O T Raitakari

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi Obesity in childhood and vascular changes in adulthood: insights into the Cardiovascular Risk in Young Finns Study
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Int J Obes (Lond) 29:S101-4. 2005
  2. doi Breast feeding in infancy and arterial endothelial function later in life. The Cardiovascular Risk in Young Finns Study
    M J Järvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Eur J Clin Nutr 63:640-5. 2009
  3. doi Follow-ups of the Cardiovascular Risk in Young Finns Study in 2001 and 2007: levels and 6-year changes in risk factors
    J R H Raiko
    Department of Cardiovascular Research Center, University of Turku, Turku, Finland
    J Intern Med 267:370-84. 2010
  4. ncbi Coronary flow reserve is reduced in young men with IDDM
    O P Pitkanen
    Department of Medicine, University of Turku, Finland
    Diabetes 47:248-54. 1998
  5. ncbi Associations between physical activity and risk factors for coronary heart disease: the Cardiovascular Risk in Young Finns Study
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Med Sci Sports Exerc 29:1055-61. 1997
  6. doi Dietary and lifestyle counselling reduces the clustering of overweight-related cardiometabolic risk factors in adolescents
    M Hakanen
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Acta Paediatr 99:888-95. 2010
  7. ncbi Angiotensin-converting enzyme gene polymorphism and coronary reactivity in young men
    M Kahonen
    Department of Clinical Physiology, Tampere University Hospital and Medical School, University of Tampere, Finland
    Scand J Clin Lab Invest 67:596-603. 2007
  8. ncbi The effect of 12-month enzyme replacement therapy on myocardial perfusion in patients with Fabry disease
    R J Kalliokoski
    Turku PET Centre, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    J Inherit Metab Dis 29:112-8. 2006
  9. ncbi Increased arterial intima-media thickness and in vivo LDL oxidation in young men with borderline hypertension
    J O Toikka
    Department of Clinical Physiology, Turku University Hospital, Finland
    Hypertension 36:929-33. 2000
  10. ncbi Large-artery elastic properties in young men : relationships to serum lipoproteins and oxidized low-density lipoproteins
    J O Toikka
    Department of Clinical Physiology, Turku University Central Hospital, Finland
    Arterioscler Thromb Vasc Biol 19:436-41. 1999

Collaborators

Detail Information

Publications47

  1. ncbi Obesity in childhood and vascular changes in adulthood: insights into the Cardiovascular Risk in Young Finns Study
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Int J Obes (Lond) 29:S101-4. 2005
    ..This paper reviews recent findings from the Cardiovascular Risk in Young Finns Study looking at the relationships between risk factors identified in childhood, including obesity, and arterial structure/function assessed in adulthood...
  2. doi Breast feeding in infancy and arterial endothelial function later in life. The Cardiovascular Risk in Young Finns Study
    M J Järvisalo
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Eur J Clin Nutr 63:640-5. 2009
    ..We examined the association between breast feeding in infancy and arterial function and structure in adulthood in a population-based cohort of Finnish adults...
  3. doi Follow-ups of the Cardiovascular Risk in Young Finns Study in 2001 and 2007: levels and 6-year changes in risk factors
    J R H Raiko
    Department of Cardiovascular Research Center, University of Turku, Turku, Finland
    J Intern Med 267:370-84. 2010
    ..To examine cardiovascular risk factor levels in 2007 and their 6-year changes between 2001 and 2007 using the data collected in the follow-ups of the Cardiovascular Risk in Young Finns Study...
  4. ncbi Coronary flow reserve is reduced in young men with IDDM
    O P Pitkanen
    Department of Medicine, University of Turku, Finland
    Diabetes 47:248-54. 1998
    ..The results imply early impairment of coronary vascular reactivity in IDDM patients, which may represent an early precursor of future coronary heart disease or may contribute to the pathogenesis of diabetic cardiomyopathy...
  5. ncbi Associations between physical activity and risk factors for coronary heart disease: the Cardiovascular Risk in Young Finns Study
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Med Sci Sports Exerc 29:1055-61. 1997
    ..The promotion of physical activity is important in childhood in preventing obesity and premature cardiovascular disease...
  6. doi Dietary and lifestyle counselling reduces the clustering of overweight-related cardiometabolic risk factors in adolescents
    M Hakanen
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Acta Paediatr 99:888-95. 2010
    ....
  7. ncbi Angiotensin-converting enzyme gene polymorphism and coronary reactivity in young men
    M Kahonen
    Department of Clinical Physiology, Tampere University Hospital and Medical School, University of Tampere, Finland
    Scand J Clin Lab Invest 67:596-603. 2007
    ..In conclusion, the ACE I/D polymorphism does not seem to affect myocardial reactivity--an early indicator of atherosclerosis--in healthy subjects...
