Harri Niinikoski

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. doi request reprint Alexander disease as a cause of nocturnal vomiting in a 7-year-old girl
    Harri Niinikoski
    Department of Paediatrics, University of Turku, Kiinamyllynkatu 4 8, Turku, 20900, Finland
    Pediatr Radiol 39:872-5. 2009
  2. pmc Growth hormone therapy is safe and effective in patients with lysinuric protein intolerance
    Harri Niinikoski
    Department of Pediatrics, University of Turku, Kiinamyllynkatu 4 8, Turku, Finland
    JIMD Rep 1:43-7. 2011
  3. doi request reprint Is carbohydrate intake in the first years of life related to future risk of NCDs?
    H Niinikoski
    Turku University Hospital, Department of Pediatrics, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Nutr Metab Cardiovasc Dis 22:770-4. 2012
  4. ncbi request reprint Impact of repeated dietary counseling between infancy and 14 years of age on dietary intakes and serum lipids and lipoproteins: the STRIP study
    Harri Niinikoski
    Department of Pediatrics, University of Turku, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Circulation 116:1032-40. 2007
  5. doi request reprint Blood pressure is lower in children and adolescents with a low-saturated-fat diet since infancy: the special turku coronary risk factor intervention project
    Harri Niinikoski
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Hypertension 53:918-24. 2009
  6. doi request reprint Association of fitness with vascular intima-media thickness and elasticity in adolescence
    Katja Pahkala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Pediatrics 132:e77-84. 2013
  7. doi request reprint Left ventricular mass and geometry in adolescence: early childhood determinants
    Hanna Hietalampi
    University of Turku, Research Centre of Applied and Preventive Cardiovascular Medicine, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Hypertension 60:1266-72. 2012
  8. doi request reprint Effect of repeated dietary counseling on serum lipoproteins from infancy to adulthood
    Harri Niinikoski
    Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
    Pediatrics 129:e704-13. 2012
  9. doi request reprint Ideal cardiovascular health in adolescence: effect of lifestyle intervention and association with vascular intima-media thickness and elasticity (the Special Turku Coronary Risk Factor Intervention Project for Children [STRIP] study)
    Katja Pahkala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Circulation 127:2088-96. 2013
  10. doi request reprint Carbohydrate intake, serum lipids and apolipoprotein E phenotype show association in children
    Soile Ruottinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Acta Paediatr 98:1667-73. 2009

Collaborators

Detail Information

Publications43

  1. doi request reprint Alexander disease as a cause of nocturnal vomiting in a 7-year-old girl
    Harri Niinikoski
    Department of Paediatrics, University of Turku, Kiinamyllynkatu 4 8, Turku, 20900, Finland
    Pediatr Radiol 39:872-5. 2009
    ..Alexander disease should be considered in young patients with atypical anorexia nervosa-type symptoms...
  2. pmc Growth hormone therapy is safe and effective in patients with lysinuric protein intolerance
    Harri Niinikoski
    Department of Pediatrics, University of Turku, Kiinamyllynkatu 4 8, Turku, Finland
    JIMD Rep 1:43-7. 2011
    ..Growth hormone (GH) therapy promotes appetite, protein synthesis and accretion, but its possible growth-promoting effects and safety in patients with LPI are poorly known...
  3. doi request reprint Is carbohydrate intake in the first years of life related to future risk of NCDs?
    H Niinikoski
    Turku University Hospital, Department of Pediatrics, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Nutr Metab Cardiovasc Dis 22:770-4. 2012
    ..In conclusion, from the point of view of CHD risk factor prevention, efforts aiming at increasing the fibre intake while restricting that of refined sugar seem justified in the child population in developed countries...
  4. ncbi request reprint Impact of repeated dietary counseling between infancy and 14 years of age on dietary intakes and serum lipids and lipoproteins: the STRIP study
    Harri Niinikoski
    Department of Pediatrics, University of Turku, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Circulation 116:1032-40. 2007
    ..The aims of the present study were to evaluate the effect of low-saturated-fat, low-cholesterol dietary counseling on fat intakes, growth, serum cholesterol values, and pubertal development in children and adolescents...
