M Knip

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. ncbi Environmental factors in the pathogenesis of type 1 diabetes mellitus
    M Knip
    Medical School, University of Tampere, and Department of Pediatrics, Tampere University Hospital, Finland
    Exp Clin Endocrinol Diabetes 107:S93-100. 1999
  2. ncbi Disease-associated autoimmunity and prevention of insulin-dependent diabetes mellitus
    M Knip
    University of Tampere, Department of Pediatrics, Tampere University Hospital, Finland
    Ann Med 29:447-51. 1997
  3. ncbi Islet cell antibodies are less predictive of IDDM among unaffected children in the general population than in sibs of children with diabetes. The Childhood Diabetes in Finland Study Group
    M Knip
    Medical School and the Department of Pediatrics, Tampere University Hospital, University of Tampere, Finland
    Diabetes Care 21:1670-3. 1998
  4. ncbi Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity
    T Kimpimäki
    Department of Pediatrics, Tampere University Hospital, Finland
    Diabetologia 44:63-9. 2001
  5. ncbi Signs of beta-cell autoimmunity and HLA-defined diabetes susceptibility in the Finnish population: the sib cohort from the Type 1 Diabetes Prediction and Prevention Study
    M Kukko
    Medical School, University of Tampere, and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Diabetologia 46:65-70. 2003
  6. ncbi Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children. Childhood Diabetes in Finland Study Group
    P Kulmala
    Department of Pediatrics, University of Oulu, Finland
    Diabetes 49:48-58. 2000
  7. pmc IA-2 antibody isotypes and epitope specificity during the prediabetic process in children with HLA-conferred susceptibility to type I diabetes
    S Hoppu
    Paediatric Research Centre, Medical School, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Clin Exp Immunol 144:59-66. 2006
  8. ncbi Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population
    M Kukko
    Juvenile Diabetes Research Foundation Center for the Prevention of Type 1 Diabetes in Finland and Medical School, University of Tampere, and Department of Pediatrics, Tampere University Hospital
    J Clin Endocrinol Metab 90:2712-7. 2005
  9. doi Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring
    B I Nwaru
    School of Health Sciences, University of Tampere, Tampere, Finland
    Eur J Clin Nutr 65:937-43. 2011
  10. ncbi Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population
    T Kimpimäki
    The Juvenile Diabetes Research Foundation Center for Type 1 Diabetes Prevention in Finland, Department of Pediatrics, Medical School, University of Tampere and Tampere University Hospital, FIN 33014 Tampere
    J Clin Endocrinol Metab 87:4572-9. 2002

Detail Information

Publications87

  1. ncbi Environmental factors in the pathogenesis of type 1 diabetes mellitus
    M Knip
    Medical School, University of Tampere, and Department of Pediatrics, Tampere University Hospital, Finland
    Exp Clin Endocrinol Diabetes 107:S93-100. 1999
    ..Ongoing prospective studies starting from birth provide an optimal setting for the identification of environmental factors affecting the risk of progression to clinical Type 1 diabetes...
  2. ncbi Disease-associated autoimmunity and prevention of insulin-dependent diabetes mellitus
    M Knip
    University of Tampere, Department of Pediatrics, Tampere University Hospital, Finland
    Ann Med 29:447-51. 1997
    ..Substantially more data have to be generated, however, on the mechanisms, efficacy and safety of such therapy before it is possible to judge its clinical applicability...
  3. ncbi Islet cell antibodies are less predictive of IDDM among unaffected children in the general population than in sibs of children with diabetes. The Childhood Diabetes in Finland Study Group
    M Knip
    Medical School and the Department of Pediatrics, Tampere University Hospital, University of Tampere, Finland
    Diabetes Care 21:1670-3. 1998
    ..To examine the controversial issue of whether islet cell antibodies (ICAs) have a higher predictive value for progression to clinical IDDM in first-degree relatives of patients with diabetes than in the general population...
  4. ncbi Short-term exclusive breastfeeding predisposes young children with increased genetic risk of Type I diabetes to progressive beta-cell autoimmunity
    T Kimpimäki
    Department of Pediatrics, Tampere University Hospital, Finland
    Diabetologia 44:63-9. 2001
    ..This study aimed to establish the relation between early infant nutrition and signs of beta-cell autoimmunity in young children...
  5. ncbi Signs of beta-cell autoimmunity and HLA-defined diabetes susceptibility in the Finnish population: the sib cohort from the Type 1 Diabetes Prediction and Prevention Study
    M Kukko
    Medical School, University of Tampere, and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Diabetologia 46:65-70. 2003
    ..To assess the role of HLA-defined genetic diabetes susceptibility in the appearance of signs of beta-cell autoimmunity in a series of children derived from the general population...
