Marie Christine Alessi

Summary

Country: France

Publications

  1. pmc Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation
    Chiara Chiellini
    ISBDC, Universite de Nice Sophia Antipolis, CNRS 28 avenue de Valrose, 06100 Nice, France
    BMC Mol Biol 9:26. 2008
  2. ncbi Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation
    Marie Christine Alessi
    Laboratoire d Hematologie, EPI 99 36, 27, Faculty of Medicine, Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Arterioscler Thromb Vasc Biol 23:1262-8. 2003
  3. ncbi Adipose tissue and atherothrombosis
    Marie Christine Alessi
    Laboratoire d ématologie, INSERM UMR626, UFR de Medecine, Universite de la Mediterranee, Marseille, France
    Pathophysiol Haemost Thromb 33:290-7. 2003
  4. ncbi Plasminogen activator inhibitor-1, adipose tissue and insulin resistance
    Marie Christine Alessi
    Laboratoire d hématologie Inserm UMR 626, Faculty of Medicine, Marseilles, France
    Curr Opin Lipidol 18:240-5. 2007
  5. doi Clinical implications of very low on-treatment platelet reactivity in patients treated with thienopyridine: the POBA study (predictor of bleedings with antiplatelet drugs)
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    JACC Cardiovasc Interv 6:854-63. 2013
  6. doi Effect of CYP2C19*2 and *17 genetic variants on platelet response to clopidogrel and prasugrel maintenance dose and relation to bleeding complications
    Charlotte Grosdidier
    INSERM, UMR1062, Nutrition, Obesity and Risk of Thrombosis, Marseille, France
    Am J Cardiol 111:985-90. 2013
  7. ncbi Lack of association between the 807 C/T polymorphism of glycoprotein Ia gene and post-treatment platelet reactivity after aspirin and clopidogrel in patients with acute coronary syndrome
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Thromb Haemost 97:212-7. 2007
  8. ncbi Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Thromb Res 120:893-9. 2007
  9. doi Clopidogrel response: head-to-head comparison of different platelet assays to identify clopidogrel non responder patients after coronary stenting
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Arch Cardiovasc Dis 103:39-45. 2010
  10. doi Adrenergic receptor polymorphisms and platelet reactivity after treatment with dual antiplatelet therapy with aspirin and clopidogrel in acute coronary syndrome
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    Thromb Haemost 103:774-9. 2010

Detail Information

Publications68

  1. pmc Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation
    Chiara Chiellini
    ISBDC, Universite de Nice Sophia Antipolis, CNRS 28 avenue de Valrose, 06100 Nice, France
    BMC Mol Biol 9:26. 2008
    ..As secreted proteins could regulate the balance between both lineages, we aimed at characterizing the secretome of human multipotent adipose-derived stem cell (hMADS) at an early step of commitment to adipocytes and osteoblasts...
  2. ncbi Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation
    Marie Christine Alessi
    Laboratoire d Hematologie, EPI 99 36, 27, Faculty of Medicine, Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Arterioscler Thromb Vasc Biol 23:1262-8. 2003
    ....
  3. ncbi Adipose tissue and atherothrombosis
    Marie Christine Alessi
    Laboratoire d ématologie, INSERM UMR626, UFR de Medecine, Universite de la Mediterranee, Marseille, France
    Pathophysiol Haemost Thromb 33:290-7. 2003
    ..Most of the data indicate that PAI-1 can effectively modulate weight gain and may be a potential therapeutic target for controlling cardiovascular morbidity in obese subjects...
  4. ncbi Plasminogen activator inhibitor-1, adipose tissue and insulin resistance
    Marie Christine Alessi
    Laboratoire d hématologie Inserm UMR 626, Faculty of Medicine, Marseilles, France
    Curr Opin Lipidol 18:240-5. 2007
    ..A role for PAI-1 in development of obesity has only partially been established, however. This review summarizes current knowledge, gives context to developments thus far and discusses controversies...
