Jerome Avouac

Summary

Country: France

Publications

  1. doi request reprint Mortality profile of patients with rheumatoid arthritis in France and its change in 10 years
    Jerome Avouac
    Paris Descartes University, Sorbonne Paris Cité, Rheumatology A Department, Cochin Hospital, Paris, France Electronic address
    Semin Arthritis Rheum . 2016
  2. doi request reprint Autoantibodies against Endothelin 1 Type A Receptor Are Strong Predictors of Digital Ulcers in Systemic Sclerosis
    Jerome Avouac
    From the Paris Descartes University, Sorbonne Paris Cité, Rheumatology A Department, Cochin Hospital Paris Descartes University, Institut National de la Sante et de la Recherche Medicale, Unité 1016 INSERM U1016, and Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104 CNRS UMR8104, Cochin Institute Paris 13 University, University Hospital of Paris Seine Saint Denis, Cardiology Department, Bobigny, France and Unité Mixte de Recherche 942 UMR 942, Paris, France Department of Rheumatology, Clinical Immunology, and German Rheumatism Research Centre, a Leibniz Institute, Charite University Medicine, Berlin, Germany J Avouac, MD, PhD, Paris Descartes University, Sorbonne Paris Cité, Rheumatology A Department, Cochin Hospital, and Paris Descartes University, Inserm U1016, and CNRS UMR8104, Cochin Institute G Riemekasten, MD, PhD, Department of Rheumatology, Clinical Immunology, and German Rheumatism Research Centre, a Leibniz Institute
    J Rheumatol 42:1801-7. 2015
  3. pmc Decreased expression of the endothelial cell-derived factor EGFL7 in systemic sclerosis: potential contribution to impaired angiogenesis and vasculogenesis
    Mirko Manetti
    Arthritis Res Ther 15:R165. 2013
  4. ncbi request reprint Targeted immunotherapies in systemic sclerosis
    Jerome Avouac
    Paris Descartes University, Sorbonne Paris Cité, Rheumatology A department and INSERM U1016, Cochin Hospital, Paris, France
    Clin Exp Rheumatol 32:165-72. 2014
  5. doi request reprint Mouse model of experimental dermal fibrosis: the bleomycin-induced dermal fibrosis
    Jerome Avouac
    Universite Paris Descartes, Service de Rhumatologie A et INSERM U1016, Hopital, Cochin, Paris, France
    Methods Mol Biol 1142:91-8. 2014
  6. doi request reprint Experimental models of dermal fibrosis and systemic sclerosis
    Jerome Avouac
    Paris Descartes University, Cochin Hospital, Rheumatology A Department, Inserm U1016, CNRS UMR8104, Cochin Institute, Paris, France
    Joint Bone Spine 80:23-8. 2013
  7. doi request reprint Critical role of the adhesion receptor DNAX accessory molecule-1 (DNAM-1) in the development of inflammation-driven dermal fibrosis in a mouse model of systemic sclerosis
    Jerome Avouac
    Rheumatology A Department, Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France
    Ann Rheum Dis 72:1089-98. 2013
  8. doi request reprint Increased risk of osteoporosis and fracture in women with systemic sclerosis: a comparative study with rheumatoid arthritis
    Jerome Avouac
    Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France
    Arthritis Care Res (Hoboken) 64:1871-8. 2012
  9. ncbi request reprint A candidate gene study identifies a haplotype of CD2 as novel susceptibility factor for systemic sclerosis
    Eugénie Koumakis
    INSERM, Institut Cochin, Inserm U1016, Sorbonne Paris Cité, and Paris Descartes University, Paris and Paris Descartes University, Rheumatology A Department, Cochin Hospital, APHP, Paris, France
    Clin Exp Rheumatol 34:43-48. 2016
  10. doi request reprint Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European Caucasian population
    Julien Wipff
    Universite Paris Descartes, AP HP, Hopital Cochin, France
    J Rheumatol 37:599-602. 2010

Detail Information

Publications66

  1. doi request reprint Mortality profile of patients with rheumatoid arthritis in France and its change in 10 years
    Jerome Avouac
    Paris Descartes University, Sorbonne Paris Cité, Rheumatology A Department, Cochin Hospital, Paris, France Electronic address
    Semin Arthritis Rheum . 2016
    ..To study the mortality profile of patients with rheumatoid arthritis (RA) in France...
