Genomes and Genes
- Henoch-Schönlein Purpura in adults: outcome and prognostic factorsEvangeline Pillebout
INSERM U426, Faculte de Medecine X Bichat, Université Paris 07, Paris, France
J Am Soc Nephrol 13:1271-8. 2002..Identification of clinical and histologic prognostic factors may permit the design of appropriate therapeutic prospective studies...
- Impact of unplanned extubation and reintubation after weaning on nosocomial pneumonia risk in the intensive care unit: a prospective multicenter studyArnaud de Lassence
Medical ICU, Avicenne Hospital, Bobigny, France
Anesthesiology 97:148-56. 2002....
- Pulmonary function tests in preschool children with asthmaNicole Beydon
Physiology Department of the Robert Debré Teaching Hospital, Grenoble, France
Am J Respir Crit Care Med 168:640-4. 2003..Pulmonary function tests that do not require active cooperation may help in the management and follow-up of preschool children with asthma who are unable to perform forced expiratory maneuvers...
- Nosocomial infection and multidrug-resistant bacteria surveillance in intensive care units: a survey in FranceFrançois L'heriteau
C CLIN Paris Nord, Paris VI University
Infect Control Hosp Epidemiol 26:13-20. 2005..To evaluate nosocomial infection (NI) surveillance strategies in French ICUs and to identify similar patterns defining subsets within which comparisons can be made...
- The spectrum of cardiac anomalies in Noonan syndrome as a result of mutations in the PTPN11 geneYves Sznajer
Department of Medical Genetics, AP HP Robert DEBRE University Hospital, Paris, France
Pediatrics 119:e1325-31. 2007..We report the heart defects and links to gene dysfunction in cardiac development in a large cohort of patients with type 1 Noonan syndrome...
- Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort studyCorinne Alberti
Department of Biostatistics, Saint Louis Hospital, Paris, France
Intensive Care Med 28:108-21. 2002..To examine the incidence of infections and to describe them and their outcome in intensive care unit (ICU) patients...
- Influence of systemic inflammatory response syndrome and sepsis on outcome of critically ill infected patientsCorinne Alberti
Service de Sante Publique, 48 Boulevard Serurier, 75019 Paris, France
Am J Respir Crit Care Med 168:77-84. 2003..Refinement of risk stratification of patients presenting with infection and no organ dysfunction is needed...
- Improving estimates of event incidence over time in populations exposed to other events: application to three large databasesCorinne Alberti
Departement de Biostatistique et Informatique Medicale, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75475 Paris, France
J Clin Epidemiol 56:536-45. 2003..A competing-risk approach must be used to analyze the risk of events other than death in cohort studies, particularly when mortality rates are high...
- Systemic inflammatory response and progression to severe sepsis in critically ill infected patientsCorinne Alberti
Clinical Epidemiology Unit, Hopital Robert Debre, Paris, France
Am J Respir Crit Care Med 171:461-8. 2005..The systemic inflammatory response syndrome has low specificity to identify infected patients at risk of worsening to severe sepsis or shock...
- Cyclophosphamide in steroid-dependent nephrotic syndromeSonia Azib
Pediatric Nephrology Department, Assistance Publique Hopitaux de Paris, Universite Paris 7, Hopital Robert Debre, Paris, France
Pediatr Nephrol 26:927-32. 2011..These findings suggest that despite the wide use of new immunosuppressive agents, a short course of CPO remains an effective second-line therapy in SDNS patients. Optimal efficiency was observed in children over 7.5 years...
- Novel modeling of reference values of cardiovascular risk factors in children aged 7 to 20 yearsHélène Mellerio
INSERM, Centre d Investigation Clinique Epidémiologie Clinique, CIE 5, Hopital Robert Debre, Paris, France
Pediatrics 129:e1020-9. 2012....
- Recruitment in pediatric clinical research was influenced by study characteristics and pediatricians' perceptions: a multicenter surveyFlorentia Kaguelidou
AP HP, Hopital Robert Debre, Unité d Epidémiologie Clinique, 48 Boulevard Serurier, 75019, Paris, France
J Clin Epidemiol 66:1151-7. 2013..The aim of this survey was to quantify refusal rates and identify factors of refusal pertaining to studies and recruiting pediatricians in the research recruitment process...
- Growth in boys with idiopathic nephrotic syndrome on long-term cyclosporin and steroid treatmentValerie Leroy
Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Service de Nephrologie Pediatrique, Paris, France
Pediatr Nephrol 24:2393-400. 2009..Careful monitoring of growth is recommended, given than up to 25% of patients experienced severe growth retardation during the course of their disease...
- Post-ICU mortality in critically ill infected patients: an international studyElie Azoulay
Intensive Care Unit, Saint Louis Hospital, Paris 7 University, 1 Avenue Claude, Vellefaux, 75010 Paris, France
Intensive Care Med 31:56-63. 2005..To determine the incidence and risk factors for post-ICU mortality in patients with infection...