  5. doi Clinical implications of very low on-treatment platelet reactivity in patients treated with thienopyridine: the POBA study (predictor of bleedings with antiplatelet drugs)
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    JACC Cardiovasc Interv 6:854-63. 2013
    ..We also aimed to identify predictors of bleeding and VLTPR in patients treated with thienopyridines...
  6. doi Effect of CYP2C19*2 and *17 genetic variants on platelet response to clopidogrel and prasugrel maintenance dose and relation to bleeding complications
    Charlotte Grosdidier
    INSERM, UMR1062, Nutrition, Obesity and Risk of Thrombosis, Marseille, France
    Am J Cardiol 111:985-90. 2013
    ..In addition, LTPR was associated with a greater risk of bleeding...
  7. ncbi Lack of association between the 807 C/T polymorphism of glycoprotein Ia gene and post-treatment platelet reactivity after aspirin and clopidogrel in patients with acute coronary syndrome
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Thromb Haemost 97:212-7. 2007
    ..104). In conclusion, our study did not show any influence of 807 C/T polymorphism of GpIa gene on post-treatment platelet reactivity assessed by ADP-Ag, PRI VASP or P-selectin expression in 601 NSTE ACS patients...
  8. ncbi Role of the T744C polymorphism of the P2Y12 gene on platelet response to a 600-mg loading dose of clopidogrel in 597 patients with non-ST-segment elevation acute coronary syndrome
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Thromb Res 120:893-9. 2007
    ..Recently, the T744C polymorphism of the P2Y12 receptor gene has been associated with enhanced platelet aggregation in healthy volunteers, suggesting a possible mechanism for modulation of clopidogrel response...
  9. doi Clopidogrel response: head-to-head comparison of different platelet assays to identify clopidogrel non responder patients after coronary stenting
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Arch Cardiovasc Dis 103:39-45. 2010
    ..We investigated the agreement between different platelet tests to identify clopidogrel non response...
  10. doi Adrenergic receptor polymorphisms and platelet reactivity after treatment with dual antiplatelet therapy with aspirin and clopidogrel in acute coronary syndrome
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    Thromb Haemost 103:774-9. 2010
    ..Common alpha2A- and beta2-adrenergic receptor polymorphisms do not show any major impact on residual platelet reactivity in non-ST-elevation ACS when a dual antiplatelet therapy with 250 mg aspirin and 600 mg clopidogrel is administered...
  11. ncbi Benefit of a 600-mg loading dose of clopidogrel on platelet reactivity and clinical outcomes in patients with non-ST-segment elevation acute coronary syndrome undergoing coronary stenting
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    J Am Coll Cardiol 48:1339-45. 2006
    ..We analyzed the benefit of a 600-mg clopidogrel loading dose on platelet reactivity and clinical outcomes after stenting for non-ST-segment elevation acute coronary syndrome (NSTE ACS)...
  12. doi Comparison of platelet reactivity and clopidogrel response in patients ≤ 75 Years Versus > 75 years undergoing percutaneous coronary intervention for non-ST-segment elevation acute coronary syndrome
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    Am J Cardiol 108:1411-6. 2011
    ..They display greater post-treatment platelet reactivity. However, this greater platelet reactivity does not seem to be related to an impaired specific response to clopidogrel...
  13. doi Comparison between initial and chronic response to clopidogrel therapy after coronary stenting for acute coronary syndrome and influence on clinical outcomes
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    Am Heart J 164:327-33. 2012
    ..Studies have addressed the benefit of tailored therapy based on initial response to clopidogrel loading dose. However, the appropriate timing for platelet testing remains uncertain...
  14. doi Usefulness of high clopidogrel maintenance dose according to CYP2C19 genotypes in clopidogrel low responders undergoing coronary stenting for non ST elevation acute coronary syndrome
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    Am J Cardiol 108:760-5. 2011
    ..The benefit of this tailored therapy was significantly reduced in CYP2C19*2 carriers. Therefore, these patients might require alternative strategies with new P2Y₁₂ blockers...
