Djillali Annane

Summary

Country: France

Publications

  1. pmc Pro-con debate: steroid use in ACTH non-responsive septic shock patients with high baseline cortisol levels
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQ, Garches, France
    Crit Care 10:210. 2006
  2. doi request reprint Masseter tissue oxygen saturation predicts normal central venous oxygen saturation during early goal-directed therapy and predicts mortality in patients with severe sepsis
    Gwenhael Colin
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, Garches, France
    Crit Care Med 40:435-40. 2012
  3. doi request reprint Brainstem responses can predict death and delirium in sedated patients in intensive care unit
    Tarek Sharshar
    General Intensive Care Unit, University of Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care Med 39:1960-7. 2011
  4. doi request reprint Plasma cortisol levels in Guillain-Barré syndrome
    Julian Strauss
    Medical Intensive Care Unit, Raymond Poincaré Teaching Hospital, Garches, France
    Crit Care Med 37:2436-40. 2009
  5. doi request reprint StO₂ guided early resuscitation in subjects with severe sepsis or septic shock: a pilot randomised trial
    Olivier Nardi
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, 104 boulevard Raymond Poincaré, 92380 Garches, France
    J Clin Monit Comput 27:215-21. 2013
  6. doi request reprint Guillain-Barré syndrome following primary cytomegalovirus infection: a prospective cohort study
    David Orlikowski
    Service de Reanimation, AP HP, Hopital Raymond Poincare, Garches, France
    Clin Infect Dis 52:837-44. 2011
  7. ncbi request reprint Brain lesions in septic shock: a magnetic resonance imaging study
    Tarek Sharshar
    Service de Reanimation Medicale, Hôpital Raymond Poincaré APHP, Faculté de Médecine Paris Ile de France Ouest UVSQ, 104, Boulevard Raymond Poincare, 92380, Garches, France
    Intensive Care Med 33:798-806. 2007
  8. ncbi request reprint Adrenal insufficiency in sepsis
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Curr Pharm Des 14:1882-6. 2008
  9. ncbi request reprint Clinical and electrophysiological predictors of respiratory failure in Guillain-Barré syndrome: a prospective study
    Marie Christine Durand
    Functional Testing Department, Raymond Poincaré Teaching Hospital, Garches, France
    Lancet Neurol 5:1021-8. 2006
  10. doi request reprint Hydrocortisone effects on cardiovascular variability in septic shock: a spectral analysis approach
    Jerome Aboab
    Réanimation Polyvalente, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin, Garches, France
    Crit Care Med 36:1481-6. 2008

Detail Information

Publications117 found, 100 shown here

  1. pmc Pro-con debate: steroid use in ACTH non-responsive septic shock patients with high baseline cortisol levels
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQ, Garches, France
    Crit Care 10:210. 2006
    ..In this article, two expert groups debate the role of steroid use in a septic shock patient with arguably no clear evidence of adrenal insufficiency...
  2. doi request reprint Masseter tissue oxygen saturation predicts normal central venous oxygen saturation during early goal-directed therapy and predicts mortality in patients with severe sepsis
    Gwenhael Colin
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, Garches, France
    Crit Care Med 40:435-40. 2012
    ..This study aimed to investigate, in patients with severe sepsis, the correlation between central venous oxygen saturation and tissue oxygen saturation at different levels...
  3. doi request reprint Brainstem responses can predict death and delirium in sedated patients in intensive care unit
    Tarek Sharshar
    General Intensive Care Unit, University of Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care Med 39:1960-7. 2011
    ..The objective of this study was to assess whether abnormal brainstem responses within the first 24 hrs of sedation are associated with mortality and altered mental status postsedation...
  4. doi request reprint Plasma cortisol levels in Guillain-Barré syndrome
    Julian Strauss
    Medical Intensive Care Unit, Raymond Poincaré Teaching Hospital, Garches, France
    Crit Care Med 37:2436-40. 2009
    ..One third of patients with Guillain-Barré syndrome develop respiratory failure, which is predicted by few early indicators. Adrenal function has rarely been studied in Guillain-Barré syndrome...
  5. doi request reprint StO₂ guided early resuscitation in subjects with severe sepsis or septic shock: a pilot randomised trial
    Olivier Nardi
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, 104 boulevard Raymond Poincaré, 92380 Garches, France
    J Clin Monit Comput 27:215-21. 2013
    ..This pilot study was the first randomised controlled trial using an algorithm derived from the SSC recommendations, which included StO₂ as a treatment goal. However, the protocol showed no clear trend for or against targeting StO₂...
  6. doi request reprint Guillain-Barré syndrome following primary cytomegalovirus infection: a prospective cohort study
    David Orlikowski
    Service de Reanimation, AP HP, Hopital Raymond Poincare, Garches, France
    Clin Infect Dis 52:837-44. 2011
    ..Little is known about the epidemiology and the prognostic factors of Guillain-Barré syndrome (GBS) following primary infection with cytomegalovirus (CMV-GBS)...
  7. ncbi request reprint Brain lesions in septic shock: a magnetic resonance imaging study
    Tarek Sharshar
    Service de Reanimation Medicale, Hôpital Raymond Poincaré APHP, Faculté de Médecine Paris Ile de France Ouest UVSQ, 104, Boulevard Raymond Poincare, 92380, Garches, France
    Intensive Care Med 33:798-806. 2007
    ..Understanding of sepsis-induced brain dysfunction remains poor, and relies mainly on data from animals or post-mortem studies in patients. The current study provided findings from magnetic resonance imaging of the brain in septic shock...
