P J Tienari

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Golli-MBP gene in multiple sclerosis susceptibility
    P J Tienari
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    J Neuroimmunol 81:158-67. 1998
  2. ncbi request reprint Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene
    P J Tienari
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Lancet 340:987-91. 1992
  3. ncbi request reprint A two-stage study on multiple sclerosis susceptibility and chromosome 2q33
    A Bonetti
    Department of Neurology, Biomedicum Helsinki, University of Helsinki, Helsinki University Central Hospital, Haartmaninkatu 4, Helsinki, Finland
    Genes Immun 5:142-6. 2004
  4. doi request reprint DARS2 mutations in mitochondrial leucoencephalopathy and multiple sclerosis
    P Isohanni
    Research Programme of Molecular Neurology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Med Genet 47:66-70. 2010
  5. ncbi request reprint Linkage disequilibrium between the MBP tetranucleotide repeat and multiple sclerosis is restricted to a geographically defined subpopulation in Finland
    H Pihlaja
    Department of Neurolofy, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Genes Immun 4:138-46. 2003
  6. ncbi request reprint A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2
    S Kuokkanen
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Nat Genet 13:477-80. 1996
  7. ncbi request reprint Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease
    P T Luoma
    Research Program of Molecular Neurology, Biomedicum Helsinki, Helsinki University, Helsinki, Finland
    Neurology 69:1152-9. 2007
  8. ncbi request reprint Contribution of APOE promoter polymorphisms to Alzheimer's disease risk
    J C Lambert
    INSERM U508, Institut Pasteur de Lille, Lille, France
    Neurology 59:59-66. 2002
  9. ncbi request reprint BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups
    G Xiromerisiou
    Neurogenetics Unit, Department of Neurology, University of Thessaly, Medical School, Papakyriazi 22 Street, Larissa 41222, Greece, and Helsinki University Centeral Hospital, Finland
    Neurosci Lett 415:59-63. 2007
  10. ncbi request reprint Cerebral amyloid angiopathy in a 95+ cohort: complement activation and apolipoprotein E (ApoE) genotype
    M Tanskanen
    Department of Pathology, University of Helsinki, Helsinki University Central Hospital, Finland
    Neuropathol Appl Neurobiol 31:589-99. 2005

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Golli-MBP gene in multiple sclerosis susceptibility
    P J Tienari
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    J Neuroimmunol 81:158-67. 1998
    ..These findings suggest a role for the Golli-MBP locus in MS susceptibility, at least in a subset of patients, and serve as a basis for highly focused attempts to identify predisposing mutation(s)...
  2. ncbi request reprint Genetic susceptibility to multiple sclerosis linked to myelin basic protein gene
    P J Tienari
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Lancet 340:987-91. 1992
    ..99 to 3.25 (theta = 0.00). The results suggest that in this population genetic predisposition to MS is closely linked to the MBP gene and that polymorphism at the MBP locus or an adjacent locus has a role in the aetiology of MS...
  3. ncbi request reprint A two-stage study on multiple sclerosis susceptibility and chromosome 2q33
    A Bonetti
    Department of Neurology, Biomedicum Helsinki, University of Helsinki, Helsinki University Central Hospital, Haartmaninkatu 4, Helsinki, Finland
    Genes Immun 5:142-6. 2004
    ..Our results provide preliminary evidence for two distinct MS susceptibility genes on 2q33 outside of CTLA4...
  4. doi request reprint DARS2 mutations in mitochondrial leucoencephalopathy and multiple sclerosis
    P Isohanni
    Research Programme of Molecular Neurology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    J Med Genet 47:66-70. 2010
    ..Mutations in DARS2, encoding mitochondrial aspartyl-tRNA synthetase, were recently shown to cause LBSL. The signs and symptoms show some overlap with the most common leucoencephalopathy of young adults, multiple sclerosis (MS)...
  5. ncbi request reprint Linkage disequilibrium between the MBP tetranucleotide repeat and multiple sclerosis is restricted to a geographically defined subpopulation in Finland
    H Pihlaja
    Department of Neurolofy, University of Helsinki and Helsinki University Hospital, Helsinki, Finland
    Genes Immun 4:138-46. 2003
    ....
  6. ncbi request reprint A putative vulnerability locus to multiple sclerosis maps to 5p14-p12 in a region syntenic to the murine locus Eae2
    S Kuokkanen
    Department of Human Molecular Genetics, National Public Health Institute, Helsinki, Finland
    Nat Genet 13:477-80. 1996
    ..Several markers yielded positive lod scores on 5p14-p12, syntenic to the murine locus Eae2. Our data provide evidence for a predisposing locus for MS on 5p14-p12...
  7. ncbi request reprint Mitochondrial DNA polymerase gamma variants in idiopathic sporadic Parkinson disease
    P T Luoma
    Research Program of Molecular Neurology, Biomedicum Helsinki, Helsinki University, Helsinki, Finland
    Neurology 69:1152-9. 2007
    ..This prompted us to carry out a detailed analysis of the coding region and intron-exon boundaries of POLG1 in Finnish patients with idiopathic sporadic Parkinson disease (PD) and in nonparkinsonian controls...
  8. ncbi request reprint Contribution of APOE promoter polymorphisms to Alzheimer's disease risk
    J C Lambert
    INSERM U508, Institut Pasteur de Lille, Lille, France
    Neurology 59:59-66. 2002
    ..To determine whether the effects of APOE promoter polymorphisms on AD are independent of the APOE-epsilon4 allele...
