Véronique Avettand-Fenoel

Summary

Country: France

Publications

  1. pmc Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications
    Véronique Avettand-Fenoel
    Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, EA 7327, Paris, France APHP, Hopital Necker Enfants Malades, Laboratoire de Virologie, Paris, France
    Clin Microbiol Rev 29:859-80. 2016
  2. doi request reprint HIV-1 DNA for the measurement of the HIV reservoir is predictive of disease progression in seroconverters whatever the mode of result expression is
    Véronique Avettand-Fenoel
    AP HP, CHU Necker Enfants Malades, Laboratoire de Virologie, Paris, France
    J Clin Virol 42:399-404. 2008
  3. doi request reprint Higher HIV-1 DNA associated with lower gains in CD4 cell count among patients with advanced therapeutic failure receiving optimized treatment (ANRS 123--ETOILE)
    Véronique Avettand-Fenoel
    Universite Paris Descartes, EA3620 Paris, France
    J Antimicrob Chemother 65:2212-4. 2010
  4. doi request reprint Greater diversity of HIV DNA variants in the rectum compared to variants in the blood in patients without HAART
    Véronique Avettand-Fenoel
    Virology Unit, AP HP, Necker Hospital for Sick Children, Paris, France Paris Descartes University, EA3620, Paris, France
    J Med Virol 83:1499-507. 2011
  5. doi request reprint LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01)
    Véronique Avettand-Fenoel
    Assistance Publique Hopitaux de Paris, CHU Necker Enfants Malades, Service de Virologie, Paris, France
    J Med Virol 81:217-23. 2009
  6. doi request reprint HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors
    Véronique Avettand-Fenoel
    AP HP, Laboratoire de Virologie, CHU Necker Enfants Malades, Universite Paris Descartes, Paris, France
    AIDS 22:1880-2. 2008
  7. doi request reprint Increasing HIV-1 non-B subtype primary infections in patients in France and effect of HIV subtypes on virological and immunological responses to combined antiretroviral therapy
    Marie Laure Chaix
    Université Paris Descartes EA 3620, Sorbonne Paris Cité, Paris
    Clin Infect Dis 56:880-7. 2013
  8. doi request reprint Impact of 48 week lopinavir/ritonavir monotherapy on blood cell-associated HIV-1-DNA in the MONARK trial
    Véronique Avettand-Fenoel
    AP HP, Laboratoire de Virologie, CHU Necker Enfants Malades, Paris, France
    J Antimicrob Chemother 65:1005-7. 2010
  9. doi request reprint CCR5 antagonists: a therapeutic option in HIV-1 perinatally infected children experiencing virologic failure?
    Pierre Frange
    Université Paris Descartes EA 3620, Sorbonne Paris Cité, Paris, France
    AIDS 26:1673-7. 2012
  10. ncbi request reprint Gag-Specific CD4 T Cell Proliferation, Plasmacytoid Dendritic Cells, and Ethnicity in Perinatally HIV-1-Infected Youths: The ANRS-EP38-IMMIP Study
    Daniel Scott-Algara
    1 Unité Cytokines et Inflammation, Institut Pasteur, Paris, France
    AIDS Res Hum Retroviruses . 2016

Detail Information

Publications38

  1. pmc Total HIV-1 DNA, a Marker of Viral Reservoir Dynamics with Clinical Implications
    Véronique Avettand-Fenoel
    Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, EA 7327, Paris, France APHP, Hopital Necker Enfants Malades, Laboratoire de Virologie, Paris, France
    Clin Microbiol Rev 29:859-80. 2016
    ..These proteins can induce immune activation, thus participating in the vicious circle of HIV pathogenesis. ..
  2. doi request reprint HIV-1 DNA for the measurement of the HIV reservoir is predictive of disease progression in seroconverters whatever the mode of result expression is
    Véronique Avettand-Fenoel
    AP HP, CHU Necker Enfants Malades, Laboratoire de Virologie, Paris, France
    J Clin Virol 42:399-404. 2008
    ..Previously, HIV-DNA levels have sometimes been reported by other means: copies/10(6) CD4(+)T cells, reflecting the proportion of infected cells; or copies/mL whole blood, reflecting the global blood reservoir size...
  3. doi request reprint Higher HIV-1 DNA associated with lower gains in CD4 cell count among patients with advanced therapeutic failure receiving optimized treatment (ANRS 123--ETOILE)
    Véronique Avettand-Fenoel
    Universite Paris Descartes, EA3620 Paris, France
    J Antimicrob Chemother 65:2212-4. 2010
    ..To describe HIV-1 DNA levels from baseline (W0) to week 52 (W52) among patients receiving either interleukin-2 (IL-2) + optimized background therapy (OBT) or OBT as salvage treatment...
