T A Lakka

Summary

Affiliation: University of Kuopio
Country: Finland

Publications

  1. pmc Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men
    Maarit Valtonen
    Department of Medicine, Central Finland Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    BMC Public Health 9:204. 2009
  2. ncbi Cardiorespiratory fitness and the progression of carotid atherosclerosis in middle-aged men
    T A Lakka
    University of Kuopio, Kuopio Research Institute of Exercise Medicine, Kuopio University Hospital, Finland
    Ann Intern Med 134:12-20. 2001
  3. ncbi Blood pressure and the progression of carotid atherosclerosis in middle-aged men
    T A Lakka
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Hypertension 34:51-6. 1999
  4. ncbi Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Eur Heart J 26:2018-25. 2005
  5. ncbi Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Physiol Genomics 27:103-7. 2006
  6. ncbi Physical activity in prevention and treatment of the metabolic syndrome
    Timo A Lakka
    Institute of Biomedicine, Department of Physiology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Appl Physiol Nutr Metab 32:76-88. 2007
  7. doi Two-minute heart rate recovery after cycle ergometer exercise and all-cause mortality in middle-aged men
    K P Savonen
    Kuopio Research Institute of Exercise Medicine, Kuopio University HospitalInformation Technology Center, Rovaniemi, Finland
    J Intern Med 270:589-96. 2011
  8. doi Diet, fitness and metabolic syndrome--the DR's EXTRA study
    R Kouki
    Kuopio Research Institute of Exercise Medicine, Haapaniementie 16, Kuopio, Finland
    Nutr Metab Cardiovasc Dis 22:553-60. 2012
  9. doi The current standard measure of cardiorespiratory fitness introduces confounding by body mass: the DR's EXTRA study
    K Savonen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Int J Obes (Lond) 36:1135-40. 2012
  10. ncbi Systolic blood pressure response to exercise stress test and risk of stroke
    S Kurl
    Research Institute of Public Health, Department of Public Health and General Practice, University of Kuopio, Finland
    Stroke 32:2036-41. 2001

Detail Information

Publications87

  1. pmc Leisure-time physical activity, cardiorespiratory fitness and feelings of hopelessness in men
    Maarit Valtonen
    Department of Medicine, Central Finland Central Hospital, Keskussairaalantie 19, 40620 Jyvaskyla, Finland
    BMC Public Health 9:204. 2009
    ..Previous studies have focused on physical exercise and depression. We examined the associations of LTPA and cardiorespiratory fitness with feelings of hopelessness...
  2. ncbi Cardiorespiratory fitness and the progression of carotid atherosclerosis in middle-aged men
    T A Lakka
    University of Kuopio, Kuopio Research Institute of Exercise Medicine, Kuopio University Hospital, Finland
    Ann Intern Med 134:12-20. 2001
    ..Good cardiorespiratory fitness has been associated with reduced risk for clinical events of atherosclerotic vascular diseases, but whether it is related to slower progression of early atherosclerosis is unclear...
  3. ncbi Blood pressure and the progression of carotid atherosclerosis in middle-aged men
    T A Lakka
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Hypertension 34:51-6. 1999
    ..Therefore, more attention should be paid to the level of SBP in the evaluation of CVD risk and in the treatment of hypertension...
  4. ncbi Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Eur Heart J 26:2018-25. 2005
    ..To study the effect of exercise training on plasma C-reactive protein, a marker of inflammation...
  5. ncbi Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Physiol Genomics 27:103-7. 2006
    ..The present findings may be useful in the ongoing effort to search for genes contributing to inflammation and to identify individuals at an increased risk of chronic inflammatory diseases...
  6. ncbi Physical activity in prevention and treatment of the metabolic syndrome
    Timo A Lakka
    Institute of Biomedicine, Department of Physiology, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Appl Physiol Nutr Metab 32:76-88. 2007
    ..The measurement of maximal oxygen consumption may provide an efficient means to target even individuals with relatively few metabolic risk factors who may benefit from more intensive intervention...
