions of BZD such as cognitive impairment...
  40. ncbi request reprint Pharmacoepidemiology of psychotropic drugs: examples of current research challenges on major public health issues
    Helene Verdoux
    INSERM U657, University Victor Segalen Bordeaux2, Bordeaux, France
    Epidemiol Psichiatr Soc 18:107-13. 2009
    ..As a large number of persons are exposed to prescribed psychotropic drugs, their utilisation and impact should be further explored at the population level...
  41. doi request reprint Pharmacoepidemiological research using French reimbursement databases: yes we can!
    Karin Martin-Latry
    Departement de Pharmacologie, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux, France
    Pharmacoepidemiol Drug Saf 19:256-65. 2010
    ..To describe the reimbursement databases available in France for pharmacoepidemiological research and their use...
  42. ncbi request reprint Potential impact of oral contraceptive choice on myocardial infarction mortality and deep vein thrombosis
    Karin Martin
    Department of Pharmacology, Victor Segalen University, Bordeaux, France
    J Fam Plann Reprod Health Care 31:37-9. 2005
    ....
  43. doi request reprint Medicine or ecstasy? The importance of the logo
    Amélie Daveluy
    Centre de pharmacodépendance, Departement de Pharmacologie, Bordeaux, France
    Fundam Clin Pharmacol 24:233-7. 2010
    ..In order to limit this diversion, prevention should be reinforced. In addition, recommendations on the appearance of medicine tablets should be set up by regulatory agencies in charge of medicine approval...
  44. ncbi request reprint Is benzodiazepine use a risk factor for cognitive decline and dementia? A literature review of epidemiological studies
    Helene Verdoux
    EA 3676, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Psychol Med 35:307-15. 2005
    ..The aim of the present review was to examine findings from prospective studies carried out in general population samples exploring whether exposure to benzodiazepines is associated with an increased risk of incident cognitive decline...
  45. ncbi request reprint Atypical antipsychotics: from potassium channels to torsade de pointes and sudden death
    Karine Titier
    Dept de Pharmacologie, Universite Victor Segalen, CHU de Bordeaux, INSERM Réseau de Pharmacoépidémiologie, Bordeaux, France
    Drug Saf 28:35-51. 2005
    ..The assessment of cardiovascular safety, both preclinical and during premarketing clinical trials, needs to be supported by appropriately powered pharmacoepidemiology studies...
  46. pmc Addition of dipeptidyl peptidase-4 inhibitors to sulphonylureas and risk of hypoglycaemia: systematic review and meta-analysis
    Francesco Salvo
    University of Bordeaux, UMR1219, F 33000 Bordeaux, France INSERM, UMR1219, Bordeaux Population Health Research Center, Pharmacoepidemiology team, Bordeaux, France CHU Bordeaux, Bordeaux, France
    BMJ 353:i2231. 2016
    ..To quantify the risk of hypoglycaemia associated with the concomitant use of dipeptidyl peptidase-4 (DPP-4) inhibitors and sulphonylureas compared with placebo and sulphonylureas...
  47. doi request reprint Fibrates and risk of cancer in tissues with high PPAR-α concentration: a nested case-control study
    Francesco Salvo
    Univ Bordeaux, Bordeaux, France
    Drug Saf 37:361-8. 2014
    ..They have been associated with cancers in experimental models, but data in humans are rare, and among published studies none has investigated cancers in tissues with high PPAR-α concentrations...
  48. ncbi request reprint Comparison of patient questionnaires and plasma assays in intentional drug overdoses
    Marcelle Diane Matsika
    EA 3676, Department of Pharmacology, Victor Segalen University, 33076 Bordeaux Cedex, France
    Basic Clin Pharmacol Toxicol 95:31-7. 2004
    ..However these results found at the population level may not be true at an individual level...
  49. ncbi request reprint Incidence of agranulocytosis in Southwest France
    Hélène Théophile
    Department de Pharmacologie, EA 3676, IFR 99, Universite Victor Segalen, CHU Pellegrin, Bordeaux Cedex, France
    Eur J Epidemiol 19:563-5. 2004
    ..Updated knowledge of background event rates is fundamental to risk assessment...
  50. doi request reprint A potential event-competition bias in safety signal detection: results from a spontaneous reporting research database in France
    Francesco Salvo
    Departement de Pharmacologie, Université Bordeaux Segalen, INSERM U657, BP 36, 33076 Bordeaux, France
    Drug Saf 36:565-72. 2013
    ..However, a symmetrical event-competition bias has not yet been explored whereby known events may mask an association with new events for a given drug or drug class...
  51. ncbi request reprint Neuroleptics and mortality in schizophrenia: prospective analysis of deaths in a French cohort of schizophrenic patients
    Christine Montout
    Departement de Pharmacologie, Universite Victor Segalen Bordeaux 2, 33076, Bordeaux, France
    Schizophr Res 57:147-56. 2002
    ..The putative role of neuroleptics in the known excess mortality of subjects with schizophrenia remains disputed. The aim of this study was to assess the link between mortality and the class of neuroleptic...
  52. doi request reprint Fluindione and drug reaction with eosinophilia and systemic symptoms: an unrecognised adverse effect?
    Amélie Daveluy
    Universite de Bordeaux, U657, 33000, Bordeaux, France
    Eur J Clin Pharmacol 68:101-5. 2012
    ..The aim of the present study was to investigate fluindione-induced DRESS cases reported in France and to describe their characteristics...