  2. doi request reprint Autoantibodies against Endothelin 1 Type A Receptor Are Strong Predictors of Digital Ulcers in Systemic Sclerosis
    Jerome Avouac
    From the Paris Descartes University, Sorbonne Paris Cité, Rheumatology A Department, Cochin Hospital Paris Descartes University, Institut National de la Sante et de la Recherche Medicale, Unité 1016 INSERM U1016, and Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8104 CNRS UMR8104, Cochin Institute Paris 13 University, University Hospital of Paris Seine Saint Denis, Cardiology Department, Bobigny, France and Unité Mixte de Recherche 942 UMR 942, Paris, France Department of Rheumatology, Clinical Immunology, and German Rheumatism Research Centre, a Leibniz Institute, Charite University Medicine, Berlin, Germany J Avouac, MD, PhD, Paris Descartes University, Sorbonne Paris Cité, Rheumatology A Department, Cochin Hospital, and Paris Descartes University, Inserm U1016, and CNRS UMR8104, Cochin Institute G Riemekasten, MD, PhD, Department of Rheumatology, Clinical Immunology, and German Rheumatism Research Centre, a Leibniz Institute
    J Rheumatol 42:1801-7. 2015
    ..To determine the predictive value of functional autoantibodies against vascular receptors for the development of ischemic digital ulcers (DU) in patients with systemic sclerosis (SSc)...
  3. pmc Decreased expression of the endothelial cell-derived factor EGFL7 in systemic sclerosis: potential contribution to impaired angiogenesis and vasculogenesis
    Mirko Manetti
    Arthritis Res Ther 15:R165. 2013
    ..In this study, we investigated the possible involvement of EGFL7 in SSc...
  4. ncbi request reprint Targeted immunotherapies in systemic sclerosis
    Jerome Avouac
    Paris Descartes University, Sorbonne Paris Cité, Rheumatology A department and INSERM U1016, Cochin Hospital, Paris, France
    Clin Exp Rheumatol 32:165-72. 2014
    ....
  5. doi request reprint Mouse model of experimental dermal fibrosis: the bleomycin-induced dermal fibrosis
    Jerome Avouac
    Universite Paris Descartes, Service de Rhumatologie A et INSERM U1016, Hopital, Cochin, Paris, France
    Methods Mol Biol 1142:91-8. 2014
    ..Here, we describe the mouse model of bleomycin-induced dermal fibrosis, which mimics early and inflammatory stages of SSc, and is widely used in SSc research. ..
  6. doi request reprint Experimental models of dermal fibrosis and systemic sclerosis
    Jerome Avouac
    Paris Descartes University, Cochin Hospital, Rheumatology A Department, Inserm U1016, CNRS UMR8104, Cochin Institute, Paris, France
    Joint Bone Spine 80:23-8. 2013
    ..Hence, we will provide an overview of the most important experimental models of dermal fibrosis and SSc and discuss their respective contribution to the better understanding of SSc pathogenesis...
  7. doi request reprint Critical role of the adhesion receptor DNAX accessory molecule-1 (DNAM-1) in the development of inflammation-driven dermal fibrosis in a mouse model of systemic sclerosis
    Jerome Avouac
    Rheumatology A Department, Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France
    Ann Rheum Dis 72:1089-98. 2013
    ..To investigate the contribution of the adhesion receptor DNAX accessory molecule-1 (DNAM-1) in the development of dermal fibrosis on gene inactivation and targeted molecular strategies...
  8. doi request reprint Increased risk of osteoporosis and fracture in women with systemic sclerosis: a comparative study with rheumatoid arthritis
    Jerome Avouac
    Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France
    Arthritis Care Res (Hoboken) 64:1871-8. 2012
    ....
  9. ncbi request reprint A candidate gene study identifies a haplotype of CD2 as novel susceptibility factor for systemic sclerosis
    Eugénie Koumakis
    INSERM, Institut Cochin, Inserm U1016, Sorbonne Paris Cité, and Paris Descartes University, Paris and Paris Descartes University, Rheumatology A Department, Cochin Hospital, APHP, Paris, France
    Clin Exp Rheumatol 34:43-48. 2016
    ..The objective of this study was to investigate whether CD2 polymorphisms are associated with SSc...
  10. doi request reprint Association of metalloproteinase gene polymorphisms with systemic sclerosis in the European Caucasian population
    Julien Wipff
    Universite Paris Descartes, AP HP, Hopital Cochin, France
    J Rheumatol 37:599-602. 2010
    ..Our aim was to determine whether polymorphisms of the MMP2, MMP9, and MMP14 genes confer susceptibility to SSc in a large population...
  11. doi request reprint Phenotype-haplotype correlation of IRF5 in systemic sclerosis: role of 2 haplotypes in disease severity
    Philippe Dieude
    Service de Rhumatologie, Hopital Bichat Claude Bernard, APHP, Université Diderot Paris 7, Paris, France
    J Rheumatol 37:987-92. 2010
    ..Our aim was to investigate whether IRF5 haplotypes confer susceptibility to SSc, and to perform genotype haplotype-phenotype correlation analyses...
  12. doi request reprint Associated autoimmune diseases in systemic sclerosis define a subset of patients with milder disease: results from 2 large cohorts of European Caucasian patients
    Jerome Avouac
    Rheumatology A Department, Paris Descartes University, Cochin Hospital, Paris, France
    J Rheumatol 37:608-14. 2010
    ..To assess the prevalence and potential associations with the systemic sclerosis (SSc) phenotype of additional autoimmune diseases (AID)...