  4. doi request reprint Greater diversity of HIV DNA variants in the rectum compared to variants in the blood in patients without HAART
    Véronique Avettand-Fenoel
    Virology Unit, AP HP, Necker Hospital for Sick Children, Paris, France Paris Descartes University, EA3620, Paris, France
    J Med Virol 83:1499-507. 2011
    ....
  5. doi request reprint LTR real-time PCR for HIV-1 DNA quantitation in blood cells for early diagnosis in infants born to seropositive mothers treated in HAART area (ANRS CO 01)
    Véronique Avettand-Fenoel
    Assistance Publique Hopitaux de Paris, CHU Necker Enfants Malades, Service de Virologie, Paris, France
    J Med Virol 81:217-23. 2009
    ..The results were equivalent to those of HIV-RNA assay. HIV-DNA may be used even in masked primary infection in newborns whose mothers have received HAART...
  6. doi request reprint HIV-DNA in rectal cells is well correlated with HIV-DNA in blood in different groups of patients, including long-term non-progressors
    Véronique Avettand-Fenoel
    AP HP, Laboratoire de Virologie, CHU Necker Enfants Malades, Universite Paris Descartes, Paris, France
    AIDS 22:1880-2. 2008
    ..They were positively correlated (r = 0.841, P<0.0001). Long-term nonprogressors and patients in 'remission' after antiretroviral treatment interruption had the lowest blood and mucosal HIV-DNA levels...
  7. doi request reprint Increasing HIV-1 non-B subtype primary infections in patients in France and effect of HIV subtypes on virological and immunological responses to combined antiretroviral therapy
    Marie Laure Chaix
    Université Paris Descartes EA 3620, Sorbonne Paris Cité, Paris
    Clin Infect Dis 56:880-7. 2013
    ..To study whether the viral diversity had an impact on the virological and immunological responses in patients initiating combined antiretroviral therapy (cART) soon after infection...
  8. doi request reprint Impact of 48 week lopinavir/ritonavir monotherapy on blood cell-associated HIV-1-DNA in the MONARK trial
    Véronique Avettand-Fenoel
    AP HP, Laboratoire de Virologie, CHU Necker Enfants Malades, Paris, France
    J Antimicrob Chemother 65:1005-7. 2010
    ..To study the impact of protease inhibitor monotherapy on the HIV-1 blood reservoir in 72 antiretroviral-naive patients...
  9. doi request reprint CCR5 antagonists: a therapeutic option in HIV-1 perinatally infected children experiencing virologic failure?
    Pierre Frange
    Université Paris Descartes EA 3620, Sorbonne Paris Cité, Paris, France
    AIDS 26:1673-7. 2012
    ..HIV-1 coreceptor usage was determined in HAART-failing children followed in Necker Hospital (Paris, France) in order to estimate the proportion of these patients who may benefit from CCR5-antagonists therapy...
  10. ncbi request reprint Gag-Specific CD4 T Cell Proliferation, Plasmacytoid Dendritic Cells, and Ethnicity in Perinatally HIV-1-Infected Youths: The ANRS-EP38-IMMIP Study
    Daniel Scott-Algara
    1 Unité Cytokines et Inflammation, Institut Pasteur, Paris, France
    AIDS Res Hum Retroviruses . 2016
    ..In conclusion, DC levels are a robust correlate of the presence of Gag-specific T cell proliferation in successfully treated youths...
  11. doi request reprint Short communication: evidence of HIV type 1 complex and second generation recombinant strains among patients infected in 1997-2007 in France: ANRS CO06 PRIMO Cohort
    Julie Galimand
    Université Paris Descartes EA 3620, Paris, France
    AIDS Res Hum Retroviruses 26:645-51. 2010
    ....
  12. doi request reprint Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission
    Antoine Cheret
    EA 7327 Paris Descartes University, Sorbonne Paris Cité, Virology Laboratory, Necker Enfants Malades Hospital, Paris, France Infectious Diseases Department, Dron Hospital, Tourcoing, France
    J Antimicrob Chemother 70:2108-20. 2015
    ..Therapeutic control of HIV replication reduces the size of the viral reservoir, particularly among central memory CD4+ T cells, and this effect might be accentuated by early treatment...
  13. doi request reprint Lopinavir/ritonavir-based antiretroviral therapy in human immunodeficiency virus type 1-infected naive children: rare protease inhibitor resistance mutations but high lamivudine/emtricitabine resistance at the time of virologic failure
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Assistance Publique Hopitaux de Paris, Hopital Necker, Paris, France
    Pediatr Infect Dis J 30:684-8. 2011
    ..Lopinavir/ritonavir (LPV/r) is now the protease inhibitor regimen of choice in the first-line antiretroviral therapy for children <6 years of age...