  7. doi Two-minute heart rate recovery after cycle ergometer exercise and all-cause mortality in middle-aged men
    K P Savonen
    Kuopio Research Institute of Exercise Medicine, Kuopio University HospitalInformation Technology Center, Rovaniemi, Finland
    J Intern Med 270:589-96. 2011
    ..We investigated the prognostic significance of HRR for premature death, particularly in relation to other exercise test variables...
  8. doi Diet, fitness and metabolic syndrome--the DR's EXTRA study
    R Kouki
    Kuopio Research Institute of Exercise Medicine, Haapaniementie 16, Kuopio, Finland
    Nutr Metab Cardiovasc Dis 22:553-60. 2012
    ..To study the independent and combined associations of diet and cardiorespiratory fitness with the prevalence of the metabolic syndrome (MetS)...
  9. doi The current standard measure of cardiorespiratory fitness introduces confounding by body mass: the DR's EXTRA study
    K Savonen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Int J Obes (Lond) 36:1135-40. 2012
    ..Our objective is to quantify the bias introduced by the per-weight standard in a population distributed across different categories of body mass...
  10. ncbi Systolic blood pressure response to exercise stress test and risk of stroke
    S Kurl
    Research Institute of Public Health, Department of Public Health and General Practice, University of Kuopio, Finland
    Stroke 32:2036-41. 2001
    ..Exercise SBP testing may be recommended as an additional tool in the prediction of future stroke...
  11. ncbi Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3-year progression of carotid atherosclerosis
    J T Salonen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland and Department of Clinical Pharmacology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J Intern Med 248:377-86. 2000
    ..To study the efficacy of vitamin E and C supplementation on the progression of carotid atherosclerosis, hypothesizing an enhanced preventive effect in men and in smokers and synergism between vitamins...
  12. doi Dietary factors associated with overweight and body adiposity in Finnish children aged 6-8 years: the PANIC Study
    A M Eloranta
    Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland
    Int J Obes (Lond) 36:950-5. 2012
    ..To investigate the associations of dietary factors with overweight, body fat percentage (BF%), waist circumference (WC) and hip circumference (HC) among children...
  13. ncbi Exercise-induced silent myocardial ischemia and coronary morbidity and mortality in middle-aged men
    J A Laukkanen
    Research Institute of Public Health, University of Kuopio, Finland
    J Am Coll Cardiol 38:72-9. 2001
    ....
  14. pmc Depression and early retirement: prospective population based study in middle aged men
    M Karpansalo
    Department of Public Health and General Practice, University of Kuopio, PO Box 1927, 70120 Kuopio, Finland
    J Epidemiol Community Health 59:70-4. 2005
    ..Mental depression is an important health problem in many countries. It reduces productivity at work and is the fastest increasing reason for early retirement...
  15. ncbi Cardiovascular fitness as a predictor of mortality in men
    J A Laukkanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, Harjulantie 1 B, 70211 Kuopio, Finland
    Arch Intern Med 161:825-31. 2001
    ..To examine the relations of cardiorespiratory fitness, as measured by maximal oxygen uptake and exercise test duration at the initiation of the study, with overall, cardiovascular disease (CVD)-related, and non-CVD-related mortality...
  16. ncbi Hyperinsulinemia is associated with the incidence of hypertension and dyslipidemia in middle-aged men
    J T Salonen
    Research Institute of Public Health and Department of Public Health and General Practice, University of Kuopio, Finland
    Diabetes 47:270-5. 1998
    ....
  17. pmc Peak oxygen pulse during exercise as a predictor for coronary heart disease and all cause death
    J A Laukkanen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Heart 92:1219-24. 2006
    ....
  18. doi Cardiorespiratory fitness in aging men and women: the DR's EXTRA study
    L Hakola
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Scand J Med Sci Sports 21:679-87. 2011
    ..001) and women (P<0.001). The present study provides clinically useful reference values of cardiorespiratory fitness for primary and secondary prevention purposes in aging people...