  6. ncbi Genetic markers, humoral autoimmunity, and prediction of type 1 diabetes in siblings of affected children. Childhood Diabetes in Finland Study Group
    P Kulmala
    Department of Pediatrics, University of Oulu, Finland
    Diabetes 49:48-58. 2000
    ..Finally, not all siblings with a broad humoral autoimmune response or high-risk genetic markers present with type 1 diabetes, while some with a low genetic risk and weak initial signs of humoral autoimmunity may progress to disease...
  7. pmc IA-2 antibody isotypes and epitope specificity during the prediabetic process in children with HLA-conferred susceptibility to type I diabetes
    S Hoppu
    Paediatric Research Centre, Medical School, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Clin Exp Immunol 144:59-66. 2006
    ..002). IgE-IA-2 antibody reactivity may be a marker of a regulatory immune response providing protection against or delaying progression to TID among IA-2 antibody-positive young children with HLA-conferred disease susceptibility...
  8. ncbi Dynamics of diabetes-associated autoantibodies in young children with human leukocyte antigen-conferred risk of type 1 diabetes recruited from the general population
    M Kukko
    Juvenile Diabetes Research Foundation Center for the Prevention of Type 1 Diabetes in Finland and Medical School, University of Tampere, and Department of Pediatrics, Tampere University Hospital
    J Clin Endocrinol Metab 90:2712-7. 2005
    ....
  9. doi Intake of antioxidants during pregnancy and the risk of allergies and asthma in the offspring
    B I Nwaru
    School of Health Sciences, University of Tampere, Tampere, Finland
    Eur J Clin Nutr 65:937-43. 2011
    ..The objective was to investigate the association between maternal intake of antioxidants during pregnancy and the risk of asthma, rhinitis and eczema in 5-year-old children...
  10. ncbi Natural history of beta-cell autoimmunity in young children with increased genetic susceptibility to type 1 diabetes recruited from the general population
    T Kimpimäki
    The Juvenile Diabetes Research Foundation Center for Type 1 Diabetes Prevention in Finland, Department of Pediatrics, Medical School, University of Tampere and Tampere University Hospital, FIN 33014 Tampere
    J Clin Endocrinol Metab 87:4572-9. 2002
    ....
  11. doi Early seroconversion and rapidly increasing autoantibody concentrations predict prepubertal manifestation of type 1 diabetes in children at genetic risk
    V Parikka
    Department of Pediatrics, Turku University Hospital, Kiinamyllynkatu 4 8, PO Box 52, 20521 Turku, Finland
    Diabetologia 55:1926-36. 2012
    ....
  12. doi Serum alpha- and gamma-tocopherol concentrations and risk of advanced beta cell autoimmunity in children with HLA-conferred susceptibility to type 1 diabetes mellitus
    L Uusitalo
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Diabetologia 51:773-80. 2008
    ..The aim of our study was to assess the associations of serum alpha- and gamma-tocopherol concentrations with the risk of advanced beta cell autoimmunity in children with HLA-conferred genetic susceptibility to type 1 diabetes mellitus...
  13. doi Maternal intake of vitamin D during pregnancy and risk of advanced beta cell autoimmunity and type 1 diabetes in offspring
    L Marjamäki
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Diabetologia 53:1599-607. 2010
    ..We evaluated the intake of vitamin D by pregnant Finnish women and examined associations between maternal intake of vitamin D and the development of advanced beta cell autoimmunity and type 1 diabetes in their offspring...
  14. doi Maternal food consumption during pregnancy and risk of advanced β-cell autoimmunity in the offspring
    S M Virtanen
    Tampere School of Public Health, University of Tampere, 33014 Tampere, Finland
    Pediatr Diabetes 12:95-9. 2011
    ..The authors study the association of food consumption during pregnancy and the development of β-cell autoimmunity in the offspring...
  15. ncbi Cow's milk consumption, HLA-DQB1 genotype, and type 1 diabetes: a nested case-control study of siblings of children with diabetes. Childhood diabetes in Finland study group
    S M Virtanen
    School of Public Health, University of Tampere, Finland
    Diabetes 49:912-7. 2000
    ..However, further studies are needed to assess the possible interaction between genetic disease susceptibility and dietary exposures in the development of this disease...
  16. ncbi Infant feeding, early weight gain, and risk of type 1 diabetes. Childhood Diabetes in Finland (DiMe) Study Group
    E Hypponen
    School of Public Health, University of Tampere, Finland
    Diabetes Care 22:1961-5. 1999
    ..To evaluate whether the increased risk of type 1 diabetes conferred by an early introduction of cow's milk supplements can be mediated by accelerated growth in formula-fed infants...