  14. doi request reprint Polyfunctional HIV-specific T cells in Post-Treatment Controllers
    Assia Samri
    aINSERM U1135 CIMI bSorbonne Universités, UPMC Univ Paris 06, CIMI, Paris cInfectious and Tropical Diseases Department, Regional Hospital Center, Orléans dUnité HIV, Inflammation et Persistance, Institut Pasteur, Paris eFaculté de Médecine, Universite Paris Descartes, Sorbonne Paris Cité fLaboratoire de Virologie, AP HP, Hôpital Necker Enfants Malades gDépartement d Immunologie, AP HP, Hopital Pitie Salpetriere, Paris, France
    AIDS 30:2299-302. 2016
    ....
  15. doi request reprint Naive T lymphocytes and recent thymic emigrants are associated with HIV-1 disease history in french adolescents and young adults infected in the perinatal period: the ANRS-EP38-IMMIP study
    Stephane Blanche
    Faculte de Medecine, EA3620, Universite Paris Descartes, Sorbonne Paris Cité
    Clin Infect Dis 58:573-87. 2014
    ..Naive T-lymphocyte restoration is essential for the maintenance of a diverse T-cell receptor repertoire and for immunity to pathogens...
  16. doi request reprint Relationships between HIV disease history and blood HIV-1 DNA load in perinatally infected adolescents and young adults: the ANRS-EP38-IMMIP study
    Véronique Avettand-Fenoel
    Universite Paris Descartes, France
    J Infect Dis 205:1520-8. 2012
    ..We evaluated blood cell-associated HIV DNA load as an indicator of cell-associated HIV reservoirs and an independent predictor of disease progression...
  17. pmc A single HIV-1 cluster and a skewed immune homeostasis drive the early spread of HIV among resting CD4+ cell subsets within one month post-infection
    Charline Bacchus
    Pierre and Marie Curie University Paris 06, Laboratory Immunity and Infection UMR_S 945, F 75013, Paris, France
    PLoS ONE 8:e64219. 2013
    ....
  18. ncbi request reprint Prevalence and clinical impact of norovirus fecal shedding in children with inherited immune deficiencies
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, AP HP, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Infect Dis 206:1269-74. 2012
    ..1% of fecal samples were still positive after a median of 9.5-months follow-up. Further large longitudinal studies are needed to evaluate the clinical consequences of norovirus shedding in patients with primary immunodeficiencies...
  19. doi request reprint HIV-1 subtype B-infected MSM may have driven the spread of transmitted resistant strains in France in 2007-12: impact on susceptibility to first-line strategies
    Pierre Frange
    Laboratoire de Microbiologie, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, Paris, France EA7327, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France
    J Antimicrob Chemother 70:2084-9. 2015
    ..Our study describes the prevalence of transmitted drug resistance (TDR) among 1318 French patients diagnosed at the time of primary HIV-1 infection (PHI) in 2007-12...
  20. doi request reprint Intensive five-drug antiretroviral therapy regimen versus standard triple-drug therapy during primary HIV-1 infection (OPTIPRIM-ANRS 147): a randomised, open-label, phase 3 trial
    Antoine Cheret
    EA 7327, Paris Descartes University Sorbonne Paris Cité, Paris, France Infectious Diseases Department, Tourcoing Hospital, Tourcoing, France Internal Medicine Department, AP HP, Bicetre Hospital, Le Kremlin Bicetre, France Electronic address
    Lancet Infect Dis 15:387-96. 2015
    ..We aimed to assess the effect of a cART regimen intensified with raltegravir and maraviroc, compared with standard triple-drug cART, on HIV-DNA load...
  21. pmc New sensitive one-step real-time duplex PCR method for group A and B HIV-2 RNA load
    Véronique Avettand-Fenoel
    Laboratoire de Virologie, AP HP, Hopital Necker Enfants Malades, Paris, France EA7327, Universite Paris Descartes, Sorbonne Paris Cité, Faculte de Medecine, Paris, France
    J Clin Microbiol 52:3017-22. 2014
    ..This new assay is highly sensitive and accurately quantifies the most prevalent HIV-2 groups. This test will be useful for monitoring low viral loads in HIV-2-infected patients. ..
  22. pmc Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    PLoS Pathog 9:e1003211. 2013
    ..Our results show that early and prolonged cART may allow some individuals with a rather unfavorable background to achieve long-term infection control and may have important implications in the search for a functional HIV cure...
