Laurent Gate

Summary

Affiliation: Avenue de Bourgogne
Country: France

Publications

  1. doi request reprint Genotoxicity of styrene-7,8-oxide and styrene in Fisher 344 rats: a 4-week inhalation study
    Laurent Gate
    Institut National de Recherche et Sécurité, rue du Morvan, CS 60027, 54519 Vandoeuvre les Nancy Cedex, France
    Toxicol Lett 211:211-9. 2012
  2. ncbi request reprint Bitumen fume-induced gene expression profile in rat lung
    Laurent Gate
    Institut National de Recherche et Sécurité, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex, France
    Toxicol Appl Pharmacol 215:83-92. 2006
  3. doi request reprint Cytotoxicity and genotoxicity of nanosized and microsized titanium dioxide and iron oxide particles in Syrian hamster embryo cells
    Yves Guichard
    Institut National de Recherche et de Securite, Département Polluants et Santé, rue du Morvan, CS 60027, 54519 Vandoeuvre les Nancy Cedex, France
    Ann Occup Hyg 56:631-44. 2012
  4. doi request reprint In vitro comet and micronucleus assays do not predict morphological transforming effects of silica particles in Syrian Hamster Embryo cells
    Christian Darne
    Département Toxicologie et Biométrologie, Institut National de Recherche et de Sécurité INRS, rue du Morvan, CS 60027, 54519 Vandoeuvre les Nancy Cedex, France Electronic address
    Mutat Res Genet Toxicol Environ Mutagen 796:23-33. 2016
  5. doi request reprint Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 2: intratracheal instillation and intravenous injection
    Yves Guichard
    INRS, Institut National de Recherche et de Securite, Département Toxicologie et Biométrologie, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France
    Environ Mol Mutagen 56:228-44. 2015
  6. pmc In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts
    Yves Guichard
    Institut National de Recherche et de Securite, Rue du Morvan CS 60027, 54519 Vandoeuvre les Nancy Cedex, France
    J Toxicol 2010:323828. 2010
  7. doi request reprint Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats
    Laurent Gate
    Institut National de Recherche et de Securite, Département Toxicologie et Biométrologie, rue du Morvan, CS 60027, F 54519 Vandœuvre Cedex, France
    Toxicol Lett 265:61-69. 2016
  8. ncbi request reprint Genotoxic effects of bitumen fumes in Big Blue transgenic rat lung
    Marie Claire Bottin
    Institut National de Recherche et Sécurité Avenue de Bourgogne, BP 27 54501, Vandoeuvre, Cedex, France
    Mutat Res 596:91-105. 2006

Collaborators

  • Frédéric Cosnier
  • François Gagnaire
  • Maciej Stepnik
  • Valérie Fessard
  • Michèle Goutet
  • Yves Guichard
  • Christian Darne
  • Stephane Binet
  • Jean Claude Micillino
  • Marie Claire Bottin
  • Caroline Fontana
  • Cristina Langlais
  • Richard Wrobel
  • Aurelie Martin
  • Francine Terzetti
  • Catherine Coulais
  • Marie Aline Maire
  • Joanna Roszak
  • Sylvie Sebillaud
  • Julien Schmit
  • Davy Rousset
  • Olivier Witschger
  • Olivier Rastoix
  • Vanessa Fierro
  • Schmit Julien
  • Binet Stéphane
  • Monhoven Nathalie
  • Lucie Ayi-Fanou
  • Bertrand Rihn
  • Gerard Keith
  • Georges Morel
  • Catherine Champmartin
  • Hervé Nunge

Detail Information

Publications8

  1. doi request reprint Genotoxicity of styrene-7,8-oxide and styrene in Fisher 344 rats: a 4-week inhalation study
    Laurent Gate
    Institut National de Recherche et Sécurité, rue du Morvan, CS 60027, 54519 Vandoeuvre les Nancy Cedex, France
    Toxicol Lett 211:211-9. 2012
    ..This experimental design helped to gather new information regarding the systemic genotoxicity of these two chemicals and may be valuable for the risk assessment associated with an occupational exposure to these molecules...
  2. ncbi request reprint Bitumen fume-induced gene expression profile in rat lung
    Laurent Gate
    Institut National de Recherche et Sécurité, Avenue de Bourgogne, BP 27, 54501 Vandoeuvre Cedex, France
    Toxicol Appl Pharmacol 215:83-92. 2006
    ..Altogether, these data give additional information concerning the bitumen fumes biological effects and would allow to better review the health effects of occupational asphalt fumes exposure...
  3. doi request reprint Cytotoxicity and genotoxicity of nanosized and microsized titanium dioxide and iron oxide particles in Syrian hamster embryo cells
    Yves Guichard
    Institut National de Recherche et de Securite, Département Polluants et Santé, rue du Morvan, CS 60027, 54519 Vandoeuvre les Nancy Cedex, France
    Ann Occup Hyg 56:631-44. 2012
    ..In agreement with previous size-comparison studies, we suggest that in vitro cytotoxicity and genotoxicity induced by metal oxide nanoparticles are not always higher than those induced by their bulk counterparts...
  4. doi request reprint In vitro comet and micronucleus assays do not predict morphological transforming effects of silica particles in Syrian Hamster Embryo cells
    Christian Darne
    Département Toxicologie et Biométrologie, Institut National de Recherche et de Sécurité INRS, rue du Morvan, CS 60027, 54519 Vandoeuvre les Nancy Cedex, France Electronic address
    Mutat Res Genet Toxicol Environ Mutagen 796:23-33. 2016
    ....
  5. doi request reprint Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 2: intratracheal instillation and intravenous injection
    Yves Guichard
    INRS, Institut National de Recherche et de Securite, Département Toxicologie et Biométrologie, rue du Morvan, CS 60027, 54519, Vandoeuvre les Nancy Cedex, France
    Environ Mol Mutagen 56:228-44. 2015
    ..It was concluded that under experimental conditions, SAS induced obvious toxic effects but did cause any genotoxicity following intratracheal instillation and intravenous injection...
  6. pmc In Vitro Study of Mutagenesis Induced by Crocidolite-Exposed Alveolar Macrophages NR8383 in Cocultured Big Blue Rat2 Embryonic Fibroblasts
    Yves Guichard
    Institut National de Recherche et de Securite, Rue du Morvan CS 60027, 54519 Vandoeuvre les Nancy Cedex, France
    J Toxicol 2010:323828. 2010
    ..The mutagenesis assay based on the coculture of NR8383 and Big Blue cannot be used as an alternative in vitro method to assess the mutagenic properties of asbestos fibres...
  7. doi request reprint Biopersistence and translocation to extrapulmonary organs of titanium dioxide nanoparticles after subacute inhalation exposure to aerosol in adult and elderly rats
    Laurent Gate
    Institut National de Recherche et de Securite, Département Toxicologie et Biométrologie, rue du Morvan, CS 60027, F 54519 Vandœuvre Cedex, France
    Toxicol Lett 265:61-69. 2016
    ..These data suggest that TiO2 NPs may translocate from the lung to extra-pulmonary organs where they could possibly promote systemic health effects...
  8. ncbi request reprint Genotoxic effects of bitumen fumes in Big Blue transgenic rat lung
    Marie Claire Bottin
    Institut National de Recherche et Sécurité Avenue de Bourgogne, BP 27 54501, Vandoeuvre, Cedex, France
    Mutat Res 596:91-105. 2006
    ..These results may provide information concerning the pulmonary mechanism of action of this aerosol and may contribute to the occupational health hazard assessment...