Peeter Karihtala

Summary

Affiliation: University of Oulu
Country: Finland

Publications

  1. doi request reprint Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis
    Peeter Karihtala
    Departments of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Histopathology 58:854-62. 2011
  2. ncbi request reprint Male Malignant Phyllodes Breast Tumor After Prophylactic Breast Radiotherapy and Bicalutamide Treatment: A Case Report
    Peeter Karihtala
    Department of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
    Anticancer Res 36:3433-6. 2016
  3. doi request reprint Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype
    Peeter Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital, PO Box 22, 90029 Oulu, Finland
    Breast Cancer Res Treat 138:81-90. 2013
  4. pmc Oxidative stress and redox state-regulating enzymes have prognostic relevance in diffuse large B-cell lymphoma
    Pekka Peroja
    Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Oulu, Finland
    Exp Hematol Oncol 1:2. 2012
  5. pmc Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype
    P Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, PO Box 22, FIN 90029, Oulu, Finland
    Br J Cancer 106:344-7. 2012
  6. doi request reprint Long-term observational follow-up study of breast cancer diagnosed in women ≤40 years old
    Peeter Karihtala
    Department of Oncology and Radiotherapy, University of Oulu, PO Box 22, FIN 90029, Oulu University Hospital, Finland
    Breast 19:456-61. 2010
  7. ncbi request reprint Front-line bevacizumab in serous epithelial ovarian cancer: biomarker analysis of the FINAVAST trial
    Peeter Karihtala
    Department of Oncology and Radiotherapy, P O Box 22, FIN 90029 Oulu University Hospital, Finland
    Anticancer Res 30:1001-6. 2010
  8. ncbi request reprint Hyaluronan in breast cancer: correlations with nitric oxide synthases and tyrosine nitrosylation
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, PO Box 5000, FIN 90014, University of Oulu, Oulu, Finland
    J Histochem Cytochem 55:1191-8. 2007
  9. ncbi request reprint Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, PO Box 5000, FIN 90014 University of Oulu, Finland
    Eur J Cancer 42:2653-9. 2006
  10. doi request reprint DNA adduct 8-hydroxydeoxyguanosine, a novel putative marker of prognostic significance in ovarian carcinoma
    Peeter Karihtala
    Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Oulo, Finland
    Int J Gynecol Cancer 19:1047-51. 2009