  5. doi request reprint Blood pressure is lower in children and adolescents with a low-saturated-fat diet since infancy: the special turku coronary risk factor intervention project
    Harri Niinikoski
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Hypertension 53:918-24. 2009
    ..The importance of childhood lifestyle counseling and primary prevention of hypertension should be emphasized, especially in those children with a family history of hypertension or atherosclerotic vascular disease...
  6. doi request reprint Association of fitness with vascular intima-media thickness and elasticity in adolescence
    Katja Pahkala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Pediatrics 132:e77-84. 2013
    ..Data on the effect of cardiorespiratory fitness on these measures of vascular health in adolescence are scarce. The aim was to examine the association of fitness with aortic and carotid artery IMT and elasticity in adolescents...
  7. doi request reprint Left ventricular mass and geometry in adolescence: early childhood determinants
    Hanna Hietalampi
    University of Turku, Research Centre of Applied and Preventive Cardiovascular Medicine, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Hypertension 60:1266-72. 2012
    ..0003), were associated with higher body mass index. Our results indicate that birth weight has a long-lasting impact on LVM and normal body weight is beneficial for cardiac structure in adolescents...
  8. doi request reprint Effect of repeated dietary counseling on serum lipoproteins from infancy to adulthood
    Harri Niinikoski
    Department of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland
    Pediatrics 129:e704-13. 2012
    ..Our aim was to study the influences of repeated low saturated fat dietary counseling on dietary intakes and lipoprotein measures from infancy to adulthood...
  9. doi request reprint Ideal cardiovascular health in adolescence: effect of lifestyle intervention and association with vascular intima-media thickness and elasticity (the Special Turku Coronary Risk Factor Intervention Project for Children [STRIP] study)
    Katja Pahkala
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Circulation 127:2088-96. 2013
    ..Additionally, we investigated the association between the concept and vascular intima-media thickness and elasticity in adolescence...
  10. doi request reprint Carbohydrate intake, serum lipids and apolipoprotein E phenotype show association in children
    Soile Ruottinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
    Acta Paediatr 98:1667-73. 2009
    ..To study the association between carbohydrate intake and serum lipids in children, and influence of apolipoprotein E phenotype (apoE) on the association...
  11. doi request reprint Association of physical activity with vascular endothelial function and intima-media thickness
    Katja Pahkala
    University of Turku, Research Centre of Applied and Preventive Cardiovascular Medicine, FI 20520 Turku, Finland
    Circulation 124:1956-63. 2011
    ..We investigated prospectively the association of leisure-time physical activity with endothelial function (brachial artery flow-mediated dilatation; FMD) and aortic IMT in adolescents...
  12. doi request reprint Effects of a home-based exercise program on metabolic risk factors and fitness in long-term survivors of childhood acute lymphoblastic leukemia
    Liisa S Järvelä
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Blood Cancer 59:155-60. 2012
    ..The purpose of this study was to evaluate the effects of a simple, inexpensive home-based exercise program on cardiometabolic risk factors and fitness in long-term ALL survivors...
  13. doi request reprint Endothelial function in long-term survivors of childhood acute lymphoblastic leukemia: effects of a home-based exercise program
    Liisa S Järvelä
    Department of Pediatrics, Turku University Hospital, Turku, Finland
    Pediatr Blood Cancer 60:1546-51. 2013
    ..IMT and FMD are intermediate markers of CVD. We studied endothelial function and the effects of an exercise program on vascular endothelium in long-term survivors of childhood ALL...
  14. ncbi request reprint Dietary patterns and nutrient intakes of 7-year-old children taking part in an atherosclerosis prevention project in Finland
    Minna Räsänen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Finland
    J Am Diet Assoc 102:518-24. 2002
    ..To evaluate the dietary patterns of 7-year-old children participating in an atherosclerosis prevention project and the relationship of those dietary patterns to nutrient intakes and serum cholesterol values...
  15. ncbi request reprint Endothelial function in healthy 11-year-old children after dietary intervention with onset in infancy: the Special Turku Coronary Risk Factor Intervention Project for children (STRIP)
    Olli T Raitakari
    Department of Clinical Physiology, University of Turku, Turku, Finland
    Circulation 112:3786-94. 2005
    ..Early childhood introduction of nutritional habits aimed at atherosclerosis prevention reduces children's serum total cholesterol concentration, but its effect on vascular endothelial function is unknown...