  17. doi Human parechovirus and the risk of type 1 diabetes
    P Kolehmainen
    Department of Virology, Medical School, University of Tampere, Tampere, Finland
    J Med Virol 85:1619-23. 2013
    ..Thus, in boys, HPeV infections cannot be excluded as a gender-specific risk factor which promotes the development of type 1 diabetes...
  18. doi Introduction of complementary foods in infancy and atopic sensitization at the age of 5 years: timing and food diversity in a Finnish birth cohort
    B I Nwaru
    School of Health Sciences, University of Tampere, Tampere, Finland
    Allergy 68:507-16. 2013
    ..To study the associations between timing and diversity of introduction of complementary foods during infancy and atopic sensitization in 5-year-old children...
  19. ncbi Serological evidence of thyroid autoimmunity among schoolchildren in two different socioeconomic environments
    Anita Kondrashova
    Department of Virology, University of Tampere, Medical School, Biokatu 10, FI 33520 Tampere, and Department of Clinical Microbiology, Tampere Pirkanmaa Hospital District, Finland
    J Clin Endocrinol Metab 93:729-34. 2008
    ..The mechanisms leading to thyroid autoimmunity are largely unknown...
  20. ncbi Obesity, increased linear growth, and risk of type 1 diabetes in children
    E Hypponen
    School of Public Health, University of Tampere, Finland
    Diabetes Care 23:1755-60. 2000
    ..The purpose of the present study was to evaluate the effect of obesity and linear growth on the risk of developing type 1 diabetes in children...
  21. pmc Humoral beta-cell autoimmunity is rare in patients with the congenital rubella syndrome
    H Viskari
    JDRF Center for Prevention of Type I Diabetes in Finland, Department of Virology, University of Tampere, Finland
    Clin Exp Immunol 133:378-83. 2003
    ..These results provide no evidence of an increased frequency of markers for humoral beta-cell autoimmunity in patients with CRS suggesting that diabetes in CRS may be caused by other than autoimmune mechanisms...
  22. doi Enterovirus infections in early childhood and the risk of atopic disease--a nested case-control study
    L Korhonen
    Department of Virology, School of Medicine, University of Tampere, Tampere, Finland
    Clin Exp Allergy 43:625-32. 2013
    ..Enterovirus infections in childhood have been associated with a reduced risk of atopy in cross-sectional studies...
  23. doi Lower economic status and inferior hygienic environment may protect against celiac disease
    Anita Kondrashova
    Department of Virology, University of Tampere, Medical School, Tampere, Finland
    Ann Med 40:223-31. 2008
    ..The populations in adjacent Russian Karelia and Finland are equally exposed to grain products and share partly the same ancestry, but live in completely different socioeconomic environments...
  24. ncbi Intake of vitamin D by Finnish children aged 3 months to 3 years in relation to sociodemographic factors
    M Rasanen
    Tampere School of Public Health, University of Tampere, Finland
    Eur J Clin Nutr 60:1317-22. 2006
    ..To study the total daily intake of vitamin D from food and supplements among Finnish children aged 3 months to 3 years, the dietary sources of vitamin D and the association between vitamin D intake and sociodemographic factors...
  25. pmc GAD65 antibody isotypes and epitope recognition during the prediabetic process in siblings of children with type I diabetes
    S Hoppu
    Paediatric Research Center, University of Tampere Medical School, and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Clin Exp Immunol 136:120-8. 2004
    ..Our findings indicate that epitope- and isotype-specific GAD65 antibodies are hardly capable of separating progressors from non-progressors among GAD65Ab-positive first-degree relatives of children with type I diabetes...
  26. ncbi Disease-associated autoantibodies as predictive markers of type 1 diabetes mellitus in siblings of affected children
    T Kimpimäki
    Department of Pediatrics, Medical School, University of Tampere, Finland
    J Pediatr Endocrinol Metab 14:575-87. 2001
    ....
  27. ncbi Soluble adhesion molecules in preclinical type 1 diabetes. The Childhood Diabetes in Finland Study Group
    A Toivonen
    Medical School, University of Tampere, and the Department of Pediatrics, Tampere University Hospital, FIN-33014 Tampere, Finland
    Pediatr Res 49:24-9. 2001
    ..Peripheral levels of soluble adhesion molecules are not able to discriminate between progressors and nonprogressors, however, due to substantial overlapping between these two groups...