  19. ncbi Hyperinsulinemia and the risk of cardiovascular death and acute coronary and cerebrovascular events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
    H M Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    Arch Intern Med 160:1160-8. 2000
    ..The role of hyperinsulinemia as a cardiovascular risk factor is controversial. We studied whether hyperinsulinemia is independently associated with increased cardiovascular morbidity and mortality...
  20. ncbi Association of waist and hip circumference with 12-year progression of carotid intima-media thickness in elderly women
    M Hassinen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Int J Obes (Lond) 31:1406-11. 2007
    ..To test the hypothesis that waist and hip circumferences together provide additional information on the progression of preclinical atherosclerosis beyond either of them alone in elderly women...
  21. ncbi Association of exercise-induced, silent ST-segment depression with the risk of stroke and cardiovascular diseases in men
    S Kurl
    Research Institute of Public Health, Kuopio, Finland
    Stroke 34:1760-5. 2003
    ..In this prospective study, we investigated the relation of silent myocardial ischemia and the risk of stroke and CVD death in men with and without conventional risk factors...
  22. doi Dietary quality indices in relation to cardiometabolic risk among Finnish children aged 6-8 years - The PANIC study
    A M Eloranta
    Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland Electronic address
    Nutr Metab Cardiovasc Dis 26:833-41. 2016
    ..We therefore investigated the associations of four dietary quality indices with cardiometabolic risk score and cardiometabolic risk factors in Finnish children...
  23. ncbi Low serum lycopene concentration is associated with an excess incidence of acute coronary events and stroke: the Kuopio Ischaemic Heart Disease Risk Factor Study
    T H Rissanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN-70211, Kuopio, Finland
    Br J Nutr 85:749-54. 2001
    ..Our study suggests that a low serum level of lycopene is associated with an increased risk of atherosclerotic vascular events in middle-aged men previously free of CHD and stroke...
  24. ncbi Low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study
    S Voutilainen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Circulation 103:2674-80. 2001
    ..Our findings provide further support in favor of a role of folate in the promotion of good cardiovascular health...
  25. ncbi Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes
    T O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Physiol Genomics 31:264-72. 2007
    ..022-0.027 for the SNPs in SLC2A2, and P = 0.007 for rs3758947). We conclude that moderate-to-vigorous PA may modify the risk of developing T2D associated with genes regulating insulin secretion (SLC2A2, ABCC8) in persons with IGT...
  26. doi Dietary factors associated with metabolic risk score in Finnish children aged 6-8 years: the PANIC study
    A M Eloranta
    Physiology, Institute of Biomedicine, University of Eastern Finland, PO Box 1627, 70211, Kuopio, Finland
    Eur J Nutr 53:1431-9. 2014
    ..We therefore investigated association of the daily number of main meals and snacks and food consumption with a metabolic risk score and individual metabolic risk factors in primary school children...
  27. ncbi Workload at the heart rate of 100 beats/min and mortality in middle-aged men with known or suspected coronary heart disease
    K P Savonen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Heart 94:e14. 2008
    ..To investigate whether a workload which an individual is able to perform at the heart rate (HR) of 100 beats/min (WL(100)) independently predicts mortality in middle-aged men with known or suspected coronary heart disease (CHD)...
  28. ncbi Mercury accumulation and accelerated progression of carotid atherosclerosis: a population-based prospective 4-year follow-up study in men in eastern Finland
    J T Salonen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211, Kuopio, Finland
    Atherosclerosis 148:265-73. 2000
    ..9%) greater in the highest fifth than in the other fifths (P<0.05 for the difference). These findings suggest that mercury accumulation in the human body is associated with accelerated progression of carotid atherosclerosis...
  29. doi The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study
    T O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Exp Clin Endocrinol Diabetes 118:757-9. 2010
    ..In conclusion, the rs1800629 SNP in the TNF gene may modify the effect of moderate-to-vigorous physical activity on serum levels of CRP...
