Mikael Skurnik

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. ncbi request reprint My life with Yersinia
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland
    Adv Exp Med Biol 603:44-73. 2007
  2. pmc Characterization of the genome, proteome, and structure of yersiniophage ϕR1-37
    Mikael Skurnik
    Department of Bacteriology and Immunology, Infection Biology Research Programme, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Virol 86:12625-42. 2012
  3. pmc ECA-immunogenicity of Proteus mirabilis strains
    Katarzyna Anna Duda
    Department of Microbiology, Faculty of Biology and Environment Protection, University of Silesia, Katowice, Poland
    Arch Immunol Ther Exp (Warsz) 57:147-51. 2009
  4. doi request reprint Identification of distinct lipopolysaccharide patterns among Yersinia enterocolitica and Y. enterocolitica-like bacteria
    M Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, Infection Biology Research Program, University of Helsinki, Finland
    Biochemistry (Mosc) 76:823-31. 2011
  5. pmc Characterization and biological role of the O-polysaccharide gene cluster of Yersinia enterocolitica serotype O:9
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland
    J Bacteriol 189:7244-53. 2007
  6. ncbi request reprint Biotechnological challenges of phage therapy
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Biotechnol Lett 29:995-1003. 2007
  7. ncbi request reprint The biosynthesis and biological role of lipopolysaccharide O-antigens of pathogenic Yersiniae
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, P O Box 63, FIN 00014 Helsinki, Finland
    Carbohydr Res 338:2521-9. 2003
  8. ncbi request reprint Phage therapy: facts and fiction
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P O Box 21, Finland
    Int J Med Microbiol 296:5-14. 2006
  9. pmc Characterization of the six glycosyltransferases involved in the biosynthesis of Yersinia enterocolitica serotype O:3 lipopolysaccharide outer core
    Elise Pinta
    Department of Bacteriology and Immunology, Infection Biology Research Program, Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland
    J Biol Chem 285:28333-42. 2010
  10. doi request reprint Yersinia pestis Ail recruitment of C4b-binding protein leads to factor I-mediated inactivation of covalently and noncovalently bound C4b
    Derek K Ho
    Immunobiology Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Eur J Immunol 44:742-51. 2014

Collaborators

Detail Information

Publications59

  1. ncbi request reprint My life with Yersinia
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland
    Adv Exp Med Biol 603:44-73. 2007
    ....
  2. pmc Characterization of the genome, proteome, and structure of yersiniophage ϕR1-37
    Mikael Skurnik
    Department of Bacteriology and Immunology, Infection Biology Research Programme, Haartman Institute, University of Helsinki, Helsinki, Finland
    J Virol 86:12625-42. 2012
    ..The tail of ϕR1-37 has a contractile sheath. We conclude that phage ϕR1-37 is a representative of a novel phage type that carries the dU-containing genome in a ϕKZ-like head...
  3. pmc ECA-immunogenicity of Proteus mirabilis strains
    Katarzyna Anna Duda
    Department of Microbiology, Faculty of Biology and Environment Protection, University of Silesia, Katowice, Poland
    Arch Immunol Ther Exp (Warsz) 57:147-51. 2009
    ....
  4. doi request reprint Identification of distinct lipopolysaccharide patterns among Yersinia enterocolitica and Y. enterocolitica-like bacteria
    M Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, Infection Biology Research Program, University of Helsinki, Finland
    Biochemistry (Mosc) 76:823-31. 2011
    ..This work forms a basis of further structural, biochemical and genetic studies of these LPSs...
  5. pmc Characterization and biological role of the O-polysaccharide gene cluster of Yersinia enterocolitica serotype O:9
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland
    J Bacteriol 189:7244-53. 2007
    ..We showed that OPS and OC confer resistance to human complement and polymyxin B; the OPS effect on polymyxin B resistance could be observed only in the absence of OC...
  6. ncbi request reprint Biotechnological challenges of phage therapy
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Biotechnol Lett 29:995-1003. 2007
    ....
  7. ncbi request reprint The biosynthesis and biological role of lipopolysaccharide O-antigens of pathogenic Yersiniae
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki and Helsinki University Central Hospital Laboratory Diagnostics, P O Box 63, FIN 00014 Helsinki, Finland
    Carbohydr Res 338:2521-9. 2003
    ....
