Genomes and Genes
Affiliation: University of Helsinki
- Crosstalk between Jagged1 and GDNF/Ret/GFRalpha1 signalling regulates ureteric budding and branchingSatu Kuure
Developmental Biology, Institute of Biomedicine, P O Box 63, Haartmaninkatu 8, University of Helsinki, Helsinki FIN 00014, Finland
Mech Dev 122:765-80. 2005..Thus, the data provide evidence for a novel crosstalk between Notch and Ret/GFRalpha1 signalling during early nephrogenesis...
- GDNF promotes tubulogenesis of GFRalpha1-expressing MDCK cells by Src-mediated phosphorylation of Met receptor tyrosine kinaseAnna Popsueva
Developmental Biology, Institute of Biomedicine, University of Helsinki, FIN 00014 Helsinki, Finland
J Cell Biol 161:119-29. 2003..The GDNF-induced branching of MDCK cells requires Src activation, whereas the HGF-induced branching does not. Our data show a mechanism for the GDNF-induced branching morphogenesis in non-Ret signaling...
- GDNF and its receptors in the regulation of the ureteric branchingH Sariola
Institute of Biotechnology, Viikki Biocentre, University of Helsinki, Finland
Int J Dev Biol 43:413-8. 1999....
- The neurotrophic factors in non-neuronal tissuesH Sariola
Developmental Biology Research Program, Institute of Biotechnology, University of Helsinki, Finland
Cell Mol Life Sci 58:1061-6. 2001..However, several examples can be presented of essential non-neuronal functions played by neurotrophins in e.g., cardiac, hair follicle, and vascular differentiation, and the maintenance of immune cells...
- Nephron induction revisited: from caps to condensatesHannu Sariola
Institute of Biomedicine, Developmental Biology, University of Helsinki, Finland
Curr Opin Nephrol Hypertens 11:17-21. 2002..Apart from being the source for the pretubular aggregates, the role of the cap condensate is unknown. It is now proposed that the cap regulates ureteric branching morphogenesis...
- The tip-top branching ureterH Sariola
Developmental Biology Research Programme, Institute of Biotechnology, Biocenter 1A, University of Helsinki, Finland
Curr Opin Cell Biol 9:877-84. 1997..The active receptor complex for GDNF includes the receptor tyrosine kinase Ret and a novel class of glycosylphosphatidylinositol-linked receptors, called GDNF family receptor alpha s...
- [The chance and necessity of life]Hannu Sariola
bioläaketieteen laitos, kehitysbiologia PL 63, 00014 Helsingin yliopisto
Duodecim 118:2425-31. 2002
- GDNF-induced seminomatous tumours in mouse--an experimental model for human seminomas?Hannu Sariola
Institute of Biomedicine and Institute of Biotechnology, P O Box 63 Haartmaninkatu 8, FIN 00014 University of Helsinki, Finland
APMIS 111:192-6; discussion 196. 2003..Thus, by several histological, molecular, and histochemical characteristics, the GDNF-induced tumours mimic classical seminomas in men, but the precursor lesions are apparently different in mouse and man...
- Novel functions and signalling pathways for GDNFHannu Sariola
Institute of Biomedicine, University of Helsinki, PO Box 63 Haartmaninkatu 8, FIN 00014, Finland
J Cell Sci 116:3855-62. 2003..GDNF family ligands also signal through the neural cell adhesion molecule NCAM. In cells lacking RET, GDNF binds with high affinity to the NCAM and GFRalpha1 complex, which activates Fyn and FAK...
- [Genes behind humanity, rage, peace and the brain of apes]Hannu Sariola
bioläaketieteen laitos, Biomedicum Helsinki, Helsingin yliopisto
Duodecim 120:1836-7. 2004
- Cell lineages in the embryonic kidney: their inductive interactions and signalling moleculesH Sariola
Developmental Biology Research Programme, University of Helsinki, Finland
Biochem Cell Biol 76:1009-16. 1998....
- Promotion of seminomatous tumors by targeted overexpression of glial cell line-derived neurotrophic factor in mouse testisX Meng
Developmental Biology and Molecular Neurobiology Research Programs, Institute of Biotechnology, Viikki Biocenter, FIN 00014 University of Helsinki, Finland
Cancer Res 61:3267-71. 2001..The data also show that a deregulated stimulation of a normal proto-oncogene by its ligand can be an initiative event in carcinogenesis...
- Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epitheliumK Sainio
Programme of Developmental Biology, Institute of Biotechnology, University of Helsinki, Finland
Development 124:4077-87. 1997..Thus, GDNF is the first defined inducer in the embryonic metanephric kidney...
- Regulation of cell fate decision of undifferentiated spermatogonia by GDNFX Meng
Research Programs of Developmental Biology, Molecular Neurobiology, Electron Microscopy Unit, Institute of Biotechnology, Viikki Biocenter, Finland
Science 287:1489-93. 2000..Nonmetastatic testicular tumors are regularly formed in older GDNF-overexpressing mice. Thus, GDNF contributes to paracrine regulation of spermatogonial self-renewal and differentiation...
- Transient disruption of spermatogenesis by deregulated expression of neurturin in testisX Meng
Institute of Biomedicine, Developmental Biology, Biomedicum Helsinki and HUCH-Diagnostics, PO Box 63 (Haartmaninkatu 8, FIN-00014 University of Helsinki, Helsinki, Finland
Mol Cell Endocrinol 184:33-9. 2001....
- Other neurotrophic factors: glial cell line-derived neurotrophic factor (GDNF)M Saarma
Program for Molecular Neurobiology, Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
Microsc Res Tech 45:292-302. 1999..NTN, ART, and PSP are also expressed in the developing kidney, and NTN and PSP induce ureteric branching in vitro, but their true in vivo role in kidney morphogenesis is still unclear...
- Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesisK Luukko
Program of Developmental Biology, Institute of Biotechnology, University of Helsinki, Finland
Dev Dyn 210:117-29. 1997..In addition, the expression patterns of NGF, NT-3, and NT-4/5 as well as of neurotrophin receptors suggest that the neurotrophin system may also serve non-neuronal functions during tooth development...
- Hirschsprung's disease genes and the development of the enteric nervous systemK Wartiovaara
Institute of Biotechnology, Developmental Biology Research Programme, University of Helsinki, Hospital for Children and Adolescents, Finland
Ann Med 30:66-74. 1998..We combine here the present clinical data on the gene mutations in Hirschsprung's disease with the experimental molecular biology data, and formulate a hypothesis on the pathogenesis of this multigenic-multifactorial disease...
- Exclusion of the p75 neurotrophin receptor gene as a candidate gene for Meckel syndromeK Wartiovaara
Institute of Biotechnology, University of Helsinki, Finland
Clin Dysmorphol 6:213-7. 1997..The sequence analysis of the coding region of the gene revealed one polymorphism but no potential disease mutation. Physical mapping of the critical chromosomal region finally showed that the NGFR gene lies outside the MKS locus...
- Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alphaP Suvanto
Institute of Biotechnology, University of Helsinki, Finland
Hum Mol Genet 6:1267-73. 1997..The distinct tissue distribution of GDNFR-beta mRNA and its ability to mediate GDNF signal in transfected cells suggest a role in signal transduction of GDNF and, possibly, related neurotrophic factors in vivo...
- BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidneyA Raatikainen-Ahokas
Developmental Biology Research Program, Institute of Biotechnology, University of Helsinki, Finland
Dev Dyn 217:146-58. 2000..Thus, BMP-4 may be a physiological regulator of the development of the periureteric smooth muscle layer and ureteric elongation...
- E6/E7 oncogenes increase and tumor suppressors decrease the proportion of self-renewing neural progenitor cellsK Piltti
Developmental Biology, Institute of Biomedicine, University of Helsinki, and HUCH Laboratory Diagnostics, Helsinki University Central Hospital, Finland
Oncogene 25:4880-9. 2006..These findings provide one explanation how oncogenes and tumour suppressors control tissue homeostasis and highlight their importance in stem cell self- renewal, linked both to cancer and life-long tissue turnover...
- Distribution of glial cell line-derived neurotrophic factor mRNA in human colon suggests roles for muscularis mucosae in innervationK Wartiovaara
Institute of Biotechnology, University of Helsinki, The Hospital for Children and Adolescents, and HUCH Diagnostics, Finland
J Pediatr Surg 33:1501-6. 1998..The aim of this study was to analyze the mRNA distribution of these genes in the developing human intestine to understand their roles in enteric innervation...