- Determinants of postintensive care unit mortality: a prospective multicenter studyElie Azoulay
Medical ICU, Hopital Saint Louis, Paris, France
Crit Care Med 31:428-32. 2003..We investigated determinants of post-ICU mortality, with special attention to this factor...
- Clinical and haematological risk factors for cerebral macrovasculopathy in a sickle cell disease newborn cohort: a prospective studyJulie Sommet
U 1123, ECEVE, Hopital Robert Debre, INSERM, Paris, France
Br J Haematol 172:966-77. 2016..Specific treatment for upper or lower-airway obstruction and indirect targeting of fetal haemoglobin and reticulocyte count by hydroxycarbamide could potentially reduce the risk of CV. ..
- Randomized controlled trial of parent therapeutic education on antibiotics to improve parent satisfaction and attitudes in a pediatric emergency departmentFrancois Angoulvant
AP HP, Hopital Robert Debre, Universite Paris Diderot, Sorbonne Paris Cité, Service d accueil des urgences pédiatriques, Paris, France AP HP, Hopital Robert Debre, Universite Paris Diderot, Sorbonne Paris Cité, Unité d Épidémiologie Clinique INSERM CIE5, Paris, France
PLoS ONE 8:e75590. 2013..To evaluate therapeutic education delivered in a pediatric emergency department to improve parents' satisfaction and attitudes about judicious antibiotic use...
- Impact of adverse events on outcomes in intensive care unit patientsMaite Garrouste Orgeas
Medical Surgical ICU, Saint Joseph Hospital Network, Paris, France
Crit Care Med 36:2041-7. 2008..To examine the association between predefined adverse events (AE) (including nosocomial infections) and intensive care unit (ICU) mortality, controlling for multiple adverse events in the same patient and confounding variables...
- Ileal involvement is age dependent in pediatric Crohn's diseaseUlrich Meinzer
Department of Paediatric Gastroenterology, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
Inflamm Bowel Dis 11:639-44. 2005..In contrast, colonic LFs are isolated and undergo little change during life. As a result, if LFs play a role in the occurrence of CD lesions, the distribution of ileal and colonic lesions is expected to be altered in small children...
- Consequences of being born small for gestational age on body composition: an 8-year follow-up studyTaly Meas
Institut National de la Santé et de la Recherche Médicale Unité 690, Hopital Robert Debre, 75019 Paris, France
J Clin Endocrinol Metab 93:3804-9. 2008..Increased fat mass has been reported in children and adults born small for gestational age (SGA). However, the progression of anthropometric parameters have been poorly documented in SGA adults...
- Effects of recombinant human growth hormone for 1 year on body composition and muscle strength in children on long-term steroid therapy: randomized controlled, delayed-start studyDominique Simon
Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Service d endocrinologie pédiatrique, 75019 Paris, France
J Clin Endocrinol Metab 98:2746-54. 2013..Recombinant human GH (rhGH) improves growth and body composition in glucocorticoid-treated children. Its effects on muscle strength are poorly evaluated...
- Impact of neutropenia duration on short-term mortality in neutropenic critically ill cancer patientsMichael Darmon
Medical Intensive Care Unit, Saint Louis University Hospital and Paris 7 University, 1 avenue Claude Vellefaux, 75010 Paris, France
Intensive Care Med 28:1775-80. 2002..To identify predictors of 30-day mortality and to assess the impact of neutropenia recovery (NR) on 30-day mortality in critically ill cancer patients (CICPs)...
- Peer review of grant applications: criteria used and qualitative study of reviewer practicesHendy Abdoul
AP HP, Hopital Robert Debre, Unité d Epidémiologie Clinique, Paris, France
PLoS ONE 7:e46054. 2012..Here, our goal was to determine how reviewers rate applications, by investigating reviewer practices and grant assessment criteria...
- Positive impact of long-term antithyroid drug treatment on the outcome of children with Graves' disease: national long-term cohort studyJuliane Leger
Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Service d endocrinologie pédiatrique, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, INSERM Unité 676, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
J Clin Endocrinol Metab 97:110-9. 2012..Drug-based therapy is usually the initial treatment for Graves' disease (GD) hyperthyroidism in children, but there is some debate about treatment duration...
- The clinical spectrum of severe imported falciparum malaria in the intensive care unit: report of 188 cases in adultsFabrice Bruneel
Clinique de Réanimation des Maladies Infectieuses et Tropicales, Hopital Bichat Claude Bernard, Assistance Publique Hopitaux de Paris, Paris, France
Am J Respir Crit Care Med 167:684-9. 2003..Severe imported malaria remains a major threat to travelers. In our population, the most relevant World Health Organization major defining criteria were coma, shock, pulmonary edema, and acidosis...
- Mycophenolate mofetil for steroid-dependent nephrotic syndrome: a phase II Bayesian trialVeronique Baudouin
Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Pediatric Nephrology Department, Universite Paris 7, 48 Boulevard Serurier, 75019, Paris, France
Pediatr Nephrol 27:389-96. 2012..MMF reduces relapse rate and steroid dose in children with SDNS and should be proposed before cyclosporine and cyclophosphamide...