  13. ncbi request reprint Association study of B-cell marker gene polymorphisms in European Caucasian patients with systemic sclerosis
    Karen Dawidowicz
    Universite Paris Diderot, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    Clin Exp Rheumatol 29:839-42. 2011
    ..BANK1 and BLK B-cell genetic markers have been reproducibly and convincingly found to contribute to susceptibility to systemic sclerosis (SSc)...
  14. doi request reprint Prevalence of pulmonary hypertension in systemic sclerosis in European Caucasians and metaanalysis of 5 studies
    Jerome Avouac
    Department of Rheumatology A, Paris Descartes University, Cochin Hospital, APHP, Paris, France
    J Rheumatol 37:2290-8. 2010
    ..To measure the prevalence of different types of pulmonary hypertension (PH) and to identify patients with systemic sclerosis (SSc) at highest risk in a multicenter European sample, with a metaanalysis of relevant studies...
  15. doi request reprint Angiotensin-converting enzyme gene does not contribute to genetic susceptibility to systemic sclerosis in European Caucasians
    Julien Wipff
    Paris Descartes Université, Rhumatologie A, Hopital Cochin, AP HP, Paris, France
    J Rheumatol 36:337-40. 2009
    ..To determine whether angiotensin-converting enzyme (ACE) polymorphisms including I/D and 2 single-nucleotide polymorphisms (SNP) affect susceptibility to systemic sclerosis (SSc) in a large French Caucasian population...
  16. doi request reprint C8orf13-BLK is a genetic risk locus for systemic sclerosis and has additive effects with BANK1: results from a large french cohort and meta-analysis
    Baptiste Coustet
    Inserm U1016, Universite Paris Descartes, Paris, France
    Arthritis Rheum 63:2091-6. 2011
    ....
  17. doi request reprint A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis
    Eugénie Koumakis
    INSERM, Institut Cochin, Cochin Hospital, AP HP, Inserm U1016, Sorbonne Paris Cité, and Paris Descartes University, Paris, France
    Arthritis Rheum 65:3202-8. 2013
    ..The present study was thus undertaken to investigate whether CCR6 polymorphisms could also be associated with susceptibility to SSc...
  18. ncbi request reprint Association study of 3 rheumatoid arthritis risk loci in systemic sclerosis in European Caucasian population
    Baptiste Coustet
    Inserm U1016, Universite Paris Descartes, Hopital Cochin, Paris, France
    Clin Exp Rheumatol 29:S6-9. 2011
    ..Systemic sclerosis (SSc) belongs to connective tissue disorders and recent data have highlighted strong associations with some autoimmunity genes shared with other autoimmune diseases...
  19. pmc Association study of ITGAM, ITGAX, and CD58 autoimmune risk loci in systemic sclerosis: results from 2 large European Caucasian cohorts
    Baptiste Coustet
    Universite Paris Descartes, Rhumatologie A, Hopital Cochin, APHP, Paris, France
    J Rheumatol 38:1033-8. 2011
    ..To determine whether novel risk loci associated with systemic lupus erythematosus or multiple sclerosis may confer susceptibility to SSc, we tested single-nucleotide polymorphisms (SNP) from ITGAM, ITGAX, and CD58 for associations...
  20. doi request reprint Prediction of pulmonary hypertension related to systemic sclerosis by an index based on simple clinical observations
    Christophe Meune
    Paris Descartes University and Department of Rheumatology A, Cochin Hospital, AP HP, Paris, France
    Arthritis Rheum 63:2790-6. 2011
    ..To develop a score to estimate the risk of developing pulmonary hypertension (PH) in patients with systemic sclerosis (SSc)...
  21. doi request reprint Insights into the pathogenesis of systemic sclerosis based on the gene expression profile of progenitor-derived endothelial cells
    Jerome Avouac
    Université Paris Descartes and Hôpital Cochin, AP HP, and INSERM U1016, Cochin Institut, Paris, France
    Arthritis Rheum 63:3552-62. 2011
    ..To determine the gene expression profile of endothelial cells derived from the endothelial progenitor cells (EPCs) of patients with systemic sclerosis (SSc)...
  22. doi request reprint Angiogenic biomarkers predict the occurrence of digital ulcers in systemic sclerosis
    Jerome Avouac
    Rheumatology A Department, Paris Descartes University, Cochin Hospital, APHP, Sorbonne Paris Cité, Paris, France
    Ann Rheum Dis 71:394-9. 2012
    ..To evaluate the possible merit of endothelial markers for the prediction of ischaemic digital ulcers in patients with systemic sclerosis (SSc)...
  23. doi request reprint Enhanced expression of ephrins and thrombospondins in the dermis of patients with early diffuse systemic sclerosis: potential contribution to perturbed angiogenesis and fibrosis
    Jerome Avouac
    Rheumatology A Department, Paris Descartes University, Cochin Hospital, AP HP, France
    Rheumatology (Oxford) 50:1494-504. 2011
    ..To determine the skin and fibroblast expression of ephrins (EphB4 and EphrinB2) and thrombospondins (TSPs: TSP1 and TSP2) in patients with SSc...
