Genomes and Genes
Affiliation: University of Helsinki
- A novel gene family encoding leucine-rich repeat transmembrane proteins differentially expressed in the nervous systemJuha Lauren
Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P O Box 56 Viikinkaari 9, FIN 00014 Helsinki, Finland
Genomics 81:411-21. 2003..The structure and expression profile of LRRTM mRNAs suggest that they may have a role in the development and maintenance of the vertebrate nervous system...
- Two novel mammalian Nogo receptor homologs differentially expressed in the central and peripheral nervous systemsJuha Lauren
Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, P O Box 56 Viikinkaari 9, FIN 00014, University of Helsinki, Helsinki, Finland
Mol Cell Neurosci 24:581-94. 2003..We also show that all four members of the reticulon family, including Nogo-A, are widely expressed in the nervous system, and therefore are possible ligands for the NgRLs...
- LRRTM3 is dispensable for amyloid-β production in miceTiina Laakso
Neuroscience Center, University of Helsinki, Helsinki, Finland Institute of Biomedicine, University of Helsinki, Helsinki, Finland
J Alzheimers Dis 31:759-64. 2012..Moreover, Aβ levels in primary cortical neurons were similar between the genotypes, indicating that LRRTM3 is not required for Aβ generation in developing mice...
- Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivoPäivi Lindholm
Institute of Biotechnology, P O Box 56, Viikki Biocenter, University of Helsinki, FIN 00014, Helsinki, Finland
Nature 448:73-7. 2007..Thus, CDNF was at least as efficient as GDNF in both experimental settings. Our results suggest that CDNF might be beneficial for the treatment of Parkinson's disease...