- Fewer infants than older patients in paediatric randomised controlled trialsFrancois Angoulvant
AP HP, Hopital Robert Debre, Université Denis Diderot Paris VII, Unité INSERM CIE5, 48 Bd Serurier, 75019, Paris, France
Eur J Epidemiol 25:593-601. 2010....
- Academic pediatric clinical research: factors associated with study implementation durationDelphine Meier-Girard
Universite Paris Diderot, Sorbonne Paris Cité, UMR 1123 ECEVE, F 75019, Paris, France
BMC Med Res Methodol 16:36. 2016..Our objective was to identify factors associated with the implementation duration of hospital-based pediatric studies...
- Triiodothyronine-predominant Graves' disease in childhood: detection and therapeutic implicationsJulie Harvengt
Assistance Publique Hôpitaux de ParisService d Endocrinologie Diabétologie Pédiatrique, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Hopital Robert Debre, F 75019 Paris, FranceUniversité Paris DiderotSorbonne Paris Cité, F 75019 Paris, FranceInstitut National de la Santé et de la Recherche Médicale Inserm Unité 1141, DHU PROTECT, F 75019 Paris, FranceINSERMCIC 1426, UMR 1123, Paris, FranceAssistance Publique Hôpitaux de ParisService de Biochimie HormonologieAssistance Publique Hôpitaux de ParisUnité d Épidémiologie Clinique, Hopital Robert Debre, Paris, France
Eur J Endocrinol 172:715-23. 2015..To assess in a pediatric population, the clinical characteristics and management of triiodothyronine-predominant Graves' disease (T3-P-GD), a rare condition well known in adults, but not previously described in children...
- Adult social and professional outcomes of pediatric renal transplant recipientsHélène Mellerio
1 INSERM, CIE 5, Paris, France 2 Unité d Epidémiologie Clinique, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France 3 Université Paris Diderot, Sorbonne Paris Cité, Paris, France 4 Agence de la Biomédecine, Direction médicale et scientifique, Saint Denis La Plaine, France 5 Service de Néphrologie, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France 6 Address correspondence to Chantal Loirat, M D, Pediatric Nephrology Department, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
Transplantation 97:196-205. 2014..This nationwide French cohort study documented the socioprofessional outcomes of adults who underwent kidney transplantation before age 16 years between 1985 and 2002...
- Impact of glucose-6-phosphate dehydrogenase deficiency on sickle cell anaemia expression in infancy and early childhood: a prospective studyMalika Benkerrou
AP HP, Hopital Robert Debre, Service d Hématologie Pédiatrique, Paris, France Centre de Référence de la Drépanocytose, Paris, France INSERM, U763, Paris, France
Br J Haematol 163:646-54. 2013..These effects decrease after 2 years of age, presumably as the decline in fetal haemoglobin levels leads to increased sickle cell haemolysis and younger red blood cells with higher G6PD activity. ..
- Noninvitation of eligible individuals to participate in pediatric studies: a qualitative studyPhilippe Amiel
Institut Gustave Roussy, Villejuif, Unité de Recherche en Sciences Humaines et Sociales, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, Paris, France
Arch Pediatr Adolesc Med 161:446-50. 2007..To identify subjective factors that lead investigators not to invite eligible individuals to participate in pediatric studies...
- Factors influencing neurological outcome of children with bacterial meningitis at the emergency departmentFatiha Bargui
Department of Pediatric Emergency Care, APHP Hospital R Debré, Paris, France
Eur J Pediatr 171:1365-71. 2012..1-6.0) were associated with having one or more long-term neurologic deficits. Identification of children at risk of death or long-term neurologic sequelae may allow therapeutic interventions to be directed to children at the highest risk...
- Serum concentrations of insulin-like growth factor (IGF)-1 and IGF binding protein-3 (IGFBP-3), IGF-1/IGFBP-3 ratio, and markers of bone turnover: reference values for French children and adolescents and z-score comparability with other referencesCorinne Alberti
INSERM, CIC EC CIE5, Paris, France
Clin Chem 57:1424-35. 2011....
- Kidney transplant in black recipients: are African Europeans different from African Americans?Nicolas Pallet
Service de transplantation rénale, Hopital Necker, Paris, France
Am J Transplant 5:2682-7. 2005..The results of renal transplantation in patients of African origin could be improved with universal immunosuppressive drug coverage...
- Junior versus senior physicians for informing families of intensive care unit patientsDelphine Moreau
Service de Reanimation Medicale, Hopital Saint Louis, Paris, France
Am J Respir Crit Care Med 169:512-7. 2004..9 vs. 34.4%, p = 0.004). Specialty residents, if given opportunities for acquiring experience, can become proficient in communicating with families and share this task with senior physicians...