  24. doi request reprint Hand and wrist involvement in systemic sclerosis: US features
    Véronique Freire
    From the Department of Radiology, Centre Hospitalier Universitaire de Montreal, Hopital Notre Dame, 1560 Sherbrooke East, Montreal, QC, Canada H2L 4M1 V F and Departments of Radiology B R B, R C, E P, J L D, H G and Rheumatology A M E, J A, Y A, Hopital Cochin, AP HP, Universite Paris Descartes, Paris, France
    Radiology 269:824-30. 2013
    ..To characterize ultrasonographic (US) features in the hand of patients with systemic sclerosis (SSc) and to evaluate the sensitivity of US in the detection of calcinosis and acroosteolysis...
  25. doi request reprint Association study of CRP gene in systemic sclerosis in European Caucasian population
    Julien Wipff
    Rhumatologie A, APHP, Hopital Cochin, Universite Paris Descartes, 27 rue du Faubourg St Jacques, 75014, Paris, France
    Rheumatol Int 34:389-92. 2014
    ..These results obtained through a large cohort of European Caucasian SSc patients do not support the implication of CRP gene in the pathogenesis of SSc. ..
  26. doi request reprint Familial autoimmunity in systemic sclerosis -- results of a French-based case-control family study
    Eugénie Koumakis
    Paris Descartes University, Rheumatology A Department, Cochin Hospital, APHP, France
    J Rheumatol 39:532-8. 2012
    ..To assess the prevalence of autoimmune diseases in first-degree relatives of patients with systemic sclerosis (SSc), and to compare those results with control families in order to identify patterns of autoimmune diseases in relatives...
  27. doi request reprint Treatment with abatacept prevents experimental dermal fibrosis and induces regression of established inflammation-driven fibrosis
    Matthieu Ponsoye
    Universite Paris Descartes, Sorbonne Paris Cité, INSERM U1016 and CNRS UMR8104, Institut Cochin, Paris, France
    Ann Rheum Dis 75:2142-2149. 2016
    ..Our aim was to investigate the efficacy of abatacept, which tempers T-cell activation, in reducing skin fibrosis in complementary mouse models of SSc...
  28. pmc Identification of NF-κB and PLCL2 as new susceptibility genes and highlights on a potential role of IRF8 through interferon signature modulation in systemic sclerosis
    Maria Arismendi
    Paris Descartes University, Inserm U1016, Institut Cochin, Sorbonne Paris Cité, Paris, France
    Arthritis Res Ther 17:71. 2015
    ..The present study was undertaken to investigate whether single-nucleotide polymorphisms (SNPs) identified by a large genome-wide association study (GWAS) in PBC might contribute to SSc susceptibility...
  29. doi request reprint A gender gap in primary and secondary heart dysfunctions in systemic sclerosis: a EUSTAR prospective study
    Muriel Elhaï
    Department of Rheumatology A, Paris Descartes University, Cochin Hospital, Paris, France
    Ann Rheum Dis 75:163-9. 2016
    ..However, unlike lupus, the effects of sex on disease phenotype and prognosis are poorly known. Therefore, we aimed to determine sex effects on outcomes...
  30. pmc Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis
    Baptiste Coustet
    Universite Paris Descartes, Rhumatologie A, Inserm U1016, Hopital Cochin, APHP, Paris, France
    J Rheumatol 39:997-1003. 2012
    ..Our objective was to validate TNFSF4 association with SSc and determine the subset with the higher risk...
  31. pmc Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis
    Yannick Allanore
    Universite Paris Descartes, Rhumatologie A, INSERM, U1016, Hopital Cochin, APHP, Paris, France
    PLoS Genet 7:e1002091. 2011
    ..The genetic signal of association with TNIP1 variants, together with tissular and cellular investigations, suggests that this pathway has a critical role in regulating autoimmunity and SSc pathogenesis...
  32. doi request reprint Systemic sclerosis at the crossroad of polyautoimmunity
    Muriel Elhaï
    Rheumatology A Dpt, Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, APHP, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Autoimmun Rev 12:1052-7. 2013
    ..Therefore to overcome these limitations of individual studies, we sought to perform a meta-analysis to determine the accurate prevalence of polyautoimmunity in SSc...
  33. doi request reprint Cardiac involvement in systemic sclerosis assessed by tissue-doppler echocardiography during routine care: A controlled study of 100 consecutive patients
    Christophe Meune
    Hopital Cochin, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Paris, France
    Arthritis Rheum 58:1803-9. 2008
    ..To assess the prevalence of primary cardiac complications in a large population of patients with systemic sclerosis (SSc), using recently developed echocardiographic techniques...