  8. ncbi request reprint Phage therapy: facts and fiction
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P O Box 21, Finland
    Int J Med Microbiol 296:5-14. 2006
    ..In vivo susceptibility of bacterial pathogens to bacteriophages is still largely poorly understood and future research on more phage-bacterium systems has to be undertaken to define the requirements for successful phage treatments...
  9. pmc Characterization of the six glycosyltransferases involved in the biosynthesis of Yersinia enterocolitica serotype O:3 lipopolysaccharide outer core
    Elise Pinta
    Department of Bacteriology and Immunology, Infection Biology Research Program, Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland
    J Biol Chem 285:28333-42. 2010
    ....
  10. doi request reprint Yersinia pestis Ail recruitment of C4b-binding protein leads to factor I-mediated inactivation of covalently and noncovalently bound C4b
    Derek K Ho
    Immunobiology Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Eur J Immunol 44:742-51. 2014
    ..Collectively, these data suggest that when C4BP is bound to Ail, fI can cleave and inactivate C4b that has bound covalently to bacterial surface structures as well as C4b bound noncovalently to Ail. ..
  11. doi request reprint Enterobacterial common antigen and O-specific polysaccharide coexist in the lipopolysaccharide of Yersinia enterocolitica serotype O:3
    Artur Muszynski
    Department of Microbiology, University of Silesia, Katowice, Poland
    Microbiology 159:1782-93. 2013
    ..Indeed, RNA-sequencing analysis showed significant downregulation of the ECA biosynthetic gene cluster at 37 °C. ..
  12. pmc Clinical isolates of Yersinia enterocolitica biotype 1A represent two phylogenetic lineages with differing pathogenicity-related properties
    Leila M Sihvonen
    Bacteriology Unit, National Institute for Health and Welfare, Helsinki, Finland
    BMC Microbiol 12:208. 2012
    ..enterocolitica BT 1A isolates in order to evaluate their relatedness and pathogenic potential...
  13. pmc Yersinia enterocolitica serum resistance proteins YadA and ail bind the complement regulator C4b-binding protein
    Vesa Kirjavainen
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    PLoS Pathog 4:e1000140. 2008
    ..These findings show that Y. enterocolitica uses two proteins, YadA and Ail, to bind C4bp. Binding of C4bp could help Y. enterocolitica to evade complement-mediated clearance in the human host...
  14. pmc The Yersinia adhesin YadA collagen-binding domain structure is a novel left-handed parallel beta-roll
    Heli Nummelin
    Macromolecular X ray Crystallography Group, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    EMBO J 23:701-11. 2004
    ..Such domains may therefore be a common bacterial strategy for avoiding host response...
  15. ncbi request reprint The Yersinia pseudotuberculosis outer membrane protein Ail recruits the human complement regulatory protein factor H
    Derek K Ho
    Infection Biology Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland
    J Immunol 189:3593-9. 2012
    ..Recruitment of both fH and C4BP by Ail may confer Y. pseudotuberculosis with the ability to resist all pathways of complement activation...
  16. doi request reprint Functional recruitment of the human complement inhibitor C4BP to Yersinia pseudotuberculosis outer membrane protein Ail
    Derek K Ho
    Infection Biology Program, Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, FIN 00014 Helsinki, Finland
    J Immunol 188:4450-9. 2012
    ..These results indicate that Y. pseudotuberculosis Ail recruits C4BP in a functional manner, facilitating resistance to attack from complement...
  17. doi request reprint Adhesins of human pathogens from the genus Yersinia
    Jack C Leo
    Institute of Biotechnology, Viikinkaari 1, University of Helsinki, FIN 00014, Helsinki, Finland
    Adv Exp Med Biol 715:1-15. 2011
    ..Also the plasminogen activator of Y. pestis can mediate adherence to host cells. Although the adhesins of the pathogenic yersiniae have been studied extensively, their exact roles in the biology of infection remain elusive...
  18. doi request reprint Bacterial cell surface structures in Yersinia enterocolitica
    Nataniel Białas
    Department of Microbiology, University of Silesia, Katowice, Poland
    Arch Immunol Ther Exp (Warsz) 60:199-209. 2012
    ..These structures ensure the correct architecture of the OM, provide adhesive properties as well as resistance to antimicrobial peptides and to host innate immune response mechanisms...