  8. ncbi request reprint Adrenal insufficiency in sepsis
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Curr Pharm Des 14:1882-6. 2008
    ....
  9. ncbi request reprint Clinical and electrophysiological predictors of respiratory failure in Guillain-Barré syndrome: a prospective study
    Marie Christine Durand
    Functional Testing Department, Raymond Poincaré Teaching Hospital, Garches, France
    Lancet Neurol 5:1021-8. 2006
    ..We sought to identify clinical and electrophysiological predictors of respiratory failure in the disease...
  10. doi request reprint Hydrocortisone effects on cardiovascular variability in septic shock: a spectral analysis approach
    Jerome Aboab
    Réanimation Polyvalente, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin, Garches, France
    Crit Care Med 36:1481-6. 2008
    ..Septic shock may be associated with a loss in cardiovascular variability and adrenal dysfunction...
  11. doi request reprint Cardiac implantable electronic devices in tracheotomized muscular dystrophy patients: Safety and risks
    Abdallah Fayssoil
    Intensive Care Unit, GNHM Neuromuscular Center, Raymond Poincare Hospital, Garches, France Clinical Investigation Center CIC 14 29, INSERM, Garches, France Electronic address
    Int J Cardiol 222:975-7. 2016
    ..We aimed to assess the risks related to cardiac implantable electronic devices (CIED) in muscular dystrophy patients ventilated by tracheostomy...
  12. pmc Prognostic Value of Initial Assessment of Residual Hypoventilation Using Nocturnal Capnography in Mechanically Ventilated Neuromuscular Patients: A 5-Year Follow-up Study
    Adam Ogna
    Service de Réanimation médicale et unité de ventilation à domicile, AP HP, Hopital Raymond Poincare, Garches, France
    Front Med (Lausanne) 3:40. 2016
    ..We aimed to compare the prognostic value of nocturnal SpO2 and TcCO2 in ventilated adult NMD patients...
  13. doi request reprint Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock: the CRISTAL randomized trial
    Djillali Annane
    Raymond Poincare Hospital, Garches, France
    JAMA 310:1809-17. 2013
    ..Evidence supporting the choice of intravenous colloid vs crystalloid solutions for management of hypovolemic shock remains unclear...
  14. doi request reprint Recombinant human acid alpha-glucosidase (rhGAA) in adult patients with severe respiratory failure due to Pompe disease
    David Orlikowski
    Medical Intensive Care Unit, Raymond Poincaré Teaching Hospital, Garches, France
    Neuromuscul Disord 21:477-82. 2011
    ..The treatment was well tolerated. Alglucosidase alfa may stabilize or even slightly improve muscle strength and respiratory function among patients with severe Pompe disease...
  15. pmc Hyperglycaemia and apoptosis of microglial cells in human septic shock
    Andrea Polito
    General Intensive Care Medicine, Raymond Poincare Hospital, University of Versailles Saint Quentin en Yvelines, 104 Boulevard R Poincaré, Garches, France
    Crit Care 15:R131. 2011
    ..The effect of hyperglycaemia on the brain cells of septic shock patients is unknown. The objective of this study was to evaluate the relationship between hyperglycaemia and apoptosis in the brains of septic shock patients...
  16. ncbi request reprint Prognosis and risk factors of early onset pneumonia in ventilated patients with Guillain-Barré syndrome
    David Orlikowski
    Medical Intensive Care Unit, Raymond Poincaré Teaching Hospital, 104 boulevard Raymond Poincaré, Garches, France
    Intensive Care Med 32:1962-9. 2006
    ..Our objective was to determine the incidence, characteristics, outcomes, and risk factors of pneumonia in GBS patients receiving mechanical ventilation...
  17. doi request reprint Adrenal insufficiency in septic shock
    Virginie Maxime
    Assistance Publique Hopitaux de Paris, Université de Versailles SQY UniverSud Paris, Hopital Raymond Poincare, Service de Reanimation, Garches, France
    Clin Chest Med 30:17-27, vii. 2009
    ..This article focuses on actual knowledge, mechanisms, definitions, and therapeutic recommendations, as well as on areas of uncertainty relative to adrenal gland insufficiency in septic shock...
  18. ncbi request reprint Effect of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care Med 34:22-30. 2006
    ..We investigated the efficacy of low doses of corticosteroids in septic shock patients with or without early acute respiratory distress syndrome (ARDS) by post hoc analysis of a previously completed clinical trial...
  19. ncbi request reprint The neuropathology of septic shock
    Tarek Sharshar
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Garches, France
    Brain Pathol 14:21-33. 2004
    ..02). We conclude that septic shock is associated with diffuse cerebral damage and specific autonomic neuronal apoptosis which may be due to circulating factors particularly iNOS...
  20. doi request reprint Neurophysiological assessment of brain dysfunction in critically ill patients: an update
    Eric Azabou
    Department of Physiology and Department of Critical Care Medicine, Assistance Publique Hopitaux de Paris AP HP, Raymond Poincare Hospital, INSERM U1173, University of Versailles Saint Quentin en Yvelines UVSQ, 104 boulevard Raymond Poincaré, Garches, 92380, Paris, France
    Neurol Sci . 2017
    ....
