Olli Jaakkola

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. pmc CYP1A2 polymorphism -1545C > T (rs2470890) is associated with increased side effects to clozapine
    Merja Viikki
    University of Tampere, Medical School, University of Tampere, Tampere 33014, Finland
    BMC Psychiatry 14:50. 2014
  2. pmc Determinants of exercise peak arterial blood pressure, circulatory power, and exercise cardiac power in a population based sample of Finnish male and female aged 30 to 47 years: the Cardiovascular Risk in Young Finns Study
    Janne Hulkkonen
    Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
    BMC Cardiovasc Disord 14:35. 2014
  3. pmc Association of resting heart rate with cardiovascular function: a cross-sectional study in 522 Finnish subjects
    Jenni K Koskela
    School of Medicine, Department of Internal Medicine, University of Tampere, Tampere FIN 33014, Finland
    BMC Cardiovasc Disord 13:102. 2013
  4. pmc TPH1 A218C polymorphism and temperament in major depression
    Kadri Andre
    Mental Health Center, City of Helsinki, Finland
    BMC Psychiatry 13:118. 2013
  5. pmc Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men
    Tuomas O Kiviniemi
    Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
    Cardiovasc Ultrasound 6:25. 2008
  6. pmc Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study
    Helena M Service
    Department of Psychology, University of Helsinki, Finland
    Behav Brain Funct 4:40. 2008
  7. pmc Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach
    Sami Anttila
    University of Tampere, Medical School, University of Tampere, Finland
    BMC Psychiatry 7:22. 2007
  8. pmc Gene expression profiles in Finnish twins with multiple sclerosis
    Silja Särkijärvi
    Neuroimmunology Unit, Department of Neurology, Tampere University Hospital, Teiskontie, 35, 33520 Tampere, Finland
    BMC Med Genet 7:11. 2006
  9. pmc The Finnish Cardiovascular Study (FINCAVAS): characterising patients with high risk of cardiovascular morbidity and mortality
    Tuomo Nieminen
    Department of Pharmacological Sciences, Medical School, University of Tampere, Finland
    BMC Cardiovasc Disord 6:9. 2006
  10. ncbi request reprint Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to functional apolipoprotein e genotype
    Terho Lehtimaki
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, University Hospital of Tampere, Finland
    J Clin Endocrinol Metab 87:4147-53. 2002

