- Filtering the reality: functional dissociation of lateral and medial pain systems during sleep in humansHélène Bastuji
Central Integration of Pain Lab Lyon Neuroscience Research Center, INSERM, U1028, CNRS, UMR5292, Bron, F 69677, France
Hum Brain Mapp 33:2638-49. 2012..Dissociation between sensory and orienting-motor networks might explain why nociceptive stimuli can be either neglected or incorporated into dreams without awakening the subject...
- Event-related potentials during forced awakening: a tool for the study of acute sleep inertiaHélène Bastuji
INSERM E0342, Lyon, France
J Sleep Res 12:189-206. 2003..In the present series, it proved to be much more discriminative than waking ERPs alone to demonstrate specific abnormalities in patients complaining of excessive daytime sleepiness...
- Laser evoked responses to painful stimulation persist during sleep and predict subsequent arousalsH Bastuji
INSERM, U 879 Central Integration of Pain, Bron F 69677, France
Pain 137:589-99. 2008..This response appeared functionally related to the P3 wave, which in waking subjects has been associated to conscious perception and memory encoding...
- Detection of verbal discordances during sleepFabien Perrin
EA 1880, University Claude Bernard, Lyon, France
Neuroreport 13:1345-9. 2002..Linguistic absurdity appears to be accepted in a different manner during paradoxical sleep than during waking, and this might explain why absurd contents are so naturally incorporated into otherwise plausible dream stories...
- Working memory is partially preserved during sleepJérôme Daltrozzo
CNRS, UMR5292, Lyon Neuroscience Research Center, Auditory Cognition and Psychoacoustics Team, Lyon, France
PLoS ONE 7:e50997. 2012..Our results suggest that WM for linguistic information is partially preserved during sleep with a smaller capacity compared to wake...
- Sleep spindles and human cortical nociception: a surface and intracerebral electrophysiological studyLéa Claude
Central Integration of Pain NeuroPain Lab Neuroscience Research Center, INSERM U1028, CNRS UMR5292, Lyon, France
J Physiol 593:4995-5008. 2015..The present study comprises the first investigation of the effect of spindles on nociceptive information processing and the results obtained challenge the classical inhibitory effect of spindles...
- Thalamic deactivation at sleep onset precedes that of the cerebral cortex in humansMichel Magnin
Institut National de la Santé et de la Recherche Médicle U879, Bron, F 69677, France
Proc Natl Acad Sci U S A 107:3829-33. 2010..Thus, asynchronous thalamo-cortical deactivation while falling asleep probably explains the production of hypnagogic hallucinations by a still-activated cortex and the common self-overestimation of the time needed to fall asleep...
- An inverse agonist of the histamine H(3) receptor improves wakefulness in narcolepsy: studies in orexin-/- mice and patientsJian Sheng Lin
INSERM U628, 69373 Lyon, France Faculté de Médecine, Universite Claude Bernard, 69373 Lyon, France
Neurobiol Dis 30:74-83. 2008..H(3)-receptor inverse agonists could constitute a novel effective treatment of EDS, particularly when associated with modafinil...
- Human thalamic medial pulvinar nucleus is not activated during paradoxical sleepMichel Magnin
Inserm EMI 342, Federative Institut of Neurosciences INSERM IFR 19, Unité d Hypnologie, Hopital Neurologique, 59 Bd Pinel, 69003 Lyon, France
Cereb Cortex 14:858-62. 2004..This discrepancy between activities in a thalamic nucleus and its related cortical areas may compromise the spatio-temporal binding of the high-frequency activities, resulting in altered perceptual experiences during dream periods...
- Heterogeneity of arousals in human sleep: A stereo-electroencephalographic studyLaure Peter-Derex
Lyon Neuroscience Research Center, Central integration of pain Lab, INSERM, U1028, CNRS, UMR5292, Universite Claude Bernard, Bron, F 69677, France Hospices civils de Lyon, Centre Hospitalier Lyon Sud, Service de Neurologie sommeil, 165 Chemin du Grand Revoyet, 69495 Pierre Benite, France Hospices civils de Lyon, Hopital Neurologique, Unité d Hypnologie, Service de Neurologie Fonctionnelle et d Epileptologie, Groupement Hospitalier Est, 59 Boulevard Pinel, 69677 Bron, France Electronic address
Neuroimage 123:229-44. 2015..This phenomenon may reflect the mechanisms involved in the negotiation between two main contradictory functional necessities, preserving the continuity of sleep, and maintaining the possibility to react. ..
- Pitolisant, an inverse agonist of the histamine H3 receptor: an alternative stimulant for narcolepsy-cataplexy in teenagers with refractory sleepinessClara Inocente
Integrative Physiology of Brain Arousal System, CRNL, INSERM U1028, CNRS UMR5292, University Lyon1, Lyon, France
Clin Neuropharmacol 35:55-60. 2012..Drugs such as pitolisant, which block histamine H3 autoreceptors, constitute a newly identified class of stimulants because they increase brain histamine and enhance wakefulness in animal and human adult narcolepsy...
- Prevalence of papilloedema in patients with sleep apnoea syndrome: a prospective studyLaure Peter
Service de Neurologie D, Hopital Neurologique, Lyon, France
J Sleep Res 16:313-8. 2007..Further studies, including more patients, might be useful to establish which patients are at particular risk for this complication...