Collaborators

Detail Information

Publications36

  1. doi request reprint Divergent behaviour of oxidative stress markers 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (HNE) in breast carcinogenesis
    Peeter Karihtala
    Departments of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Histopathology 58:854-62. 2011
    ....
  2. ncbi request reprint Male Malignant Phyllodes Breast Tumor After Prophylactic Breast Radiotherapy and Bicalutamide Treatment: A Case Report
    Peeter Karihtala
    Department of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
    Anticancer Res 36:3433-6. 2016
    ..The imaging findings of the tumor and pathological correlation are also presented. ..
  3. doi request reprint Vimentin, zeb1 and Sip1 are up-regulated in triple-negative and basal-like breast cancers: association with an aggressive tumour phenotype
    Peeter Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital, PO Box 22, 90029 Oulu, Finland
    Breast Cancer Res Treat 138:81-90. 2013
    ..002) in the whole cohort. The current results emphasize the increased role of EMT in TNBC and especially in basal-like breast cancers. These observations also support the role of studied parameters in tumour progression...
  4. pmc Oxidative stress and redox state-regulating enzymes have prognostic relevance in diffuse large B-cell lymphoma
    Pekka Peroja
    Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Oulu, Finland
    Exp Hematol Oncol 1:2. 2012
    ..All patients were treated with CHOP-like therapy combined with rituximab. Immunostaining results were correlated with progression-free survival, disease-specific survival and traditional prognostic factors of DLBCL...
  5. pmc Absence of the DNA repair enzyme human 8-oxoguanine glycosylase is associated with an aggressive breast cancer phenotype
    P Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, PO Box 22, FIN 90029, Oulu, Finland
    Br J Cancer 106:344-7. 2012
    ..8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) is the most abundant marker of DNA damage and it reflects oxidative stress. Human 8-oxoguanine glycosylase (hOGG1) is a DNA-repair enzyme that participates in 8-oxodG removal...
  6. doi request reprint Long-term observational follow-up study of breast cancer diagnosed in women ≤40 years old
    Peeter Karihtala
    Department of Oncology and Radiotherapy, University of Oulu, PO Box 22, FIN 90029, Oulu University Hospital, Finland
    Breast 19:456-61. 2010
    ..This study revealed a high relapse rate in the youngest women as early as during the first few years after diagnosis, although their prognosis as a whole was surprisingly good...
  7. ncbi request reprint Front-line bevacizumab in serous epithelial ovarian cancer: biomarker analysis of the FINAVAST trial
    Peeter Karihtala
    Department of Oncology and Radiotherapy, P O Box 22, FIN 90029 Oulu University Hospital, Finland
    Anticancer Res 30:1001-6. 2010
    ..Potential tissue and serum biomarkers were assessed for predicting efficacy of bevacizumab in ovarian cancer (OC)...
  8. ncbi request reprint Hyaluronan in breast cancer: correlations with nitric oxide synthases and tyrosine nitrosylation
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, PO Box 5000, FIN 90014, University of Oulu, Oulu, Finland
    J Histochem Cytochem 55:1191-8. 2007
    ....
  9. ncbi request reprint Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, PO Box 5000, FIN 90014 University of Oulu, Finland
    Eur J Cancer 42:2653-9. 2006
    ..On the other hand, a significant reduction in expression of mismatch repair proteins occurs during the progression of in situ lesions to invasive tumours...
  10. doi request reprint DNA adduct 8-hydroxydeoxyguanosine, a novel putative marker of prognostic significance in ovarian carcinoma
    Peeter Karihtala
    Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Oulo, Finland
    Int J Gynecol Cancer 19:1047-51. 2009
    ..The purpose of the current study was to identify the role of oxidative stress and major antioxidant enzymes in ovarian carcinomas...
  11. ncbi request reprint Reactive oxygen species and antioxidant mechanisms in human tissues and their relation to malignancies
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, Oulu, Finland
    APMIS 115:81-103. 2007
    ..The present review aims to clarify the significance of oxidative stress and the role of cell redox state modulating systems in human malignancies in light of the current literature...
  12. pmc Oxidative stress and counteracting mechanisms in hormone receptor positive, triple-negative and basal-like breast carcinomas
    Peeter Karihtala
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    BMC Cancer 11:262. 2011
    ..This is the first study to assess oxidative stress and or cell redox state-regulating enzymes in TNBC and BLBC...
  13. doi request reprint Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma
    Siria Lemma
    Department of Radiotherapy and Oncology, Oulu University Hospital, Oulu, Finland
    Histopathology 62:326-33. 2013
    ..EMT has been shown to enhance solid tumour metastasis, invasion, and proliferation...
  14. doi request reprint Oxidative stress-induced antioxidant enzyme expression is an early phenomenon in ovarian carcinogenesis