  30. doi Food consumption, nutrient intake and the risk of having metabolic syndrome: the DR's EXTRA Study
    R Kouki
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Eur J Clin Nutr 65:368-77. 2011
    ..The associations of different components of diet with metabolic syndrome (MetS) are largely unknown. We therefore studied the associations of intakes of selected food items and nutrients with the risk of having MetS...
  31. doi Association of plasma fatty acid composition with plasma irisin levels in normal weight and overweight/obese children
    A Viitasalo
    Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
    Pediatr Obes 11:299-305. 2016
    ..Irisin has been suggested to protect against overweight. There are no previous data on the association of plasma fatty acid (FA) composition with plasma irisin...
  32. doi Plasma polyunsaturated fatty acids are directly associated with cognition in overweight children but not in normal weight children
    E A Haapala
    Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland
    Acta Paediatr 105:1502-1507. 2016
    ..Polyunsaturated fatty acids are essential nutrients for the normal development of the brain. We investigated the associations between plasma polyunsaturated fatty acids and cognition in normal weight and overweight children...
  33. doi Correlates of low physical activity levels in aging men and women: the DR's EXTRA Study (ISRCTN45977199)
    L Hakola
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    J Aging Phys Act 23:247-55. 2015
    ..In women, cardiovascular disease and depressive symptoms were associated with low PA. These results can be applied in targeting PA interventions. ..
  34. ncbi Obesity and weight gain are associated with increased incidence of hyperinsulinemia in non-diabetic men
    H M Lakka
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Horm Metab Res 34:492-8. 2002
    ..Hyperinsulinemia at baseline was not associated with weight gain during the follow-up. This prospective population-based study emphasizes the importance of avoiding obesity and weight gain during adulthood in preventing hyperinsulinemia...
  35. doi Dietary factors and their associations with socioeconomic background in Finnish girls and boys 6-8 years of age: the PANIC Study
    A M Eloranta
    Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland
    Eur J Clin Nutr 65:1211-8. 2011
    ..To study nutrient intake, food consumption and meal pattern, and their associations with socioeconomic background in Finnish children...
  36. pmc Cardiorespiratory fitness and risk of disability pension: a prospective population based study in Finnish men
    M Karpansalo
    Research Institute of Public Health, University of Kuopio, Finland
    Occup Environ Med 60:765-9. 2003
    ..Early retiring is a major social problem in many western countries...
  37. ncbi Serum fatty acid composition predicts development of impaired fasting glycaemia and diabetes in middle-aged men
    D E Laaksonen
    Department of Physiology, and Research Institute of Public Health, University of Kuopio, and Department of Medicine, Kuopio University Hospital, Kuopio, and Inner Savo Health Centre, Suonerjoki, Finland
    Diabet Med 19:456-64. 2002
    ..We assessed the association of serum fatty acid composition with development of IFG or DM...
  38. doi Associations of cardiorespiratory fitness, physical activity, and adiposity with arterial stiffness in children
    A Veijalainen
    Institute of Biomedicine Physiology, School of Medicine, University of Eastern Finland, Kuopio, Finland
    Scand J Med Sci Sports 26:943-50. 2016
    ..005) had higher arterial stiffness than children in the opposite halves of these variables. Poor CRF was independently associated with increased arterial stiffness and impaired arterial dilation capacity among children. ..
  39. ncbi Abdominal obesity is associated with increased risk of acute coronary events in men
    H M Lakka
    Department of Public Health and General Practice, Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Eur Heart J 23:706-13. 2002
    ..The purpose of the study was to investigate the associations of abdominal obesity and overall obesity with the risk of acute coronary events...
  40. ncbi Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
    V P Valkonen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Lancet 358:2127-8. 2001
    ..62 micromol/L) had a 3.9-fold (95% CI 1.25-12.3, p=0.02) increase in risk of acute coronary events compared with the other quartiles. Our findings suggest that ADMA is a predictor of acute coronary events...