  21. doi request reprint Comparison of ventilator-integrated end-tidal CO2 and transcutaneous CO2 monitoring in home-ventilated neuromuscular patients
    David Orlikowski
    AP HP, Hopital Raymond Poincare, Service de Réanimation médicale et unité de ventilation à domicile, 92380, Garches, France AP HP, Hopital Raymond Poincare, INSERM CIC 14 29, 92380, Garches, France
    Respir Med 117:7-13. 2016
    ..Recently, end-tidal CO2 (ETCO2) sensors have been integrated in life-support home ventilators. The purpose of this study was to compare the ventilator-integrated ETCO2 with TcCO2, in home-ventilated neuromuscular disease patients...
  22. doi request reprint Nocturnal hypoventilation in neuromuscular disease: prevalence according to different definitions issued from the literature
    Adam Ogna
    Service de Réanimation médicale et unité de ventilation à domicile, AP HP, Hopital Raymond Poincare, 92380, Garches, France
    Sleep Breath 20:575-81. 2016
    ..We aimed to compare the prevalence of hypoventilation in an unselected adult NMD population according to different definitions issued from the literature...
  23. ncbi request reprint Apoptosis of neurons in cardiovascular autonomic centres triggered by inducible nitric oxide synthase after death from septic shock
    Tarek Sharshar
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculté de Médecine Paris, Ile de France Ouest, Garches, France
    Lancet 362:1799-805. 2003
    ..Thus, we aimed to investigate the existence of ischaemia and apoptosis within the cerebral autonomic centres that control the cardiovascular system in patients with septic shock...
  24. doi request reprint Recombinant human activated protein C for adults with septic shock: a randomized controlled trial
    Djillali Annane
    Department of Intensive Care, Raymond Poincare University Hospital, Versailles Saint Quentin University, Garches, France
    Am J Respir Crit Care Med 187:1091-7. 2013
    ..A decade after drotrecogin alfa (activated) (DAA) was released on the market worldwide, its benefit-to-risk ratio remains a matter of debate...
  25. ncbi request reprint Decompression sickness in urban divers in France
    Jacques Bessereau
    General Intensive Care Unit, Hyperbaric Medicine Department, Raymond Poincare Hospital, University of Versailles SQY, Garches, France
    Int Marit Health 63:170-3. 2012
    ..Thus, this study investigated the epidemiology and outcomes of such urban divers...
  26. pmc Science review: mechanisms of impaired adrenal function in sepsis and molecular actions of glucocorticoids
    Helene Prigent
    Service de Reanimation Medicale, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care 8:243-52. 2004
    ..Nongenomic effects are probably subsequent to cytosolic interaction between the glucocorticoid receptor and proteins, or to interaction between glucocorticoids and specific membrane binding sites...
  27. ncbi request reprint Diagnosis of adrenal insufficiency in severe sepsis and septic shock
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Faculté de Médecine Paris Ile de France Ouest UVSQ, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Am J Respir Crit Care Med 174:1319-26. 2006
    ..Diagnosis of adrenal insufficiency in critically ill patients has relied on random or cosyntropin-stimulated cortisol levels, and has not been corroborated by a more accurate diagnostic standard...
  28. pmc Changes in CRH and ACTH synthesis during experimental and human septic shock
    Andrea Polito
    Department of Intensive Care, Raymond Poincare Hospital, Garches, France
    PLoS ONE 6:e25905. 2011
    ....
  29. ncbi request reprint Adrenal function in sepsis: the retrospective Corticus cohort study
    Diane Lipiner-Friedman
    Service de Reanimation, Hôpital Raymond Poincaré APHP, Faculté de Médecine Paris Ile de France Ouest UVSQ, Garches, France
    Crit Care Med 35:1012-8. 2007
    ..To refine the value of baseline and adrenocorticotropin hormone (ACTH)-stimulated cortisol levels in relation to mortality from severe sepsis or septic shock...
  30. ncbi request reprint Endocrine effects of vasopressin in critically ill patients
    Tarek Sharshar
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Best Pract Res Clin Anaesthesiol 22:265-73. 2008
    ..The absence of endocrine effects of vasopressin during critical illness is unclear and may relate to an already maximal hormonal stimulation or to down-regulation of vasopressin receptors...
  31. doi request reprint Corticosteroids and human recombinant activated protein C for septic shock
    Gwenhael Colin
    Assistance Publique Hopitaux de Paris, General Intensive Care Unit, hôpital Raymond Poincaré AP HP, Université de Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Clin Chest Med 29:705-12, x. 2008
    ..The optimal timing for initiating these treatments is from 6 to 24 hours from onset of shock. When patients are receiving these drugs, physicians should systematically screen for superinfection and serious bleeding events...
  32. pmc Science review: The brain in sepsis--culprit and victim
    Tarek Sharshar
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care 9:37-44. 2005
    ..In parallel, damage within autonomic nervous and neuroendocrine systems may contribute to sepsis induced organ dysfunction...
  33. ncbi request reprint Glucocorticoids in the treatment of severe sepsis and septic shock
    Djillali Annane
    Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, Faculté de médecine Paris Ouest, Université Versailles Saint Quentin, 92380 Garches, France
    Curr Opin Crit Care 11:449-53. 2005
    ..This review provides opinion-based guidelines for the use of corticosteroids in severe sepsis and septic shock...
  34. pmc Design and conduct of the activated protein C and corticosteroids for human septic shock (APROCCHSS) trial
    Djillali Annane
    General ICU, Service de Reanimation, Hopital Raymond Poincare, Laboratory of Infection and Inflammation, U1173, AP HP, University of Versailles SQY and INSERM, 104 boulevard Raymond Poincaré, 92380, Garches, France
    Ann Intensive Care 6:43. 2016
    ..We aimed at assessing the benefit-to-risk ratio of activated protein C (drotrecogin-alfa activated, DAA) and corticosteroids, given alone or in combination, in patients with septic shock...