  19. doi request reprint The ail gene is present in some Yersinia enterocolitica biotype 1A strains
    Leila M Sihvonen
    Bacteriology Unit, National Institute for Health and Welfare THL, Helsinki, Finland
    Foodborne Pathog Dis 8:455-7. 2011
    ..The finding suggests that ail-based detection methods for Y. enterocolitica alone are insufficient to detect real pathogenic strains...
  20. pmc Functional mapping of YadA- and Ail-mediated binding of human factor H to Yersinia enterocolitica serotype O:3
    Marta Biedzka-Sarek
    Department of Bacteriology and Immunology, Haartman Institute, P O Box 21, 00014 University of Helsinki, Helsinki, Finland
    Infect Immun 76:5016-27. 2008
    ..On the other hand, the complement-sensitive Ail mutants were not affected in FH binding. Our results also suggested that Ail- and YadA-mediated CR does not depend solely on FH binding...
  21. ncbi request reprint Structural studies of Yersinia adhesin YadA
    Heli Nummelin
    Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Adv Exp Med Biol 529:85-8. 2003
  22. doi request reprint Real-time multiplex PCR assay for detection of Yersinia pestis and Yersinia pseudotuberculosis
    Pirjo Matero
    Helsinki University Central Hospital Laboratory Diagnostics, Helsinki, Finland
    APMIS 117:34-44. 2009
    ..pestis or Y. pseudotuberculosis total DNA. The sensitivity of the tetraplex assay was determined to be 1 cfu for the ypo2088 and pla probe labelled with FAM and JOE fluorescent dyes, respectively...
  23. ncbi request reprint ECA-antibodies in antisera against R mutants of Yersinia enterocolitica O:3
    Joanna Radziejewska-Lebrecht
    Department of Microbiology, University of Silesia, Katowice, Poland
    Adv Exp Med Biol 529:215-8. 2003
  24. pmc First analysis of a bacterial collagen-binding protein with collagen Toolkits: promiscuous binding of YadA to collagens may explain how YadA interferes with host processes
    Jack C Leo
    Macromolecular X ray Crystallography Group, Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, Helsinki, Finland
    Infect Immun 78:3226-36. 2010
    ..This leads to the intriguing possibility that YadA may interfere in vivo with host processes mediated by endogenous collagen-binding proteins...
  25. ncbi request reprint Molecular genetics, biochemistry and biological role of Yersinia lipopolysaccharide
    Mikael Skurnik
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland
    Adv Exp Med Biol 529:187-97. 2003
    ..Even though the amount of O-antigen is known to fluctuate under different growth conditions in many bacteria very little detailed information is available on the control of the O-antigen biosynthetic machinery...
  26. doi request reprint Identification and role of a 6-deoxy-4-keto-hexosamine in the lipopolysaccharide outer core of Yersinia enterocolitica serotype O:3
    Elise Pinta
    Infection Biology Research Program, Haartman Institute, Department of Bacteriology and Immunology, P O Box 21 Haartmaninkatu 3, 00014 University of Helsinki, Finland
    Chemistry 15:9747-54. 2009
    ....
  27. doi request reprint Identification of three oligo-/polysaccharide-specific ligases in Yersinia enterocolitica
    Elise Pinta
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Mol Microbiol 83:125-36. 2012
    ..This is the first report on the presence of three different oligo-/polysaccharide-specific ligases in a single bacterium...
  28. pmc Multilocus variable-number tandem-repeat analysis, pulsed-field gel electrophoresis, and antimicrobial susceptibility patterns in discrimination of sporadic and outbreak-related strains of Yersinia enterocolitica
    Leila M Sihvonen
    Department of Infectious Disease Surveillance and Control, Bacteriology Unit, National Institute for Health and Welfare THL, Helsinki, FI 00271, Finland
    BMC Microbiol 11:42. 2011
    ..MLVA using six VNTR markers was performed in two separate multiplex PCRs, and the fluorescently labeled PCR products were accurately sized on an automated DNA sequencer...
  29. pmc Role of YadA, Ail, and Lipopolysaccharide in Serum Resistance of Yersinia enterocolitica Serotype O:3
    Marta Biedzka-Sarek
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, P O Box 21, 00014, Finland
    Infect Immun 73:2232-44. 2005
    ..In normal serum, the bacteria were less resistant to C3b deposition. However, no direct correlation between the C3 deposition pattern and bacterial resistance was observed...