  8. ncbi The effect of 12-month enzyme replacement therapy on myocardial perfusion in patients with Fabry disease
    R J Kalliokoski
    Turku PET Centre, University of Turku, PO Box 52, FIN 20521 Turku, Finland
    J Inherit Metab Dis 29:112-8. 2006
    ..However, individual variation in the response to therapy was large and the results suggest that the success of the therapy may depend on the degree of cardiac hypertrophy...
  9. ncbi Increased arterial intima-media thickness and in vivo LDL oxidation in young men with borderline hypertension
    J O Toikka
    Department of Clinical Physiology, Turku University Hospital, Finland
    Hypertension 36:929-33. 2000
    ..These results are consistent with the idea that enhanced ox-LDL may be one of the pathophysiological events related to development of atherosclerosis in men with borderline elevated blood pressure...
  10. ncbi Large-artery elastic properties in young men : relationships to serum lipoproteins and oxidized low-density lipoproteins
    J O Toikka
    Department of Clinical Physiology, Turku University Central Hospital, Finland
    Arterioscler Thromb Vasc Biol 19:436-41. 1999
    ..The current study demonstrates for the first time an in vivo association between ox-LDL and arterial elasticity suggesting that oxidative modification of LDL may play a role in the alteration of arterial wall elastic properties...
  11. ncbi Associations of education with cardiovascular risk factors in young adults: the Cardiovascular Risk in Young Finns Study
    M Leino
    Cardiorespiratory Research Unit, University of Turku, Finland
    Int J Epidemiol 28:667-75. 1999
    ..Low educational level is associated with an increased risk of coronary heart disease. The aim of the present study was to examine the relationships between education and common cardiovascular risk factors in young adults...
  12. ncbi Reduced myocardial flow reserve relates to increased carotid intima-media thickness in healthy young men
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Atherosclerosis 156:469-75. 2001
    ....
  13. ncbi Increased aortic intima-media thickness: a marker of preclinical atherosclerosis in high-risk children
    M J Järvisalo
    Department of Clinical Physiology, Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Circulation 104:2943-7. 2001
    ....
  14. doi Migration at early age from a high to a lower coronary heart disease risk country lowers the risk of subclinical atherosclerosis in middle-aged men
    L Jartti
    Department of Geriatric Medicine, University of Turku, Turku, Finland
    J Intern Med 265:345-58. 2009
    ..In Sweden, CHD risk has been markedly lower than in Finland from where a large migration occurred in the 1970s...
  15. ncbi In vivo low density lipoprotein oxidation relates to coronary reactivity in young men
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    J Am Coll Cardiol 30:97-102. 1997
    ..This study was undertaken to examine the relation of in vivo low density lipoprotein (LDL) oxidation and other lipid risk factors to coronary reactivity in normal subjects...
  16. doi The Leu7Pro polymorphism of the signal peptide of neuropeptide Y (NPY) gene is associated with increased levels of inflammatory markers preceding vascular complications in patients with type 2 diabetes
    U Jaakkola
    Centre for Biotechnology, University of Turku, Tykistokatu 6, Turku, Finland
    Microvasc Res 80:433-9. 2010
    ..Currently, we followed diabetes patients to investigate, if the Pro7 allele is associated with the inflammation related to atherosclerosis...
  17. ncbi The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: risk factor levels, secular trends and east-west difference
    M Juonala
    The Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    J Intern Med 255:457-68. 2004
    ..We have collected risk factor data in the 21-year follow-up performed in 2001. The aims of this analysis were to examine the levels, secular trends and east-west difference in risk factors amongst young adults...
  18. doi Metabolic syndrome and short-term heart rate variability in young adults. The cardiovascular risk in young Finns study
    T Koskinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    Diabet Med 26:354-61. 2009
    ....
  19. ncbi Impaired myocardial perfusion reserve but preserved peripheral endothelial function in patients with Fabry disease
    R J Kalliokoski
    Turku PET Centre, University of Turku, Turku, Finland
    J Inherit Metab Dis 28:563-73. 2005
    ..6, p=0.02), while the brachial artery flow-mediated dilatation was similar (5.9%+/-3.9% vs 4.5%+/-3.6%, p=0.27). Thus, inFabry disease, myocardial perfusion reserve is reduced while the peripheral artery endothelial function is preserved...
  20. ncbi Patterns of intense physical activity among 15- to 30-year-old Finns. The Cardiovascular Risk in Young Finns Study
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Finland
    Scand J Med Sci Sports 6:36-9. 1996
    ..Young males seem to be physically more active than females...
  21. ncbi Cardiovascular risk factors of young adults in relation to parental socioeconomic status: the Cardiovascular Risk in Young Finns Study
    M Leino
    Cardiorespiratory Research Unit, University of Turku, Finland
    Ann Med 32:142-51. 2000
    ....