    Marjo Pylväs
    Department of Obstetrics and Gynecology, University of Oulu and Oulu University Hospital, Finland
    Eur J Cancer 46:1661-7. 2010
    ..This difference could also offer a potential tool for differential diagnosis between benign and borderline epithelial ovarian tumours...
  15. doi request reprint Expression and prognostic evaluation of oxidative stress markers in an immunohistochemical study of B-cell derived lymphomas
    Anna Kaisa Pasanen
    Department of Oncology and Radiotherapy, University of Oulu and Oulu University Hospital, Oulu, Finland
    Leuk Lymphoma 53:624-31. 2012
    ..These markers seem to have strong prognostic value, but this has to be verified in larger studies...
  16. ncbi request reprint Antioxidative response for nitric oxide production in breast carcinoma
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, FIN 90014 Oulu, Finland
    Oncol Rep 12:755-9. 2004
    ..The current results also imply the attempt of cells to hedge against effects of NO by increasing their MnSOD and catalase expression...
  17. ncbi request reprint Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma
    Hamid Bur
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Anticancer Res 36:4677-83. 2016
    ..Epigenetic regulators, including Jumonji domain 2 (JMJD2/KDM4) proteins are involved in post-translational modification of histone demethylation and have a major role in carcinogenesis of many solid tumors...
  18. doi request reprint High intensity of cytoplasmic peroxiredoxin VI expression is associated with adverse outcome in diffuse large B-cell lymphoma independently of International Prognostic Index
    Milla Elvi Linnea Kuusisto
    Department of Oncology and Radiotherapy, University of Oulu, Medical Research Center and Oulu University Hospital, Oulu, Finland
    J Clin Pathol 68:552-6. 2015
    ..There is a need for more accurate biomarkers to select patients for more aggressive first-line treatments. Peroxiredoxins (Prxs) are a family of potent antioxidant proteins. Their prognostic role in DLBCL is unknown...
  19. ncbi request reprint Elevated serum 8-OHdG is associated with poor prognosis in epithelial ovarian cancer
    Marjo Pylväs
    Department of Obstetrics, University of Oulu, Finland
    Anticancer Res 31:1411-5. 2011
    ..8-Hydroxydeoxyguanosine (8-OHdG) is a marker of oxidative stress in DNA. This study was undertaken to reveal whether serum 8-OHdG could be a prognostic factor in epithelial ovarian carcinoma (EOC)...
  20. doi request reprint Oxidative stress markers and mitochondrial antioxidant enzyme expression are increased in aggressive Hodgkin lymphomas
    Hamid Bur
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Histopathology 65:319-27. 2014
    ....
  21. ncbi request reprint Thioredoxin is associated with proliferation, p53 expression and negative estrogen and progesterone receptor status in breast carcinoma
    Nina Turunen
    Department of Pathology, Oulu University Hospital, Oulu, Finland
    APMIS 112:123-32. 2004
    ....
  22. doi request reprint Total peroxiredoxin expression is associated with survival in patients with follicular lymphoma
    Pekka Peroja
    Department of Oncology and Radiotherapy, University of Oulu and Medical Research Center, Oulu University Hospital, P O Box 22, 90029, Oulu, Finland
    Virchows Arch 468:623-30. 2016
    ..In conclusion, our results demonstrate an association between high total Prx expression and prolonged survival and suggest that Prxs may have a protective role in FL that cannot be compensated by other antioxidant mechanisms. ..
  23. pmc Antithrombin III is probably not a suitable biomarker for diagnosis of primary central nervous system lymphoma
    Milla Elvi Linnea Kuusisto
    Department of Oncology and Radiotherapy, University of Oulu, Medical Research Center, and Oulu University Hospital, Kajaanintie 50, 90220, Oulu, Finland
    Ann Hematol 94:1167-74. 2015
    ..Thus, AT III fails to be a specific marker for diagnosis of lymphoma CNS involvement. ..
  24. ncbi request reprint Peroxiredoxins in breast carcinoma
    Peeter Karihtala
    Department of Pathology, University of Oulu and Oulu University Hospital, 90014 Oulu, Finland
    Clin Cancer Res 9:3418-24. 2003
    ..The mammalian Prx family has six distinct members located in various subcellular locations, including peroxisomes and mitochondria, places where oxidative stress is most evident...
  25. ncbi request reprint Nrf2/Keap1 Pathway and Expression of Oxidative Stress Lesions 8-hydroxy-2'-deoxyguanosine and Nitrotyrosine in Melanoma
    Hanna Riikka Hintsala
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Cancer Center of Eastern Finland and Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland University of Oulu and Department of Pathology, Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland Department of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
    Anticancer Res 36:1497-506. 2016
    ..Increased expression and prognostic significance of major redox regulator nuclear factor erythroid-2-related factor (Nrf2) is recognized in many cancers. Our aim was to investigate the role of oxidative stress markers in melanoma...