  34. doi request reprint Cardiac biomarkers in systemic sclerosis: contribution of high-sensitivity cardiac troponin in addition to N-terminal pro-brain natriuretic peptide
    Jerome Avouac
    Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, and Paris Descartes University, INSERM U1016 and CNRS UMR8104, Cochin Institute, Paris, France
    Arthritis Care Res (Hoboken) 67:1022-30. 2015
    ....
  35. doi request reprint Trabecular bone score in female patients with systemic sclerosis: comparison with rheumatoid arthritis and influence of glucocorticoid exposure
    Eugénie Koumakis
    From the Rheumatology Department A, Cochin Hospital, Assistance Publique Hopitaux de Paris APHP, Paris Descartes University Institut national de la santé et de la recherche médicale INSERM, Unité INSERM U845, Centre de Recherche Croissance et Signalisation, Paris Descartes University, Sorbonne Paris Cité, Paris Med Imaps Plateforme Technologique d Innovation Biomédicale PTIB Hôpital Xavier Arnozan, CHU Bordeaux, Pessac, France E Koumakis, MD, Rheumatology Department A, Cochin Hospital, APHP, Paris Descartes University, and INSERM, Unité INSERM U845, Centre de Recherche Croissance et Signalisation, Paris Descartes University, Sorbonne Paris Cité J Avouac, MD, PhD E Toth, MD J Payet, MD A Kahan, MD, PhD Y Allanore, MD, PhD Catherine Cormier, MD, Rheumatology Department A, Cochin Hospital, APHP, Paris Descartes University R Winzenrieth, PhD, PTIB Hôpital Xavier Arnozan, Leicester Royal Infirmary
    J Rheumatol 42:228-35. 2015
    ..The aims were to assess bone involvement in SSc using TBS in comparison with a "high-risk" population with rheumatoid arthritis (RA) and controls, and to investigate the determinants of a low TBS...
  36. pmc Enhanced late-outgrowth circulating endothelial progenitor cell levels in rheumatoid arthritis and correlation with disease activity
    Vanina Jodon de Villeroché
    INSERM U781, Paris Descartes University, Necker Hospital, 149 rue de Sevres, 75015 Paris, France
    Arthritis Res Ther 12:R27. 2010
    ..Contradictory results have been published regarding circulating endothelial progenitor cells (EPCs) in RA. We herein investigated late outgrowth EPC sub-population using recent recommendations in patients with RA and healthy controls...
  37. doi request reprint Dermal tissue and cellular expression of fibrillin-1 in diffuse cutaneous systemic sclerosis
    Julien Wipff
    Universite Paris Descartes, Rhumatologie A, Hopital Cochin, AP HP, Paris, France
    Rheumatology (Oxford) 49:657-61. 2010
    ..To assess dermal expression and fibroblast production of fibrillin-1 (FBN-1) in SSc...
  38. doi request reprint Impaired quality of life in systemic sclerosis and patient perception of the disease: A large international survey
    Camelia Frantz
    Rheumatology A Department, Cochin Hospital, Paris Descartes University, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Semin Arthritis Rheum 46:115-23. 2016
    ..The purpose of this study was to assess health-related quality of life (HRQoL) and disease perception in a large, international group of patients with systemic sclerosis (SSc)...
  39. doi request reprint A right ventricular diastolic impairment is common in systemic sclerosis and is associated with other target-organ damage
    Christophe Meune
    Department of Cardiology, Paris 13 University, Avicenne Hospital, AP HP, 125 rue de Stalingrad, Bobigny 93000, France UMR S 942, Lariboisiere Hospital, Paris, France Department of Cardiology, Paris Descartes University, Cochin Hospital, AP HP, Paris, France Electronic address
    Semin Arthritis Rheum 45:439-45. 2016
    ..Heart involvement in systemic sclerosis (SSc) is a strong prognostic factor. Our aim was to examine left ventricle (LV) and right ventricle (RV) involvement...
  40. doi request reprint Joint and tendon involvement predict disease progression in systemic sclerosis: a EUSTAR prospective study
    Jerome Avouac
    Rheumatology A Department, Paris Descartes University, Cochin Hospital, Paris, France
    Ann Rheum Dis 75:103-9. 2016
    ..To determine whether joint synovitis and tendon friction rubs (TFRs) can predict the progression of systemic sclerosis (SSc) over time...
  41. doi request reprint Outcomes of patients with systemic sclerosis-associated polyarthritis and myopathy treated with tocilizumab or abatacept: a EUSTAR observational study
    Muriel Elhaï
    Rheumatology A Department, Paris Descartes University, Cochin Hospital, Paris, France
    Ann Rheum Dis 72:1217-20. 2013
    ..To evaluate the safety and effectiveness of tocilizumab and abatacept in systemic sclerosis (SSc)-polyarthritis or SSc-myopathy...