  15. doi Impact of obesity and the metabolic syndrome on response to clopidogrel or prasugrel and bleeding risk in patients treated after coronary stenting
    Mathieu Pankert
    Departement de Cardiologie, Centre Hospitalo Universitaire Timone, Marseille, France Aix Marseille Univ, Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 1062, Institut National de la Recherche Agronomique, Unité Mixte de Recherche 1260, Nutrition, Obesity and Risk of Thrombosis, Faculty of Medicine, Marseille, France
    Am J Cardiol 113:54-9. 2014
    ..However, among obese patients, the presence of the MS strongly affects response to antiplatelet agents, indicating that the metabolic status might be a better predictor of platelet inhibition than BMI...
  16. ncbi ADP-induced platelet aggregation and platelet reactivity index VASP are good predictive markers for clinical outcomes in non-ST elevation acute coronary syndrome
    Corinne Frere
    INSERM, UMR 626, Faculté de Médecine CHU Timone, Marseille, France
    Thromb Haemost 98:838-43. 2007
    ..In patients with NSTE ACS undergoing PCI, ADP-Ag and PRI VASP identify low responders to clopidogrel with an increased risk of recurrent ischemic events with respective cut-off values of 70% and 53%...
  17. doi CYP2C19*2 and *17 alleles have a significant impact on platelet response and bleeding risk in patients treated with prasugrel after acute coronary syndrome
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, France
    JACC Cardiovasc Interv 5:1280-7. 2012
    ..The present study was designed to assess the effect of genetic variants on chronic biological response to prasugrel and bleeding complications...
  18. ncbi Stromal cells are the main plasminogen activator inhibitor-1-producing cells in human fat: evidence of differences between visceral and subcutaneous deposits
    Delphine Bastelica
    Laboratoire d Hematologie, Faculte de Medecine Timone, France
    Arterioscler Thromb Vasc Biol 22:173-8. 2002
    ..These results could explain the strong relationship observed between circulating PAI-1 levels and the accumulation of visceral fat...
  19. ncbi Polymorphism A36G of the tumor necrosis factor receptor 1 gene is associated with PAI-1 levels in obese women
    Alenka Mavri
    Inserm UMR 626 and Université de la Méditerranée, Marseille, France
    Thromb Haemost 97:62-6. 2007
    ..Our results suggest that association between TNFRSF1A +36G/G genotype and the MetS renders obese women more prone to activation of the TNF pathway reflected by high circulating sTNFR1 and PAI-1 levels...
  20. doi Effects of bariatric surgery on cardiac ectopic fat: lesser decrease in epicardial fat compared to visceral fat loss and no change in myocardial triglyceride content
    Benedicte Gaborit
    Department of Endocrinology, Metabolic Diseases and Nutrition, Centre Hospitalier Universitaire Nord, Marseille, France
    J Am Coll Cardiol 60:1381-9. 2012
    ..This study investigated the effect of bariatric surgery (BS)-induced weight loss on cardiac ectopic fat using 3T magnetic resonance imaging in morbid obesity...
  21. pmc The plasminogen activation system modulates differently adipogenesis and myogenesis of embryonic stem cells
    Ola Hadadeh
    INSERM U626, Faculte de Medecine, Marseille, France
    PLoS ONE 7:e49065. 2012
    ..Our results show that the PA system is capable to specifically modulate adipogenesis and skeletal myogenesis of ESCs by successive different molecular mechanisms...
  22. ncbi Quantification of thrombin activatable fibrinolysis inhibitor (TAFI) gene polymorphism effects on plasma levels of TAFI measured with assays insensitive to isoform-dependent artefact
    Corinne Frere
    INSERM UMR 626, Faculte de Medecine, Marseille, France
    Thromb Haemost 94:373-9. 2005
    ..This effect seems to be the consequence of the joint independent action of two polymorphisms, one in the 5' (G-1102T) and the other in the 3' region (T+1583A) of the TAFI gene...