  41. doi Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study
    A Viitasalo
    Department of Physiology, Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland Institute of Dentistry, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
    Pediatr Obes 10:84-90. 2015
    ..We studied the associations and interactions of overweight and the PNPLA3 I148M polymorphism with plasma ALT levels during 2-year follow-up in children...
  42. ncbi Increased risk of acute myocardial infarction in carriers of the hemochromatosis gene Cys282Tyr mutation : a prospective cohort study in men in eastern Finland
    T P Tuomainen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Circulation 100:1274-9. 1999
    ..1 to 4.8; P=0.03) risk of acute myocardial infarction compared with noncarriers. Conclusions-Male carriers of the common hemochromatosis gene mutation are at 2-fold risk for first acute myocardial infarction compared with noncarriers...
  43. doi Usefulness of chronotropic incompetence in response to exercise as a predictor of myocardial infarction in middle-aged men without cardiovascular disease
    Kai P Savonen
    Kuopio Research Institute of Exercise Medicine, University of Kuopio, Kuopio, Finland
    Am J Cardiol 101:992-8. 2008
    ..1-times higher incidence of AMI than those with a normal HR40-100 and SBP increase (95% CI 1.7 to 5.7). In conclusion, a low HR40-100 predicted AMI in men without previous CVD independent of other exercise test or clinical variables...
  44. doi Cardiorespiratory fitness as a feature of metabolic syndrome in older men and women: the Dose-Responses to Exercise Training study (DR's EXTRA)
    Maija Hassinen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Diabetes Care 31:1242-7. 2008
    ..We studied the associations of cardiorespiratory fitness with metabolic syndrome in older men and women, because such data are limited in representative population samples...
  45. doi Interaction of single nucleotide polymorphisms in ADRB2, ADRB3, TNF, IL6, IGF1R, LIPC, LEPR, and GHRL with physical activity on the risk of type 2 diabetes mellitus and changes in characteristics of the metabolic syndrome: The Finnish Diabetes Prevention
    Tuomas O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio 70211, Finland
    Metabolism 57:428-36. 2008
    ..In conclusion, genetic variation may modify the magnitude of the beneficial effects of PA on characteristics of the metabolic syndrome in persons with IGT...
  46. ncbi SNPs in PPARG associate with type 2 diabetes and interact with physical activity
    Tuomas O Kilpeläinen
    Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland
    Med Sci Sports Exerc 40:25-33. 2008
    ....
  47. ncbi Cardiorespiratory fitness and the risk for stroke in men
    Sudhir Kurl
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Arch Intern Med 163:1682-8. 2003
    ..We also compared VO(2)max with conventional risk factors as a predictor for future strokes...
  48. ncbi Sedentary lifestyle, poor cardiorespiratory fitness, and the metabolic syndrome
    Timo A Lakka
    Research Institute of Public Health, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 35:1279-86. 2003
    ....
  49. ncbi Carotid intima-media thickness and cognitive function in elderly women: a population-based study
    Pirjo Komulainen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Neuroepidemiology 28:207-13. 2007
    ..We investigated whether carotid intima-media thickness (IMT) predicts the risk of cognitive impairment and whether the putative impairment is specific for some cognitive domains...
  50. ncbi Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline
    Kai P Savonen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Am J Cardiol 100:563-8. 2007
    ..In conclusion, WL(100) predicts CVD and CHD mortality in men without previous CHD. The association of WL(100) with CVD and CHD mortality is not explained by maximal cardiorespiratory performance...
  51. ncbi Association of age and education with different types of leisure-time physical activity among 4437 Finnish adults
    Katja Borodulin
    National Public Health Institute, Dept of Health Promotion and Chronic Disease Prevention, Helsinki, Finland
    J Phys Act Health 5:242-51. 2008
    ..The aim of this study was to investigate the associations of age and education with types of leisure-time physical activity in a population sample of Finnish adults...
  52. ncbi Cardiorespiratory fitness and vigorous leisure-time physical activity modify the association of small size at birth with the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Diabetes Care 26:2156-64. 2003
    ..We studied the association of size at birth with the metabolic syndrome...