  30. ncbi request reprint Yersiniophages. Special reference to phi YeO3-12
    Maria I Pajunen
    Institute of Biotechnology, University of Helsinki, Department of Medical Biochemistry and Molecular Biology, University of Turku, Finland
    Adv Exp Med Biol 529:233-40. 2003
  31. ncbi request reprint Detection of a novel repeated sequence useful for epidemiological typing of pathogenic Yersinia enterocolitica
    Saija Hallanvuo
    Laboratory of Enteric Pathogens, National Public Health Institute KTL, Helsinki, Finland
    Int J Med Microbiol 292:215-25. 2002
    ..65 kb region was detected in European pathogenic serotypes O:1 and O:2 in addition to serotypes O:3, O:5,27 and O:9, indicating that it can be exploited in detecting and typing of European pathogenic serotypes in general...
  32. pmc Characterization of complement factor H binding to Yersinia enterocolitica serotype O:3
    Marta Biedzka-Sarek
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, 00014 Helsinki, Finland
    Infect Immun 76:4100-9. 2008
    ..We thus conclude that Y. enterocolitica, via YadA and Ail, recruits functionally active FH to its surface. FH binding appears to be an important mechanism of the complement resistance of this pathogen...
  33. pmc Identification of the lipopolysaccharide core of Yersinia pestis and Yersinia pseudotuberculosis as the receptor for bacteriophage φA1122
    Saija Kiljunen
    Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Turku, Turku, Finland
    J Bacteriol 193:4963-72. 2011
    ..e., also missing the Kdo/Ko region, was fully φA1122 resistant. Our data thus conclusively demonstrated that the φA1122 receptor is the Hep/Glc-Kdo/Ko region of the LPS core, a common structure in Y. pestis and Y. pseudotuberculosis...
  34. doi request reprint Several Hfq-dependent alterations in physiology of Yersinia enterocolitica O:3 are mediated by derepression of the transcriptional regulator RovM
    Katarzyna Leskinen
    Department of Bacteriology and Immunology, Medicum, Research Programs Unit, Immunobiology, University of Helsinki, Finland
    Mol Microbiol . 2016
    ..Finally, the impact of hfq and rovM mutations on the virulence was assessed in the mouse infection model. This article is protected by copyright. All rights reserved...
  35. pmc Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing
    Riikka Laukkanen-Ninios
    Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, P O Box 66, FI 00014, University of Helsinki, Finland
    Environ Microbiol 13:3114-27. 2011
    ..pseudotuberculosis s.s. In contrast, Y. pseudotuberculosis s.s., the Korean group and Y. pestis can all cause disease in humans...
  36. doi request reprint Detection and quantification of five major periodontal pathogens by single copy gene-based real-time PCR
    Kati Hyvärinen
    Institute of Dentistry, University of Helsinki, and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Helsinki, Finland
    Innate Immun 15:195-204. 2009
    ..821 (95% CI, 0.758-0.885, P50.001). Our prominently sensitive and specific assay may have major importance in the diagnosis, prevention, and treatment of periodontitis...
  37. ncbi request reprint Complete nucleotide sequence and likely recombinatorial origin of bacteriophage T3
    Maria I Pajunen
    Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, Finland
    J Mol Biol 319:1115-32. 2002
    ..This represents the first experimentally observed recombination between lytic phages whose normal hosts are different bacterial genera...
  38. doi request reprint Generation of a CRISPR database for Yersinia pseudotuberculosis complex and role of CRISPR-based immunity in conjugation
    Katja A Koskela
    Research and Development Department, Centre for Military Medicine, Helsinki, Finland
    Environ Microbiol 17:4306-21. 2015
    ..Also some spacer-positive strains were intermediate resistant to conjugation. This suggests that one or more other defence systems are determining conjugation efficiency independent of the CRISPR-Cas system. ..
  39. ncbi request reprint Isolation and characterisation of new Planococcus sp. strain able for aromatic hydrocarbons degradation
    Sylwia Labuzek
    Department of Biochemistry, Faculty of Biology and Environmental Protection, University of Silesia, Jagiellonska 28, 40 032 Katowice, Poland
    Acta Microbiol Pol 52:395-404. 2003
    ..Curing of the plasmid from the strain showed that plasmid pLS5 was involved in salicylate degradation by the meta pathway...