  23. doi request reprint Congenital cytomegalovirus is the second most frequent cause of bilateral hearing loss in young French children
    Véronique Avettand-Fenoel
    Laboratory of Virology, Reference National Center for Cytomegalovirus Associated Laboratory, Hospital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France University Paris, Descartes, Sorbonne Paris Cité, Paris, France
    J Pediatr 162:593-9. 2013
    ..To estimate the prevalence of congenital cytomegalovirus (cCMV) among causes of bilateral hearing loss in young French children...
  24. pmc Long-Term Spontaneous Control of HIV-1 Is Related to Low Frequency of Infected Cells and Inefficient Viral Reactivation
    Nicolas Noel
    Universite Paris Sud, UMR 1184, Paris, France CEA, DSV iMETI, Division of Immuno Virology, IDMIT, Fontenay aux Rose, France INSERM, U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Le Kremlin Bicetre, France APHP, Service de Médecine Interne Immunologie clinique, Hôpitaux Universitaires Paris Sud, Le Kremlin Bicetre, France
    J Virol 90:6148-58. 2016
    ....
  25. doi request reprint Quantification of total HIV1-DNA in peripheral blood mononuclear cells
    Christine Rouzioux
    Laboratoire de Virologie, Hopital Necker, Paris, France
    Methods Mol Biol 1087:261-70. 2014
    ..Such a series of results might help to adapt simplification or structured interruption strategies, design new clinical trials targeting HIV reservoirs, and select populations that could benefit of such new treatments. ..
  26. pmc The kidney as a reservoir for HIV-1 after renal transplantation
    Guillaume Canaud
    Institut National de la Santé et de la Recherche Médicale U845, Growth and Signaling Research Center, Paris Descartes University, Necker Hospital, Paris, France
    J Am Soc Nephrol 25:407-19. 2014
    ..In conclusion, HIV-1 can infect kidney allografts after transplantation despite undetectable viremia, and this infection might influence graft outcome. ..
  27. doi request reprint Immune responses driven by protective human leukocyte antigen alleles from long-term nonprogressors are associated with low HIV reservoir in central memory CD4 T cells
    Benjamin Descours
    Immunity and Infection Laboratory, Pierre and Marie Curie University, INSERM UMRS 945, Pitie Salpetriere Hospital, Paris, France
    Clin Infect Dis 54:1495-503. 2012
    ....
  28. pmc Enhanced T cell recovery in HIV-1-infected adults through IL-7 treatment
    Yves Levy
    1INSERM U955, Universite Paris 12, and Assistance Publique Hôpitaux de Paris AP HP, Groupe Henri Mondor Albert Chenevier, Immunologie Clinique, Creteil, France
    J Clin Invest 119:997-1007. 2009
    ..Therefore, patients may benefit from intermittent therapy with IL-7 in combination with c-ART...
  29. doi request reprint Elite controllers as a model of functional cure
    Brigitte Autran
    Laboratory Immunity and Infection, Pierre and Marie Curie University, INSERM UMRS 945, France
    Curr Opin HIV AIDS 6:181-7. 2011
    ....
  30. pmc Adenoviral infection presenting as an isolated central nervous system disease without detectable viremia in two children after stem cell transplantation
    Pierre Frange
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Clin Microbiol 49:2361-4. 2011
    ....
  31. doi request reprint Efficacy and tolerance of dolutegravir-based combined ART in perinatally HIV-1-infected adolescents: a French multicentre retrospective study
    Coralie Briand
    Unite d immunologie, Hématologie et Rhumatologie pédiatriques, Assistance Publique Hopitaux de Paris AP HP, Hôpital Universitaire Necker Enfants Malades, Paris, France
    J Antimicrob Chemother . 2016
    ..To assess the safety and efficacy of a dolutegravir-based regimen in perinatally HIV-1-infected adolescents...
  32. doi request reprint HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report
    Pierre Frange
    Laboratoire de Microbiologie Clinique, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris, France Unité d Immunologie, Hématologie et Rhumatologie pédiatriques, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris, France EA7327, Universite Paris Descartes, Sorbonne Paris Cité, Paris, France Electronic address
    Lancet HIV 3:e49-54. 2016
    ..We report a case of a young adult perinatally infected with HIV-1 with viral remission despite long-term treatment interruption...
  33. doi request reprint Blimp-1 overexpression is associated with low HIV-1 reservoir and transcription levels in central memory CD4+ T cells from elite controllers
    Adèle de Masson
    aLaboratoire Immunité et Infection, INSERM UMRS 945, Hôpital Pitié Salpêtrière bUniversité Paris VI Pierre et Marie Curie cLaboratoire de Virologie, Hopital Necker Enfants Malades, Universite Paris Descartes, Sorbonne Paris Cité, EA3620, AP HP, Paris, France Adèle de Masson and Amos Kirilovsky equally contributed to this article
    AIDS 28:1567-77. 2014
    ....