  23. ncbi The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: possible contribution to elevated plasma levels of soluble TNF alpha receptors
    Matthias Canault
    INSERM, U626, Faculte de Medecine Timone, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Atherosclerosis 187:82-91. 2006
    ..In conclusion, TACE expression is associated with lesions in atherosclerosis-prone sites. Our data suggest that atherosclerotic lesions-expressing TACE may contribute to the elevated levels of circulating sTNFRs...
  24. doi Palmitoylation of TNF alpha is involved in the regulation of TNF receptor 1 signalling
    Marjorie Poggi
    INSERM, UMR1062, Nutrition, Obesity and Risk of Thrombosis, F 13385, Marseille, France
    Biochim Biophys Acta 1833:602-12. 2013
    ..Therefore, our data introduce the new concept that palmitoylation of TNF is one of the means by which TNF-producing cells regulate their sensitivity to soluble TNF...
  25. doi Factors associated with the failure of clopidogrel dose-adjustment according to platelet reactivity monitoring to optimize P2Y12-ADP receptor blockade
    Laurent Bonello
    Departement de Cardiologie, Hopital Universitaire Nord, Faculte de Medecine, Aix Marseille Universite, Marseille, France
    Thromb Res 130:70-4. 2012
    ..We aimed to investigate the impact of 3 genetic polymorphisms involved in clopidogrel metabolism on a strategy of dose-adjustment according to platelet reactivity (PR) monitoring...
  26. doi Thrombosis in central obesity and metabolic syndrome: mechanisms and epidemiology
    Pierre Emmanuel Morange
    Marie Christine Alessi, Laboratoire d Hematologie, Inserm UMR 1062, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, Marseille, F 13385 France, Tel 33 4 91 32 45 06, Fax 33 4 91 25 43 36, E mail
    Thromb Haemost 110:669-80. 2013
    ..In support of these data, central obesity independently predisposes not only to atherothrombosis but also to venous thrombosis. ..
  27. ncbi Expression of the mRNAs coding for the glucocorticoid receptor isoforms in obesity
    Sandrine Boullu-Ciocca
    Service d Endocrinologie and Centre d Investigation Clinique, Assistance Publique Hopitaux de Marseille, Marseille, France
    Obes Res 11:925-9. 2003
    ....
  28. doi Platelet reactivity in diabetic patients undergoing coronary stenting for acute coronary syndrome treated with clopidogrel loading dose followed by prasugrel maintenance therapy
    Thomas Cuisset
    Departement de Cardiologie, CHU Timone, Marseille, F 13385 France
    Int J Cardiol 168:523-8. 2013
    ..The present study was designed to assess response to thienopyridine in diabetic patients undergoing PCI for ACS...
  29. doi Diet modulates endogenous thrombin generation, a biological estimate of thrombosis risk, independently of the metabolic status
    Caroline Sanchez
    INSERM, UMR1062, Nutrition, Obesity, and Risk of Thrombosis, Marseille, France
    Arterioscler Thromb Vasc Biol 32:2394-404. 2012
    ..High endogenous thrombin potential (ETP) is associated with venous and arterial thrombosis. Better knowledge of environmental influences on ETP may help to prevent thrombosis...
  30. doi Recent advances in the pharmacogenetics of clopidogrel
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    Hum Genet 131:653-64. 2012
    ..The purpose of this review is to discuss the contribution of individual genetic differences responsible for variations of action and clopidogrel efficacy...
  31. doi An evaluation of the effects of Lactobacillus ingluviei on body weight, the intestinal microbiome and metabolism in mice
    Emmanouil Angelakis
    Unite des Rickettsies, CNRS UMR 6020, IFR 48, Faculte de Medecine, Universite de la Mediterranee, 27 Bd Jean Moulin, 13385 Marseille Cedex 05, France
    Microb Pathog 52:61-8. 2012
    ..Food can modify the intestinal flora, and Lactobacillus ingluviei has been shown to cause weight gain in chicks and ducks but not in mammals...