  40. ncbi request reprint Expression, purification and crystallization of a collagen-binding fragment of Yersinia adhesin YadA
    Heli Nummelin
    Structural Biology and Biophysics, Institute of Biotechnology, University of Helsinki, Viikinkaari 1, PO Box 65, FIN 00014 University of Helsinki, Finland
    Acta Crystallogr D Biol Crystallogr 58:1042-4. 2002
    ..Crystals belong to the trigonal space group R3, with unit-cell parameters a = b = 67.05, c = 221.95 A, and diffract to 1.55 A resolution on a synchrotron-radiation source...
  41. pmc RNA-Sequencing Reveals the Progression of Phage-Host Interactions between φR1-37 and Yersinia enterocolitica
    Katarzyna Leskinen
    Department of Bacteriology and Immunology, Medicum, and Research Programs Unit, Immunobiology, University of Helsinki, P O Box 21 Haartmaninkatu 3, FIN 00014 HY Helsinki, Finland
    Viruses 8:111. 2016
    ....
  42. doi request reprint Expression of the Yersinia enterocolitica O:3 LPS O-antigen and outer core gene clusters is RfaH-dependent
    Katarzyna Leskinen
    1Department of Bacteriology and Immunology, Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland
    Microbiology 161:1282-94. 2015
    ..enterocolitica O:3. It may be speculated that RfaH might have an in vivo role in controlling tissue-specific expression of bacterial surface oligo/polysaccharides. ..
  43. ncbi request reprint Characterization of the lipopolysaccharide outer core biosynthesis of Yersinia enterocolitica serotype O:3
    Elise Pinta
    Department of Medical Biochemistry and Molecular Biology, University of Turku
    Adv Exp Med Biol 529:211-3. 2003
  44. pmc Functional characterization of Gne (UDP-N-acetylglucosamine-4-epimerase), Wzz (chain length determinant), and Wzy (O-antigen polymerase) of Yersinia enterocolitica serotype O:8
    José Antonio Bengoechea
    Department of Medical Biochemistry and Molecular Biology, University of Turku, Finland
    J Bacteriol 184:4277-87. 2002
    ..coli galE mutant. Finally, we report that Yersinia Wzx has relaxed specificity for the translocated oligosaccharide, contrary to Wzy, which is strictly specific for the O-unit to be polymerized...
  45. ncbi request reprint Cloning and characterization of the Yersinia enterocolitica serotype O:9 lipopolysaccharide O-antigen gene cluster
    Peter S Lübeck
    Department of Bacteriology, Danish Veterinary Institute, Copenhagen, Denmark
    Adv Exp Med Biol 529:207-9. 2003
  46. pmc Nonessential genes of phage phiYeO3-12 include genes involved in adaptation to growth on Yersinia enterocolitica serotype O:3
    Saija Kiljunen
    Department of Medical Biochemistry and Molecular Biology, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland
    J Bacteriol 187:1405-14. 2005
    ..enterocolitica. These results indicate that phiYeO3-12 has adapted to utilize Y. enterocolitica as its host and that these adaptations include the products of genes 1.3 and 3.5, DNA ligase and lysozyme, respectively...
  47. ncbi request reprint Regulatory network of lipopolysaccharide O-antigen biosynthesis in Yersinia enterocolitica includes cell envelope-dependent signals
    José Antonio Bengoechea
    Department of Medical Biochemistry and Molecular Biology, University of Turku, Finland
    Mol Microbiol 44:1045-62. 2002
    ..Finally, we demonstrate that overexpression of Wzz causes membrane stress that activates the CpxAR two-component signal transduction system...
  48. ncbi request reprint Transposon mutagenesis of the phage phi YeO3-12
    Saija Kiljunen
    Department of Medical Biochemistry and Molecular Biology, University of Turku, Finland
    Adv Exp Med Biol 529:245-8. 2003
  49. ncbi request reprint Analysis of enterocoliticin, a phage tail-like bacteriocin
    Eckhard Strauch
    Robert Koch Institut, Freie Universitat, Berlin, Germany
    Adv Exp Med Biol 529:249-51. 2003
  50. ncbi request reprint Experimental pig yersiniosis to assess attenuation of Yersinia enterocolitica O:8 mutant strains
    Hristo Najdenski
    The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria
    FEMS Immunol Med Microbiol 47:425-35. 2006
    ....