  22. ncbi Reduced myocardial flow reserve does not impair exercise capacity in asymptomatic men
    O T Raitakari
    Department of Clinical Physiology, Turku PET Center, University of Turku, Finland
    Am J Cardiol 84:1253-5, A8. 1999
    ....
  23. doi High serum n6 fatty acid proportion is associated with lowered LDL oxidation and inflammation: the Cardiovascular Risk in Young Finns Study
    J E Kaikkonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Free Radic Res 48:420-6. 2014
    ....
  24. ncbi Associations between diet and the hyperapobetalipoproteinemia phenotype expression in children and young adults: the Cardiovascular Risk in Young Finns Study
    I O Nuotio
    Department of Medicine, University of Turku, Finland
    Arterioscler Thromb Vasc Biol 17:820-5. 1997
    ..33) than in others (0.28, P=.019). Our results imply that the fatty acid composition of the diet may be one of the environmental factors that influence the hyperapoB phenotype expression...
  25. pmc Relationship between limb and muscle blood flow in man
    M Raitakari
    Turku PET Center, Department of Medicine, University of Turku, Finland
    J Physiol 496:543-9. 1996
    ..4. These data provide a new equation for estimation of resting muscle blood flow in normal subjects, and demonstrate that muscle blood flow is the primary determinant of resting blood flow in man...
  26. ncbi Carotid artery compliance in users of plant stanol ester margarine
    O T Raitakari
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Eur J Clin Nutr 62:218-24. 2008
    ..To investigate the effects of stanol ester margarine use in healthy subjects on arterial compliance, endothelial function and intima-media thickness...
  27. doi Depressive symptoms are associated with lower bone mineral density in young adults with high job strain. The Cardiovascular Risk in Young Finns Study
    M Oikonen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, 20520, Turku, Finland
    Int J Behav Med 21:464-9. 2014
    ..Job strain has been associated with depressive symptoms, and depression has been associated with low bone mineral density (BMD)...
  28. ncbi Risk factors for coronary heart disease in children and young adults
    J S A Viikari
    Department of Medicine, University of Turku, Turku, Finland
    Acta Paediatr Suppl 93:34-42. 2004
    ..Neurological development of the intervention children at age 5 y was at least as good as that of the control children. Counselling had no effect on children's growth...
  29. ncbi The prevalence of the metabolic syndrome in young adults. The Cardiovascular Risk in Young Finns Study
    N Mattsson
    The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    J Intern Med 261:159-69. 2007
    ..We also investigated the secular trend in the metabolic syndrome amongst 24-year-old adults from 1986 to 2001...
  30. ncbi Testing for endothelial dysfunction
    O T Raitakari
    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
    Ann Med 32:293-304. 2000
    ..This review outlines the current status of markers of endothelial dysfunction, particularly those related to vasomotor control, as well as circulating markers of vascular health...
  31. ncbi Diabetic background retinopathy is associated with impaired coronary vasoreactivity in people with Type 1 diabetes
    J Sundell
    Turku PET Centre, Turku University Central Hospital, Turku, Finland
    Diabetologia 47:725-31. 2004
    ..We examined whether diabetic background retinopathy is associated with reduced coronary vasoreactivity in people with Type 1 diabetes...
  32. ncbi High-sensitivity C-reactive protein and impaired coronary vasoreactivity in young men with uncomplicated type 1 diabetes
    J Sundell
    Turku PET Centre, Turku University Central Hospital, P O Box 52, 20521 Turku, Finland
    Diabetologia 47:1888-94. 2004
    ..Elevated high-sensitivity C-reactive protein (hsCRP) concentrations indicate increased risk of future coronary events. The association between hsCRP and coronary vasoreactivity has not yet been examined in type 1 diabetic subjects...
  33. ncbi Decreased large artery distensibility in borderline hypertension is related to increased in vivo low-density lipoprotein oxidation
    J O Toikka
    Department of Clinical Physiology, Turku University Central Hospital, Finland
    Scand J Clin Lab Invest 62:301-6. 2002
    ....
  34. ncbi Pulse wave velocity reference values in healthy adults aged 26-75 years
    T Koivistoinen
    Department of Clinical Physiology, Medical School, University of Tampere, and Tampere University Hopsital, Tampere, Finland
    Clin Physiol Funct Imaging 27:191-6. 2007
    ..Reference values can be useful in the clinical management of patients, especially in detecting early vascular disease or an increased risk of cardiovascular complications...
  35. ncbi Lifetime glycaemic exposure predicts reduced coronary vasoreactivity in Type 1 diabetic subjects
    J Sundell
    Turku PET Centre, University of Turku, FIN 2052 Turku, Finland
    Diabet Med 22:45-51. 2005
    ..We examined the effect of lifetime glycaemic exposure on coronary vasoreactivity in 43 otherwise healthy Type 1 diabetic subjects...