  35. pmc Natural History of Cardiac and Respiratory Involvement, Prognosis and Predictive Factors for Long-Term Survival in Adult Patients with Limb Girdle Muscular Dystrophies Type 2C and 2D
    Abdallah Fayssoil
    Service de Réanimation médicale et unité de ventilation à domicile, centre de référence neuromusculaire GNHM, CHU Raymond Poincaré, APHP, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    PLoS ONE 11:e0153095. 2016
    ..We aimed to describe the long-term cardiac and respiratory follow-up of these patients and to determine predictive factors of cardio-respiratory events and mortality in LGMD 2C and 2D...
  36. doi request reprint Cardiac asynchrony in Duchenne muscular dystrophy
    Abdallah Fayssoil
    Réanimation Médicale, hôpital Raymond Poincaré AP HP, Universite de Versailles SQY, 104 boulevard Raymond Poincaré, 92380, Garches, France
    J Clin Monit Comput 27:587-9. 2013
    ..Intra-ventricular asynchrony was present in 6 % of patients with EF < 35 %. We found a high prevalence of LV dysfunction in DMD. Systolic ventricular asynchrony seems frequent particularly in patients with EF < 35 %. ..
  37. doi request reprint Whole-body muscle MRI in 20 patients suffering from late onset Pompe disease: Involvement patterns
    Robert Yves Carlier
    Service de Radiologie, Hopital Raymond Poincare, 104 boulevard Raymond Poincaré, Garches, France
    Neuromuscul Disord 21:791-9. 2011
    ..Whole-body MRI provides a very evocative description of muscle involvement in Pompe disease in adults...
  38. doi request reprint Hyperbaric oxygen therapy for acute domestic carbon monoxide poisoning: two randomized controlled trials
    Djillali Annane
    Medical Intensive Care Unit and Hyperbaric Center, Raymond Poincaré Teaching Hospital, University of Versailles SQY, Garches, 92380, France
    Intensive Care Med 37:486-92. 2011
    ..Although hyperbaric oxygen therapy (HBO) is broadly used for carbon monoxide (CO) poisoning, its efficacy and practical modalities remain controversial...
  39. doi request reprint Masseter muscle oxygen saturation is associated with central venous oxygen saturation in patients with severe sepsis
    Olivier Nardi
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, University of Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380, Garches, France
    J Clin Monit Comput 24:289-93. 2010
    ....
  40. ncbi request reprint Circulating vasopressin levels in septic shock
    Tarek Sharshar
    Servue de Réanimation Médicale, Hopital Raymond Poincare, Faculté de médecine Paris Ile de France Ouest Université Versailles Saint Quentiun en Yvelinnes, Garches, France
    Crit Care Med 31:1752-8. 2003
    ..To assess the frequency of vasopressin deficiency in septic shock...
  41. ncbi request reprint Metabolism modulators in sepsis: the abnormal pituitary response
    Virginie Maxime
    Service de Reanimation, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Crit Care Med 35:S596-601. 2007
    ..Summarize the current knowledge on the role of the hypothalamic pituitary axis in the development of sepsis...
  42. ncbi request reprint Norepinephrine plus dobutamine versus epinephrine alone for management of septic shock: a randomised trial
    Djillali Annane
    Raymond Poincaré Hospital AP HP, University of Versailles Saint Quentin, PRES UniverSud, Paris, France
    Lancet 370:676-84. 2007
    ..However, no large comparative trial has yet been done. We aimed to compare the efficacy and safety of norepinephrine plus dobutamine (whenever needed) with those of epinephrine alone in septic shock...
  43. pmc Detection of Campylobacter jejuni by culture and real-time PCR in a French cohort of patients with Guillain-Barre syndrome
    Valérie Sivadon-Tardy
    Laboratoire de Microbiologie, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, Boulogne Billancourt, France
    J Clin Microbiol 48:2278-81. 2010
    ..We provide evidence that diverse serotypes and genotypes of C. jejuni are a major trigger of GBS in France...
  44. doi request reprint Automatic air-leak compensation in neuromuscular patients: a feasibility study
    David Orlikowski
    Intensive Care Unit And Home Ventilation Unit, Raymond Poincaré Teaching Hospital Versailles University SQY, APHP, 104 Boulevard R Poincaré, 92380 Garches, France
    Respir Med 103:173-9. 2009
    ..The automatic air-leak compensation system tested here should be evaluated in long-term efficacy and tolerance studies and compared to other ventilation modes capable of compensating for leaks, such as pressure support...
  45. pmc Corticosteroids for sepsis: registry versus Cochrane systematic review!
    Djillali Annane
    General Intensive Care Unit, Raymond Poincare Hospital, University of Versailles SQY, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Crit Care 14:185. 2010
    ..In this commentary, these findings are contrasted with those of a recent Cochrane systematic review...
  46. doi request reprint Health-related quality of life in family members of intensive care unit patients
    Virginie Lemiale
    FAMIREA Group Study, Saint Louis Teaching Hospital, Medical Intensive Care Unit and Biostatistics Department, Paris 7 University, Assistance Publique Hopitaux de Paris, France
    J Palliat Med 13:1131-7. 2010
    ..The objective of this study was to evaluate health-related quality of life (HRQOL) in relatives of patients 90 days after ICU discharge or death...