- A proGDNF-related peptide BEP increases synaptic excitation in rat hippocampusTiina Immonen
Department of Medical Biochemistry and Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, FI 00014 University of Helsinki, Finland
Exp Neurol 210:793-6. 2008..The excitation is sensitive to N-ethylmaleimide, suggesting involvement of a G-protein-coupled receptor...
- [From infected bandages to genome of the individual]Tiina Immonen
Biomedicum Helsinki, bioläaketieteen laitos, kehitysbiologia PL 63 Haartmanin katu 8, 00014 Helsingin yliopisto
Duodecim 119:2453-9. 2003
- Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidneyNina Perälä
Institute of Biomedicine Medical Biochemistry and Developmental Biology, Biomedicum Helsinki, PO Box 63, FI 00014 University of Helsinki, Finland
Differentiation 81:81-91. 2011....
- SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidneyMinna Kujala
Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Nephron Exp Nephrol 101:e50-8. 2005..They are expressed in kidney, but their exact localization in human kidney has not been studied. We therefore examined SLC26A6 and A7 expression in human kidneys...
- [Nematode--the mother or father of programmed cell death]Kirsi Sainio
Helsingin yliopiston biolääketieteen laitos PL 63, 00014 Helsingin yliopisto
Duodecim 118:2267-9. 2002
- Glycogen synthase kinase-3 inactivation and stabilization of beta-catenin induce nephron differentiation in isolated mouse and rat kidney mesenchymesSatu Kuure
Biochemistry and Developmental Biology, Institute of Biomedicine, PO Box 63, Haartmaninkatu 8, University of Helsinki, FIN 00014, Finland
J Am Soc Nephrol 18:1130-9. 2007..These data show that activation of canonical Wnt pathway is sufficient to induce nephrogenesis and suggest that this pathway mediates the nephron induction in murine kidney mesenchymes...
- High frequency of SNAIL-expressing cells confirms and predicts metastatic potential of phaeochromocytomaV Häyry
Institute of Biomedicine, Developmental Biology, University of Helsinki, Biomedicum, Helsinki, Finland
Endocr Relat Cancer 16:1211-8. 2009..We conclude that the expression of SNAIL may be of use in predicting the metastatic potential of phaeochromocytoma...
- Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumoursV Häyry
Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Neuropathol Appl Neurobiol 34:555-63. 2008..However, the significance of BMI-1 in human glioma has not been investigated. Here we describe expression of the polycomb protein BMI-1 and its downstream targets p16(Ink4a) and MDM2 in both high- and low-grade human glioma...
- Differential regulation of two sets of mesonephric tubules by WT-1K Sainio
Department of Pathology, Haartman Institute, University of Helsinki, Finland
Development 124:1293-9. 1997..WT-1 therefore seems to be necessary for the mesenchyme to epithelium transitions at different stages of nephrogenesis...
- Nephron inductionHannu Sariola
Institute of Biomedicine, Developmental Biology, University of Helsinki, FIN 00014, Finland
Nephrol Dial Transplant 17:88-90. 2002..In the rat, fibroblast growth factor-2 maintains the nephrogenic mesenchyme; leukaemia inhibitory factor together with transforming growth factor beta-2 induce its condensation; and autocrine secretion of Wnt-4 converts it to epithelium...
- The expression of plexins during mouse embryogenesisNina M Perälä
Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, P O Box 63, FIN 00014, Finland
Gene Expr Patterns 5:355-62. 2005..In the testis, Plxna1, Plxnb1 and Plxnc1 are expressed in the developing sex chords. This study shows that during development, plexins are expressed in specific and distinct patterns also in non-neuronal tissues...
- Congenital hypoplastic anemia, diabetes, and severe renal tubular dysfunction associated with a mitochondrial DNA deletionA Majander
Department of Medical Chemistry, University of Helsinki, Finland
Pediatr Res 30:327-30. 1991..Decreased respiratory chain enzyme activities were demonstrated in muscle, and an mtDNA deletion was demonstrated in muscle, kidney, leukocytes, and fibroblasts...
- Myc increases self-renewal in neural progenitor cells through Miz-1Laura Kerosuo
Developmental Biology, Institute of Biomedicine, Haartmaninkatu 8, PO Box 63, 00014 University of Helsinki, Finland
J Cell Sci 121:3941-50. 2008..Our results suggest that Myc, through Miz-1, enhances self-renewal of NPCs and influences the way progenitor cells react to the environmental cues that normally dictate the cellular identity of tissues containing self-renewing cells...