  28. ncbi Unaltered antioxidant activity of plasma in subjects at increased risk for IDDM
    J S Leinonen
    Medical School, University of Tampere, and Department of Clinical Chemistry, Tampere University Hospital, Finland
    Free Radic Res 29:159-64. 1998
    ..Furthermore, the results suggest that the clinical onset of IDDM is not preceded by signs of increased systemic oxidative stress in plasma...
  29. doi Maternal fatty acid intake during pregnancy and the development of childhood overweight: a birth cohort study
    L Hakola
    School of Health Sciences, University of Tampere, Tampere, Finland
    Pediatr Obes . 2016
    ..Maternal diet during pregnancy may contribute to the risk of offspring adiposity...
  30. ncbi Soluble adhesion molecules in pre-clinical Type 1 diabetes: a prospective study
    A M Toivonen
    Medical School, University of Tampere and Department of Paediatrics, Tampere University Hospital, Tampere, Finland
    Diabetologia 46:492-5. 2003
    ....
  31. ncbi The first signs of beta-cell autoimmunity appear in infancy in genetically susceptible children from the general population: the Finnish Type 1 Diabetes Prediction and Prevention Study
    T Kimpimäki
    The Juvenile Diabetes Research Foundation Center for Type 1 Diabetes Prevention in Finland, Department of Pediatrics, Medical School, University of Tampere, FIN 33014 Tampere, Finland
    J Clin Endocrinol Metab 86:4782-8. 2001
    ..The seasonal variation in the emergence of the first signs of beta-cell autoimmunity suggests that infectious agents may play a role in the induction of such autoimmunity...
  32. ncbi Autoantibodies to glutamic acid decarboxylase in patients with therapy-resistant epilepsy
    J Peltola
    Department of Neurology, Tampere University Hospital, Finland
    Neurology 55:46-50. 2000
    ..Epilepsy was present in 4 of 19 patients with SMS and GAD-A, implying that epilepsy sometimes is associated with anti-GAD autoimmunity...
  33. ncbi Metabolic characteristics and urine albumin excretion rate in relation to pubertal maturation in Type 1 diabetes
    P H Riihimaa
    Department of Pediatrics, Oulu University Hospital, Oulu, Finland
    Diabetes Metab Res Rev 16:269-75. 2000
    ..The objective of this study was to assess the impact of pubertal maturation on urinary albumin excretion rate (AER) and persistent microalbuminuria, and to identify possible factors affecting urinary AER in adolescents with Type 1 diabetes...
  34. pmc Allergic sensitization and microbial load--a comparison between Finland and Russian Karelia
    T Seiskari
    Department of Virology, University of Tampere, Finland
    Clin Exp Immunol 148:47-52. 2007
    ..Enterovirus infections represent a new candidate to the list of markers of such a protective environment. However, possible causal relationship needs to be confirmed in further studies...
  35. ncbi Peripheral nerve function is increasingly impaired during puberty in adolescents with type 1 diabetes
    P H Riihimaa
    Department of Pediatrics, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    Diabetes Care 24:1087-92. 2001
    ..To evaluate the impact of puberty on peripheral nerve function in adolescents with type 1 diabetes...
  36. doi Analysis of pancreas tissue in a child positive for islet cell antibodies
    M Oikarinen
    Department of Virology, Medical School, University of Tampere, Biokatu 10, Tampere, Finland
    Diabetologia 51:1796-802. 2008
    ..The present study assesses whether positivity for a single autoantibody correlates with pathological changes in the pancreas...
  37. ncbi Infant feeding patterns in the Finnish type I diabetes prediction and prevention nutrition study cohort
    M Erkkola
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Eur J Clin Nutr 59:107-13. 2005
    ..To investigate infant feeding patterns during the first 2 y and their relation to sociodemographic factors...
  38. ncbi Validity and reproducibility of a food frequency questionnaire for pregnant Finnish women
    M Erkkola
    Tampere School of Public Health, University of Tampere, Tampere, Finland
    Am J Epidemiol 154:466-76. 2001
    ..44 (ice cream) to 0.91 (coffee). The authors conclude that the FFQ has an acceptable reproducibility and represents a useful tool for categorizing pregnant women according to their dietary intake...
  39. ncbi Severe antibody-mediated human insulin resistance: successful treatment with the insulin analog lispro. A case report
    J T Lahtela
    Department of Medicine, University of Tampere, Finland
    Diabetes Care 20:71-3. 1997
    ..To evaluate the efficacy of the insulin analog lispro (Lys B28, Pro B29) in severe insulin resistance caused by human insulin antibodies...
