- Clustering and switching processes in semantic verbal fluency in the course of Alzheimer's disease subjects: results from the PAQUID longitudinal studyNadine Raoux
INSERM, U897, Bordeaux Cedex, France University Victor Segalen Bordeaux 2, Bordeaux Cedex, France
Cortex 44:1188-96. 2008..Therefore the results support the hypothesis that impaired shifting abilities - rather than semantic memory storage degradation - could explain the early decline in semantic fluency performance occurring in the predementia phase of AD...
- A subtest of the MMSE as a valid test of episodic memory? Comparison with the Free and Cued Reminding TestLaure Carcaillon
INSERM, Unit 897, Bordeaux, France
Dement Geriatr Cogn Disord 27:429-38. 2009..Episodic memory impairment is known to be the core of Alzheimer's disease (AD) dementia syndrome and one of the earliest domains to decline. However, episodic memory tests are long and expensive...
- ETNA3, a clinical randomized study assessing three cognitive-oriented therapies in dementia: rationale and general designH Amieva
INSERM U897, Epidémiologie et Biostatistique, Université Bordeaux Segalen, 146, rue Leo Saignat, 33076 Bordeaux Cedex, France Electronic address
Rev Neurol (Paris) 169:752-6. 2013..This article presents the rationale and methodology of the study...
- Ginkgo biloba extract and long-term cognitive decline: a 20-year follow-up population-based studyHelene Amieva
University of Bordeaux, ISPED, Centre INSERM U897 Epidemiologie Biostatistique, Bordeaux, France
PLoS ONE 8:e52755. 2013..The present study assesses the association between intake of EGb761® and cognitive function of elderly adults over a 20-year period...
- Inhibitory breakdown and dementia of the Alzheimer type: a general phenomenon?Helene Amieva
INSERM U330, University of Bordeaux II, Bordeaux, France
J Clin Exp Neuropsychol 24:503-16. 2002..However, no evidence was found for an impairment on the Go-No go task and only limited impairment on the Stop Signal task, suggesting that in the early stages of the disease, not all inhibitory mechanisms are uniformly impaired...
- Prodromal Alzheimer's disease: successive emergence of the clinical symptomsHelene Amieva
Institut National de la Sante et de la Recherche Medicale, U897, France
Ann Neurol 64:492-8. 2008..Utilizing the long follow-up of the PAQUID study, we examined the emergence of the first clinical symptoms over a 14-year period of follow-up before the dementia phase of AD...
- The multiple-choice formats (forms F and G) of the Benton Visual Retention Test as a tool to detect age-related memory changes in population-based studies and clinical settingsHelene Amieva
INSERM U 593, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
Nat Protoc 1:1936-8. 2006..Another advantage is the possibility of referring to recent geriatric norms, which can help clinicians or researchers identify individuals with low scores and potentially at risk for dementia...
- What aspects of social network are protective for dementia? Not the quantity but the quality of social interactions is protective up to 15 years laterHelene Amieva
INSERM, U897, Universite Victor Segalen Bordeaux 2, 146 rue Leo Saignat, F 33076 Bordeaux cedex, France
Psychosom Med 72:905-11. 2010..To test the association between several social networks variables reflecting both structural characteristics and quality of relationships with the risk of dementia and Alzheimer's disease 5 and up to 15 years later...
- The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based studyHelene Amieva
INSERM Institut National de la Santé et de la Recherche Médicale Unit 593, Bordeaux, France
Brain 128:1093-101. 2005....
- Evidencing inhibitory deficits in Alzheimer's disease through interference effects and shifting disabilities in the Stroop testHelene Amieva
INSERM U593, University of Bordeaux II, France
Arch Clin Neuropsychol 19:791-803. 2004....
- Annual rate and predictors of conversion to dementia in subjects presenting mild cognitive impairment criteria defined according to a population-based studyHelene Amieva
INSERM Unit 593, Universite Victor Segalen, Bordeaux, France
Dement Geriatr Cogn Disord 18:87-93. 2004..Among the variables considered, the Letter Cancellation Test proved to be a major predictor of short-term conversion to dementia...
- Cognitive slowing and learning of target detection skills in pre-demented subjectsHelene Amieva
INSERM U593, Universite de Bordeaux II, Bordeaux, France
Brain Cogn 54:212-4. 2004..Additionally, the two groups significantly improved their time performances all along the test suggesting that both groups including the pre-demented group were able to progressively acquire a target detection skill...
- Inhibitory functioning in Alzheimer's diseaseHelene Amieva
Department of Psychology, University of Aberdeen, UK
Brain 127:949-64. 2004....
