Affiliation: University of Helsinki
- Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjectsJarkko Soronen
FIMM, Institute for Molecular Medicine Finland, University of Helsinki, Finland
BMC Med Genomics 5:9. 2012..To get insight into molecular mechanisms underlying insulin resistance, we compared acute in vivo effects of insulin on adipose tissue transcriptional profiles between obese insulin-resistant and lean insulin-sensitive women...
- Genomic, transcriptomic, and lipidomic profiling highlights the role of inflammation in individuals with low high-density lipoprotein cholesterolPirkka Pekka Laurila
Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Finland
Arterioscler Thromb Vasc Biol 33:847-57. 2013....
- USF1 deficiency activates brown adipose tissue and improves cardiometabolic healthPirkka Pekka Laurila
Genomics and Biomarkers Unit, National Institute for Health and Welfare, Helsinki FI 00251, Finland Department of Medical Genetics, University of Helsinki, Helsinki FI 00014, Finland Institute for Molecular Medicine Finland, FIMM, Helsinki FI 00251, Finland
Sci Transl Med 8:323ra13. 2016..Our findings identify a new molecular link between lipid metabolism and energy expenditure, and point to the potential of USF1 as a therapeutic target for cardiometabolic disease. ..