  53. ncbi Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Am J Epidemiol 156:1070-7. 2002
    ..The NCEP definition including waist > 102 cm also identifies persons at high risk for diabetes, but it is relatively insensitive in predicting diabetes...
  54. ncbi Arginine intake, blood pressure, and the incidence of acute coronary events in men: the Kuopio Ischaemic Heart Disease Risk Factor Study
    Birgitta Venho
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Am J Clin Nutr 76:359-64. 2002
    ..Evidence suggests that dietary supplementation of L-arginine, the precursor of nitric oxide, may protect arteries against atherosclerosis...
  55. ncbi Physical exercise and blood pressure with reference to the angiotensinogen M235T polymorphism
    Rainer Rauramaa
    Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, 70100 Kuopio, Finland
    Physiol Genomics 10:71-7. 2002
    ..026 and 0.024 for net effects), respectively. Regular moderate intensity exercise attenuates aging-related increase in systolic BP and decreases diastolic BP among the M homozygotes of the AGT gene M235T polymorphism...
  56. ncbi Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome
    David E Laaksonen
    Department of Physiology, University of Kuopio, Kuopio, Finland Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Diabetes Care 25:1612-8. 2002
    ..We studied the associations of LTPA and cardiorespiratory fitness with development of the metabolic syndrome (World Health Organization [WHO] and the National Cholesterol Education Program [NCEP] definitions)...
  57. ncbi Associations between estimated aerobic fitness and cardiovascular risk factors in adults with different levels of abdominal obesity
    Katja Borodulin
    National Public Health Institute, Department of Epidemiology and Health Promotion, Helsinki, Finland
    Eur J Cardiovasc Prev Rehabil 12:126-31. 2005
    ..We investigated the association between estimated aerobic fitness and cardiovascular risk factors, and how the association is affected by abdominal obesity...
  58. ncbi Physical workload and risk of early retirement: prospective population-based study among middle-aged men
    Minna Karpansalo
    Research Institute of Public Health, University of Kuopio, PO Box 1927, 70120 Kuopio, Finland
    J Occup Environ Med 44:930-9. 2002
    ..In heavy physical work, the risk is increased especially among men with musculoskeletal or cardiovascular disease and poor cardiorespiratory fitness...
  59. ncbi The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
    Hanna Maaria Lakka
    Research Institute of Public Health, University of Kuopio, Finland
    JAMA 288:2709-16. 2002
    ..Despite its high prevalence, little is known of the prospective association of the metabolic syndrome with cardiovascular and overall mortality...
  60. ncbi A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Diabetes 52:1583-7. 2003
    ..The present findings may be important in identifying individuals at increased risk of developing type 2 diabetes and who are most likely to benefit from a physically active lifestyle...
  61. ncbi Metabolic syndrome and cognitive function: a population-based follow-up study in elderly women
    Pirjo Komulainen
    Kuopio Research Institute of Exercise Medicine, Department of Physiology, University of Kuopio, Kuopio, Finland
    Dement Geriatr Cogn Disord 23:29-34. 2007
    ..To test the hypothesis that metabolic syndrome predicts cognitive impairment, and to examine the association of single metabolic risk factors with cognitive functioning...
  62. ncbi Serum high sensitivity C-reactive protein and cognitive function in elderly women
    Pirjo Komulainen
    Kuopio Research Institute of Exercise Medicine, Finland
    Age Ageing 36:443-8. 2007
    ..Inflammation has been linked to cognitive impairment. However, limited data are available on the association between inflammatory markers and cognitive function...
  63. ncbi Heart rate response during exercise test and cardiovascular mortality in middle-aged men
    Kai P Savonen
    Kuopio Research Institute of Exercise Medicine, Haapaniementie 16, 70100 Kuopio, Finland
    Eur Heart J 27:582-8. 2006
    ..The objective is to study whether a heart rate (HR) response during exercise test independently predicts cardiovascular disease (CVD) mortality...