- CIP2A increases self-renewal and is linked to Myc in neural progenitor cellsLaura Kerosuo
Medical Biochemistry and Developmental Biology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Differentiation 80:68-77. 2010....
- GDNF maintains mouse spermatogonial stem cells in vivo and in vitroHannu Sariola
Institute of Biomedicine, Biochemistry and Developmental Biology, University of Helsinki, Finland
Methods Mol Biol 450:127-35. 2008..We describe in detail the culture system of SSCs developed by Dr. Takashi Shinohara in 2003...
- RET tyrosine kinase signaling in development and cancerElena Arighi
Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, University of Helsinki, Finland
Cytokine Growth Factor Rev 16:441-67. 2005..We now review the role and mechanisms of RET signaling in development and carcinogenesis...
- Transgene insertion induced dominant male sterility and rescue of male fertility using round spermatid injectionXiaojuan Meng
Developmental Biology Program, Institute of Biotechnology, University of Helsinki, FIN 00014 Helsinki, Finland
Biol Reprod 66:726-34. 2002..Furthermore, mice carrying this genetic trait might be useful for studies of assisted reproductive technologies and male contraceptives...
- Biological effects of the dual phenotypic Janus mutation of ret cosegregating with both multiple endocrine neoplasia type 2 and Hirschsprung's diseaseElena Arighi
Developmental Biology, Institute of Biomedicine, Biomedicum Helsinki, P O Box 63, University of Helsinki, Helsinki, Finland FIN 00014
Mol Endocrinol 18:1004-17. 2004....
- The GDNF target Vsnl1 marks the ureteric tipRoxana Ola
Biochemistry and Developmental Biology, Institute of Biomedicine, P O Box 63, Haartmaninkatu 8, University of Helsinki, FIN 00014, Finland
J Am Soc Nephrol 22:274-84. 2011..In summary, Vsnl1 marks ureteric bud tips in embryonic kidneys, and its mosaic pattern demonstrates a heterogeneity of cell types that may be critical for normal ureteric branching...
- An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferationFu Ping Zhang
Biomedicum Helsinki, Institute of Biomedicine, University of Helsinki, Haartmaninkatu 8, FI 00014, Helsinki, Finland
Mol Endocrinol 21:1430-42. 2007..Collectively, ARIP4 plays an essential role in mouse embryonic development and cell proliferation, and it appears to coordinate multiple essential biological processes, possibly through a complex chromatin remodeling system...
- Copy number alterations of the polycomb gene BMI1 in gliomasValtteri Häyry
Developmental Biology, Institute of Biomedicine, University of Helsinki, Helsinki, Finland
Acta Neuropathol 116:97-102. 2008..This data suggests that BMI1 gene is aberrant at the chromosomal level in a subset of gliomas, and possibly contributes to brain tumour pathogenesis...
- Differential requirement of Tyr1062 multidocking site by RET isoforms to promote neural cell scattering and epithelial cell branchingDebora Degl'Innocenti
Department of Experimental Oncology, Research Unit 3, Istituto Nazionale Tumori, Via G Venezian, 1 20133 Milan, Italy
Oncogene 23:7297-309. 2004..GRB2 is the only known adaptor protein binding to Tyr1096. Dominant-negative GRB2 expressed in MDCK cells together with RET9 or RET51 significantly reduces branching. Therefore, GRB2 is necessary for RET-mediated branching of MDCK cells...
- Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in miceLiya Shen
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814 2790, USA
Am J Hum Genet 70:435-47. 2002..These findings may have general implications for the genetic analysis of cause and effect in complex human diseases...
- Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complicationsCraig M Stolen
MediCity Research Laboratory, University of Turku and National Public Health Institute, Turku, Finland
FASEB J 18:702-4. 2004..These findings suggest that, although manipulation of VAP-1/SSAO has potential to serve as a therapeutic treatment in insulin-resistant conditions, care must be taken to fully understand its impact on obesity and vascular damage...
- Neural precursor cells from a fatal human motoneuron disease differentiate despite aberrant gene expressionNiklas Pakkasjärvi
Department of Molecular Medicine, National Public Health Institute, Biomedicum, Helsinki, Finland
Dev Neurobiol 67:270-84. 2007....
- [Time is our most important capital]Hannu Sariola
Duodecim 118:2357-9. 2002
- [Micro-RNAs--a new way to regulate protein synthesis]Tiina Immonen
Duodecim 118:661-2. 2002