- Aetiology of arthritis in hospitalised children: an observational studyCamille Aupiais
Unité d Epidémiologie Clinique, AP HP, Hopital Robert Debre, Paris, France INSERM, U1123, Paris, France Univ Denis Diderot Paris 7, Sorbonne Paris Cité, Paris, France
Arch Dis Child 100:742-7. 2015..We aimed to describe the different types of arthritis among children hospitalised for a first episode of arthritis...
- Adjunctive steroid in HIV-negative patients with severe Pneumocystis pneumoniaVirginie Lemiale
Medical Intensive Care Unit, Saint Louis Teaching Hospital, 1 avenue Claude Vellefaux, Paris 75010, France
Respir Res 14:87. 2013..High-dose steroid therapy has been proven effective in AIDS-related Pneumocystis pneumonia (PCP) but not in non-AIDS-related cases. We evaluated the effects on survival of steroids in HIV-negative patients with PCP...
- Apparent diffusion coefficient measurements of the fetal brain during the third trimester of pregnancy: how reliable are they in clinical practice?Agnès Sartor
Service de Gynecologie Obstetrique, Hopital Robert Debre, AP HP, Inserm UMR 676, Université Paris Diderot Sorbonne Paris Cité, Paris, France
Prenat Diagn 34:357-66. 2014..The objective of this study was to determine the reproducibility, the inter-hemispheric difference and the reference apparent diffusion coefficient (ADC) values of the fetal brain according to gestational age...
- POPI (Pediatrics: Omission of Prescriptions and Inappropriate prescriptions): development of a tool to identify inappropriate prescribingSonia Prot-Labarthe
Pharmacie, AP HP Hôpital Robert Debré, Paris, France
PLoS ONE 9:e101171. 2014..Our aim is to develop a screening tool to identify omissions and inappropriate prescriptions in pediatrics based on French and international guidelines...
- How to improve the implementation of academic clinical pediatric trials involving drug therapy? A qualitative study of multiple stakeholdersDelphine Girard
Universite Paris Diderot, Sorbonne Paris Cité, Paris, France
PLoS ONE 8:e64516. 2013..The objective of this qualitative study was to collect information on the perceptions and experience of health professionals involved in hospital-based pediatric drug trials...
- Calibration and discrimination by daily Logistic Organ Dysfunction scoring comparatively with daily Sequential Organ Failure Assessment scoring for predicting hospital mortality in critically ill patientsJean Francois Timsit
Service de Reanimation Polyvalente, Hopital St Joseph, Paris, France
Crit Care Med 30:2003-13. 2002..The objective of this study was to evaluate how accurately daily LOD scoring predicts mortality comparatively with daily Sequential Organ Failure Assessment (SOFA) scoring...
- Nod2 mediates susceptibility to Yersinia pseudotuberculosis in miceUlrich Meinzer
INSERM, U843, Universite Paris 7, Hopital Robert Debre, Paris, France
PLoS ONE 3:e2769. 2008..This resistance phenotype was lost in case of intraperitoneal infection. We concluded that Nod2 contributes to the susceptibility to Y. pseudotuberculosis in mice...
- Malignant and benign thyroid nodules after total body irradiation preceding hematopoietic cell transplantation during childhoodMaritza Vivanco
Assistance Publique Hopitaux de Paris, Service d endocrinologie pédiatrique, Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
Eur J Endocrinol 167:225-33. 2012..The risk of radiation-induced benign and malignant thyroid nodules is well known...
- Aetiology and epidemiology of fever in children presenting to the emergency department of a French paediatric tertiary care centre after international travelJerome Naudin
Assistance Publique des Hopitaux de Paris, Service de Réanimation Pédiatrique, Hopital Robert Debre, Paris, France
Arch Dis Child 97:107-11. 2012..As few data are available on the causes of fever in children returning from international travel, the authors studied children presenting to a French tertiary care centre with fever...
- Addition of cyclophosphamide to steroids provides no benefit compared with steroids alone in treating adult patients with severe Henoch Schönlein PurpuraEvangeline Pillebout
Nephrology Department, Hopital Saint Louis, 1 av C Vellefaux, Paris, France
Kidney Int 78:495-502. 2010..The small population size of our study does not permit definitive conclusions; however, we suggest that treatment of adults with severe HSP by adding cyclophosphamide provides no benefit compared with steroids alone...
- Microstructural development of human brain assessed in utero by diffusion tensor imagingTony Bui
Department of Paediatric Imaging, Hopital Robert Debre, AP HP, 48 Boulevard Serurier, Paris 75019, France
Pediatr Radiol 36:1133-40. 2006..Comparison of cerebral diffusion properties between preterm infants and fetuses of corresponding ages should assist in determining the impact of premature ex utero life on brain maturation...
- Alternate-site testing is reliable in children and adolescents with type 1 diabetes, except at the forearm for hypoglycemia detectionNadine Lucidarme
Department of Endocrinology, Robert Debre Teaching Hospital, 75019 Paris, France
Diabetes Care 28:710-1. 2005
- Pre/postbronchodilator interrupter resistance values in healthy young childrenNicole Beydon
Physiology Department, Robert Debre Teaching Hospital, Paris, France
Am J Respir Crit Care Med 165:1388-94. 2002..Sex did not affect pre- or postbronchodilator values. Data from the present study may prove useful for testing lung function in young children with respiratory disorders who failed to cooperate with forced expiratory maneuvers...