  40. pmc Analyses of regulatory CD4+ CD25+ FOXP3+ T cells and observations from peripheral T cell subpopulation markers during the development of type 1 diabetes in children
    S Hamari
    Department of Pediatrics, Medical Research Center Oulu, PEDEGO Research Unit, Oulu University Hospital and University of Oulu, Oulu, Finland
    Scand J Immunol 83:279-87. 2016
    ....
  41. ncbi Long-term survivors of childhood cancer have an increased risk of manifesting the metabolic syndrome
    K K Talvensaari
    Department of Pediatrics, University of Oulu, Kajaanintie 50, Finland
    J Clin Endocrinol Metab 81:3051-5. 1996
    ..02). Long term survivors of childhood cancer appear to have an increased risk of manifestations of the metabolic syndrome. Decreased GH secretion may contribute to these metabolic abnormalities...
  42. ncbi Long-term reproductive endocrine health in young women with epilepsy during puberty
    K Mikkonen
    Department of Pediatrics, University of Oulu, Finland
    Neurology 62:445-50. 2004
    ..To evaluate the outcome of epilepsy and later reproductive endocrine health in girls who had epilepsy during puberty, using a population-based controlled study...
  43. ncbi The HLA-DR phenotype modulates the humoral immune response to enterovirus antigens
    K Sadeharju
    Department of Virology, Medical School, University of Tampere, PO Box 33014, Tampere, Finland
    Diabetologia 46:1100-5. 2003
    ..The aim of this study was to evaluate virus-host interaction by analysing the enterovirus antibody levels in subjects carrying different HLA-DR alleles associated with either increased or decreased risk of Type 1 diabetes...
  44. ncbi Leptin concentrations are elevated in newborn infants of diabetic mothers
    P Tapanainen
    Department of Pediatrics, University of Oulu, FIN 90230 Oulu, Finland
    Horm Res 55:185-90. 2001
    ..Infants of diabetic mothers have been characterized by macrosomia due to hyperinsulinism. A relation has been observed between circulating levels of leptin and the intrauterine growth pattern...
  45. ncbi The occurrence of type 1 diabetes in patients with dermatitis herpetiformis and their first-degree relatives
    K Hervonen
    Department of Dermatology, Tampere University Hospital and Medical School, University of Tampere, PO Box 2000, FIN 33531, Tampere, Finland
    Br J Dermatol 150:136-8. 2004
    ..The increased prevalence of type 1 diabetes (T1D) is well documented in patients with coeliac disease, whereas evidence is scanty in patients with dermatitis herpetiformis (DH)...
  46. ncbi Alterations in bone turnover and impaired development of bone mineral density in newly diagnosed children with cancer: a 1-year prospective study
    P Arikoski
    Department of Pediatrics, Kuopio University Hospital, Finland
    J Clin Endocrinol Metab 84:3174-81. 1999
    ..Deficient accumulation of bone mass may lead to impaired development of peak bone mass and predispose children with cancer to increased risk of osteoporosis and diminished skeletal resistance to fractures later in life...
  47. pmc Antibody responses to deamidated gliadin peptide show high specificity and parallel antibodies to tissue transglutaminase in developing coeliac disease
    M Ankelo
    Department of Biochemistry and Pharmacy, Abo Akademi University, Turku, Finland
    Clin Exp Immunol 150:285-93. 2007
    ..In a prospective study, almost all the tTGA-positive sera drawn from children who later developed CD were also positive for gliadin peptide antibodies...
  48. ncbi Prediction of type 1 diabetes among siblings of affected children and in the general population
    H T Siljander
    Hospital for Children and Adolescents, University of Helsinki, P O Box 22 Stenbäckinkatu 11, 00014 Helsinki, Finland
    Diabetologia 50:2272-5. 2007
    ..To compare the predictive characteristics of autoantibodies to GAD (GADA) and islet antigen 2 (IA-2A) for type 1 diabetes between siblings of affected children and children from the general population...
  49. pmc Disease-associated autoantibodies during pregnancy and at birth in families affected by type 1 diabetes
    A M Hämäläinen
    Department of Paediatrics, University of Oulu, Oulu, Finland
    Clin Exp Immunol 126:230-5. 2001
    ..Our data do not provide any support for fetal induction of beta-cell autoimmunity...
  50. pmc Association of interferon-gamma and interleukin 10 genotypes and serum levels with partial clinical remission in type 1 diabetes
    B Z Alizadeh
    Department of Immunohaematology and Blood Transfusion, Leiden University Medical Centre, Leiden, The Netherlands
    Clin Exp Immunol 145:480-4. 2006
    ..These data imply that remission is partially immune-mediated and involves regulation of IFN-gamma transcription...