  64. ncbi Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial
    Rainer Rauramaa
    Kuopio Research Institute of Exercise Medicine, University of Kuopio, and Kuopio University Hospital, Kuopio, Finland
    Ann Intern Med 140:1007-14. 2004
    ..Although regular physical activity is recommended for prevention of cardiovascular diseases, no data are available on its antiatherosclerotic effects in the general population...
  65. ncbi Physical activity, cardiovascular risk factors, and mortality among Finnish adults with diabetes
    Gang Hu
    Diabetes and Genetic Epidemiology Unit, Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Diabetes Care 28:799-805. 2005
    ..The aim of this study was to examine both single and joint associations of physical activity and conventional cardiovascular risk factors with total and cardiovascular mortality among patients with diabetes...
  66. ncbi Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study
    Leo K Niskanen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Arch Intern Med 164:1546-51. 2004
    ..Despite abundant epidemiologic evidence, the role of elevated serum uric acid level as a cardiovascular risk factor is controversial. We assessed the predictive value of serum uric acid levels for cardiovascular and overall mortality...
  67. ncbi Low physical activity as a predictor for antihypertensive drug treatment in 25-64-year-old populations in eastern and south-western Finland
    Noel C Barengo
    Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    J Hypertens 23:293-9. 2005
    ....
  68. ncbi Effects of exercise training on glucose homeostasis: the HERITAGE Family Study
    Normand G Boule
    Division of Kinesiology, Laval University, Sainte Foy, Quebec, Canada
    Diabetes Care 28:108-14. 2005
    ..To determine the effect of a 20-week endurance training program in healthy, previously sedentary participants on measures derived from an intravenous glucose tolerance test (i.v.GTT)...
  69. ncbi Physical activity in the prevention of type 2 diabetes: the Finnish diabetes prevention study
    David E Laaksonen
    Department of Clinical Nutrition and Food and Health Research Center, University of Kuopio, P O Box 1627, Kuopio, Finland
    Diabetes 54:158-65. 2005
    ..34, 0.19-0.62) was the most strongly associated with incident diabetes. Thus increasing physical activity may substantially reduce the incidence of type 2 diabetes in high-risk individuals...
  70. ncbi Occupational, commuting, and leisure-time physical activity in relation to total and cardiovascular mortality among Finnish subjects with type 2 diabetes
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Circulation 110:666-73. 2004
    ..Some previous studies have assessed the association between leisure-time physical activity and mortality among patients with diabetes, but the potential effect of occupational and commuting physical activity remains uncertain...
  71. ncbi Low physical activity as a predictor for total and cardiovascular disease mortality in middle-aged men and women in Finland
    Noel C Barengo
    Department of Public Health and General Practice, University of Kuopio, PL 1627, 70211 Kuopio, Finland
    Eur Heart J 25:2204-11. 2004
    ....
  72. ncbi Systolic blood pressure during recovery from exercise and the risk of acute myocardial infarction in middle-aged men
    Jari A Laukkanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, FIN 70211 Kuopio, Finland
    Hypertension 44:820-5. 2004
    ..This emphasizes the importance of SBP measurements after the exercise test because it provides additional valuable prognostic measure with regard to acute myocardial infarction...
  73. ncbi Epidemiology and treatment of the metabolic syndrome
    David E Laaksonen
    Department of Medicine, Kuopio University Hospital, Kuopio, Finland
    Ann Med 36:332-46. 2004
    ..In the meantime, efforts to curb obesity and overweight, increase physical activity and improve compliance with current dietary recommendations should continue...
  74. ncbi Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    Timo A Lakka
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Diabetes 53:1603-8. 2004
    ..Similar interaction was observed in blacks (P = 0.046). Variations in the LEP and LEPR genes are associated with the magnitude of the effects of regular exercise on glucose homeostasis in nondiabetic individuals...