  16. doi request reprint High sucrose intake is associated with poor quality of diet and growth between 13 months and 9 years of age: the special Turku Coronary Risk Factor Intervention Project
    Soile Ruottinen
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Kiinamyllynkatu 10, FI 20520 Turku, Finland
    Pediatrics 121:e1676-85. 2008
    ..Previous studies have suggested that interventions to lower dietary fat content and improved fat quality lead to a compensatory increase in sucrose content...
  17. doi request reprint Metabolic syndrome from adolescence to early adulthood: effect of infancy-onset dietary counseling of low saturated fat: the Special Turku Coronary Risk Factor Intervention Project (STRIP)
    Mari Nupponen
    From the Research Centre of Applied and Preventive Cardiovascular Medicine, Turku, Finland M N, K P, M J, C G M, M S, O S, O T R Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Health and Physical Activity, Turku, Finland K P Department of Medicine, University of Turku and Division of Medicine, Turku University Hospital, Turku, Finland M J, T R, J S A V Murdoch Children s Research Institute, Melbourne, Australia M J Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia C G M Departments of Pediatrics and Adolescent Medicine H N, O S and Clinical Physiology and Nuclear Medicine O T R, University of Turku and Turku University Hospital, Turku, Finland Turku Institute for Child and Youth Research, Turku, Finland A J and Institute for Health and Welfare, Turku, Finland A J
    Circulation 131:605-13. 2015
    ..Our aim was to establish the relationship between an infancy-onset dietary intervention and risk of having MetS between 15 and 20 years of age...
  18. doi request reprint Distensibility of the aorta and carotid artery and left ventricular mass from childhood to early adulthood
    Hanna Mikola
    From the Research Centre of Applied and Preventive Cardiovascular Medicine H M, K P, P S, O S, M J, O T R, Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Health and Physical Activity K P, Department of Medicine T R, J S A V, and Department of Clinical Physiology and Nuclear Medicine OT R, University of Turku, Turku, Finland Division of Medicine T R, J S A V, M J, Department of Clinical Physiology and Nuclear Medicine OT R, and Department of Paediatrics and Adolescent Medicine H N, O S, Turku University Hospital, Turku, Finland and Department of Paediatrics, Children s Hospital, Helsinki University Hospital, University of Helsinki, Helsinki, Finland E J
    Hypertension 65:146-52. 2015
    ..The longitudinal progression of aortic and carotid distensibility was related with changes in left ventricular mass...
  19. doi request reprint Dysfunction in macrophage toll-like receptor signaling caused by an inborn error of cationic amino acid transport
    Johanna Kurko
    Department of Medical Biochemistry and Genetics, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland Electronic address
    Mol Immunol 67:416-25. 2015
    ..In conclusion, our results strengthen the relevance of macrophages in the pathogenesis of LPI and, furthermore, suggest that cationic amino acid transport plays an important role in the regulation of innate immune responses. ..
  20. doi request reprint Combined hyperlipidemia in patients with lysinuric protein intolerance
    Laura M Tanner
    Department of Pediatrics, University of Turku, Turku, Finland
    J Inherit Metab Dis 33:S145-50. 2010
    ..The objective of this retrospective study was to investigate lipid values and efficacy of lipid-lowering therapy in patients with LPI...
  21. doi request reprint Carnitine deficiency and L-carnitine supplementation in lysinuric protein intolerance
    Laura M Tanner
    Department of Pediatrics, University of Turku, 20520 Turku, Finland
    Metabolism 57:549-54. 2008
    ..Furthermore, decreased ratio of free and total serum carnitine was common even in LPI patients with normal total serum carnitine concentration...
  22. ncbi request reprint Nutrient intake, weight, and Leu7Pro polymorphism in prepro-neuropeptide Y in children
    Matti K Karvonen
    Department of Neurology, University of Turku, 20520 Turku, Finland
    J Clin Endocrinol Metab 91:4664-8. 2006
    ..Pro7 substitution has been associated with the following: plasma NPY concentration, the risk factors of cardiovascular disease, birth weight of children, serum triglyceride concentration, and the function of vascular endothelium...
  23. doi request reprint Home-Based Exercise Training Improves Left Ventricle Diastolic Function in Survivors of Childhood ALL: A Tissue Doppler and Velocity Vector Imaging Study
    Liisa S Järvelä
    Department of Pediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, Turku, Finland
    Pediatr Blood Cancer 63:1629-35. 2016
    ..We studied echocardiographic tissue Doppler imaging (TDI) and velocity vector imaging (VVI) in long-term survivors of childhood acute lymphoblastic leukemia (ALL) before and after an exercise intervention...