  51. pmc No evidence of abnormal regulation of antibody response to coxsackievirus B4 antigen in prediabetic children
    L Heino
    JDRF-Centre for the Prevention of Type 1 Diabetes in Finland, Tampere, Finland
    Clin Exp Immunol 126:432-6. 2001
    ..In conclusion, our data suggest that children affected by a beta-cell damaging autoimmune process show normal responses to coxsackievirus B4 antigens...
  52. pmc Affinity maturation of immunoglobulin A anti-tissue transglutaminase autoantibodies during development of coeliac disease
    A Westerlund
    Department of Biochemistry and Pharmacy, Abo Akademi University, Turku, Finland
    Clin Exp Immunol 148:230-40. 2007
    ..According to our results, high autoantibody titres have a higher predictive value than avidity maturation of TGA-IgA in screening for CD...
  53. doi Cytomegalovirus infection in early infancy: risk of induction and progression of autoimmunity associated with type 1 diabetes
    J Aarnisalo
    Immunogenetics Laboratory, University of Turku, MediCity, BioCity 4th floor, Tykistokatu 6A, 20520, Turku, Finland
    Diabetologia 51:769-72. 2008
    ..We aimed to clarify the possible correlation between CMV infections and type 1 diabetes-associated autoimmunity at the time point of autoantibody appearance in young children with HLA-conferred disease susceptibility...
  54. ncbi Enterovirus antibody levels during the first two years of life in prediabetic autoantibody-positive children
    K Sadeharju
    Department of Virology, University of Tampere and Tampere University Hospital, Finland
    Diabetologia 44:818-23. 2001
    ..Accordingly, the results imply a stronger enterovirus exposure in prediabetic children supporting the role of enteroviruses in the pathogenesis of Type I diabetes...
  55. doi Relation among mannose-binding lectin 2 genotype, beta-cell autoantibodies, and risk for type 1 diabetes in Finnish children
    J Aittoniemi
    Department of Clinical Microbiology, Centre for Laboratory Medicine, Pirkanmaa Hospital District, Tampere, Finland
    Hum Immunol 69:108-11. 2008
    ..The association of the biallelic variant genotype with positivity for multiple autoantibodies suggests that intermolecular epitope spreading may be linked with impaired clearance of autoantigens as a result of MBL deficiency...
  56. doi Intermittent prednisolone and autoantibodies to GAD65 in juvenile neuronal ceroid lipofuscinosis
    L Aberg
    Pediatric Neurology, University of Helsinki, Helsinki, Finland
    Neurology 70:1218-20. 2008
  57. ncbi Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort
    A Kupila
    Dept of Paediatrics, Univ of Turku, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Diabetologia 44:290-7. 2001
    ..Population-wide genetic screening of susceptibility to multifactorial diseases will become relevant as knowledge of the pathogenesis of these diseases increases and preventive interventions are identified...
  58. ncbi Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B
    S Nejentsev
    Juvenile Diabetes Foundation Center for Type 1 Diabetes Prevention in Finland, Turku
    Diabetes 49:2217-21. 2000
    ..Our data indicate that an additional gene associated with type 1 diabetes is located in the 240-kb region near HLA-B. We excluded STR MICA polymorphism as a mutation responsible for diabetes association...
  59. ncbi Geographical differences within Finland in the frequency of HLA-DQ genotypes associated with type 1 diabetes susceptibility. The Childhood Diabetes in Finland Study Group
    J Ilonen
    Department of Virology, University of Turku, Finland
    Eur J Immunogenet 27:225-30. 2000
    ..These differences also affect the sensitivity and efficiency of the screening programme used for identifying infants with genetic susceptibility to IDDM in the ongoing Finnish Diabetes Prediction and Prevention Study...
  60. ncbi Production of the islet cell antigen ICA69 (p69) with baculovirus expression system: analysis with a solid-phase time-resolved fluorescence method of sera from patients with IDDM and rheumatoid arthritis
    P Kerokoski
    Turku Immunology Centre and Department of Virology, University of Turku, Finland
    Autoimmunity 29:281-9. 1999
    ..003). The results show that some subjects have specific autoreactive antibodies against the ICA69 protein produced with recombinant technology...
  61. ncbi Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes
    R Hermann
    JDRF Centre for Prevention of Type 1 Diabetes in Finland, Turku, Finland
    Diabetologia 49:1198-208. 2006
    ..We also explored the heterogeneity in the disease-predisposing effect of this polymorphism in relation to known disease loci, sex and age at disease onset...
