Pirkka T Pekkarinen

Summary

Affiliation: University of Helsinki
Country: Finland

Publications

  1. doi Impaired intestinal tolerance in the absence of a functional complement system
    Pirkka T Pekkarinen
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland
    J Allergy Clin Immunol 131:1167-75. 2013
  2. doi A functional complement system is required for normal T helper cell differentiation
    Pirkka T Pekkarinen
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland
    Immunobiology 216:737-43. 2011
  3. doi The FOXP3+ subset of human CD4+CD8+ thymocytes is immature and subject to intrathymic selection
    Heli Tuovinen
    1Department of Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Immunol Cell Biol 86:523-9. 2008
  4. doi Thymic production of human FOXP3(+) regulatory T cells is stable but does not correlate with peripheral FOXP3 expression
    Heli Tuovinen
    Haartman Institute, Department of Immunology, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki, Finland
    Immunol Lett 117:146-53. 2008
  5. doi Lymphopenia-induced proliferation in the absence of functional Autoimmune regulator (Aire) induces colitis in mice
    Eliisa Kekäläinen
    Haartman Institute, Department of Bacteriology and Immunology, Immunobiology Research Program, University of Helsinki, PB 21, Helsinki 00014, Finland Electronic address
    Immunol Lett 167:17-22. 2015
  6. doi Dysregulation of adaptive immune responses in complement C3-deficient patients
    Pirkka T Pekkarinen
    Haartman Institute and Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland
    Eur J Immunol 45:915-21. 2015

Collaborators

Detail Information

Publications6

  1. doi Impaired intestinal tolerance in the absence of a functional complement system
    Pirkka T Pekkarinen
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, and Helsinki University Central Hospital, Helsinki, Finland
    J Allergy Clin Immunol 131:1167-75. 2013
    ..Cells of the innate immune system regulate both adaptive immune responses and the maintenance of tolerance, especially in the gut. However, relatively little is known about the effects of complement on lymphocyte homeostasis...
  2. doi A functional complement system is required for normal T helper cell differentiation
    Pirkka T Pekkarinen
    Department of Bacteriology and Immunology, Haartman Institute, University of Helsinki, Finland
    Immunobiology 216:737-43. 2011
    ..Our results show that the complement system and its component C3 participate in the regulation of T cell responses, and that complement function is required for normal T helper cell differentiation...
  3. doi The FOXP3+ subset of human CD4+CD8+ thymocytes is immature and subject to intrathymic selection
    Heli Tuovinen
    1Department of Immunology, Haartman Institute, University of Helsinki, Helsinki, Finland
    Immunol Cell Biol 86:523-9. 2008
    ..The upregulation of FOXP3 may thus not be the final determining factor in the commitment of human thymocytes to the Treg cell lineage...
  4. doi Thymic production of human FOXP3(+) regulatory T cells is stable but does not correlate with peripheral FOXP3 expression
    Heli Tuovinen
    Haartman Institute, Department of Immunology, University of Helsinki, Haartmaninkatu 3, 00290 Helsinki, Finland
    Immunol Lett 117:146-53. 2008
    ....
  5. doi Lymphopenia-induced proliferation in the absence of functional Autoimmune regulator (Aire) induces colitis in mice
    Eliisa Kekäläinen
    Haartman Institute, Department of Bacteriology and Immunology, Immunobiology Research Program, University of Helsinki, PB 21, Helsinki 00014, Finland Electronic address
    Immunol Lett 167:17-22. 2015
    ..Our results identify Aire as an important regulator of peripheral T cell homeostasis in gastrointestinal tissues. Given a suitable trigger the absence of peripheral Aire leads to dysregulated T cell proliferation and disease. ..
  6. doi Dysregulation of adaptive immune responses in complement C3-deficient patients
    Pirkka T Pekkarinen
    Haartman Institute and Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland
    Eur J Immunol 45:915-21. 2015
    ..Since IgG4 has been linked to tolerogenic responses, the data also suggest that in the absence of functional complement at least some aspects of systemic tolerance are impaired. ..