  9. ncbi request reprint BDNF tagging polymorphisms and haplotype analysis in sporadic Parkinson's disease in diverse ethnic groups
    G Xiromerisiou
    Neurogenetics Unit, Department of Neurology, University of Thessaly, Medical School, Papakyriazi 22 Street, Larissa 41222, Greece, and Helsinki University Centeral Hospital, Finland
    Neurosci Lett 415:59-63. 2007
    ..In conclusion, our results do not provide statistically significant evidence that common genetic variability in BDNF would associate with the risk for PD in the Caucasian populations studied here...
  10. ncbi request reprint Cerebral amyloid angiopathy in a 95+ cohort: complement activation and apolipoprotein E (ApoE) genotype
    M Tanskanen
    Department of Pathology, University of Helsinki, Helsinki University Central Hospital, Finland
    Neuropathol Appl Neurobiol 31:589-99. 2005
    ..Our results demonstrate a strong association between CAA and ApoE epsilon4 as well as dementia and suggest that the contribution of CAA to dementia is largely independent of ApoE epsilon4...
  11. ncbi request reprint Assessment of a DJ-1 (PARK7) polymorphism in Finnish PD
    J Eerola
    Department of Neurology, Helsinki University Central Hospital and University of Helsinki, Biomedicum Helsinki, Neuroscience Programme, Finland
    Neurology 61:1000-2. 2003
    ..168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic PD in a Finnish case-control series. This gene does not play a major role in the genetic predisposition to PD in this population...
  12. ncbi request reprint Confirmation of the protective effect of iNOS in an independent cohort of Parkinson disease
    S Hague
    Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA
    Neurology 62:635-6. 2004
    ..The authors confirm the protective effect of this genotype (OR = 0.5, 95% CI 0.27 to 0.93) in an independent Finnish case-control series...
  13. ncbi request reprint Apolipoprotein E (APOE), PARKIN and catechol-O-methyltransferase (COMT) genes and susceptibility to sporadic Parkinson's disease in Finland
    J Eerola
    Department of Neurology, Helsinki University Central Hospital, and University of Helsinki, Biomedicum Helsinki, Neuroscience Programme C524, PL 700, Haartmaninkatu 8, Helsinki, Finland
    Neurosci Lett 330:296-8. 2002
    ..In contrast to reports in oriental populations, our results do not support a major role of APOE, PARKIN and COMT polymorphisms in PD susceptibility in the Finnish population...
  14. ncbi request reprint Association of lipoprotein lipase Ser447Ter polymorphism with brain infarction: a population-based neuropathological study
    L Myllykangas
    Department of Pathology, University of Helsinki and the Helsinki University Central Hospital, Finland
    Ann Med 33:486-92. 2001
    ..Here we tested for an association between brain infarction and two common polymorphisms of the LPL gene, Ser447Ter and Asn291 Ser...
  15. ncbi request reprint Chromosome 19q13 and multiple sclerosis susceptibility in Finland: a linkage and two-stage association study
    K Reunanen
    Department of Neurology, Helsinki University Central Hospital, and University of Helsinki, Neuroscience Programme, Biomedicum Helsinki, Haartmaninkatu 8, PL700, Finland
    J Neuroimmunol 126:134-42. 2002
    ..8). Taken together these results do not support a major role of chromosome 19q13.2-q13.3 in MS susceptibility among Finnish MS patients, whereas conclusions on the 19q13.1 subregion are less clear and this region requires further study...
  16. pmc Multiple sclerosis in Finland: incidence trends and differences in relapsing remitting and primary progressive disease courses
    M L Sumelahti
    School of Public Health, University of Tampere, PO Box 607, FIN 33101 Tampere, Finland
    J Neurol Neurosurg Psychiatry 74:25-8. 2003
    ....
  17. pmc Testing association between LRRK2 and Parkinson's disease and investigating linkage disequilibrium
    C Paisan-Ruiz
    J Med Genet 43:e9. 2006
    ..Common genetic variability in genes that contain PD causing mutations has previously been implicated as a risk factor for typical sporadic disease...
  18. ncbi request reprint Association of tau haplotype-tagging polymorphisms with Parkinson's disease in diverse ethnic Parkinson's disease cohorts
    H C Fung
    Molecular Genetics Unit, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurodegener Dis 3:327-33. 2006
    ..Several MAPT polymorphisms that define the tau H1 haplotype have been investigated for an association with PD with conflicting results; however, two meta-analyses support an association between haplotype H1 and PD...
  19. ncbi request reprint Survival of multiple sclerosis in Finland between 1964 and 1993
    M L Sumelahti
    School of Public Health, University of Tampere, Finland
    Mult Scler 8:350-5. 2002
    ..We were unable to show any significant effect due to calendar time of diagnosis or gender, as the risk of men was similar (risk ratio [RR] = 1.1, confidence interval [CI] 0.8-1.6) as compared to women...
  20. pmc Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations
    G Kristjansdottir
    Molecular Medicine, Department of Medical Sciences, Uppsala University, Uppsala, Sweden
    J Med Genet 45:362-9. 2008
    ..Here we investigated whether polymorphisms in the IRF5 gene would be associated with yet another disease with features of autoimmunity, multiple sclerosis (MS)...
  21. pmc How useful is [123I]beta-CIT SPECT in clinical practice?
    J Eerola
    Department of Neurology, HUCH, PO Box 340, FIN 00029 HUS, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 76:1211-6. 2005
    ..To assess the accuracy and clinical usefulness of [(123)I]beta-CIT (2beta-carbomethoxy-3beta-(4-iodophenyl)tropane) SPECT in the differential diagnosis of Parkinson's disease...