M Tarkkanen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint Comparative genomic hybridization of postirradiation sarcomas
    M Tarkkanen
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Haartmaninkatu 3, FIN 00014 Helsinki, Finland
    Cancer 92:1992-8. 2001
  2. ncbi request reprint Comparison of genetic changes in primary sarcomas and their pulmonary metastases
    M Tarkkanen
    Department of Medical Genetics, Haartman Institute, University of Helsinki and Laboratory of Medical Genetics, Helsinki University Central Hospital, Finland
    Genes Chromosomes Cancer 25:323-31. 1999
  3. ncbi request reprint Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry
    Maija Tarkkanen
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, P O Box 21, FI 00014 Helsinki, Finland
    Eur J Cancer 42:1172-80. 2006
  4. ncbi request reprint Comparison of cytogenetics, interphase cytogenetics, and DNA flow cytometry in bone tumors
    M Tarkkanen
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Cytometry 26:185-91. 1996
  5. ncbi request reprint DNA sequence copy number increase at 8q: a potential new prognostic marker in high-grade osteosarcoma
    M Tarkkanen
    Helsinki University Central Hospital, and Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Int J Cancer 84:114-21. 1999
  6. ncbi request reprint Comparative genomic hybridization of low-grade central osteosarcoma
    M Tarkkanen
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Mod Pathol 11:421-6. 1998
  7. pmc DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies
    S Knuutila
    Laboratory of Medical Genetics, Helsinki University Central Hospital, Finland
    Am J Pathol 152:1107-23. 1998
  8. pmc Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridization
    G Armengol
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Br J Cancer 75:1403-9. 1997
  9. pmc Growth rate of lung metastases and S-phase fraction as determined by flow cytometry from the primary tumour in 25 patients with bone or soft-tissue sarcomas
    C Blomqvist
    Department of Radiotherapy and Oncology, University of Helsinki, Finland
    Br J Cancer 73:1556-9. 1996
  10. pmc Measurement of growth rate of lung metastases in 21 patients with bone or soft-tissue sarcoma
    C Blomqvist
    Department of Radiotherapy and Oncology, University of Helsinki, Finland
    Br J Cancer 68:414-7. 1993

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Comparative genomic hybridization of postirradiation sarcomas
    M Tarkkanen
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Haartmaninkatu 3, FIN 00014 Helsinki, Finland
    Cancer 92:1992-8. 2001
    ..Postirradiation sarcomas arise within the radiation field after a latency period of several years and usually are highly malignant. Very little is yet known about their genetic changes...
  2. ncbi request reprint Comparison of genetic changes in primary sarcomas and their pulmonary metastases
    M Tarkkanen
    Department of Medical Genetics, Haartman Institute, University of Helsinki and Laboratory of Medical Genetics, Helsinki University Central Hospital, Finland
    Genes Chromosomes Cancer 25:323-31. 1999
    ..However, despite the heterogeneous and numerous changes, all pairs with aberrations in both specimens had some shared alterations in both samples. Genes Chromosomes Cancer 25:323-331, 1999...
  3. ncbi request reprint Malignant fibrous histiocytoma of bone: analysis of genomic imbalances by comparative genomic hybridisation and C-MYC expression by immunohistochemistry
    Maija Tarkkanen
    Department of Pathology, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, P O Box 21, FI 00014 Helsinki, Finland
    Eur J Cancer 42:1172-80. 2006
    ..Finally, the findings of the present study reflect well the high malignancy and aggressive nature of bone MFH...
  4. ncbi request reprint Comparison of cytogenetics, interphase cytogenetics, and DNA flow cytometry in bone tumors
    M Tarkkanen
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Cytometry 26:185-91. 1996
    ..Thus, the combined use of all three methods increased the sensitivity of aneuploidy detection...
  5. ncbi request reprint DNA sequence copy number increase at 8q: a potential new prognostic marker in high-grade osteosarcoma
    M Tarkkanen
    Helsinki University Central Hospital, and Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Int J Cancer 84:114-21. 1999
    ..04). Thus, specific genetic aberrations detected at the time of the diagnosis could be used in prognostic evaluation of high-grade osteosarcoma...
  6. ncbi request reprint Comparative genomic hybridization of low-grade central osteosarcoma
    M Tarkkanen
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Mod Pathol 11:421-6. 1998
    ..This simplicity differs from the complex aberrations seen in conventional high-grade osteosarcomas...
  7. pmc DNA copy number amplifications in human neoplasms: review of comparative genomic hybridization studies
    S Knuutila
    Laboratory of Medical Genetics, Helsinki University Central Hospital, Finland
    Am J Pathol 152:1107-23. 1998
    ..The paper with more than 150 references and two tables can be accessed from our web site http://www.helsinki.fi/lglvwww/CMG.html. The data will be updated biannually until the year 2001...
  8. pmc Recurrent gains of 1q, 8 and 12 in the Ewing family of tumours by comparative genomic hybridization
    G Armengol
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Br J Cancer 75:1403-9. 1997
    ..In conclusion, our findings confirm that secondary changes, which may have prognostic significance in ET, are trisomy 8, trisomy 12 and a gain of DNA sequences in 1q...