  36. ncbi Testing a model of physical activity and obesity tracking from youth to adulthood: the cardiovascular risk in young Finns study
    X Yang
    LIKES Research Center, Jyvaskyla, Finland
    Int J Obes (Lond) 31:521-7. 2007
    ..To test a potential model of the relationship between physical activity and obesity from youth to adulthood...
  37. ncbi Longitudinal changes in diet from childhood into adulthood with respect to risk of cardiovascular diseases: The Cardiovascular Risk in Young Finns Study
    V Mikkilä
    Division of Nutrition, University of Helsinki, Finland
    Eur J Clin Nutr 58:1038-45. 2004
    ..To assess nutrient intakes relevant in the prevention of cardiovascular diseases (CVD) among young adults in Finland and to find past and present determinants of quality of diet...
  38. pmc Insulin induced increase in coronary flow reserve is abolished by dexamethasone in young men with uncomplicated type 1 diabetes
    H Laine
    Turku PET Centre, Turku University Central Hospital, Turku, Finland
    Heart 90:270-6. 2004
    ..To examine the role of the sympathetic nervous system in regulating insulin's action on coronary perfusion in uncomplicated type 1 diabetes by blocking centrally mediated sympathetic activity with dexamethasone...
  39. pmc Socioeconomic position in childhood and adult cardiovascular risk factors, vascular structure, and function: cardiovascular risk in young Finns study
    M Kivimaki
    Department of Psychology, University of Helsinki, Helsinki, Finland
    Heart 92:474-80. 2006
    ..To examine the association of childhood socioeconomic position (SEP) with adult cardiovascular risk factors, vascular structure, and vascular function in a contemporary population of young adults...
  40. ncbi C-reactive protein genetics is associated with carotid artery compliance in men in The Cardiovascular Risk in Young Finns Study
    C Eklund
    Department of Microbiology and Immunology, University of Tampere Medical School, 33014 University of Tampere, Finland
    Atherosclerosis 196:841-8. 2008
    ..Men carrying the SNP -286 allele C had increased CAC after adjusting for risk factors. These data suggest that the presence of high producer CRP genotype is deleterious to carotid elasticity in men...
  41. ncbi When do social inequalities in C-reactive protein start? A life course perspective from conception to adulthood in the Cardiovascular Risk in Young Finns Study
    D Gimeno
    Department of Epidemiology and Public Health, International Institute for Society and Health, UCL Medical School, London, UK
    Int J Epidemiol 37:290-8. 2008
    ....
  42. ncbi Associations of methylenetetrahydrofolate reductase C677T polymorphism with markers of subclinical atherosclerosis: the Cardiovascular Risk in Young Finns Study
    A Collings
    Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, and Medical School at the University of Tampere, Finland
    Scand J Clin Lab Invest 68:22-30. 2008
    ....
  43. ncbi Population-based twin study of the effects of migration from Finland to Sweden on endothelial function and intima-media thickness
    L Jartti
    Department of Medicine, University of Oulu, Finland
    Arterioscler Thromb Vasc Biol 22:832-7. 2002
    ..We conclude that in Finnish monozygous twins the endothelial function is better among the twins that have migrated to a country with lower CHD prevalence...
  44. ncbi Distribution and determinants of serum high-sensitive C-reactive protein in a population of young adults: The Cardiovascular Risk in Young Finns Study
    M Raitakari
    Department of Clinical Chemistry, Satakunta District Hospital, Pori, Finland
    J Intern Med 258:428-34. 2005
    ..Elevated C-reactive protein (CRP) is a suggested risk marker for cardiovascular disease. We aimed at investigating the distribution and determinants of CRP levels in young adults...
  45. pmc Indoleamine 2,3-dioxygenase enzyme activity correlates with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study
    M Pertovaara
    Department of Microbiology and Immunology, University of Tampere, Medical School, Finland
    Clin Exp Immunol 148:106-11. 2007
    ....
  46. ncbi Consistent dietary patterns identified from childhood to adulthood: the cardiovascular risk in Young Finns Study
    V Mikkilä
    Division of Nutrition, PO Box 66, FIN 00 014 University of Helsinki, Helsinki, Finland
    Br J Nutr 93:923-31. 2005
    ..Our results suggest that food behaviour and concrete food choices are established already in childhood or adolescence and may significantly track into adulthood...
  47. ncbi Impaired vascular responses to nitroglycerin in subjects with coronary atherosclerosis
    O T Raitakari
    Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia
    Am J Cardiol 87:217-9, A8. 2001
    ..The doses required to produce a 50% maximal dilator response were significantly higher in patients with coronary artery disease than in controls (p <0.002), suggesting smooth muscle dysfunction in atherosclerosis...