Fabrizio Andreelli

Summary

Country: France

Publications

  1. ncbi request reprint [How to manage the metabolic syndrome?]
    F Andreelli
    Service d endocrinologie, Diabetologie, Maladies Métaboliques CHU Bichat Claude Bernard, Paris, France
    Ann Endocrinol (Paris) 66:2S36-45. 2005
  2. ncbi request reprint [Hypothalamic AMP-activated protein kinase, a regulator of body weight and food intake]
    Fabrizio Andreelli
    Service de Diabétologie Endocrinologie Nutrition, Hopital Bichat Claude Bernard, 16, rue Henri Huchard, 75877 Paris Cedex 18, France
    Med Sci (Paris) 21:131-2. 2005
  3. pmc Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    Marc Foretz
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 120:2355-69. 2010
  4. pmc AMPK: Lessons from transgenic and knockout animals
    Benoit Viollet
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Department Endocrinology, Metabolism and Cancer, Paris, France
    Front Biosci (Landmark Ed) 14:19-44. 2009
  5. doi request reprint Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice
    Stephanie Troy
    Institut National de la Sante et de la Recherche Medicale, U695, Faculte de Medecine Xavier Bichat, Universite Paris 7, Paris, F 75870, France
    Cell Metab 8:201-11. 2008
  6. pmc AMPK inhibition in health and disease
    Benoit Viollet
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Crit Rev Biochem Mol Biol 45:276-95. 2010
  7. pmc Cellular and molecular mechanisms of metformin: an overview
    Benoit Viollet
    INSERM, U1016, Institut Cochin, Paris, France Centre National de la Recherche Scientifique CNRS, UMR8104, Paris, France University Paris Descartes, Paris, France
    Clin Sci (Lond) 122:253-70. 2012
  8. ncbi request reprint Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
    Marc Foretz
    Institut Cochin, Département de génétique, Developpement et Pathologie Moleculaire, Universite Rene Descartes Paris 5, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique UMR8104, Paris, France
    Diabetes 54:1331-9. 2005
  9. doi request reprint Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit
    Marc Foretz
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique UMR8104, Paris, France INSERM, U1016, Paris, France
    FEBS Lett 584:3667-71. 2010
  10. doi request reprint [Role of intestinal flora in insulin resistance and obesity]
    Amal Yazigi
    Service de Diabétologie Endocrinologie Nutrition, CHU Bichat Claude Bernard, F 75877 Paris Cedex 18, France
    Presse Med 37:1427-30. 2008