  26. doi request reprint Metformin decreases serum 8-hydroxy-2'-deoxyguanosine levels in polycystic ovary syndrome
    Henri Sova
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Fertil Steril 99:593-8. 2013
    ..To learn whether metformin treatment affects oxidative stress as measured by serum concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG)...
  27. ncbi request reprint Down-regulation of 8-hydroxydeoxyguanosine and peroxiredoxin II in the pathogenesis of endometriosis-associated ovarian cancer
    Henri Sova
    Department of Oncology and Radiotherapy, P O Box 22, FIN 90029 Oulu University Hospital, Finland
    Anticancer Res 32:3037-44. 2012
    ..To evaluate the roles of oxidative stress marker 8-hydroxydeoxyguanosine (8-OHdG) and peroxiredoxin (PRX) antioxidants in the development of endometriosis and endometriosis-associated ovarian cancer (EAC)...
  28. pmc Keap1 expression has independent prognostic value in pancreatic adenocarcinomas
    Joel Isohookana
    Department of Pathology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P O Box 50, 90020, Oulu University Hospital, Finland
    Diagn Pathol 10:28. 2015
    ..Oxidative DNA damage can be estimated e.g. by 8-hydroxy-2'-deoxyguanosine (8-OHdG) expression. The aim of this study was to evaluate the expression and possible prognostic role of Keap1 and 8-OHdG in pancreatic cancer...
  29. ncbi request reprint Cancer Stem Cell Properties as Factors Predictive of Chemoresistance in Neoadjuvantly-treated Patients with Ovarian Cancer
    Marjo Pylväs-Eerola
    Medical Research Center Oulu, University of Oulu, Oulu, Finland Department of Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland
    Anticancer Res 36:3425-31. 2016
    ..Our objective was to investigate the possible association between platinum resistance, cellular redox-state regulation and stem cell properties in ovarian cancer...
  30. ncbi request reprint Loss of Peroxiredoxin Expression Is Associated with an Aggressive Phenotype in Pancreatic Adenocarcinoma
    Joel Isohookana
    Department of Pathology, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland Department of Pathology and Forensic Medicine, University of Eastern Finland, Cancer Center of Eastern Finland, Kuopio, Finland Department of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland
    Anticancer Res 36:427-33. 2016
    ..The role of the redox-regulating peroxiredoxin (Prx) enzymes I-VI in pancreatic carcinoma is poorly characterized...
  31. doi request reprint Dysregulation of redox-state-regulating enzymes in melanocytic skin tumours and the surrounding microenvironment
    Hanna Riikka Hintsala
    Institute of Clinical Medicine, Pathology and Forensic Medicine, University of Eastern Finland, Cancer Center of Eastern Finland, Kuopio, Finland
    Histopathology 67:348-57. 2015
    ..To investigate redox-regulating enzymes that may have a special role in melanoma pathogenesis due to continuous exposure to microenvironment-produced and ultraviolet radiation-induced oxidative stress...
  32. doi request reprint Distinctively low levels of serum 8-hydroxydeoxyguanosine in women with polycystic ovary syndrome
    Henri Sova
    Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland
    Fertil Steril 94:2670-3. 2010
    ..To investigate oxidative stress and angiogenetic factors in polycystic ovary syndrome (PCOS)...
  33. doi request reprint Remote Ischemic Preconditioning Reduces Cerebral Oxidative Stress Following Hypothermic Circulatory Arrest in a Porcine Model
    Oiva Arvola
    Department of Surgery, Oulu University Hospital, Oulu, Finland
    Semin Thorac Cardiovasc Surg 28:92-102. 2016
    ..Our findings demonstrate that the positive effects of remote ischemic preconditioning can be seen in cellular oxidative balance regulators in an animal model after 7 days of preconditioned ischemic insult. ..
  34. pmc Primary neuroendocrine breast carcinomas are associated with poor local control despite favourable biological profile: a retrospective clinical study
    Nelli Roininen
    Department of Oncology and Radiotherapy, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, P O Box 22, FIN 90029, Oulu, Finland
    BMC Cancer 17:72. 2017
    ..There are very limited data available about the clinical behaviour and treatment options of NEBC...
  35. pmc Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin
    Hanna Riikka Hintsala
    Department of Pathology, Oulu University Hospital and University of Oulu Oulu, Finland
    Int J Clin Exp Pathol 6:2855-63. 2013
    ..Other claudins investigated in this study did not show progressive changes even though occasional overexpression of them was found in skin squamous cell carcinoma. ..
  36. pmc Preoperative serum 8-hydroxydeoxyguanosine is associated with chemoresistance and is a powerful prognostic factor in endometrioid-type epithelial ovarian cancer
    Marjo Pylväs-Eerola
    Department of Obstetrics and Gynecology, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland
    BMC Cancer 15:493. 2015
    ..We investigated redox status in different histotypes of EOC by measuring serum 8-OHdG and DJ-1 concentrations and their associations with known prognostic factors...