  62. ncbi Age at introduction of new foods and advanced beta cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes
    S M Virtanen
    Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Mannerheimintie 166, 00300, Helsinki, Finland
    Diabetologia 49:1512-21. 2006
    ..We set out to study the effects of breastfeeding and of age at introduction of supplementary foods on the development of beta cell autoimmunity...
  63. pmc Rotavirus infections and development of diabetes-associated autoantibodies during the first 2 years of life
    M Blomqvist
    JDRF Center for Prevention of Type 1 Diabetes in Finland, Department of Virology, University of Turku, Finland
    Clin Exp Immunol 128:511-5. 2002
    ..Accordingly, our data suggest that rotavirus infections are unlikely triggers of beta-cell autoimmunity in young children with genetic susceptibility to type 1 diabetes...
  64. ncbi Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure?
    R Hermann
    Department of Virology, University of Turku, Finland
    Diabetologia 46:420-5. 2003
    ..The aim of this study was to test the possible effect of a changing environment on distribution of genotypes associated with disease susceptibility...
  65. ncbi Isolation of enterovirus strains from children with preclinical Type 1 diabetes
    K K Salminen
    Juvenile Diabetes Research Foundation Center for Prevention of Type 1 Diabetes in Finland
    Diabet Med 21:156-64. 2004
    ..To develop methods for isolation of enterovirus strains from subjects with preclinical Type 1 diabetes and evaluate if their presence in stools is associated with beta-cell damage...
  66. ncbi Natural course of preclinical type 1 diabetes in siblings of affected children
    S Mrena
    Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland
    Acta Paediatr 92:1403-10. 2003
    ..To define the dynamics of preclinical type 1 diabetes in siblings of affected children and to characterize the siblings experiencing a progressive process...
  67. ncbi The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population
    A P Laine
    JDRF Centre for Prevention of Type 1 Diabetes, Department of Virology, University of Turku, Turku, Finland
    Tissue Antigens 63:72-4. 2004
    ....
  68. ncbi Intranasally administered insulin intended for prevention of type 1 diabetes--a safety study in healthy adults
    A Kupila
    Department of Paediatrics, University of Turku, Turku, Finland
    Diabetes Metab Res Rev 19:415-20. 2003
    ..The possibility that the therapy may cause hypoglycaemia or local irritation and the poorly known immunological safety of mucosal application of the antigen in healthy subjects prompted this study...
  69. ncbi -to: Pani MA, Van Autreve J, Van Der Auwera BJ, Gorus FK, Badenhoop K (2002) Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type I diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules. Diabetologia
    R Hermann
    Diabetologia 46:588-9; author reply 591-2. 2003
  70. ncbi HLA DR-DQ-encoded genetic determinants of childhood-onset type 1 diabetes in Finland: an analysis of 622 nuclear families
    R Hermann
    JDRF Centre for Prevention of Type I Diabetes in Finland, University of Turku, Turku, Finland
    Tissue Antigens 62:162-9. 2003
    ..Comparison of our findings with published data from other populations indicates a significant disease-specific heterogeneity of the (DR8)-DQB1*04, (DR7)-DQA1*0201-DQB1*02 and (DR3)-DQA1*05-DQB1*02 haplotypes...
  71. ncbi Genetic modification of risk assessment based on staging of preclinical type 1 diabetes in siblings of affected children
    S Mrena
    Hospital for Children and Adolescents, University of Helsinki, FIN 00029 Helsinki, Finland
    J Clin Endocrinol Metab 88:2682-9. 2003
    ..Genetic susceptibility has an impact on both the initiation and progression of the autoimmune process leading to clinical diabetes in siblings of affected children...
  72. pmc Enterovirus infections as a risk factor for type I diabetes: virus analyses in a dietary intervention trial
    K Sadeharju
    JDRF Center for Prevention of Type 1 Diabetes in Finland, Department of Virology, University of Tampere Medical School and Tampere University Hospital, Tampere, Finland
    Clin Exp Immunol 132:271-7. 2003
    ..These results suggest that enterovirus infections are associated with the induction of beta-cell autoimmunity in young children with increased genetic susceptibility to type I diabetes...
  73. ncbi Antibodies to GAD65 epitopes at diagnosis and over the first 10 years of clinical type 1 diabetes mellitus
    M S Ronkainen
    Department of Paediatrics, University of Oulu, Oulu, Finland
    Scand J Immunol 59:334-40. 2004
    ..An enhanced humoral immune response to GAD65 after diagnosis is related to persistent immune reactivity to the middle and C-terminal regions...