  42. doi request reprint Inflammation and disease activity are associated with high circulating cardiac markers in rheumatoid arthritis independently of traditional cardiovascular risk factors
    Jerome Avouac
    From the Paris Descartes University, Sorbonne Paris Cité, Rheumatology A Department, Cochin Hospital Paris Descartes University, INSERM U1016 and CNRS UMR8104, Cochin Institute, Paris Paris 13 University, University Hospital of Paris Seine Saint Denis, Cardiology Department, Bobigny Clinical Chemistry Laboratory, Cochin and Hôtel Dieu Hospitals Paris 7 University, Rheumatology Department, Bichat Claude Bernard Hospital Clinical Chemistry and Hormonology Department, Tenon Hospital, Paris, France
    J Rheumatol 41:248-55. 2014
    ..To measure concentrations of high-sensitivity cardiac troponin (HS-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with rheumatoid arthritis (RA) and to examine correlates...
  43. doi request reprint Characteristics of joint involvement and relationships with systemic inflammation in systemic sclerosis: results from the EULAR Scleroderma Trial and Research Group (EUSTAR) database
    Jerome Avouac
    Service de Rhumatologie A, Hopital Cochin, Universite Paris Descartes, 75014 Paris, France
    J Rheumatol 37:1488-501. 2010
    ..To determine the prevalence of and independent factors associated with joint involvement in a large population of patients with systemic sclerosis (SSc)...
  44. doi request reprint Trends in mortality in patients with systemic sclerosis over 40 years: a systematic review and meta-analysis of cohort studies
    Muriel Elhaï
    Rheumatology A Department, Descartes University, Paris, France
    Rheumatology (Oxford) 51:1017-26. 2012
    ..Thus, we set out to determine whether mortality rate in SSc patients has decreased over the past 40 years through a meta-analysis of cohort studies...
  45. pmc Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis
    Nadira Ruzehaji
    INSERM, U1016, Institut Cochin, Paris, France
    Ann Rheum Dis 75:2175-2183. 2016
    ..Evidence suggests that peroxisome proliferator-activated receptors (PPARs) play an important role in SSc-related fibrosis and their agonists may become effective therapeutic targets...
  46. pmc OX40L blockade protects against inflammation-driven fibrosis
    Muriel Elhaï
    INSERM, U1016 UMR8104, Cochin Institute, Paris Descartes University, Sorbonne Paris Cité, 75014 Paris, France Rheumatology A Department, Cochin Hospital, Paris Descartes University, 75014 Paris, France
    Proc Natl Acad Sci U S A 113:E3901-10. 2016
    ..OX40L exerts potent profibrotic effects by promoting the infiltration of inflammatory cells into lesional tissues and therefore the release of proinflammatory mediators, thereafter leading to fibroblast activation. ..
  47. ncbi request reprint Effects of rituximab in connective tissue disorders related interstitial lung disease
    Gemma Lepri
    Dept of Clinical and Experimental Medicine, AOUC, University of Florence, Italy and Paris Descartes University, Rheumatology A Dept, APHP, Cochin Hospital, Paris, France
    Clin Exp Rheumatol 34:181-185. 2016
    ....
  48. pmc Combined effect of genetic background and gender in a mouse model of bleomycin-induced skin fibrosis
    Nadira Ruzehaji
    INSERM U1016 UMR 8104, Cochin Institute, Paris, France
    Arthritis Res Ther 17:145. 2015
    ..Murine model of bleomycin-induced dermal fibrosis encapsulates important events that take place early in the disease course...
  49. pmc Combination of echocardiographic and pulmonary function test measures improves sensitivity for diagnosis of systemic sclerosis-associated pulmonary arterial hypertension: analysis of 2 cohorts
    Heather Gladue
    From the University of Michigan Scleroderma Program Division of Rheumatology, Department of Medicine, Georgetown University, Washington, DC, USA Department of Rheumatology A, Paris Descartes University, Cochin Hospital, Assistance Publique Hopitaux de Paris, Paris, France St Joseph s Hospital and Medical Center, Division of Pulmonary, Department of Medicine, Phoenix, AZ David Geffen School of Medicine at UCLA, Division of Pulmonary, Department of Medicine, Los Angeles, CA Arizona State University, Biodesign Institute, Tempe, AZ Department of Biostatistics, University of Michigan, School of Public Health, Ann Arbor, MI, USA and Paris XIII University, Cardiology Department, Avicenne Hospital, Bobigny, France
    J Rheumatol 40:1706-11. 2013
    ....
  50. doi request reprint Ultrasonographic hand features in systemic sclerosis and correlates with clinical, biologic, and radiographic findings
    Muriel Elhaï
    Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, AP HP, France
    Arthritis Care Res (Hoboken) 64:1244-9. 2012
    ..To investigate ultrasonographic (US) hand features in systemic sclerosis (SSc) patients and their relationship with clinical, biologic, and radiographic data...