  53. doi request reprint An updated method improved the assessment of adverse drug reaction in routine pharmacovigilance
    Hélène Théophile
    Universite de Bordeaux, U657, 146 rue Leo Saignat, F 33076 Bordeaux cedex, France
    J Clin Epidemiol 65:1069-77. 2012
    ..Updating a logistic causality assessment method to improve its agreement with consensual expert judgment (CEJ)...
  54. ncbi request reprint Biases affecting the proportional reporting ratio (PPR) in spontaneous reports pharmacovigilance databases: the example of sertindole
    Nicholas Moore
    Departement de Pharmacologie, Universite Victor Segalen Bordeaux 2, BP36, 33076 Bordeaux, France
    Pharmacoepidemiol Drug Saf 12:271-81. 2003
    ..This excess risk was not predicted in preclinical data and had not been found in premarketing trials...
  55. ncbi request reprint Agreement of expert judgment in causality assessment of adverse drug reactions
    Yannick Arimone
    INSERM, U 657, 33076, Bordeaux Cedex, France
    Eur J Clin Pharmacol 61:169-73. 2005
    ..Global introspection is, with operational algorithms and Bayes' theorem, one of the three main approaches used to assess the causal relationship between a drug treatment and the occurrence of an adverse event...
  56. doi request reprint Signal of Gastrointestinal Congenital Malformations with Antipsychotics After Minimising Competition Bias: A Disproportionality Analysis Using Data from Vigibase(®)
    Francois Montastruc
    INSERM, U1219 Pharmacoepidemiology, Universite de Bordeaux, 33000, Bordeaux, France
    Drug Saf 39:689-96. 2016
    ..To gain further knowledge regarding their safety, we evaluated signals of congenital malformations with antipsychotics using VigiBase(®), the World Health Organization (WHO) Global Individual Case Safety Report (ICSR) database...
  57. ncbi request reprint A simple method to estimate sample sizes for safety equivalence studies using inverse sampling
    Nicholas Moore
    Department de Pharmacologie, Universite Victor Segalen, Case 36, 33076, Bordeaux, Cedex, France
    J Clin Epidemiol 56:433-5. 2003
    ..The number of patients to be included can be derived directly from expected event rates...
  58. doi request reprint Compliance of psychotropic drug prescription with clinical practice guidelines in older inpatients
    Fanny Etchepare
    INSERM U657, INSERM, Bordeaux, F 33000, France
    Fundam Clin Pharmacol 30:82-92. 2016
    ..Practitioners should take into account the risks associated with non-recommended patterns of psychotropic drug use in this vulnerable population. ..
  59. ncbi request reprint [Epidemiology of leg ulcers]
    Bernard Begaud
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux, France
    Ann Dermatol Venereol 129:1225-6. 2002
  60. ncbi request reprint [Some questions about statins]
    Jacques Dangoumau
    Departement de Pharmacologie, Universite Victor Segalen Bordeaux 2, Bordeaux, France
    Therapie 58:91-5. 2003
    ....
  61. ncbi request reprint [Charter of medicines promotion and rational use by physicians]
    Marie Baumevieille
    INSERM U657, IFR 99, Universite Victor Segalen Bordeaux 2, France
    Therapie 62:39-44. 2007
    ..A challenge for health authorities would be to assess the actual impact of ethical and non ethical promotion...
  62. ncbi request reprint Benzodiazepine use and risk of dementia: a nested case-control study
    Rajaa Lagnaoui
    Departement de Pharmacologie, Universite Victor Segalen, Bordeaux 2, 33 076 Bordeaux, France
    J Clin Epidemiol 55:314-8. 2002
    ..0; 95% CI, 0.6-1.6). Our finding suggest that former use of benzodiazepines could be a risk factor for dementia, but more detailed investigation are needed...
  63. doi request reprint Benzodiazepine, psychotropic medication, and dementia: A population-based cohort study
    Dalia Shash
    Inserm Research Center for Epidemiology and Biostatistics U897 Team Neuroepidemiology, Bordeaux, France University of Bordeaux, Bordeaux, France
    Alzheimers Dement 12:604-13. 2016
    ..Benzodiazepine use has been associated with increased risk of dementia. However, it remains unclear whether the risk relates to short or long half-life benzodiazepines and whether it extends to other psychotropic drugs...
  64. ncbi request reprint Trough imatinib plasma levels are associated with both cytogenetic and molecular responses to standard-dose imatinib in chronic myeloid leukemia
    Stephane Picard
    Department of Clinical Pharmacology and Toxicology, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France
    Blood 109:3496-9. 2007
    ..Therefore, monitoring of imatinib plasma levels could be very useful for the management of patients with CML or should at least be checked in the case of treatment failure or suboptimal response...
  65. ncbi request reprint Effects of armagnac extracts on human platelet function in vitro and on rat arteriovenous shunt thrombosis in vivo
    Anwar Umar
    Departement de Pharmacologie, EA525, Universite Victor Segalen, 33076 Bordeaux, France
    Thromb Res 110:135-40. 2003
    ..These have among other effects an antioxidant and antithrombotic effect. The French paradox is maximal in southwest France, a region which is the region of production of armagnac, an oak cask aged spirit also rich in polyphenols...