  47. doi request reprint Incidence and prognosis of sustained arrhythmias in critically ill patients
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Am J Respir Crit Care Med 178:20-5. 2008
    ..Sustained arrhythmias are common in postoperative and cardiac intensive care units (ICUs), but their incidence and prognosis in general ICUs have never been reported...
  48. pmc A balanced view of balanced solutions
    Bertrand Guidet
    INSERM, Unité de Recherche en Épidémiologie Systèmes d Information et Modélisation U707, Paris F 75012, France
    Crit Care 14:325. 2010
    ....
  49. doi request reprint Adjunct therapy for sepsis: how early?
    Djillali Annane
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, University of Versailles SQY, 104 boulevard Raymond Poincaré, 92380, Garches, France
    Curr Infect Dis Rep 12:361-7. 2010
    ..These treatments should optimally be started within 24 hours of the onset of shock. They should be initiated in those patients who did not adequately respond after 6 hours of optimal anti-infective and symptomatic treatments...
  50. pmc Sepsis-associated delirium: the pro and con of C5a blockade
    Djillali Annane
    General Intensive Care Unit, Raymond Poincaré Hospital AP HP, University of Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Crit Care 13:135. 2009
    ..Thus, blockade of C5a may be detrimental, resulting in an attenuated response of the stress system...
  51. pmc Pharmacokinetics of oral fludrocortisone in septic shock
    Andrea Polito
    Department of Intensive Care, Raymond Poincaré Hospital AP HP, Garches, France
    Br J Clin Pharmacol 82:1509-1516. 2016
    ..However, the specific role of fludrocortisone remains controversial and its pharmacokinetics (PK) has never been investigated in septic shock. This study aimed at characterizing the PK of fludrocortisone in septic shock...
  52. doi request reprint Corticosteroids for treating sepsis
    Djillali Annane
    Critical Care Department, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, 104 boulevard Raymond Poincaré, Garches, Ile de France, France, 92380
    Cochrane Database Syst Rev . 2015
    ..Sepsis may be complicated by impaired corticosteroid metabolism. Giving corticosteroids may benefit patients. The original review was published in 2004 and was updated in 2010 and again in 2015...
  53. doi request reprint Neuropathological Correlates of Hyperglycemia During Prolonged Polymicrobial Sepsis in Mice
    Romain Sonneville
    Division of Cellular and Molecular Medicine, Clinical Department and Laboratory of Intensive Care Medicine, KU Leuven, Leuven, Belgium and EA4342 et Réanimation Médicale, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris AP HP, Garches, Faculte de Medecine Paris Ile de France Ouest, Université Versailles Saint Quentin, Versailles and Histopathologie Humaine et Modèles Animaux, Département Infection and Epidémiologie, and Unité de Génétique Moléculaire des Levures, CNRS UMR3525 Team Stability of Nuclear and Mitochondrial DNA, Institut Pasteur, Paris, France
    Shock 44:245-51. 2015
    ..These changes were partially prevented or attenuated when hyperglycemia was prevented with insulin. Frontal cortex appeared more vulnerable to hyperglycemic insults than hippocampus. ..
  54. doi request reprint Left ventricular function in alpha-sarcoglycanopathy and gamma-sarcoglycanopathy
    Abdallah Fayssoil
    Réanimation Médicale, hôpital Raymond Poincaré AP HP, Universite de Versailles SQY, 104 boulevard Raymond Poincaré, 92380, Garches, France
    Acta Neurol Belg 114:257-9. 2014
    ..6 ± 18 vs. 59.6 ± 5.9 % p 0.018). We found a significant alteration of the left ventricular function in gamma-sarcoglycanopathy compared to alpha-sarcoglycanopathy. ..
  55. doi request reprint Right ventricular function in late-onset Pompe disease
    Abdallah Fayssoil
    Réanimation Médicale, hôpital Raymond Poincaré AP HP, Universite de Versailles SQY, 104 boulevard Raymond Poincaré, 92380, Garches, France
    J Clin Monit Comput 28:419-21. 2014
    ..6 ± 5.6 vs 18.2 ± 4.9 cm/s p = 0.34). According to our data, RV systolic function seems preserved in late-onset Pompe disease. ..
  56. pmc Guillain-Barré syndrome, greater Paris area
    Valérie Sivadon-Tardy
    Laboratoire de Microbiologie, Hopital Raymond Poincare, Garches, France
    Emerg Infect Dis 12:990-3. 2006
    ..The cases with no known agent (60%) peaked in winter, and half were preceded by respiratory infection, influenza-like syndrome, or gastrointestinal illness...
  57. ncbi request reprint Corticosteroids for sepsis: controversial forever?
    Djillali Annane
    Service de Reanimation, hôpital Raymonc Poincaré AP HP, Universite de Versailles Saint Quentin, 92380 Garches, France
    J Crit Care 22:329-30. 2007
  58. doi request reprint Human and experimental septic shock are characterized by depletion of lipid droplets in the adrenals
    Andrea Polito
    General Intensive Care Unit and Laboratoire d étude de la réponse neuroendocrine au sepsis EA4342, Service de Reanimation, Raymond Poincaré Hospital AP HP, University Versailles Saint Quentin en Yvelines, 92380, Garches, France
    Intensive Care Med 36:1852-8. 2010
    ..Cholesteryl ester deficiency which results in adrenal lipid store depletion has been proposed as a potential mechanism of sepsis associated adrenal insufficiency...