  74. ncbi Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence
    R Hermann
    JDRF Center for Prevention of Type I Diabetes in Finland, University of Turku, Turku, Finland
    Diabetes Metab Res Rev 20:322-9. 2004
    ..To develop screening strategies for identification of individuals at increased genetic risk for type 1 diabetes in three populations with variable disease incidence rates and distinct ethnic origin...
  75. ncbi Impact of IDDM2 on disease pathogenesis and progression in children with newly diagnosed type 1 diabetes: reduced insulin antibody titres and preserved beta cell function
    L B Nielsen
    Department of Paediatrics, Glostrup University Hospital, Ndr Ringvej 57, D 2600 Glostrup, Denmark
    Diabetologia 49:71-4. 2006
    ..We investigated the association between INS VNTR class III alleles (-23HphIA/T) and both insulin antibody presentation and residual beta cell function during the first year after diagnosis in 257 children with type 1 diabetes...
  76. ncbi Onset of beta-cell autoimmunity is not associated with elevated concentration of C-reactive protein in children at genetic risk for Type 1 diabetes
    M E Waris
    Diabet Med 22:1123-4. 2005
  77. ncbi The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity
    Robert Hermann
    JDRF Centre for Prevention of Type 1 Diabetes in Finland, Turku, Finland
    Diabetologia 48:1766-75. 2005
    ..The aim of this study was to explore the contribution of genetic factors to the emergence of beta-cell-specific humoral autoimmunity...
  78. ncbi Relationship between the incidence of type 1 diabetes and maternal enterovirus antibodies: time trends and geographical variation
    H Viskari
    JDRF Center for Prevention of Type 1 Diabetes in Finland, Finland
    Diabetologia 48:1280-7. 2005
    ....
  79. ncbi CD86 gene polymorphisms: no association with Type I diabetes among Finnish subjects
    H Turpeinen
    Diabetologia 45:1041-2. 2002
  80. ncbi Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study
    H K Akerblom
    Hospital for Children and Adolescents, Biomedicum Helsinki, University of Helsinki, Haartmaninkatu 8, PO Box 700, 00029 Helsinki, Finland
    Diabetologia 48:829-37. 2005
    ....
  81. ncbi First-phase insulin response in young healthy children at genetic and immunological risk for Type I diabetes
    P Keskinen
    The JDRF Center for Prevention of Type I Diabetes in Finland
    Diabetologia 45:1639-48. 2002
    ..We studied the first-phase insulin responses of small children soon after observed seroconversion to autoantibody positivity...
  82. ncbi Association of immune mediators at diagnosis of Type 1 diabetes with later clinical remission
    N C Schloot
    German Diabetes Centre, Heinrich Heine University, Dusseldorf, Germany
    Diabet Med 24:512-20. 2007
    ..We tested the hypothesis that systemic concentrations of cytokines, chemokines or soluble cytokine receptors predict or accompany clinical remission in Type 1 diabetes (T1D)...
  83. ncbi Cytokine expression in unstimulated PBMC of children with type 1 diabetes and subjects positive for diabetes-associated autoantibodies
    M Halminen
    JDFI Centre for Diabetes Prevention in Finland, Turku, Finland
    Scand J Immunol 53:510-3. 2001
    ....
  84. pmc Pregnancy induces nonimmunoglobulin insulin-binding activity in both maternal and cord blood serum
    M S Ronkainen
    Department of Paediatrics, University of Oulu, Oulu, Finland
    Clin Exp Immunol 124:190-6. 2001
    ....
  85. ncbi A linkage analysis of the CTLA4 gene region in Finnish patients with type 1 diabetes
    H Turpeinen
    JDRF Centre for Prevention of Type 1 Diabetes in Finland, and Department of Virology, University of Turku
    Eur J Immunogenet 30:289-93. 2003
    ....
  86. pmc Rotavirus-specific T cell responses and cytokine mRNA expression in children with diabetes-associated autoantibodies and type 1 diabetes
    M Makela
    Immunogenetics Laboratory, University of Turku, MediCity, Biocity 4 krs, Tykistokatu 6A, 20520 Turku, Finland
    Clin Exp Immunol 145:261-70. 2006
    ..In conclusion, our lymphocyte proliferation studies did not provide evidence supporting an association between rotavirus infections and the development of type 1 diabetes or diabetes-associated autoantibodies in young children...
  87. ncbi Cardiovascular autonomic reactivity is decreased in adolescents with Type 1 diabetes
    P H Riihimaa
    Department of Paediatrics, University of Oulu, Finland
    Diabet Med 19:932-8. 2002
    ..To characterize autonomic nervous system function by means of the heart rate and blood pressure responses to various stimuli in relation to pubertal maturation in patients with Type 1 diabetes mellitus (DM)...