  32. ncbi Is platelet inhibition correlated with time from last intake on P2Y12 blockers after an acute coronary syndrome? A pilot study
    Pierre Deharo
    a Département de Cardiologie, CHU Timone, Marseille, France
    Platelets 27:791-795. 2016
    ..02, p = 0.82; r = 0.11, p = 0.12 respectively), no correlation exists. In conclusion, ticagrelor, unlike thienopyridines, is associated with a significant correlation between delay from the last intake and platelet inhibition...
  33. pmc Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1
    Matthias Canault
    INSERM, U626, Marseille, Paris, France
    Am J Pathol 171:1713-23. 2007
    ....
  34. ncbi HDLs activate ADAM17-dependent shedding
    Edwige Tellier
    INSERM, U626, Marseilles, France
    J Cell Physiol 214:687-93. 2008
    ..In conclusion, these data demonstrate that HDLs alter the lipid raft structure, which in turn activates the ADAM17-dependent processing of transmembrane substrates...
  35. doi Association of vitronectin and plasminogen activator inhibitor-1 levels with the risk of metabolic syndrome and type 2 diabetes mellitus. Results from the D.E.S.I.R. prospective cohort
    Marie Christine Alessi
    U626, INSERM, Marseille, France
    Thromb Haemost 106:416-22. 2011
    ..0009). In conclusion, baseline plasma vitronectin is a marker of incident MetS at nine years. Its predictive ability for MetS and T2DM should not be assessed independently of PAI-1 levels...
  36. ncbi PAI-1 and the metabolic syndrome: links, causes, and consequences
    Marie Christine Alessi
    Laboratory of Hematology, INSERM UMR 626, Faculty of Medicine, Marseilles, France
    Arterioscler Thromb Vasc Biol 26:2200-7. 2006
    ..These findings suggest PAI-1 inhibitors serve in the control of atherothrombosis and insulin resistance...
  37. pmc Platelets alter gene expression profile in human brain endothelial cells in an in vitro model of cerebral malaria
    Mathieu Barbier
    Laboratoire de Pharmacogénétique des Maladies Parasitaires EA 864, IFR 48, Faculte de Pharmacie, Aix Marseille Universite, Marseille, France
    PLoS ONE 6:e19651. 2011
    ..Overall, our results support the hypothesis that platelets play a pathogenic role in CM...
  38. ncbi MRI follow-up of TNF-dependent differential progression of atherosclerotic wall-thickening in mouse aortic arch from early to advanced stages
    Frank Kober
    Centre de Resonance Magnetique Biologique et Medicale, CNRS UMR n 6612, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard J Moulin, 13005 Marseille, France
    Atherosclerosis 195:e93-9. 2007
    ....
  39. doi ABO blood group and von Willebrand factor levels partially explained the incomplete penetrance of congenital thrombophilia
    William Cohen
    Inserm UMR 1062, Aix Marseille University, Marseille, France
    Arterioscler Thromb Vasc Biol 32:2021-8. 2012
    ..We aimed to study the association among ABO blood group, von Willebrand factor, factor VIII plasma levels, and the risk of venous thrombosis (VT) in a cohort of 1774 relatives from 500 families with inherited thrombophilia...
  40. doi p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells
    Emilie Barruet
    INSERM U626, Universite de la Mediterranee, Faculte de Medecine, Marseille, France
    Stem Cells Dev 20:1233-46. 2011
    ..In conclusion, by genetic and biochemical approaches, we demonstrate that p38MAPK activity is essential for the commitment of ES cell into cardiac, endothelial, smooth muscle, and skeletal muscle mesodermal lineages...
  41. doi High prevalence of laminopathies among patients with metabolic syndrome
    Anne Dutour
    INSERM UMR_S626, Universite de la Mediterranee, Marseille, France
    Hum Mol Genet 20:3779-86. 2011
    ....