- Gender differences in the prodromal signs of dementia: memory complaint and IADL-restriction. a prospective population-based cohortKarine Pérès
INSERM, U897, Université Victor Segalen Bordeaux2, Bordeaux, France
J Alzheimers Dis 27:39-47. 2011..To conclude, women would report the first symptoms very early in the process by SMC, whereas men would tend to later report their difficulties and only in terms of IADL-restriction...
- [An alternative word-list for the Free and cued selective reminding test (FCSRT): list presentation and reliability study]Ralitsa Stoykova
INSERM, U897, Bordeaux, France
Geriatr Psychol Neuropsychiatr Vieil 11:317-22. 2013..This new list of words should be helpful to minimise potential practice effect and better assess memory decline in situations where the FCSRT has to be repeated across follow-up. ..
- Plasma long-chain omega-3 fatty acids and atrophy of the medial temporal lobeCecilia Samieri
Epidemiologie de la nutrition et des comportements alimentaires, Centre INSERM U897 Epidemiologie Biostatistique, Bordeaux, France
Neurology 79:642-50. 2012..We aimed at determining whether plasma levels of EPA or DHA predict atrophy of medial temporal lobe (MTL) gray matter regions in older subjects...
- Gender and education impact on brain aging: a general cognitive factor approachCécile Proust-Lima
Biostatistics Department, INSERM U897, Bordeaux Cedex 33076, France
Psychol Aging 23:608-20. 2008..Subjects with higher education exhibited a better mean score for the 4 tests, but this difference tended to attenuate with age for tests involving a speed component...
- Compensatory mechanisms in higher-educated subjects with Alzheimer's disease: a study of 20 years of cognitive declineHelene Amieva
1 INSERM, U897, Bordeaux, F 33076 France Univ Bordeaux Segalen, Bordeaux, F 33076 France
Brain 137:1167-75. 2014..In contrast, higher education protects against further cognitive decline for ∼7 years until pathology becomes more severe...
- Adherence to a Mediterranean diet, cognitive decline, and risk of dementiaCatherine Feart
Research Center INSERM U897, Universite Victor Segalen Bordeaux 2, Bordeaux, France
JAMA 302:638-48. 2009..Higher adherence to a Mediterranean-type diet is linked to lower risk for mortality and chronic diseases, but its association with cognitive decline is unclear...
- The STAI-Y trait scale: psychometric properties and normative data from a large population-based study of elderly peopleValérie Bergua
Univ Bordeaux, Psychologie, Santé et Qualité de Vie, EA 4139, Bordeaux, France
Int Psychogeriatr 24:1163-71. 2012..The objective of the present study was to provide normative data for the STAI-Y trait scale from a large elderly cohort and to identify the main sociodemographic and health-related determinants of trait anxiety...
- Cognitive impairment improves the predictive validity of the phenotype of frailty for adverse health outcomes: the three-city studyJosé Alberto Avila-Funes
Centre de Recherche INSERM, U897, Bordeaux, France
J Am Geriatr Soc 57:453-61. 2009..To determine whether adding cognitive impairment to frailty improves its predictive validity for adverse health outcomes...
- Gender-related differences in visuospatial memory persist in Alzheimer's diseaseXavier Millet
Inserm U 897, Universite Victor Segalen Bordeaux 2, Bordeaux, France
Arch Clin Neuropsychol 24:783-9. 2009..Therefore, this study suggests that, besides other variables such as education or lifestyle factors, gender might also modulate the cognitive manifestation of AD...
- Cube drawing performances in normal ageing and Alzheimer's disease: data from the PAQUID elderly population-based cohortYann Gaestel
INSERM U 593, University Victor Segalen Bordeaux 2, Bordeaux, France
Dement Geriatr Cogn Disord 21:22-32. 2006..7% did not benefit from the presentation of the model. Analysis showed that persistent failure in the copy condition was the best level of differentiation between normal and AD subjects...
- Natural history of decline in instrumental activities of daily living performance over the 10 years preceding the clinical diagnosis of dementia: a prospective population-based studyKarine Pérès
Institut National de la Santé et de la Recherche Médicale U593, Bordeaux, France
J Am Geriatr Soc 56:37-44. 2008..To study the subtle changes in instrumental activities of daily living (IADLs) over the 10 years preceding the clinical diagnosis of dementia...
- Impact of social network on cognitive performances and age-related cognitive decline across a 20-year follow-upRalitsa Stoykova
Research Center INSERM, U897, Bordeaux 2 University, France
Int Psychogeriatr 23:1405-12. 2011..The objective of this study was to investigate the relationship between social network and cognitive decline, taking into account the potential bias of reverse causality...