  34. doi request reprint Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    J Immunol 182:7828-37. 2009
    ..These results, on the one hand, suggest the importance of Gag responses in the antiviral potency of CD8(+) T cells from HICs and, on the other hand, propose that other host mechanisms may contribute to restraining HIV infection in HICs...
  35. doi request reprint Drug resistance and tropism as markers of the dynamics of HIV-1 DNA quasispecies in blood cells of heavily pretreated patients who achieved sustained virological suppression
    Pierre Gantner
    Universite Paris Descartes, EA 7327, Université Paris Descartes PRES Sorbonne Paris Cité, Paris, France Laboratoire de Virologie, Hopitaux Universitaires de Strasbourg, Strasbourg, France
    J Antimicrob Chemother 71:751-61. 2016
    ..The objective of this study was to address the dynamics of archived resistant quasispecies in cell-associated HIV-1 DNA over time in heavily ART-experienced patients with currently suppressed plasma HIV-1 RNA...
  36. doi request reprint Prospective identification of congenital cytomegalovirus infection in newborns using real-time polymerase chain reaction assays in dried blood spots
    Marianne Leruez-Ville
    Laboratoire de Virologie, Hopital Necker Enfants Malades, Centre National de Référence du Cytomégalovirus Laboratoire Associé, Paris, France
    Clin Infect Dis 52:575-81. 2011
    ..The goal of this study was to prospectively assess the performance of 2 CMV PCR assays of DBS for CMV neonatal screening in a selected population of neonates...
  37. ncbi request reprint Reactivation capacity by latency-reversing agents ex vivo correlates with the size of the HIV-1 reservoir
    Gilles Darcis
    aService of Molecular Virology, Département de Biologie Moléculaire DBM, Universite Libre de Bruxelles ULB, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium bService des Maladies Infectieuses, Universite de Liege, Centre Hospitalier Universitaire CHU de Liège, Domaine Universitaire du Sart Tilman, B35, 4000 Liege, Belgium cService de Virologie, Universite Paris Descartes, AP HP, Hôpital Necker Enfants Malades 149, rue de Sevres, 75015 Paris, France dService des Maladies Infectieuses, CHU St Pierre, ULB, Rue Haute 322, 1000 Bruxelles, Belgium eInstitut de Parasitologie et de Pathologie Tropicale, EA7292, University of Strasbourg, 3 Rue Koeberle, 67000 Strasbourg, France fInstitut Universitaire de Technologie Louis Pasteur de Schiltigheim, University of Strasbourg, Allée d Athènes 1, 67300 Schiltigheim, France
    AIDS . 2016
    ..Stimulation of patient cell cultures with LRAs ex vivo results in heterogeneous responses among HIV-infected patients. Determinants of this heterogeneity are unknown and consequently, important to determine...
  38. pmc Genotypic resistance profiles of HIV-2-treated patients in West Africa
    Charlotte Charpentier
    aLaboratoire de Virologie, Assistance Publique Hopitaux de Paris AP HP, Groupe Hospitalier Bichat Claude Bernard, HUPNVS, Universite Paris Diderot, Sorbonne Paris Cité, Paris, France bDepartment of Infectious and Tropical Diseases, Treichville University Teaching Hospital cDepartment of Dermatology Infectiology, Medical School, University Felix Houphouët Boigny dProgramme PACCI, Site ANRS, Abidjan, Côte d Ivoire eUniversité Bordeaux, INSERM, IPSED, Centre INSERM U897 Epidémiologie et Biostatistique fINSERM, IPSED, Centre Inserm U897 Épidémiologie et Biostatistique, Bordeaux gLaboratoire de Virologie, Faculte de Medecine, AP HP, Hopital Necker, Universite Rene Descartes, Sorbonne Paris Cité, Paris hLaboratoire de Virologie, Pôle de Biologie Clinique, Hopital Charles Nicolle, CHU de Rouen and EA2656, IRIB, Universite de Rouen, Rouen iLaboratoire de Pharmaco Toxicologie, AP HP, Groupe Hospitalier Bichat Claude Bernard, Veterans Affairs Puget Sound Health Care System and the University of Washington
    AIDS 28:1161-9. 2014
    ..To assess the virological response, genotypic resistance profiles, and antiretroviral plasma concentrations in HIV-2 antiretroviral-treated (antiretroviral therapy, ART) patients in Côte d'Ivoire...