- Identification of women at high risk for severe perineal lacerationsThomas Schmitz
AP HP, Hopital Robert Debre, Service de Gynecologie Obstetrique, 75019 Paris, France Université Paris Diderot, Sorbonne Paris Cité, 75019 Paris, France Electronic address
Eur J Obstet Gynecol Reprod Biol 182:11-5. 2014..To evaluate the frequency and to identify the risk factors of severe perineal lacerations and the subgroup of women exposed to the highest risk for these complications...
- Aspergillus in the lower respiratory tract of immunocompetent critically ill patientsMaxime Lugosi
Medical Intensive Care Unit, Research Group on Acute Respiratory Failure in Hematology and Oncology Patients, Saint Louis Hospital and Paris 7 Denis Diderot University, Paris, France Grenoble 1 University, Medical Intensive Care Unit, Albert Michallon University Hospital, Grenoble, France Grenoble 1 University, Albert Bonniot Institute, Team 11 Outcome of Airway Cancers and Mechanically Ventilated Patients, Grenoble, France
J Infect 69:284-92. 2014..To shed light on the meaning of Aspergillus-positive lower-respiratory-tract samples in non immunocompromized critically ill patients...
- Quality indicator development and implementation in maternity unitsRym Boulkedid
AP HP, Hopital Robert Debre, Unité d Epidémiologie Clinique, Paris, France INSERM, CIE 5, Paris, France
Best Pract Res Clin Obstet Gynaecol 27:609-19. 2013..Cumulative sum charts provide clinicians with a picture of current practices, and rapidly detect unwanted changes in quality indicator rates. ..
- Crohn's disease: the cold chain hypothesisJean Pierre Hugot
Laboratoire de Génétique des Maladies Inflammatoires de l Intestin, Projet Avenir INSERM, Fondation Jean Dausset CEPH, Paris, France
Lancet 362:2012-5. 2003....
- Subtle health impairment and socioeducational attainment in young adult patients with congenital hypothyroidism diagnosed by neonatal screening: a longitudinal population-based cohort studyJuliane Leger
Pediatric Endocrinology Department, centre de référence maladies endocriniennes rares de la croissance, Institut National de la Santé et de la Recherche Médicale Unité 676, Hopital Robert Debre, 48 Bd Serurier, 75019 Paris, France
J Clin Endocrinol Metab 96:1771-82. 2011..Screening programs resulting in the early treatment of patients with congenital hypothyroidism (CH) have successfully improved neurodevelopmental outcome, but little is known about long-term health...
- Variation in serum and plasma PTH levels in second-generation assays in hemodialysis patients: a cross-sectional studyDominique Joly
Service de Nephrologie, Laboratoire d Explorations Fonctionnelles and Inserm Unit 845, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Universite Paris Descartes, Paris, France
Am J Kidney Dis 51:987-95. 2008..In this cross-sectional study, we aim to determine the usefulness of standardizing blood handling for optimal interpretation of PTH in patients with chronic kidney disease...
- Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndromeAnne Laure Sellier-Leclerc
Service de Nephrologie, Assistance Publique Hopitaux de Paris, Hopital Robert Debre, 48 Boulevard Serurier, 75 019 Paris, France
J Am Soc Nephrol 18:2392-400. 2007..New therapies are urgently needed, and further research should elucidate the unexplained HUS group...
- Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatmentFlorentia Kaguelidou
Institut National de la Santé et de la Recherche Médicale U690, Hopital Robert Debre, 75019 Paris, France
J Clin Endocrinol Metab 93:3817-26. 2008..There is debate about how Graves' disease (GD) should be treated in children...
- Pulmonary function tests in preschool children with cystic fibrosisNicole Beydon
Department of Physiology of the Robert Debré Teaching Hospital, Paris, France
Am J Respir Crit Care Med 166:1099-104. 2002..04). Genotype did not influence the data. We conclude that Rint(exp) and functional residual capacity measurements may help to follow young children with CF who are unable to perform reproducible forced expiratory maneuvers...
- Insulin treatment of maternal diabetes mellitus and respiratory outcome in late-preterm and term singletonsOdile Becquet
Neonatal Intensive Care Unit, Universite Paris Diderot, Sorbonne Paris Cité, Paris, France Assistance Publique Hôpitaux de Paris, Hopital Robert Debre, Paris, France PremUP Foundation, Paris, France
BMJ Open 5:e008192. 2015..We asked the question whether DM status and its treatment during pregnancy could influence the risk of neonatal respiratory distress...