- Short- versus long-term prediction of dementia among subjects with low and high educational levelsEmilie Chary
Universite Bordeaux, ISPED, centre Inserm U897, Bordeaux, France
Alzheimers Dement 9:562-71. 2013....
- Normative data for the Mini-Mental State Examination, the Free and Cued Selective Reminding Test and the Isaacs Set Test for an older adult Mexican population: the Coyoacán cohort studyHind Mokri
Inserm U 897, Bordeaux Segalen University, Bordeaux, France
Clin Neuropsychol 27:1004-18. 2013..Therefore, the aim of the present work was to produce age, educational level, and gender-adjusted normative scores for these tests for the population of older adults living in Mexico...
- Health and aging in elderly farmers: the AMI cohortKarine Pérès
INSERM, ISPED, Centre INSERM U897 Epidemiologie Biostatistique, Bordeaux F 33000, France
BMC Public Health 12:558. 2012..The general aim of the AMI cohort was to study health and aging in elderly farmers living in rural area through a multidisciplinary approach, with a main focus on dementia...
- Is frailty a prodromal stage of vascular dementia? Results from the Three-City StudyJosé Alberto Avila-Funes
Department of Geriatrics, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico
J Am Geriatr Soc 60:1708-12. 2012..To investigate the relationship between frailty and incident vascular dementia (VaD)...
- ω-3 fatty acids and cognitive decline: modulation by ApoEε4 allele and depressionCecilia Samieri
INSERM, U897, Department of Nutritional Epidemiology, Bordeaux, F 33076, France
Neurobiol Aging 32:2317.e13-22. 2011..EPA and DHA may contribute to delaying decline in visual working memory in ApoE-ε4 carriers. In older depressed subjects, EPA, but not DHA, may slow cognitive decline...
- Exploring different routes of recovery from memory in Alzheimer's disease: evidence for preserved long-term primingXavier Millet
INSERM U593, Universite Victor Segalen, Bordeaux, France
J Clin Exp Neuropsychol 30:828-35. 2008..Therefore, whereas explicit retrieval is definitely impaired in Alzheimer's disease, implicit processes allowing the retrieval of that same information operate relatively normally, including after a long delay...
- Gray matter characteristics associated with trait anxiety in older adults are moderated by depressionOlivier Potvin
Institut National de la Sante et de la Recherche Medicale, INSERM U897, Bordeaux, France
Int Psychogeriatr 27:1813-24. 2015..Structural gray matter characteristics of anxiety remain unclear. The aim of this study was to assess the influence of current depressive symptoms and history of depression on the gray matter characteristics of trait anxiety...
- [Paquid 2012: illustration and overview]Jean Francois Dartigues
Unité Inserm 897, Université Bordeaux Segalen, Bordeaux, CMRR Bordeaux, CHU de Bordeaux, Bordeaux
Geriatr Psychol Neuropsychiatr Vieil 10:325-31. 2012..On the basis of the Paquid data, we have shown that the prodromal phase of AD was longer than ten years and that dementia represented the major cause of dependency in the elderly...
- Influence of age, circadian and homeostatic processes on inhibitory motor control: a Go/Nogo task studyPatricia Sagaspe
CNRS USR 3413 SANPSY, Sleep, Attention and NeuroPSYchiatrie, Universite de Bordeaux, Bordeaux, France
PLoS ONE 7:e39410. 2012..The aim of our study was to determine the age-related evolution of inhibitory motor control (i.e., ability to suppress a prepotent motor response) and sustained attention under controlled high or low sleep pressure conditions...
- Semi-parametric latent process model for longitudinal ordinal data: Application to cognitive declineHélène Jacqmin-Gadda
INSERM, U897, F 33076, Bordeaux, France
Stat Med 29:2723-31. 2010..The method is applied to the Paquid cohort data to compare the time-course over 14 years of two cognitive scores in a sample of 350 future Alzheimer patients and in a matched sample of healthy subjects...
- Encoding processes influence word-stem completion priming in Alzheimer's disease: a meta-analysisXavier Millet
INSERM U897, Universite Victor Segalen Bordeaux 2, 33076 Bordeaux, France
J Clin Exp Neuropsychol 32:494-504. 2010....