  42. doi Immediate Postnatal Overfeeding in Rats Programs Aortic Wall Structure Alterations and Metalloproteinases Dysregulation in Adulthood
    Vincent Achard
    INSERM, UMR1062, Marseille, France INRA, UMR 1260, Marseille, France Aix Marseille Université, Marseille, France
    Am J Hypertens 29:719-26. 2016
    ..However, experimental evidences demonstrating that changes in the nutritional perinatal environment can program MMP-2 and -9 with subsequent alterations of vessel wall are lacking...
  43. ncbi Insulin resistance induced by hydrocortisone is increased in patients with abdominal obesity
    Patrice Darmon
    Endocrinology and Nutrition Department, Hopital Nord, Marseille, France
    Am J Physiol Endocrinol Metab 291:E995-E1002. 2006
    ..These deleterious effects are correlated with the amount of visceral fat...
  44. doi Metabolic syndrome, haemostasis and thrombosis
    Marie Christine Alessi
    Laboratoire d Hematologie, Faculte de Medecine, Universite de la Mediterranee, INSERM UMR 626, Marseille, France
    Thromb Haemost 99:995-1000. 2008
    ..In support of these data, the metS, may predispose not only to atherosclerosis but also to venous thrombosis...
  45. doi Epicardial fat volume is associated with coronary microvascular response in healthy subjects: a pilot study
    Benedicte Gaborit
    Centre de Résonance Magnétique Biologique et Médicale CRMBM, CNRS UMR 6612, Marseille, France
    Obesity (Silver Spring) 20:1200-5. 2012
    ..A high EF amount is associated with a lower coronary microvascular response, suggesting that EF could early influence endothelial function...
  46. pmc A follow-up study of a genome-wide association scan identifies a susceptibility locus for venous thrombosis on chromosome 6p24.1
    Pierre Emmanuel Morange
    INSERM, UMR_S 626, Universite de la Mediterranee, Marseille, F 13385 France
    Am J Hum Genet 86:592-5. 2010
    ..The current results provide the identification of a locus involved in VT susceptibility that lies outside the traditional coagulation/fibrinolysis pathway...
  47. pmc Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation
    Denis Bernot
    INSERM, U626, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, Marseilles 13385 Cedex 5, France
    J Biol Chem 285:6508-14. 2010
    ..Our results indicate that during preadipocyte differentiation, the Sp1-dependent decrease in TIMP-3 expression is required for the successful implementation of the adipocyte differentiation program...
  48. ncbi [The link between molecules produced by the adipose tissue, obesity and atherothrombosis]
    Marie Christine Alessi
    Laboratoire hématologie, 27 Bd Jean Moulin, Faculte de Medecine Timone, 13385 Marseille 05
    Presse Med 34:820-4. 2005
    ..Here we review new advances in our understanding of the mechanisms linking the endocrine activity of adipose tissue to vascular risk...
  49. doi The first intracellular loop of GLUT4 contains a retention motif
    Maya Talantikite
    Inserm U1062, INRA1260, Aix Marseille University, Faculty of Medicine, Marseille F 13385, France
    J Cell Sci 129:2273-84. 2016
    ..We conclude that the first intracellular loop of GLUT4 contains the retention motif WLGRK, in which W105 plays a prominent role. ..
  50. ncbi The insulin resistance syndrome: implications for thrombosis and cardiovascular disease
    Irene Juhan-Vague
    Lab Haematology, CHU Timone, Inserm EPI 99 36, Marseille, France
    Pathophysiol Haemost Thromb 32:269-73. 2002
    ..Interestingly, modulation of PAI-1 expression in adipose tissue influences adipose tissue growth, increasing once more the spectrum of the non hemostatic functions of coagulation/fibrinolysis parameters...