- Abnormal spindle-like microcephaly-associated (ASPM) mutations strongly disrupt neocortical structure but spare the hippocampus and long-term memorySandrine Passemard
INSERM, U1141, Hopital Robert Debre, Paris, France Université Paris Diderot Sorbonne Paris Cité, Paris, France Département de Génétique, Hopital Robert Debre, AP HP, Paris, France Service de neuropédiatrie, Hopital Robert Debre, AP HP, Paris, France Electronic address
Cortex 74:158-76. 2016..The precise characterization of the cortical map and cognitive abilities of patients with ASPM mutations should allow developing more focused reeducative interventions well-suited to their real abilities. ..
- Hemodialysis without systemic anticoagulation: a prospective randomized trial to evaluate 3 strategies in patients at risk of bleedingBruno Guery
Universite Paris Descartes, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Service de Nephrologie, Hopital Necker Enfants Malades, Paris, France
PLoS ONE 9:e97187. 2014..In this clinical trial, we aimed to compare three means of performing chronic hemodialysis in patients with contra-indication to systemic heparinization...
- Quality indicators for continuous monitoring to improve maternal and infant health in maternity departments: a modified Delphi survey of an international multidisciplinary panelRym Boulkedid
AP HP, Hopital Robert Debre, Unité d Epidémiologie Clinique, Paris, France
PLoS ONE 8:e60663. 2013..However, there is no consensus about which measures are optimal. We describe a modified Delphi method to identify a set of indicators for continuously monitoring the quality of maternity care by healthcare professionals...
- Non-financial conflicts of interest in academic grant evaluation: a qualitative study of multiple stakeholders in FranceHendy Abdoul
AP HP, Hopital Robert Debre, Unité d Epidémiologie Clinique, Paris, France
PLoS ONE 7:e35247. 2012..Few observational studies have assessed these issues. We report the results of a qualitative study on reviewers' and applicants' perceptions and experiences of CoIs in reviews of French academic grant applications...
- Octogenarians reaching end-stage renal disease: cohort study of decision-making and clinical outcomesDominique Joly
Nephrology Unit, Necker Hospital and Université René Descartes Paris V, Paris, France
J Am Soc Nephrol 14:1012-21. 2003....
- Inter-observer variability in chest radiograph reading for diagnosing acute lung injury in childrenFrancois Angoulvant
Service de réanimation et surveillance continue pédiatriques, Hopital Robert Debre, Assistance Publique Hôpitaux de Paris et Université Paris Diderot Paris VII, Paris, France
Pediatr Pulmonol 43:987-91. 2008..Given the low incidence of ALI/ARDS in children, this variability may have a large impact in studies of pediatric ALI/ARDS...
- Enhanced expression of the CD71 mesangial IgA1 receptor in Berger disease and Henoch-Schönlein nephritis: association between CD71 expression and IgA depositsElie Haddad
Service de Nephrologie, Service de Sante Publique, EA 3102, Université Paris 7 and Service de Pathologie, Hopital Robert Debre, Assistance Publique Hopitaux de Paris, Paris, France
J Am Soc Nephrol 14:327-37. 2003..However, the association between IgA deposits and CD71 expression and their co-localization in the mesangium provide strong evidence that CD71 is a major IgA receptor on mesangial cells...
- Drug administration errors and their determinants in pediatric in-patientsSonia Prot
Pharmacy Unit, Hôpital Robert Debré AP HP, Paris, France
Int J Qual Health Care 17:381-9. 2005..To quantify the type and frequency of drug administration errors to pediatric in-patients and to identify associated factors...
- Genotype-phenotype correlations in fetuses and neonates with autosomal recessive polycystic kidney diseaseErick Denamur
Assistance Publique Hopitaux de Paris, Universite Paris Diderot, Hopital Robert Debre, Laboratoire de Biochimie Genetique, INSERM U722, Paris, France
Kidney Int 77:350-8. 2010..Their absence, however, does not guarantee survival to the neonatal period...
- Juvenile myelomonocytic leukaemia and Noonan syndromeMarion Strullu
INSERM UMR_S1131, Institut Universitaire d Hematologie, Universite Paris Diderot, Paris Sorbonne Cité, Paris, France Département de Génétique, Assistance Publique des Hopitaux de Paris AP HP, Hopital Robert Debre, Paris, France
J Med Genet 51:689-97. 2014..Whereas sporadic JMML is known to be aggressive, JMML occurring in patients with NS is often considered as benign and transitory. However, little information is available regarding the occurrence and characteristics of JMML in NS...
- Measuring the outcome of biomedical research: a systematic literature reviewFrédérique Thonon
European and International Affairs Unit, Gustave Roussy, Villejuif, France AP HP, Hopital Robert Debre, Unité d Epidémiologie Clinique, Paris, France Université Paris Diderot, Sorbonne Paris Cité, UMR S 1123 and CIC EC 1426, ECEVE, Paris, France
PLoS ONE 10:e0122239. 2015....
- Describing ICU data with tablesCorinne Alberti
AP HP, Hopital Robert Debre, Unité d Epidémiologie Clinique, 48 Bd Serurier, 75019, Paris, France
Intensive Care Med 40:667-73. 2014..Good tables are an integral part of the manuscript. To help researchers communicate their results, we present practical guidance for reporting statistical results using tables...