- PCC characteristics at rest in 10-year memory declinersCharlotte Bernard
Institut de Neurosciences Cognitives et Intégratives d Aquitaine INCIA, University of Bordeaux, UMR 5287, Talence, France Centre National de la Recherche Scientifique CNRS, INCIA, UMR 5287, Talence, France Ecole Pratique des Hautes Etudes EPHE, Bordeaux, France Electronic address
Neurobiol Aging 36:2812-20. 2015..Because functional alterations of this region are currently described in Alzheimer's disease, this functional signature could constitute a risk for Alzheimer's disease...
- Mobile technologies in the early detection of cognitive declineMichele Allard
Univ Bordeaux, INCIA, UMR 5287, Bordeaux, France CNRS, INCIA, UMR 5287, Bordeaux, France EPHE, Bordeaux, France CHU de Bordeaux, Bordeaux, France
PLoS ONE 9:e112197. 2014..The combination of both novel and traditional methods should provide the best opportunity for identifying the earliest risk factors and biomarkers for Alzheimer's disease and other forms of dementia. ..
- Time course of brain volume changes in the preclinical phase of Alzheimer's diseaseCharlotte Bernard
University of Bordeaux, INCIA, Talence, France CNRS, INCIA, Talence, France EPHE, Bordeaux, France Electronic address
Alzheimers Dement 10:143-151.e1. 2014..The dynamic of these alterations was examined in the AD preclinical phase using data from the 10-year follow-up of a population-based cohort (Bordeaux-3City)...
- Sensitivity of four psychometric tests to measure cognitive changes in brain aging-population-based studiesCécile Proust-Lima
INSERM E0338, Bordeaux, France
Am J Epidemiol 165:344-50. 2007....
- Anxiety and 10-year risk of incident and recurrent depressive symptomatology in older adultsOlivier Potvin
Centre de Recherche de l Institut Universitaire en Santé Mentale de Québec, Quebec, Canada
Depress Anxiety 30:554-63. 2013....
- Association between frailty and carotid central structure changes: the Three-City StudyJosé Alberto Avila-Funes
Department of Geriatrics, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico Centre de Recherche Inserm, Bordeaux, France University Victor Segalen Bordeaux 2, Bordeaux, France
J Am Geriatr Soc 62:1906-11. 2014..To demonstrate the association between carotid central structure changes and frailty...
- Normative Scores for Standard Neuropsychological Tests in the Oldest Old From the French Population-Based PAQUID StudyCaroline Giulioli
INSERM U897 Epidemiology and Biostatistics, University of Bordeaux, Bordeaux, France
Arch Clin Neuropsychol 31:58-65. 2016..The norms provided in the present study involve 7 tests that are widely used in the neuropsychological assessment of geriatrics populations and should be of help for clinicians. ..
- Detection of Alzheimer's disease signature in MR images seven years before conversion to dementia: Toward an early individual prognosisPierrick Coupe
Laboratoire Bordelais de Recherche en Informatique, Unité Mixte de Recherche CNRS UMR 5800, PICTURA Research Group, Bordeaux, France
Hum Brain Mapp 36:4758-70. 2015..Hum Brain Mapp 36:4758-4770, 2015. © 2015 Wiley Periodicals, Inc. ..
- Normalized Mini-Mental State Examination for assessing cognitive change in population-based brain aging studiesViviane Philipps
INSERM U897, Bordeaux, France
Neuroepidemiology 43:15-25. 2014..We propose a normalizing transformation that corrects these properties, and makes possible the use of standard statistical methods to analyze change in MMSE scores...
- Cognitive decline after entering a nursing home: a 22-year follow-up study of institutionalized and noninstitutionalized elderly peopleMagali Gonzalez-Colaço Harmand
Centre de Recherche INSERM, U897, Univ Victor Segalen, Bordeaux, France Electronic address
J Am Med Dir Assoc 15:504-8. 2014..The objective of this study is to compare cognitive decline of elderly people after entering an institution with that of elders living in the community with similar clinical conditions...
- Education, occupation, leisure activities, and brain reserve: a population-based studyAlexandra Foubert-Samier
CMRR d Aquitaine, CHU Bordeaux, Bordeaux, France
Neurobiol Aging 33:423.e15-25. 2012..Education, occupation attainment, and leisure activities were found to contribute differently to reserve capacity. Education could play a role in the constitution of cerebral reserve capacity...
- Behavioral dysexecutive symptoms in normal agingHelene Amieva
Department of Psychology, University of Aberdeen, Scotland, UK
Brain Cogn 53:129-32. 2003..The relationship between these factors and neuropsychological measures of Executive Functions were also briefly explored...