  59. doi request reprint Efficacy and safety of oral conivaptan, a vasopressin-receptor antagonist, evaluated in a randomized, controlled trial in patients with euvolemic or hypervolemic hyponatremia
    Djillali Annane
    Department of General Critical Care Medicine Division of Acute Medicine and Surgery, University of Versailles SQY Raymond Poincaré Hospital, Garches, France
    Am J Med Sci 337:28-36. 2009
    ..This placebo-controlled, randomized, double-blind multicenter study evaluated the efficacy and safety of oral conivaptan, a V1A/V2-receptor antagonist, in patients with euvolemic or hypervolemic hyponatremia...
  60. doi request reprint Improving clinical trials in the critically ill: unique challenge--sepsis
    Djillali Annane
    Service de Reanimation, hôpital Raymond Poincaré AP HP, Universite de Versailles SQY, Paris, France
    Crit Care Med 37:S117-28. 2009
    ..This article aimed at providing suggestions to improve the success rate of future sepsis trials...
  61. ncbi request reprint The effect of waiving consent on enrollment in a sepsis trial
    Djillali Annane
    Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, Universite de Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Intensive Care Med 30:321-4. 2004
    ....
  62. doi request reprint A lethal case of meningitis due to Lactobacillus rhamnosus as a late complication of anterior cervical spine surgery
    Matthieu Schmidt
    Service de Reanimation, Assistance Publique, Hopitaux de Paris, Raymond Poincare Hospital, Garches, France
    J Infect 62:309-10. 2011
    ..This case illustrated the difficulty of early diagnosis of such infrequent complication and suggested that dysphagia following anterior cervical spine surgery should prompt cervical imaging...
  63. doi request reprint Effects of esmolol on systemic and pulmonary hemodynamics and on oxygenation in pigs with hypodynamic endotoxin shock
    Jerome Aboab
    Service de Reanimation, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin, 104, bd Raymond Poincaré, 92380 Garches, France
    Intensive Care Med 37:1344-51. 2011
    ..The aim of this experimental study is to investigate cardiovascular tolerance of blockade of beta-adrenergic receptors in an endotoxin model...
  64. doi request reprint Long-term outcome of iatrogenic gas embolism
    Jacques Bessereau
    General Intensive Care Unit, Hyperbaric Centre, Raymond Poincaré Hospital AP HP, University of Versailles SQY UniverSud Paris, 104 boulevard Raymond Poincaré, 92380, Garches, France
    Intensive Care Med 36:1180-7. 2010
    ..To establish the incidence and long-term prognosis of iatrogenic gas embolism...
  65. ncbi request reprint Sepsis-associated delirium
    Marion Ebersoldt
    Universite de Versailles Saint Quentin, Service de Reanimation Medicale, hôpital Raymond Poincaré AP HP, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Intensive Care Med 33:941-50. 2007
    ..This review provides an update of the diagnostic criteria and treatment strategies and the current knowledge about the mechanisms involved in sepsis associated brain dysfunction...
  66. doi request reprint Prospective Cohort Study Evaluating the Prognostic Value of Simple EEG Parameters in Postanoxic Coma
    Eric Azabou
    Department of Physiology and Functional Explorations and Department of Critical Care Medicine, Assistance Publique Hopitaux de Paris AP HP, Raymond Poincare Hospital, INSERM U1173, University of Versailles St Quentin UVSQ, Garches, France Department of Clinical Neurophysiology, Hospices Civils de Lyon, Neurological Hospital of Lyon, Lyon Neuroscience Research Center CRNL, Brain Dynamics and Cognition Team Dycog, INSERM U1028, CNRS UMR5292, Universite Lyon 1, Lyon, France
    Clin EEG Neurosci 47:75-82. 2016
    ..In this study (a) discontinuous, isoelectric, or delta-dominant EEG were constantly associated with unfavorable outcome and (b) nonreactive EEG performed prognostic as accurate as a Synek score>3...
  67. doi request reprint Nocturnal mechanical ventilation for chronic hypoventilation in patients with neuromuscular and chest wall disorders
    Djillali Annane
    Critical Care Department, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, 104 boulevard Raymond Poincaré, Garches, Ile de France, 92380, France
    Cochrane Database Syst Rev . 2014
    ..Long-term nocturnal mechanical ventilation is commonly used to treat it. This is a 2014 update of a review first published in 2000 and previously updated in 2007...
  68. pmc Year in review 2010: Critical Care--Multiple organ dysfunction and sepsis
    Etienne de Montmollin
    Service de Reanimation Polyvalente, hôpital Raymond Poincaré AP HP, Universite de Versailles Saint Quentin, 104, Bd, Raymond Poincaré, 92380 Garches, France
    Crit Care 15:236. 2011
    ..The results of these experimental studies and clinical trials are discussed in the context of the current relevant scientific and clinical background...
  69. doi request reprint Plasma exchange for Guillain-Barré syndrome
    Jean Claude Raphael
    Hopital Raymond Poincare, Garches, France
    Cochrane Database Syst Rev 7:CD001798. 2012
    ..Guillain-Barré syndrome is an acute paralysing disease caused by peripheral nerve inflammation. This is an update of a review first published in 2001 and last updated in 2008...
  70. doi request reprint Percutaneous extracorporeal membrane oxygenation for cardiogenic shock due to acute fulminant myocarditis
    Abdallah Fayssoil
    Critical Care Medicine, Raymond Poincare Hospital, Garches, France
    Ann Thorac Surg 89:614-6. 2010
    ..We report a favorable outcome of an acute fulminant myocarditis in a 25-year-old myasthenia patient with cardiogenic shock supported by percutaneous extracorporeal membrane oxygenation...