  75. ncbi High dietary methionine intake increases the risk of acute coronary events in middle-aged men
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Nutr Metab Cardiovasc Dis 16:113-20. 2006
    ..To date, the effects of dietary intake of methionine, the key amino acid in homocysteine metabolism, on CVD have not been studied. Our aim was to examine the effects of dietary methionine intake on the risk of acute coronary events...
  76. ncbi Epidemiological studies of exercise in diabetes prevention
    Gang Hu
    Diabetes Unit, Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Appl Physiol Nutr Metab 32:583-95. 2007
    ..Our review of the scientific evidence confirms that 30 min/d of moderate- or high-level physical activity is an effective and safe way to prevent type 2 diabetes in all populations...
  77. ncbi Relationship of physical activity and body mass index to the risk of hypertension: a prospective study in Finland
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Hypertension 43:25-30. 2004
    ..The present study indicates that regular physical activity and weight control can reduce the risk of hypertension. The protective effect of physical activity was observed in both sexes regardless of the level of obesity...
  78. ncbi Asymmetrical dimethylarginine (ADMA) and risk of acute coronary events. Does statin treatment influence plasma ADMA levels?
    Veli Pekka Valkonen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Atheroscler Suppl 4:19-22. 2003
    ..However, aggressive treatment with either simvastatin or atorvastatin did not reduce plasma ADMA levels...
  79. ncbi Exercise, genetics and prevention of type 2 diabetes
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Essays Biochem 42:177-92. 2006
    ....
  80. ncbi Occupational, commuting and leisure-time physical activity in relation to coronary heart disease among middle-aged Finnish men and women
    Gang Hu
    Department of Epidemiology and Health Promotion, National Public Health Institute, Mannerheimintie 166, FIN 00300 Helsinki, Finland
    Atherosclerosis 194:490-7. 2007
    ..To examine the association of different levels of occupational, commuting, and leisure-time physical activity with the risk of coronary heart disease (CHD) events...
  81. ncbi Systolic blood pressure response to exercise testing is related to the risk of acute myocardial infarction in middle-aged men
    Jari A Laukkanen
    Research Institute of Public Health, University of Kuopio, Kuopio, Finland
    Eur J Cardiovasc Prev Rehabil 13:421-8. 2006
    ..We assessed the association of systolic blood pressure response to exercise with the risk of an acute myocardial infarction...
  82. ncbi The TNF-alpha G-308A polymorphism is associated with C-reactive protein levels: the HERITAGE Family Study
    Hanna Maaria Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
    Vascul Pharmacol 44:377-83. 2006
    ..Pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), stimulate the release of C-reactive protein (CRP). We investigated the association between the TNF-alpha G-308A polymorphism and plasma CRP levels...
  83. ncbi C-reactive protein and metabolic syndrome in elderly women: a 12-year follow-up study
    Maija Hassinen
    Kuopio Research Institute of Exercise Medicine, Haapaniementie 16, FIN 70100 Kuopio, Finland
    Diabetes Care 29:931-2. 2006
  84. ncbi Metabolic syndrome and the progression of carotid intima-media thickness in elderly women
    Maija Hassinen
    Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
    Arch Intern Med 166:444-9. 2006
    ..We investigated the association of the metabolic syndrome with the progression of carotid intima-media thickness (IMT) in elderly women...
  85. ncbi Genetics, physical activity, fitness and health: what does the future hold?
    Timo A Lakka
    J R Soc Promot Health 124:14-5. 2004
  86. ncbi Physical activity and diabetes complications in patients with type 1 diabetes: the Finnish Diabetic Nephropathy (FinnDiane) Study
    Johan Wadén
    Folkhalsan Institute of Genetics, Folkhalsan Research Center, Helsinki, Finland
    Diabetes Care 31:230-2. 2008
  87. ncbi Perceived health as a predictor of early retirement
    Minna Karpansalo
    Department of Public Health and General Practice, University of Kuopio, Kuopio, Finland
    Scand J Work Environ Health 30:287-92. 2004
    ..This study examined the association between perceived health and early retirement...