- Impact of unlabeled French antibiotic guidelines on antibiotic prescriptions for acute respiratory tract infections in 7 Pediatric Emergency Departments, 2009-2012Francois Angoulvant
From the Hôpitaux de Paris APHP, Pediatric Emergency Department, Hôpital Robert Debré and Université Paris 7 Denis Diderot, Paris Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Reproduction and Child Development Team, Villejuif Hôpitaux de Paris APHP, Pediatric Department, Hôpital Antoine Béclère and Université Paris 11, Clamart Hôpitaux de Paris APHP, Pediatric Department, Hôpital Ambroise Paré and Université Versailles Saint Quentin en Yvelines, Boulogne Hôpitaux de Paris APHP, Pediatric Department, Hôpital Bicêtre and Université Paris 11, Kremlin Bicêtre Hôpitaux de Paris APHP, Pediatric Department, Hôpital Jean Verdier and Université Paris 13, Bondy Hôpitaux de Paris APHP, Pediatric Department, Hôpital Louis Mourier and Université Paris 7 Denis Diderot, Colombes Hôpitaux de Paris APHP, Pediatric Emergency Department, Hôpital Armand Trousseau and Université Paris 6 Descartes, Paris Pediatric Department, Centre Hospitalier Intercommunal, Créteil and Hôpitaux de Paris APHP, Clinical Epidemiologic Unit and INSERM CIE 5, Hôpital Robert Debré and Université Paris 7 Denis Diderot, Paris, France
Pediatr Infect Dis J 33:330-3. 2014..Amoxicillin prescriptions rose from 30.0% to 84.7%, while amoxicillin-clavulanate and cefpodoxime prescriptions decreased to 10.2% and 2.5%, respectively. ..
- A prospective study of the efficacy and tolerance of a chimeric antibody to tumor necrosis factors (remicade) in severe pediatric crohn diseaseJean Pierre Cezard
Pediatric Gastroenterology Unit, Hopital Robert Debre, dagger Pediatric Gastroenterology Unit, Hopital Necker Enfants Malades, and double dagger Laboratory of Coprology, Hopital Pitie Salpetriere, Paris, France
J Pediatr Gastroenterol Nutr 36:632-6. 2003..One patient received only one injection. Eighteen patients were corticosteroid dependent, and 6 were receiving parenteral nutrition. Three patients were corticoid resistant (1 mg/kg/d >15 days). Sixteen had perianal disease...
- Randomized controlled trials of antibiotics for neonatal infections: a systematic reviewFlorentia Kaguelidou
Department of Paediatric Pharmacology and Pharmacogenetics, INSERM CIC9202, Hopital Robert Debre, 48 Boulevard Serurier, Paris, France
Br J Clin Pharmacol 76:21-9. 2013..We reviewed medical literature to assess the characteristics and quality of randomized controlled trials on antibiotics in neonatal infections...
- Atropine for critical care intubation in a cohort of 264 children and reduced mortality unrelated to effects on bradycardiaPeter Jones
Critical Care Group Portex Unit, Institute of Child Health, University College London, London, Great Britain
PLoS ONE 8:e57478. 2013..Atropine has is currently recommended to facilitate haemodynamic stability during critical care intubation. Our objective was to determine whether atropine use at induction influences ICU mortality...
- Proficiency program for real-time PCR diagnosis of Bordetella pertussis infections in French hospital laboratories and at the French National Reference Center for Whooping Cough and other BordetellosesValerie Caro
Institut Pasteur, Centre National de Référence CNR de la Coqueluche et autres Bordetelloses, Paris, France
J Clin Microbiol 47:3197-203. 2009..However, the risk of false-positive results remains quite high, and we strongly recommend establishment of uniform quality control procedures performed regularly...
- Time course of catch-up in adiposity influences adult anthropometry in individuals who were born small for gestational ageNadia Ezzahir
INSERM U457, Robert Debre Hospital, 75019 Paris, France
Pediatr Res 58:243-7. 2005..Whether this observation holds through regarding the metabolic syndrome remains to be elucidated...
- HLA alleles and haplotypes in French North African immigrantsBeatrice Pedron
Laboratory of Immunology, Hopital Robert Debre, Paris, France
Hum Immunol 67:540-50. 2006..6% of the total haplotypes in North Africans but 2.4% in controls. These results thus suggest a low degree of admixture between the two populations...
- Clinical outcome of cystic fibrosis presenting with or without meconium ileus: a matched cohort studyAnne Munck
Cystic Fibrosis Centre, Hospital Robert Debré 48, bd Serurier, 75019 Paris, France
J Pediatr Surg 41:1556-60. 2006..This matched case-control study compared the nutritional and the pulmonary long-term outcomes of cystic fibrosis (CF) patients presenting a history of meconium ileus (MI) with early-diagnosed symptomatic CF without MI (non-MI)...