  51. doi [The two sides of ADAM17 in inflammation: implications in atherosclerosis and obesity]
    Franck Peiretti
    INSERM U626, Faculte de Medecine, 27, Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Med Sci (Paris) 25:45-50. 2009
    ..The multitude of substrates cleaved by ADAM17 makes this enzyme an attractive candidate to study its role in inflammation-driven pathologies...
  52. ncbi Modulation of T Cell Activation in Obesity
    Stéphanie O Morin
    1 INSERM, U1068, Centre de Recherche en Cancerologie de Marseille, Marseille, France
    Antioxid Redox Signal . 2016
    ..Immune T cells are present in adipose tissues (AT), and the stoichiometry of the different T cell subsets is altered during diet-induced obesity (DIO). T cells contribute to the early steps of AT inflammation during DIO...
  53. doi Multilevel systems biology modeling characterized the atheroprotective efficiencies of modified dairy fats in a hamster model
    Jean Charles Martin
    INRA UMR1260, Nutrition, Obésité et Risque Thrombotique, Marseille, France Aix Marseille Université, Faculte de Medecine, Marseille, France and INSERM, UMR1062, Nutrition, Obésité et Risque Thrombotique, Marseille, France
    Am J Physiol Heart Circ Physiol 309:H935-45. 2015
    ..Our modeling approach allowed for identifying and quantifying the contribution of complex factors to atherogenic development in each dietary setup. ..
  54. doi Secretory type II phospholipase A2 is produced and secreted by epicardial adipose tissue and overexpressed in patients with coronary artery disease
    Anne Dutour
    Institut National de la Sante et de la Recherche Medicale, Unité 626, Faculte de Medecine Timone, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    J Clin Endocrinol Metab 95:963-7. 2010
    ..Epicardial adipose tissue (EAT) is a visceral adipose tissue in close contact with coronary vessels, the excess of which is associated with coronary artery disease (CAD)...
  55. pmc Circulating matrix metalloproteinases in infective endocarditis: a possible marker of the embolic risk
    Franck Thuny
    Departement de Cardiologie, Hopital de la Timone, Assistance Publique Hopitaux de Marseille, Universite de la Mediterranee, Marseille, France
    PLoS ONE 6:e18830. 2011
    ..We aimed to determine whether, in addition to the vegetation size, circulating MMPs could provide accurate predictive value of embolism in IE...
  56. pmc Germline variants in ETV6 underlie reduced platelet formation, platelet dysfunction and increased levels of circulating CD34+ progenitors
    Marjorie Poggi
    Aix Marseille Univ, INSERM, INRA, NORT, Marseille, France
    Haematologica 102:282-294. 2017
    ....
  57. doi Effect of cytochrome p450 polymorphisms on platelet reactivity after treatment with clopidogrel in acute coronary syndrome
    Corinne Frere
    INSERM U626, Marseille, France
    Am J Cardiol 101:1088-93. 2008
    ..03). In conclusion, the present data suggest that the CYPC19*2 allele influences post-treatment platelet reactivity and clopidogrel response in patients with non-ST elevation acute coronary syndromes...
  58. pmc Endocytosis and intracellular processing of platelet microparticles by brain endothelial cells
    Dorothee Faille
    Department of Pathology, University of Sydney, Camperdown, Australia
    J Cell Mol Med 16:1731-8. 2012
    ..These findings identify new processes by which PMP could modify endothelial cell phenotype and functions...
  59. ncbi Predictive value of post-treatment platelet reactivity for occurrence of post-discharge bleeding after non-ST elevation acute coronary syndrome. Shifting from antiplatelet resistance to bleeding risk assessment?
    Thomas Cuisset
    Department of Cardiology, CHU Timone, Marseille, France
    EuroIntervention 5:325-9. 2009
    ..We assessed prospectively the association between occurrence of post-discharge non-CABG-related TIMI major and minor bleeding and post-treatment platelet reactivity in patients with non-ST elevation acute coronary syndrome (NSTE ACS)...
  60. ncbi Does the anti-prothrombin antibodies measurement provide additional information in patients with thrombosis?