  51. doi request reprint Lack of specificity of the 6-minute walk test as an outcome measure for patients with systemic sclerosis
    Yoland Schoindre
    Universite Paris Descartes, Service de Rhumatologie A, Departement de Cardiologie, and Service Physiologie et Explorations Fonctionnelles, Hopital Cochin, AP HP, 75014 Paris, France
    J Rheumatol 36:1481-5. 2009
    ..However, conflicting results have been reported in systemic sclerosis (SSc). Our objective was to evaluate the relationships of the 6-min walking distance (6MWD) and organ damage in SSc...
  52. doi request reprint Systemic sclerosis: an update in 2008
    Yannick Allanore
    Paris Descartes University, Medical Faculty, Department of Rheumatology A, Cochin Hospital, AP HP and INSERM U781, Necker Hospital, Paris, France
    Joint Bone Spine 75:650-5. 2008
    ..This article deals with current and possible future therapeutic options...
  53. doi request reprint Skin Telangiectasia and the Identification of a Subset of Systemic Sclerosis Patients With Severe Vascular Disease
    Charlotte Hurabielle
    Paris Descartes University, Sorbonne Paris Cité, Hopital Cochin, Paris, France
    Arthritis Care Res (Hoboken) 68:1021-7. 2016
    ..We aimed to determine whether the number and size of CT were associated with the pattern of microvascular lesions assessed by nailfold videocapillaroscopy (NVC) and markers reflecting the severity of SSc-related vasculopathy...
  54. doi request reprint N-terminal pro-brain natriuretic peptide is a strong predictor of mortality in systemic sclerosis
    Yannick Allanore
    Department of Rheumatology A, Paris Descartes University, Cochin Hospital, Inserm U1016, Paris, France
    Int J Cardiol 223:385-389. 2016
    ..Cardiovascular involvement is a major contributor to mortality in systemic sclerosis (SSc). We examined whether N-terminal pro-brain natriuretic peptide (NT-proBNP) is a reliable predictor of mortality in SSc...
  55. doi request reprint Systemic sclerosis: Recent insights
    Muriel Elhaï
    Paris Descartes University, Sorbonne Paris Cité, Rheumatology A Department, Cochin Hospital, 27, rue du Faubourg Saint Jacques 75014 Paris, France INSERM U1016, Cochin Hospital, 27, rue du Faubourg Saint Jacques 75014 Paris, France
    Joint Bone Spine 82:148-53. 2015
    ..This article deals with recent insights into classification criteria, pathogenesis, organ involvements, outcome and current and possible future therapeutic options in systemic sclerosis. ..
  56. doi request reprint Anticyclic citrullinated peptide antibodies in rheumatoid and nonrheumatoid rheumatic disorders: experience with 1162 patients
    Judith Payet
    From Paris Descartes University, Cochin Hospital, Rheumatology A and Rheumatology B, and Immunology Laboratory, Paris, France J Payet, MD, Rheumatology A J Avouac, PhD, Rheumatology A J Wipff, MD, Rheumatology A C Job Deslandre, MD, Rheumatology A A Kahan, PhD, Rheumatology A Y Allanore, PhD, Rheumatology A C Goulvestre, MD, Immunology Laboratory F Batteux, MD, Immunology Laboratory L Bialé, MD, Rheumatology B M Dougados, MD, Rheumatology B, Paris Descartes University, Cochin Hospital
    J Rheumatol 41:2395-402. 2014
    ....
  57. doi request reprint Prevalence, correlates and outcomes of gastric antral vascular ectasia in systemic sclerosis: a EUSTAR case-control study
    Etienne Ghrenassia
    From the Department of Rheumatology A, Paris Descartes University, Cochin Hospital, AP HP, Paris, France University of Michigan Scleroderma Program, Ann Arbor, Michigan, USA Division of Rheumatology, University of Pennsylvania, Philadelphia, USA Department of Rheumatology, University Hospital Zurich, Switzerland Rheumatology and Clinical Immunology Unit, Spedali Civili and University of Brescia, Brescia, Italy Rheumatology Department, Hospital Universitario 12 de Octubre, Madrid, Spain Rheumatology Unit, Azienda Ospedaliera Universitaria V Emanuele, Ferrarotto, S Bambino, Catania, Italy Service de Médecine Interne, Centre Hospitalier Nord, Marseille, France Service de Médecine Interne, University Hospital Centre CHU Cochin Service de Médecine Interne, CHU Saint Antoine, Paris, France Division of Rheumatology, Istituto Gaetano Pini, University of Milan, Italy Department of Clinical Medicine, Clinical Immunology Unit, Sapienza University of Rome, Rome, Italy Rheumatology Unit, Azienda Ospedaliera Universitaria Integrata, USA
    J Rheumatol 41:99-105. 2014
    ..To estimate the prevalence, determine the subgroups at risk, and the outcomes of patients with systemic sclerosis (SSc) and gastric antral vascular ectasia (GAVE)...