Detail Information

Publications27

  1. ncbi request reprint [How to manage the metabolic syndrome?]
    F Andreelli
    Service d endocrinologie, Diabetologie, Maladies Métaboliques CHU Bichat Claude Bernard, Paris, France
    Ann Endocrinol (Paris) 66:2S36-45. 2005
    ..Steps to diagnose it and guidance for the therapeutic management of metabolic syndrome in primary care practice are described...
  2. ncbi request reprint [Hypothalamic AMP-activated protein kinase, a regulator of body weight and food intake]
    Fabrizio Andreelli
    Service de Diabétologie Endocrinologie Nutrition, Hopital Bichat Claude Bernard, 16, rue Henri Huchard, 75877 Paris Cedex 18, France
    Med Sci (Paris) 21:131-2. 2005
  3. pmc Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    Marc Foretz
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    J Clin Invest 120:2355-69. 2010
    ..In conclusion, we demonstrate that metformin inhibits hepatic gluconeogenesis in an LKB1- and AMPK-independent manner via a decrease in hepatic energy state...
  4. pmc AMPK: Lessons from transgenic and knockout animals
    Benoit Viollet
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Department Endocrinology, Metabolism and Cancer, Paris, France
    Front Biosci (Landmark Ed) 14:19-44. 2009
    ..Although there are inevitable caveats with genetic models, some important findings have emerged. In the present review, we discuss recent findings obtained from animal models with inhibition or activation of AMPK signaling pathway...
  5. doi request reprint Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice
    Stephanie Troy
    Institut National de la Sante et de la Recherche Medicale, U695, Faculte de Medecine Xavier Bichat, Universite Paris 7, Paris, F 75870, France
    Cell Metab 8:201-11. 2008
    ..We thus provide mechanistic evidence that the beneficial effects of the EGA procedure on food intake and glucose homeostasis involve intestinal gluconeogenesis and its detection via a GLUT-2 and hepatoportal sensor pathway...
  6. pmc AMPK inhibition in health and disease
    Benoit Viollet
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Paris, France
    Crit Rev Biochem Mol Biol 45:276-95. 2010
    ..In this review, we discuss recent findings that support the role and function of AMPK inhibition under physiological and pathological states...
  7. pmc Cellular and molecular mechanisms of metformin: an overview
    Benoit Viollet
    INSERM, U1016, Institut Cochin, Paris, France Centre National de la Recherche Scientifique CNRS, UMR8104, Paris, France University Paris Descartes, Paris, France
    Clin Sci (Lond) 122:253-70. 2012
    ....
  8. ncbi request reprint Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
    Marc Foretz
    Institut Cochin, Département de génétique, Developpement et Pathologie Moleculaire, Universite Rene Descartes Paris 5, Institut National de la Sante et de la Recherche Medicale U567, Centre National de la Recherche Scientifique UMR8104, Paris, France
    Diabetes 54:1331-9. 2005
    ..Thus, short-term AMPK activation in the liver reduces blood glucose levels and results in a switch from glucose to fatty acid utilization to supply energy needs...
  9. doi request reprint Maintenance of red blood cell integrity by AMP-activated protein kinase alpha1 catalytic subunit
    Marc Foretz
    Institut Cochin, Universite Paris Descartes, Centre National de la Recherche Scientifique UMR8104, Paris, France INSERM, U1016, Paris, France
    FEBS Lett 584:3667-71. 2010
    ..Further, AMPKalpha1-/- red blood cells (RBC) showed less deformability in response to shear stress limiting their membrane flexibility. Thus, our results highlight the crucial role of AMPK to preserve RBC integrity...
  10. doi request reprint [Role of intestinal flora in insulin resistance and obesity]
    Amal Yazigi
    Service de Diabétologie Endocrinologie Nutrition, CHU Bichat Claude Bernard, F 75877 Paris Cedex 18, France
    Presse Med 37:1427-30. 2008
    ..This inflammation plays a role in the genesis of insulin resistance and hepatic steatosis in rodents. Pharmacological or dietary manipulation of intestinal flora may be a new strategy for treatment of overweight and its complications...
  11. pmc Targeting the AMPK pathway for the treatment of Type 2 diabetes
    Benoit Viollet
    Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, Department Endocrinology, Metabolism and Cancer, Paris, France
    Front Biosci (Landmark Ed) 14:3380-400. 2009
    ..In the present review, we update these topics and discuss the concept of targeting the AMPK pathway for the treatment of type 2 diabetes...
  12. ncbi request reprint Subcutaneous adipose tissue expression of tumour necrosis factor-alpha is not associated with whole body insulin resistance in obese nondiabetic or in type-2 diabetic subjects
    H A Koistinen
    Helsinki University Central Hospital, Finland Hôpital de la Salpétrière, Paris, France
    Eur J Clin Invest 30:302-10. 2000
    ..In the second part of the study we examined the relationship between adipose tissue TNFalpha mRNA levels and BMI in 81 nondiabetic subjects spanning a wide range of BMIs...
  13. ncbi request reprint What kind of simple fasting index should be used to estimate insulin sensitivity in humans?
    J P Bastard
    Service de Biochimie et Hormonologie, Hopital Tenon AP HP, Paris, France
    Diabetes Metab 29:285-8. 2003
    ....
  14. ncbi request reprint Molecular aspects of insulin therapy in critically ill patients
    Fabrizio Andreelli