  51. ncbi request reprint Yersiniophage phiR1-37 is a tailed bacteriophage having a 270 kb DNA genome with thymidine replaced by deoxyuridine
    Saija Kiljunen
    Department of Medical Biochemistry and Molecular Biology, Institute of Biomedicine, University of Turku, Turku, Finland
    Microbiology 151:4093-102. 2005
    ..Genes for two of the structural proteins, p24 and p46, were identified from the partially sequenced phiR1-37 genome...
  52. ncbi request reprint Lipopolysaccharide O antigen status of Yersinia enterocolitica O:8 is essential for virulence and absence of O antigen affects the expression of other Yersinia virulence factors
    José Antonio Bengoechea
    Unidad de Investigación and Institut Universitari d Investigacions en Ciències de la Salut, Hospital Son Dureta, Palma de Mallorca, Spain
    Mol Microbiol 52:451-69. 2004
    ..Together these findings suggest that the absence of O antigen in the outer membrane of Yersinia either directly or indirectly, for example through a cellular or membrane stress, could act as a regulatory signal...
  53. pmc Use of O-antigen gene cluster-specific PCRs for the identification and O-genotyping of Yersinia pseudotuberculosis and Yersinia pestis
    Tatiana Bogdanovich
    Department of Medical Biochemistry, University of Turku, Turku, Finland
    J Clin Microbiol 41:5103-12. 2003
    ..pseudotuberculosis isolates that had lost the expression of the O-antigen. The PCR-based O-genotyping can easily be applied in conventional laboratories, without the need for tedious preparation of a large set of specific antisera...
  54. ncbi request reprint Genetic (sero) typing of Yersinia pseudotuberculosis
    Tatiana M Bogdanovich
    Department of Medical Biochemistry and Molecular Biology, University of Turku, Finland
    Adv Exp Med Biol 529:337-40. 2003
  55. pmc Expression of the Yersinia enterocolitica pYV-encoded type III secretion system is modulated by lipopolysaccharide O-antigen status
    Camino Pérez-Gutiérrez
    Fundació Caubet CIMERA Illes Balears, Recinto Hospital Joan March, Carretera Soller km 12, 07110 Bunyola, Spain
    Infect Immun 75:1512-6. 2007
    ..H-NS might underlie flhDC upregulation in YeO8-R, and the data suggest a relationship between the absence of O antigen and the expression of H-NS...
  56. ncbi request reprint Temperature and growth phase regulate the transcription of the O-antigen gene cluster of Yersinia enterocolitica O:3
    Pia Lahtinen
    Department of Medical Biochemistry and Molecular Biology, University of Turku, Finland
    Adv Exp Med Biol 529:289-92. 2003
  57. ncbi request reprint A multiplex PCR-detection assay for Yersinia enterocolitica serotype O:9 and Brucella spp. based on the perosamine synthetase gene. Application to Brucella diagnostics
    Peter S Lübeck
    Department of Bacteriology, Danish Veterinary Institute, Copenhagen, Denmark
    Adv Exp Med Biol 529:451-3. 2003
  58. pmc Yersinia enterocolitica adhesin A induces production of interleukin-8 in epithelial cells
    Yvonne Schmid
    Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Universitätsklinikum Tübingen Elfriede Aulhorn Strasse 6, D 72060 Tübingen, Germany
    Infect Immun 72:6780-9. 2004
    ..These data present YadA, in addition to Inv, YopB, and Yersinia lipopolysaccharide, as a further inducer of proinflammatory molecules by which Y. enterocolitica might promote inflammatory tissue reactions...
  59. pmc Human dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin (CD209) is a receptor for Yersinia pestis that promotes phagocytosis by dendritic cells
    Pei Zhang
    Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago UIC, 1601 Parkview Avenue, Rockford, IL 61107, USA
    Infect Immun 76:2070-9. 2008
    ..pestis and human DCs can be reduced by a combination treatment with anti-CD209 and anti-CD207 antibodies. This study shows that human DC-SIGN is a receptor for Y. pestis that promotes phagocytosis by DCs in vitro...