  9. pmc Growth rate of lung metastases and S-phase fraction as determined by flow cytometry from the primary tumour in 25 patients with bone or soft-tissue sarcomas
    C Blomqvist
    Department of Radiotherapy and Oncology, University of Helsinki, Finland
    Br J Cancer 73:1556-9. 1996
    ..48) was found between the logarithm of the S-phase fraction of the primary tumour (SPF) and the logarithm of the doubling time of lung metastases (T2). The estimated median cell loss factor was 88% (range 35-99%)...
  10. pmc Measurement of growth rate of lung metastases in 21 patients with bone or soft-tissue sarcoma
    C Blomqvist
    Department of Radiotherapy and Oncology, University of Helsinki, Finland
    Br J Cancer 68:414-7. 1993
    ..T2 was not a significant factor for survival in Cox-analysis (P = 0.10)...
  11. ncbi request reprint Primary soft tissue sarcoma and its local recurrence: genetic changes studied by comparative genomic hybridization
    P Popov
    Department of Plastic Surgery, , Helsinki University Central Hospital, Finland
    Mod Pathol 14:978-84. 2001
    ..3 was not detected in any of the primary tumors. Although all these alterations were not specific to local recurrences, they may represent changes important during tumor progression...
  12. pmc A web-based prognostic tool for extremity and trunk wall soft tissue sarcomas and its external validation
    M Sampo
    Department of Pathology, HUSLAB and University of Helsinki, PO Box 400, HUCH 00029, Helsinki, Finland
    Br J Cancer 106:1076-82. 2012
    ..We developed a web-based, prognostic tool for extremity and trunk wall soft tissue sarcoma to predict 10-year sarcoma-specific survival. External validation was performed...
  13. pmc No evidence of microsatellite instability in bone tumours
    M Tarkkanen
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Finland
    Br J Cancer 74:453-5. 1996
    ..e. in 38% of the tumour samples, most frequently with markers D2S136 at 2p (eight of 28 informative specimens, 29%) and D11S904 at 11p (four of 21 informative specimens, 19%)...
  14. ncbi request reprint Impact of the smallest surgical margin on local control in soft tissue sarcoma
    M Sampo
    Department of Pathology, HUSLAB and University of Helsinki, Helsinki, Finland
    Br J Surg 95:237-43. 2008
    ..The aim was to review a single-institution experience of a prospective treatment protocol for soft tissue sarcoma of the extremity and trunk wall, with particular focus on the smallest surgical margin leading to local control...
  15. doi request reprint Microvascular reconstruction after resection of soft tissue sarcoma of the leg
    I Barner-Rasmussen
    Department of Plastic Surgery, Toolo Hospital, Helsinki, Finland
    Br J Surg 96:482-9. 2009
    ..Limb-sparing surgery and satisfactory functional outcome is the goal of extremity soft tissue sarcoma (STS) surgery. Tissue defects after tumour excision are often extensive, and microvascular reconstruction is frequently required...
  16. doi request reprint Osteosarcoma in Finland from 1971 through 1990: a nationwide study of epidemiology and outcome
    Mika M Sampo
    Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland
    Acta Orthop 79:861-6. 2008
    ..There have only been a few nationwide studies on the epidemiology and outcome of osteosarcoma. We report the clinical features, treatment, and prognosis of osteosarcoma in Finland for the period 1971-1990...
  17. pmc DNA copy number losses in human neoplasms
    S Knuutila
    Department of Medical Genetics, Haartman Institute University of Helsinki, Finland
    Am J Pathol 155:683-94. 1999
    ..The chromosomal regions in which the most frequent losses are found implicate locations of essential tumor suppressor genes and DNA repair genes that may be involved in the pathogenesis of several tumor types...
  18. ncbi request reprint Gene amplifications in osteosarcoma-CGH microarray analysis
    Jassu Atiye
    Departments of Pathology and Medical Genetics, Haartman Institute and HUSLAB, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
    Genes Chromosomes Cancer 42:158-63. 2005
    ..Details (www.helsinki.fi/cmg) of the amplified genes in each amplicon provide valuable raw data for further in silico studies...
  19. ncbi request reprint Amplification of 17p11.2 approximately p12, including PMP22, TOP3A, and MAPK7, in high-grade osteosarcoma
    Maaike van Dartel
    Department of Human Genetics, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
    Cancer Genet Cytogenet 139:91-6. 2002
    ..2. Our findings suggest that multiple amplification targets, including PMP22, TOP3A, and MAPK7 or genes close to these candidate oncogenes, may be present in 17p11.2 approximately p12 and thus contribute to osteosarcoma tumorigenesis...
  20. ncbi request reprint Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone
    Claudia Maria Hattinger
    Laboratorio di Ricerca Oncologica, Istituti Ortopedici Rizzoli, Bologna, Italy
    Eur J Cell Biol 83:483-91. 2004
    ..Moreover, these findings suggest the possible presence of an autocrine loop in FS of bone, which might be taken into account for planning innovative therapeutic strategies for patients unresponsive to conventional treatments...