    Department of Diabetology Endocrinology Nutrition, Bichat Hospital, Paris, France
    Curr Opin Clin Nutr Metab Care 9:124-30. 2006
    ..This review provides an overview of molecular mechanisms involved in beneficial effects of insulin in insulin resistant critically ill patients...
  15. pmc The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity
    Benoit Viollet
    Department of Genetic, Development, and Molecular Pathology, Institut National de la Sante et de la Recherche Medicale INSERM, Centre National de la Recherche Scientifique CNRS, Rene Descartes University, Paris, France
    J Clin Invest 111:91-8. 2003
    ..Therefore, extramuscular AMPKalpha2 catalytic subunit is important for whole-body insulin action in vivo, probably through modulation of sympathetic nervous activity...
  16. pmc AMP-activated protein kinase and metabolic control
    Benoit Viollet
    INSERM, U1016, Institut Cochin, Paris, France
    Handb Exp Pharmacol . 2011
    ..g., adiponectin adiponectin ). Taken together, such findings highlight the logic underlying the concept of targeting the AMPK pathway for the treatment of metabolic syndrome and type 2 diabetes...
  17. ncbi request reprint Therapeutic perspectives for type 2 diabetes mellitus: molecular and clinical insights
    F Mauvais-Jarvis
    Service de Medecine B, Unité d Endocrinologie et Maladies Métaboliques, Hopital Lariboisiere, Paris, France
    Diabetes Metab 27:415-23. 2001
    ..Animal studies predict beneficial effects on B-cell mass. Finally we will discuss the potential use of gene therapy to treat insulin resistance and B-cell dysfunction...
  18. doi request reprint What can bariatric surgery teach us about the pathophysiology of type 2 diabetes?
    F Andreelli
    CHU Bichat Claude Bernard, AP HP, Service de Diabétologie Endocrinologie Nutrition, 75877 Paris Cedex 18, France
    Diabetes Metab 35:499-507. 2009
    ..The intestine is, thus, a key organ in the regulation of glycaemic equilibrium and may even be involved in the pathophysiology of type 2 diabetes...
  19. ncbi request reprint Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders
    B Viollet
    Departement Endocrinologie, Métabolisme et Cancer, Institut Cochin, Universite Paris Descartes, CNRS UMR 8104, and INSERM, U567, Paris, France
    Diabetes Metab 33:395-402. 2007
    ..Thus, the relationship between AMPK activation and beneficial metabolic effects provide the rationale for the development of new therapeutic strategies in metabolic disorders...
  20. ncbi request reprint [Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases]
    Marc Foretz
    INSERM U567, CNRS URM8104, Université Paris5, Institut Cochin, Departement Endocrinologie, Métabolisme et Cancer, 24, rue du Faubourg Saint Jacques, 75014 Paris, France
    Med Sci (Paris) 22:381-8. 2006
    ..Thus, pharmacological AMPK activation may, through signaling, metabolic and gene expression effects, reduce the risk of Type 2 diabetes, metabolic syndrome and cardiac diseases...
  21. pmc Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders
    Benoit Viollet
    Institut Cochin, INSERM U567, Department of Endocrinology, Metabolism and Cancer, 24 rue du Faubourg Saint Jacques, Paris 75014, France
    J Physiol 574:41-53. 2006
    ....
  22. ncbi request reprint [Obesity in adults. Physiopathology and treatment]
    Fabrizio Andreelli
    Serviço de diabetologia endocrinologia nutrição, CHU Bichat Claude Bernard, Paris, Franca
    Servir 52:298-304. 2004
  23. ncbi request reprint Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, Institute of Exercise and Sport Sciences, University of Copenhagen, Copenhagen, Denmark
    FASEB J 19:1146-8. 2005
    ....
  24. pmc AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside
    Bruno Guigas
    Université catholique de Louvain and Institute of Cellular Pathology, Hormone and Metabolic Research Unit, Brussels, Belgium
    Biochem J 404:499-507. 2007
    ..Our data also demonstrate that the cellular effects of AICA riboside are not necessarily caused by AMPK activation and that their interpretation should be taken with caution...
  25. ncbi request reprint Expression and regulation by insulin of low-density lipoprotein receptor-related protein mRNA in human skeletal muscle
    Philippe Boucher
    Department of Biochemistry, E Herriot Hospital, Lyons, France
    Biochim Biophys Acta 1588:226-31. 2002
    ..Taken together, these results did not support the hypothesis that a higher capacity for clearance or hydrolysis of circulating triglycerides in skeletal muscle is present during obesity- or type 2 diabetes-associated insulin resistance...
  26. ncbi request reprint Liver adenosine monophosphate-activated kinase-alpha2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin
    Fabrizio Andreelli
    Institut National de la Santé et de la Recherche Médicale Unité 567, Centre National de la Recherche Scientifique Unite Mixte de Recherche 8104, Universite Rene Descartes Paris 5, France
    Endocrinology 147:2432-41. 2006
    ..We also demonstrate that regulation of hepatic glucose production by leptin and adiponectin, but not insulin, requires hepatic AMPKalpha2 activity...
  27. ncbi request reprint Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle
    Sebastian B Jørgensen
    Copenhagen Muscle Research Centre, Department of Human Physiology, 13 Universitetsparken, University of Copenhagen, DK 2100 Copenhagen, Denmark
    J Biol Chem 279:1070-9. 2004
    ..Alternatively, neither alpha-isoform of AMPK is involved in contraction-induced muscle glucose uptake...