  58. doi request reprint Late Nailfold Videocapillaroscopy Pattern Associated With Hand Calcinosis and Acro-Osteolysis in Systemic Sclerosis
    Laëtitia Morardet
    Paris Descartes University, Sorbonne Paris Cité, Cochin Hospital, Paris, France
    Arthritis Care Res (Hoboken) 68:366-73. 2016
    ..To determine whether calcinosis and acro-osteolysis are related to specific nailfold videocapillaroscopy (NVC) features in patients with systemic sclerosis (SSc; scleroderma)...
  59. doi request reprint All-cause Mortality Associated with TNF-α Inhibitors in Rheumatoid Arthritis: A Meta-Analysis of Randomized Controlled Trials
    Lucile Poiroux
    Paris Descartes University, Sorbonne Paris Cité, Rheumatology A Department, Cochin Hospital, Paris, France
    Am J Med 128:1367-73.e1. 2015
    ..To compare mortality data obtained from randomized controlled trials for the 5 tumor necrosis factor-α (TNF-α) inhibitors used in the treatment of rheumatoid arthritis...
  60. doi request reprint Outcome of Patients with Systemic Sclerosis in the Intensive Care Unit
    Frédéric Pène
    From the Réanimation médicale, and Médecine Interne, and Rhumatologie A, Centre National de Référence des maladies systémiques et autoimmunes rares, Hopital Cochin, Assistance Publique Hôpitaux de Paris AP HP Faculté de Médecine, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France F Pène, MD, PhD, Réanimation Médicale, Hopital Cochin, AP HP, and Faculté de Médecine, Universite Paris Descartes, Sorbonne Paris Cité T Hissem, MD, Réanimation Médicale, Hopital Cochin, AP HP A Bérezné, MD, Medecine Interne, and Centre National de Référence des maladies systémiques et autoimmunes rares, Hopital Cochin, AP HP Y Allanore, MD, PhD, Rhumatologie A, Hopital Cochin, AP HP, and Faculté de Médecine, Universite Paris Descartes, Sorbonne Paris Cité G Geri, MD, Réanimation Médicale
    J Rheumatol 42:1406-12. 2015
    ..We assessed the characteristics and current outcome of patients with SSc admitted to the ICU...
  61. doi request reprint The nuclear receptor constitutive androstane receptor/NR1I3 enhances the profibrotic effects of transforming growth factor β and contributes to the development of experimental dermal fibrosis
    Jerome Avouac
    University of Erlangen Nuremberg, Erlangen, Germany Paris Descartes University, Inserm U1016, and Cochin Hospital, AP HP, Paris, France
    Arthritis Rheumatol 66:3140-50. 2014
    ..This study was undertaken to investigate the effects of constitutive androstane receptor (CAR)/NR1I3, an orphan nuclear receptor, on fibroblast activation and experimental dermal fibrosis...
  62. doi request reprint Endothelial progenitor cells and rheumatic disorders
    Jerome Avouac
    Rheumatology A Department, Rene Descartes University, Cochin Hospital, APHP, 27 rue du Faubourg Saint Jacques, 75014 Paris, France
    Joint Bone Spine 75:131-7. 2008
    ..EPCs are important in vasculogenesis, and may be involved in other systemic features of inflammatory rheumatic disorders...
  63. doi request reprint Expert consensus for performing right heart catheterisation for suspected pulmonary arterial hypertension in systemic sclerosis: a Delphi consensus study with cluster analysis
    Jerome Avouac
    Sorbonne Paris Cité, Rheumatology A Department, Cochin Hospital, Paris Descartes University, Paris, France
    Ann Rheum Dis 73:191-7. 2014
    ..To establish an expert consensus on which criteria are the most appropriate in clinical practice to refer patients with systemic sclerosis (SSc) for right heart catheterisation (RHC) when pulmonary hypertension (PH) is suspected...
  64. doi request reprint High DNA oxidative damage in systemic sclerosis
    Jerome Avouac
    Service de Rhumatologie A, Hopital Cochin, Universite Paris Descartes, AP HP, Paris, France
    J Rheumatol 37:2540-7. 2010
    ....
  65. ncbi request reprint New therapeutic strategies in the management of systemic sclerosis
    Yannick Allanore
    Rene Descartes University, Medical Faculty, Department of Rheumatology A, Cochin Hospital, Paris, France
    Expert Opin Pharmacother 8:607-15. 2007
    ..However, recent epidemiological data have revealed a decrease in excess mortality, which may be mostly due to the use of cardiovascular drugs. This article deals with present and possible future therapeutic options...
  66. ncbi request reprint Polymorphic markers of the fibrillin-1 gene and systemic sclerosis in European Caucasian patients
    Julien Wipff
    Department of Rheumatology A, Paris Descartes University, Medical Faculty, Cochin Hospital, AP HP, Paris, France
    J Rheumatol 35:643-9. 2008
    ..Significant associations have been found with the fibrillin-1 gene (FBN1) in Choctaw and Japanese populations. We investigated FBN1 polymorphisms in cohorts of European Caucasian patients...