    Nathalie Bardin
    Fédération Autoimmunité et Thrombose, Lab Immunologie, Hopital de la Conception, 27 bd jean Moulin 13005, and INSERM U608, UFR de Pharmacie, Universite de la Mediterranee, Marseille, France
    Immunobiology 212:557-65. 2007
    ..Nevertheless, the substantial prevalence of anti-prothrombin antibodies in the aPL- group should be further explored in a large prospective study...
  61. ncbi Tiplaxtinin impairs nutritionally induced obesity in mice
    H Roger Lijnen
    Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, O and N 1, Box 911, Herestraat 49, B 3000 Leuven, Belgium
    Thromb Haemost 96:731-7. 2006
    ..03). Thus, in this model of diet-induced obesity in mice administration of tiplaxtinin resulted in impaired adipose tissue development...
  62. ncbi Modulation of adipose tissue development by pharmacological inhibition of PAI-1
    David L Crandall
    Cardiovascular and Metabolic Disease Research, Wyeth Research, N2265A, PO Box 42528, Philadelphia, PA 19101, USA
    Arterioscler Thromb Vasc Biol 26:2209-15. 2006
    ..The effect of a novel small molecule plasminogen activator inhibitor (PAI-1) inhibitor on adipose tissue physiology was investigated...
  63. ncbi PPARalpha deficiency does not modify age dependency but prevents high fat diet increase in plasma PAI-1 as well as insulin resistance
    Alenka Mavri
    Thromb Haemost 91:1051-2. 2004
  64. ncbi Nutritionally induced obesity is attenuated in transgenic mice overexpressing plasminogen activator inhibitor-1
    H Roger Lijnen
    Center for Molecular and Vascular Biology, University of Leuven, Belgium
    Arterioscler Thromb Vasc Biol 23:78-84. 2003
    ..The objective of this study was to investigate the role of plasminogen activator inhibitor-1 (PAI-1) in adipose tissue development in vivo...
  65. ncbi Relationships between fibrinolytic and inflammatory parameters in human adipose tissue: strong contribution of TNFalpha receptors to PAI-1 levels
    Delphine Bastelica
    Thromb Haemost 88:481-7. 2002
    ..Association between t-PA, which is mainly produced by endothelial cells, and IL-6 or TNF suggest that inflammation might be involved in angiogenesis in adipose tissue...
  66. ncbi Antiphosphatidylethanolamine antibodies are associated with an increased odds ratio for thrombosis. A multicenter study with the participation of the European Forum on antiphospholipid antibodies
    Marielle Sanmarco
    Fédération Autoimmunité et Thrombose, Laboratoire d Immunologie, Hopital de la Conception, CHU 147, Bd Baille, 13385 Marseille Cedex 05, France
    Thromb Haemost 97:949-54. 2007
    ....
  67. ncbi Development of a genotype 325-specific proCPU/TAFI ELISA
    Ann Gils
    Laboratory for Pharmaceutical Biology and Phytopharmacology, Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, E Van Evenstraat 4, B 3000 Leuven, Belgium
    Arterioscler Thromb Vasc Biol 23:1122-7. 2003
    ..A Thr/Ile polymorphism at position 325 in the coding region of proCPU has been reported. Immunological assays, fully characterized (including genotype dependency), are required for the quantitation of proCPU levels...
  68. ncbi Expression of the mRNA coding for 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue from obese patients: an in situ hybridization study
    Odile Paulmyer-Lacroix
    Laboratoire de Neuroendocrinologie Experimentale, Institut National de la Santé et de la Recherche Médicale U501, UFR de Médecine secteur Nord, Boulevard Pierre Dramard, 13916 Marseille Cedex 20, France
    J Clin Endocrinol Metab 87:2701-5. 2002
    ..This observation suggests that an overexpression of 11beta-HSD-1 may explain part of the glucocorticoid-induced metabolic disorders linked to obesity and may promote visceral fat deposition...