  24. doi request reprint Association of Adiponectin with Adolescent Cardiovascular Health in a Dietary Intervention Study
    Johanna M Jaakkola
    Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland Electronic address
    J Pediatr 167:353-60.e1. 2015
    ....
  25. doi request reprint Hyperglycemia and lower diet quality in pregnant overweight women and increased infant size at birth and at 13 months of age--STEPS study
    Johanna Mäkelä
    Turku Institute for Child and Youth Research, University of Turku, Turku, Finland
    Early Hum Dev 89:439-44. 2013
    ..To study whether maternal overweight and/or hyperglycemia combined with life-style factors in healthy women predisposes to adverse pregnancy or infant health outcomes, such as differences in growth...
  26. ncbi request reprint Nephropathy advancing to end-stage renal disease: a novel complication of lysinuric protein intolerance
    Laura M Tanner
    Department of Pediatrics, University of Turku, Turku, Finland
    J Pediatr 150:631-4, 634.e1. 2007
    ..To analyze systemically the prevalence of renal involvement in a cohort of Finnish patients with lysinuric protein intolerance (LPI) and to describe the course and outcome of end-stage renal disease in 4 patients...
  27. doi request reprint The initiatives and outcomes for cardiovascular risks that can be achieved through paediatric counselling
    Jorma Viikari
    Department of Medicine, University of Turku, Turku, Finland
    Curr Opin Lipidol 20:17-23. 2009
    ..Dietary patterns have a central role in the development of coronary heart disease through effects on serum lipids and development of body fatness. It is the purpose of this review to describe progress in this field...
  28. doi request reprint Growth patterns and obesity development in overweight or normal-weight 13-year-old adolescents: the STRIP study
    Hanna Lagström
    Turku Institute for Child and Youth Research, Turku, Finland
    Pediatrics 122:e876-83. 2008
    ..Our goal was to study childhood growth patterns and development of overweight in children who were overweight or normal weight at 13 years of age...
  29. doi request reprint Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS)
    Tomi T Laitinen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland Electronic address
    Int J Cardiol . 2016
    ..However, association of the ideal CVH in childhood with current and future cardiac structure and function has not been studied...
  30. ncbi request reprint Inhaled Sargramostim Induces Resolution of Pulmonary Alveolar Proteinosis in Lysinuric Protein Intolerance
    Laura M Tanner
    Department of Clinical Genetics, Turku University Hospital, PL 52, 20521, Turku, Finland
    JIMD Rep . 2016
    ..In conclusion, inhaled rhuGM-CSF might be of benefit in patients with LPI-associated PAP...
  31. doi request reprint Breast milk fatty acid composition differs between overweight and normal weight women: the STEPS Study
    Johanna Mäkelä
    Turku Institute for Child and Youth Research, University of Turku, Turku, Finland
    Eur J Nutr 52:727-35. 2013
    ..We studied differences in breast milk fatty acid (FA) composition between overweight and normal weight women and the effect of FA composition on children's cholesterol concentrations at 13 months and growth from birth to 13 months...
  32. doi request reprint When and how to start prevention of atherosclerosis? Lessons from the Cardiovascular Risk in the Young Finns Study and the Special Turku Coronary Risk Factor Intervention Project
    Costan G Magnussen
    Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Kiinamyllynkatu 10, 20520, Finland, Finland
    Pediatr Nephrol 27:1441-52. 2012
    ....
  33. doi request reprint Imbalance of plasma amino acids, metabolites and lipids in patients with lysinuric protein intolerance (LPI)
    Johanna Kurko
    Department of Medical Biochemistry and Genetics, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland Electronic address
    Metabolism 65:1361-75. 2016
    ..LPI is characterized by protein malnutrition, failure to thrive and hyperammonemia. Many patients also suffer from combined hyperlipidemia and chronic kidney disease (CKD) with an unknown etiology...
  34. ncbi request reprint Hazards associated with pregnancies and deliveries in lysinuric protein intolerance
    Laura Tanner
    Department of Pediatrics, University of Turku, 20520 Turku, Finland
    Metabolism 55:224-31. 2006
    ..We propose centralization of deliveries to obstetric units with capability to deal with bleeding complications and rare inborn errors of metabolism...