  71. doi request reprint [Human toxicokinetic of hexobarbital after acute multi-drug intoxication]
    Emmanuelle Guillot
    Laboratoire de Pharmacologie Toxicologie, Centre Hospitalier Universitaire Raymond Poincare, AP HP, Garches, France
    Therapie 64:325-30. 2009
    ..Half-life value of 61,8 h was found, being much longer than already published hexobarbital half-lives (between 3.2 h and 6.9 h). The reasons of this long half-life were discussed according to metabolism and pharmacogenetic...
  72. ncbi request reprint [Anesthetic management of patients with muscular disease?]
    Najla Akrout
    Service de Reanimation, Centre de Référence des maladies Neuromusculaires, CIC IT 805 Inserm, hôpital Raymond Poincard, AP HP, Université de Versailles SOY PRES UniverSud, 92380 Garches Cedex, France
    Rev Prat 58:2265-71. 2008
    ..A growing number of muscular disorders have been subjected to specific guidelines for anesthetic procedures...
  73. ncbi request reprint Septic shock
    Djillali Annane
    Service de Reanimation, Hopital Raymond Poincare, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Ile de France Ouest, Universite de Versailles Saint Quentin en Yvelines, Garches, France
    Lancet 365:63-78. 2005
    ..Other therapeutic strategies are under investigation, including those that target late proinflammatory mediators, endothelium, or the neuroendocrine system...
  74. pmc Clinical review: corticotherapy in sepsis
    Helene Prigent
    Service de Reanimation Medicale, Hopital Raymond Poincare, Garches, France
    Crit Care 8:122-9. 2004
    ..Finally, we propose a decision tree for diagnosis of adrenal insufficiency and institution of cortisol replacement therapy...
  75. doi request reprint [Outcome for adults with acute respiratory distress syndrome]
    Gwenhael Colin
    Service de Reanimation, Hopital Raymond Poincare, Assistance Publique des Hopitaux de Paris, Universite de Versailles SQY, PRES Universud Paris, F 92380 Garches, France
    Presse Med 37:1803-8. 2008
    ..Patients with ARDS are only a subgroup of more severe illness among all patients in critical care departments...
  76. ncbi request reprint Multifocal necrotizing leukoencephalopathy in septic shock
    Tarek Sharshar
    Service de Réanimation Médiale, Hôpital Raymond Poincaré Faculté de Médecine Paris Ouest Université Paris, Garches, France
    Crit Care Med 30:2371-5. 2002
    ..The role of circulating cytokines has been suggested but remains to be assessed...
  77. pmc Cortisol replacement for severe sepsis and septic shock: what should I do?
    Djillali Annane
    Intensive Care Department, Raymond Poincare University Hospital, Garches, France
    Crit Care 6:190-1. 2002
    ..Similarly, in patients with severe sepsis who do not need vasopressors, the benefit/risk ratio of cortisol replacement remains to be assessed...
  78. ncbi request reprint Using corticosteroids in intensive care
    Paul E Marik
    Arch Surg 141:946-7; author reply 947. 2006
  79. ncbi request reprint Clinical equipoise remains for issues of adrenocorticotropic hormone administration, cortisol testing, and therapeutic use of hydrocortisone
    Djillali Annane
    Crit Care Med 31:2250-1; author reply 2252-3. 2003
  80. ncbi request reprint Corticosteroids in sepsis: from bench to bedside?
    Djillali Annane
    Raymond Poincare Hospital, School of Medicine Paris Ile de France Ouest, University of Versailles Saint Quentin en Yvelinnes, 92380 Garches, France
    Shock 20:197-207. 2003
    ..Through these anti-inflammatory and cardiovascular effects, low doses of glucorticoids may improve septic shock survival...
  81. ncbi request reprint Relative adrenal failure in the ICU: an identifiable problem requiring treatment
    Hélène Gonzalez
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Crit Care Clin 22:105-18, vii. 2006
    ..Diagnosis relies on clinical suspicion and ACTH test results. The length of cortisol replacement therapy should be at least 7 days and the adjunction of fludrocortisone is recommended...
  82. ncbi request reprint ICU physicians should abandon the use of etomidate!
    Djillali Annane
    Intensive Care Med 31:325-6. 2005
  83. ncbi request reprint Current epidemiology of septic shock: the CUB-Réa Network
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, Faculte de Medecine Paris Ile de France Ouest, Université de Versaille Saint Quentinen Yvelinnes, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Am J Respir Crit Care Med 168:165-72. 2003
    ..The frequency of septic shock is increasing with more multiresistant strains. Its crude mortality rate is decreasing, but patients with septic shock still have a high excess risk of death than critically ill patients who are nonseptic...
  84. ncbi request reprint Time for a consensus definition of corticosteroid insufficiency in critically ill patients
    Djillali Annane
    Crit Care Med 31:1868-9. 2003
  85. ncbi request reprint Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock
    Djillali Annane
    Service de Reanimation Medicale, Hopital Raymond Poincare, 104 Blvd Raymond Poincaré, 92380 Garches, France
    JAMA 288:862-71. 2002
    ..Septic shock may be associated with relative adrenal insufficiency. Thus, a replacement therapy of low doses of corticosteroids has been proposed to treat septic shock...