- A longitudinal study of quantitative and qualitative features of category verbal fluency in incident Alzheimer's disease subjects: results from the PAQUID studySophie Auriacombe
Hospital of the University of Bordeaux, France
Dement Geriatr Cogn Disord 21:260-6. 2006....
- Group and individual cognitive therapies in Alzheimer's disease: the ETNA3 randomized trialHelene Amieva
INSERM, U897 Epidemiology Biostatistics, University of Bordeaux, F 33076, Bordeaux, France
Int Psychogeriatr 28:707-17. 2016..ETNA3 trial compares the effect of cognitive training, reminiscence therapy, and an individualized cognitive rehabilitation program in Alzheimer's disease to usual care...
- Self-Reported Hearing Loss, Hearing Aids, and Cognitive Decline in Elderly Adults: A 25-Year StudyHelene Amieva
Epidemiology and Biostatistics, Institut National de la Santé et de la Recherche Médicale U897, University of Bordeaux, Bordeaux, France
J Am Geriatr Soc 63:2099-104. 2015..To investigate the association between hearing loss, hearing aid use, and cognitive decline...
- Muscular weakness in individuals with HIV associated with a disorganization of the cortico-spinal tract: a multi-modal MRI investigationCharlotte Bernard
Universite de Bordeaux, INCIA, UMR 5287, Talence, France
PLoS ONE 8:e66810. 2013..The absence of alterations in cortical regions holding motor-neurons might argue against neurodegenerative process as an explanation of White Matter (WM) disorganization. ..
- Time may not fully attenuate solvent-associated cognitive deficits in highly exposed workersErika L Sabbath
From the Harvard Center for Population and Development Studies E L S, Cambridge, MA INSERM U1061 L A G, C B, neuropsychiatrie recherche épidémiologique et clinique, Universite Montpellier I, Hôpital La Colombière, France Department of Society, Human Development, and Health C A O, Harvard School of Public Health, Boston, MA INSERM U1018 A S M, Centre for research in Epidemiology and Population Health, AP HP University of Bordeaux H A, ISPED, Centre INSERM U897 Epidemiologie Biostatistique University of Bordeaux H A, Department of Psychology, Bordeaux Population based Cohort Platform M G, M Z, Epidemiology and Public Health Research Center, UMRS INSERM 1018, Villejuif Université Versailles Saint Quentin UMRS 1018 M G, M Z CMRR Languedoc Roussillon C B, CHU Montpellier, France
Neurology 82:1716-23. 2014..To test the effects of lifetime occupational solvent exposure, as measured by dose and timing, on performance on multiple cognitive tests among retired French utility workers...
- Analysis of multivariate mixed longitudinal data: a flexible latent process approachCécile Proust-Lima
INSERM, ISPED, Centre INSERM U897 Epidemiologie Biostatistique, Bordeaux, France Université Bordeaux, ISPED, Centre INSERM U897 Epidemiologie Biostatistique, Bordeaux, France
Br J Math Stat Psychol 66:470-87. 2013..Then, change over time of the latent construct underlying directly the 20 items is described using two-parameter longitudinal item response models that are specific cases of the approach. ..
- As long as you've got your health: Longitudinal relationships between positive affect and functional health in old ageKamel Gana
University of Bordeaux, France Electronic address
Soc Sci Med 150:231-8. 2016..The aim of the present study was to test these two approaches by investigating thirteen-year longitudinal relationships between PA, as an affective dimension of SWB, and functional health in older people...
- Epidemiology of Cognitive Aging in the Oldest OldCaroline Giulioli
INSERM U1219 Bordeaux Population Health, University of Bordeaux, Bordeaux, France
Rev Invest Clin 68:33-9. 2016..This article presents an overview of the epidemiology of cognitive functioning in the oldest old, and discusses the issues regarding neuropsychological assessment and dementia in this specific elderly population. ..
- Subjective memory impairment, objective cognitive functioning and social activity in French older people: findings from the Three Cities studyMirella Genziani
Institute of Psychiatry, King s College London, London, UK
Geriatr Gerontol Int 13:139-45. 2013..To investigate the association between subjective memory impairment (SMI) and objective cognitive impairment in later life, and to ascertain whether this is modified by level of social activity, education or living alone...
- Deep brain stimulation of the ventral caudate nucleus in the treatment of obsessive-compulsive disorder and major depression. Case reportBruno Aouizerate
Services de Psychiatrie A and B, Centre Hospitalier Charles Perrens, Bordeaux, France
J Neurosurg 101:682-6. 2004..No neuropsychological deterioration was observed, indicating that DBS of the ventral caudate nucleus could be a promising strategy in the treatment of refractory cases of both OCD and major depression...