  35. ncbi request reprint Long-term oral lysine supplementation in lysinuric protein intolerance
    Laura M Tanner
    Department of Pediatrics, University of Turku, 20520 Turku, Finland
    Metabolism 56:185-9. 2007
    ..In conclusion, low-dose oral lysine supplementation is potentially beneficial to patients with LPI and can be started safely at an early age...
  36. doi request reprint Exploring the transcriptomic variation caused by the Finnish founder mutation of lysinuric protein intolerance (LPI)
    Maaria Tringham
    Department of Medical Biochemistry and Genetics, University of Turku, Kiinamyllynkatu 10, 20520 Turku, Finland
    Mol Genet Metab 105:408-15. 2012
    ..We conclude that changes in the expression of genes other than SLC7A7 may be linked to the various symptoms of LPI, indicating a complex interplay between amino acid transporters and various cellular processes...
  37. doi request reprint Genitopatellar syndrome in an adolescent female with severe osteoporosis and endocrine abnormalities
    Maila Penttinen
    Clinical Genetics Unit, Department of Pediatrics, Turku University Hospital, Turku, Finland
    Am J Med Genet A 149:451-5. 2009
    ..We suggest that these novel findings are also manifestations of GPS...
  38. pmc Urine Beta2-Microglobulin Is an Early Marker of Renal Involvement in LPI
    Mari Kärki
    Department of Pediatrics, University of Turku, Turku, Finland
    JIMD Rep 25:47-55. 2016
    ..The aim of this study was to analyse in detail urine beta2-microglobulin values, renal dysfunction, oral L-citrulline doses and plasma citrulline concentrations in Finnish LPI patients...
  39. ncbi request reprint Case 2: Two young children with polydipsia, polyuria and severe hypertension
    Timo Jahnukainen
    Department of Paediatrics, Turku University Hospital, Turku, Finland
    Acta Paediatr 95:881-3; discussion 884-5. 2006
  40. doi request reprint Physical activity and fitness in adolescent and young adult long-term survivors of childhood acute lymphoblastic leukaemia
    Liisa S Järvelä
    Department of Paediatrics, Turku University Hospital, Kiinamyllynkatu 4 8, FI 20520, Turku, Finland
    J Cancer Surviv 4:339-45. 2010
    ..There is a lack of data on physical activity (PA) and fitness of adolescent and young adult very long-term survivors of childhood acute lymphoblastic leukemia (ALL)...
  41. ncbi request reprint [Phenylketonuria]
    Harri Niinikoski
    TYKS n lastenklinikka, Kiinamyllynkatu 4 8, 20520 Turku
    Duodecim 125:1069-75. 2009
    ..A newborn affected with phenylketonuria is asymptomatic but will rapidly become disabled without therapy. The leading principle of the therapy is careful limitation of phenylalanine intake...
  42. doi request reprint Initiation and exclusivity of breastfeeding: association with mothers' and fathers' prenatal and postnatal depression and marital distress
    Sari Ahlqvist-Björkroth
    Turku Institute for Child and Youth Research, University of Turku, Turku, Finland
    Acta Obstet Gynecol Scand 95:396-404. 2016
    ..This study explored the effects of mothers' and fathers' prenatal and postnatal depressive symptoms and marital distress on breastfeeding initiation and exclusive breastfeeding (EBF) duration...
  43. doi request reprint Interactions between genetic variants and dietary lipid composition: effects on circulating LDL cholesterol in children
    Ari V Ahola-Olli
    From the Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland AVA O, NP, MKO, VM, KP, and TR the Department of Food and Environmental Sciences VM and the Institute for Molecular Medicine Finland FIMM JK, University of Helsinki, Helsinki, Finland the Department of Clinical Chemistry, Fimlab Laboratories, Pirkanmaa Hospital District, School of Medicine, University of Tampere, Tampere, Finland TL the Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland MK Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland KP the Department of Pediatrics, Turku University Hospital, Turku, Finland HN and OS Computational Medicine, Institute of Health Sciences, University of Oulu, Oulu, Finland AJK, PS, and MA K NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland PS and MA K Oulu University Hospital, Oulu, Germany
    Am J Clin Nutr 100:1569-77. 2014
    ..Interindividual differences in response to diet exist, but the underlying genetic factors remain largely unknown...