  86. ncbi request reprint Emerging drugs for the treatment of sepsis
    Jerome Aboab
    Intensive Care Unit, University of Versailles Saint Quentin, Hospital Raymond Poincare, 104 Bd Raymond Poincaré, 92380 Garches, France
    Expert Opin Emerg Drugs 11:7-22. 2006
    ..This review discusses the current management of septic shock and the potential development of new therapeutics following impressive advances in the pathomechanisms of septic shock...
  87. ncbi request reprint The use of corticosteroids in severe sepsis and acute respiratory distress syndrome
    Karim Chadda
    Medical Intensive Care Unit, Raymond Poincare University Hospital, School of Medicine Paris Ile de France Ouest, 104 boulevard Raymond Poincaré, FR 92380 Garches, France
    Ann Med 34:582-9. 2002
    ..Further studies are ongoing to better identify the target population. In the meantime, cortisol replacement (i.e. 200 to 300 mg daily of hydrocortisone or equivalent) should be considered as standard care for these patients...
  88. pmc Effects of high doses of selenium, as sodium selenite, in septic shock: a placebo-controlled, randomized, double-blind, phase II study
    Xavier Forceville
    Service de Reanimation Polyvalente, Centre Hospitalier de Meaux, Hôpital Saint Faron, 6 8 rue Saint Fiacre, 77104 Meaux, France
    Crit Care 11:R73. 2007
    ..We investigated the effects of a continuous administration of high doses of selenium in septic shock patients...
  89. ncbi request reprint Corticosteroid insufficiency in acutely ill patients
    Djillali Annane
    N Engl J Med 348:2157-9. 2003
  90. ncbi request reprint Corticoids normalize leukocyte production of macrophage migration inhibitory factor in septic shock
    Virginie Maxime
    Unit Cytokines and Inflammation, Institut Pasteur, 75015 Paris, France
    J Infect Dis 191:138-44. 2005
    ..Renewed interest in glucocorticoid treatment for septic shock offers an opportunity to analyze this regulatory loop in humans...
  91. ncbi request reprint Prohormones: novel biomarkers for corticosteroids in septic shock?
    Djillali Annane
    Intensive Care Med 34:395-6. 2008
  92. ncbi request reprint Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model: risk and corticosteroids in sepsis
    Yan Li
    Critical Care Medicine Department, Clinical Center, Building 10, Room 7D43, National Institutes of Health, Bethesda, MD 20892, USA
    Intensive Care Med 34:568-77. 2008
    ..We investigated whether risk of death altered the effects of hydrocortisone in a mouse pneumonia model...
  93. doi request reprint Hydrocortisone therapy for patients with septic shock
    Charles L Sprung
    Hadassah Hebrew University Medical Center, Jerusalem, Israel 91120
    N Engl J Med 358:111-24. 2008
    ....
  94. pmc Cost-effectiveness of activated protein C in real-life clinical practice
    Jean Francois Dhainaut
    Department of Intensive Care, Cochin Port Royal University Hospital, AP HP, Rene Descartes University, Paris 5, Paris, France
    Crit Care 11:R99. 2007
    ..We evaluated the cost-effectiveness of rhAPC in patients with severe sepsis and multiple organ failure in real-life intensive care practice...
  95. pmc Corticosteroids for severe sepsis and septic shock: a systematic review and meta-analysis
    Djillali Annane
    Critical Care Department, Universite de Versailles Saint Quentin en Yvelines, Assistance Publique Hopitaux de Paris, Hopital Raymond Poincare, Garches 92380, France
    BMJ 329:480. 2004
    ..To assess the effects of corticosteroids on mortality in patients with severe sepsis and septic shock...
  96. ncbi request reprint Glucocorticoids for ARDS: Just Do It!
    Djillali Annane
    Chest 131:945-6. 2007
  97. doi request reprint Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  98. ncbi request reprint The hypothalamic pituitary adrenal axis in sepsis
    Andrea Polito
    Hospital Raymond Poincaré AP HP, University of Versailles SQY, 104 boulevard Raymond Poincaré, Garches 92380
    Novartis Found Symp 280:182-99; discussion 199-203. 2007
    ..This finding prompted renewed interest in a replacement therapy with low doses of corticosteroids during longer periods. We will review the key role of the hypothalamic-pituitary-adrenal axis in the host response to stress...
  99. ncbi request reprint Managing toxic shock syndrome with antibiotics
    Djillali Annane
    Intensive Care Unit Raymond Poincaré University Hospital, AP HP, School of Medicine Paris Ile de France Ouest, University Versailles Saint Quentin en Yvelines, 104 boulevard Raymond Poincaré, 92380 Garches, France
    Expert Opin Pharmacother 5:1701-10. 2004
    ..This paper aims to provide an overview of the epidemiology, pathomechanisms, and clinical presentation of TSS, and criteria for selecting drugs among available antibiotics...
  100. ncbi request reprint Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature
    G Umberto Meduri
    University of Tennessee Health Science Center and Memphis VA Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Room H316, 956 Court Avenue, TN 38163, Memphis, USA
    Intensive Care Med 34:61-9. 2008
    ....
  101. ncbi request reprint Dissociation of serum dehydroepiandrosterone and dehydroepiandrosterone sulfate in septic shock
    Wiebke Arlt
    Medical Research Council Senior Clinical Fellow, Division of Medical Sciences, University of Birmingham, Institute of Biomedical Research, Room 233, Birmingham B15 2TT, United Kingdom
    J Clin Endocrinol Metab 91:2548-54. 2006
    ..However, experimental sepsis in rodents leads to down-regulation of DHEA sulfotransferase, which inactivates DHEA to DHEAS, theoretically resulting in higher DHEA levels...