- Lower bone mineral content in children with type 1 diabetes mellitus is linked to female sex, low insulin-like growth factor type I levels, and high insulin requirementJuliane Leger
Pediatric Endocrinology Unit and INSERM U 690, Hopital Robert Debre, 48 Boulevard Serurier, 75019 Paris, France
J Clin Endocrinol Metab 91:3947-53. 2006..Studies on bone mineral characteristics in children with type 1 diabetes mellitus (T1DM) have generated conflicting results...
- Effect of transfusion therapy on cerebral vasculopathy in children with sickle-cell anemiaBrigitte Bader-Meunier
Assistance Publique Hopitaux de Paris, Service d Hématologie Pédiatrique, Hopital Necker, Paris, France
Haematologica 94:123-6. 2009..Further studies are needed to determine whether different therapeutic approaches have to be considered according to these different evolutive patterns in SS children...
- Improvement in bone mineral density and body composition in survivors of childhood acute lymphoblastic leukemia: a 1-year prospective studyDaniela Marinovic
Pediatric Endocrinology Unit and Institut National de la Santé et de la Recherche Médicale U 457, Paris, France
Pediatrics 116:e102-8. 2005..In the present study, 1-year longitudinal changes in BMD, body composition, and bone metabolism were evaluated in children with ALL during the first 3 years after completion of therapy without cranial irradiation...
- Tracheostomy does not improve the outcome of patients requiring prolonged mechanical ventilation: a propensity analysisChristophe Clec'h
Intensive Care Unit, Avicenne Teaching Hospital, 125 route de Stalingrad, 93000 Bobigny, France
Crit Care Med 35:132-8. 2007..To examine the association between the performance of a tracheostomy and intensive care unit and postintensive care unit mortality, controlling for treatment selection bias and confounding variables...
- Pneumothorax in the intensive care unit: incidence, risk factors, and outcomeArnaud de Lassence
Medical Intensive Care Unit, Assistance Publique Hopitaux de Paris, Louis Mourier Teaching Hospital, Colombes, France
Anesthesiology 104:5-13. 2006..The risk factors and outcomes of critically ill patients with iatrogenic pneumothorax (IP) have not been studied in a large unselected intensive care unit (ICU) population...
- The relationship between the GH/IGF-I axis and serum markers of bone turnover metabolism in healthy childrenJuliane Leger
Pediatric Endocrinology Department, Centre de Référence des Maladies Endocriniennes Rares de la Croissance and INSERM Unit 690, Assistance Publique Hopitaux de Paris, Universite Paris VII, Robert Debre Hospital, France
Eur J Endocrinol 157:685-92. 2007..There is evidence to suggest that IGF-I plays a role in regulating bone turnover...
- Epidemiology and economic evaluation of severe sepsis in France: age, severity, infection site, and place of acquisition (community, hospital, or intensive care unit) as determinants of workload and costChristophe Adrie
Medical Surgical ICU, Delafontaine Hospital, Saint Denis, France
J Crit Care 20:46-58. 2005..Severe sepsis is a leading cause of death in critically ill patients. We evaluated cost and workload according to infection site, place and time of acquisition, and severity...
- [Epidemiology of infection and sepsis in intensive care unit patients]Jean Roger Le Gall
Réanimation Médicale, Hopital Saint Louis, 1 avenue Claude Vellefaux 75010 Paris
Bull Acad Natl Med 188:1115-25; discussion 1125-6. 2004..Crude incidence rates of ICU infection were high, varying among ICUs and patient subsets. Thus, vital outcome depends not only on the severity of sepsis but also on the characteristics of the infection...
- High-dose plasma infusion versus plasma exchange as early treatment of thrombotic thrombocytopenic purpura/hemolytic-uremic syndromePaul Coppo
Laboratoire Hématopoïèse et Cellules souches, Institut Gustave Roussy, Villejuif, France
Medicine (Baltimore) 82:27-38. 2003..However, the large volumes of plasma required to reach complete remission may result in fluid overload, which may necessitate subsequent therapeutic plasma exchange...
- [Comparative study of hospital costs associated with human albumin 20% (Vialebex 20%) or polygeline as a fluid resuscitation strategy for cirrhotic ascites]Isabelle Durand-Zaleski
Santé Publique, Hopital Henri Mondor, Créteil 94
Presse Med 36:867-73. 2007..To compare the hospital costs associated with two fluid resuscitation strategies for cirrhotic ascites: one with human albumin 20% (Vialebex 20%) and one with polygeline...
- ICUs: from performance appraisal to executive dashboard?Corinne Alberti
Intensive Care Med 33:1313-5. 2007
- Efficacy of adequate early antibiotic therapy in ventilator-associated pneumonia: influence of disease severityChristophe Clec'h
Medical and Surgical ICU, Réanimation Médico Chirurgicale, Hopital Avicenne, 125 route de Stalingrad, 93009, Bobigny, France
Intensive Care Med 30:1327-33. 2004..To test the hypothesis that the outcome of patients with ventilator-associated pneumonia (VAP) depends on both their baseline severity at VAP onset and the adequacy of empirical antibiotic therapy...