Detail Information

Publications103 found, 100 shown here

  1. pmc CYP1A2 polymorphism -1545C > T (rs2470890) is associated with increased side effects to clozapine
    Merja Viikki
    University of Tampere, Medical School, University of Tampere, Tampere 33014, Finland
    BMC Psychiatry 14:50. 2014
    ..The aim of the present study was to test for an association between the CYP1A2 -1545C > T (rs2470890) polymorphism and side effects in a larger sample of patients during long-term clozapine treatment...
  2. pmc Determinants of exercise peak arterial blood pressure, circulatory power, and exercise cardiac power in a population based sample of Finnish male and female aged 30 to 47 years: the Cardiovascular Risk in Young Finns Study
    Janne Hulkkonen
    Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland
    BMC Cardiovasc Disord 14:35. 2014
    ..However, the determinants of these factors are poorly characterized in the general population...
  3. pmc Association of resting heart rate with cardiovascular function: a cross-sectional study in 522 Finnish subjects
    Jenni K Koskela
    School of Medicine, Department of Internal Medicine, University of Tampere, Tampere FIN 33014, Finland
    BMC Cardiovasc Disord 13:102. 2013
    ..We studied the association of resting HR with cardiovascular function, and examined whether the hemodynamics remained similar during passive head-up tilt...
  4. pmc TPH1 A218C polymorphism and temperament in major depression
    Kadri Andre
    Mental Health Center, City of Helsinki, Finland
    BMC Psychiatry 13:118. 2013
    ..This interaction was studied in 97 subjects with major depression treated for six weeks with selective serotonine reuptake inhibitors...
  5. pmc Effects of cognac on coronary flow reserve and plasma antioxidant status in healthy young men
    Tuomas O Kiviniemi
    Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland
    Cardiovasc Ultrasound 6:25. 2008
    ..The purpose of this randomized controlled cross-over study was to determine whether moderate doses of cognac improve coronary reactivity as assessed with cold pressor testing (CPT) and coronary flow reserve (CFR) measurement...
  6. pmc Does neuregulin-1 play a role in Type A behavior? The cardiovascular risk in young Finns study
    Helena M Service
    Department of Psychology, University of Helsinki, Finland
    Behav Brain Funct 4:40. 2008
    ..abstract:..
  7. pmc Association between 5-HT2A, TPH1 and GNB3 genotypes and response to typical neuroleptics: a serotonergic approach
    Sami Anttila
    University of Tampere, Medical School, University of Tampere, Finland
    BMC Psychiatry 7:22. 2007
    ..One major problem in the treatment is finding the right the drug for the right patients. However, pharmacogenetic results in psychiatry can seldom be replicated...
  8. pmc Gene expression profiles in Finnish twins with multiple sclerosis
    Silja Särkijärvi
    Neuroimmunology Unit, Department of Neurology, Tampere University Hospital, Teiskontie, 35, 33520 Tampere, Finland
    BMC Med Genet 7:11. 2006
    ....
  9. pmc The Finnish Cardiovascular Study (FINCAVAS): characterising patients with high risk of cardiovascular morbidity and mortality
    Tuomo Nieminen
    Department of Pharmacological Sciences, Medical School, University of Tampere, Finland
    BMC Cardiovasc Disord 6:9. 2006
    ..The purpose of the Finnish Cardiovascular Study (FINCAVAS) is to construct a risk profile--using genetic, haemodynamic and electrocardiographic (ECG) markers--of individuals at high risk of cardiovascular diseases, events and deaths...
  10. ncbi request reprint Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to functional apolipoprotein e genotype
    Terho Lehtimaki
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, University Hospital of Tampere, Finland
    J Clin Endocrinol Metab 87:4147-53. 2002
    ..These results may help us to understand, in more detail, the benefit and possible risk of HRT on atherosclerotic diseases...
  11. ncbi request reprint Interleukin-1B genotype modulates the improvement of coronary artery reactivity by lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men
    Terho Lehtimaki
    Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Department of Clinical Chemistry, Tampere University Hospital and University of Tampere Medical School, Tampere, Finland
    Pharmacogenetics 13:633-9. 2003
    ..0001 for both). In conclusion, coronary function improves after 6 months of pravastatin therapy in subjects with the IL-1B A2- allele but not in those with the IL-1B A2+ allele...
  12. doi request reprint Adult-type hypolactasia is not a predisposing factor for the early functional and structural changes of atherosclerosis: the Cardiovascular Risk in Young Finns Study
    Terho Lehtimaki
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, 33014 Tampere, Finland
    Clin Sci (Lond) 115:265-71. 2008
    ..In conclusion, the finding does not support the involvement of ATH in the pathogenesis of early atherosclerosis...
  13. ncbi request reprint The effects of adult-type hypolactasia on body height growth and dietary calcium intake from childhood into young adulthood: a 21-year follow-up study--the Cardiovascular Risk in Young Finns Study
    Terho Lehtimaki
    Department of Clinical Chemistry, Tampere University Hospital, PO Box 2000, FI33521 Tampere, Finland
    Pediatrics 118:1553-9. 2006
    ..We studied whether this polymorphism was associated with body height growth, the use of milk products, or dietary calcium intake...
  14. ncbi request reprint Interleukin-6 modulates plasma cholesterol and C-reactive protein concentrations in nonagenarians
    Terho Lehtimaki
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Tampere, Finland
    J Am Geriatr Soc 53:1552-8. 2005
    ..To establish whether the relationship between interleukin-6 (IL-6) and plasma lipid and C-reactive protein (CRP) concentrations is different in Finnish nonagenarians than in middle-aged subjects with lower inflammatory status...
  15. ncbi request reprint Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms do not affect early functional and structural changes in atherosclerosis: the Cardiovascular Risk in Young Finns study
    Tuomo Nieminen
    Department of Pharmacological Sciences, Medical School, University of Tampere, Tampere, Finland
    Circ J 71:741-5. 2007
    ....
  16. doi request reprint Interleukin-6 promoter polymorphism and cardiovascular risk factors: the Health 2000 Survey
    Antti Riikola
    The Medical School at the University of Tampere, Tampere, Finland
    Atherosclerosis 207:466-70. 2009
    ..The aim of this study was to investigate whether IL6 -174 G>C is associated with the risk factors and early markers of atherosclerosis...
  17. doi request reprint Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow-mediated dilation and carotid artery distensibility: the Cardiovascular Risk in Young Finns Study and the Health 2000 Survey
    Teemu Koivistoinen
    Department of Clinical Physiology, University of Tampere and Tampere University Hospital, FI 33521, Tampere, Finland
    Atherosclerosis 220:387-93. 2012
    ....
  18. doi request reprint Interleukin 18 gene promoter polymorphism: a link between hypertension and pre-hospital sudden cardiac death: the Helsinki Sudden Death Study
    Jussi A Hernesniemi
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, Centre for Laboratory Medicine, University of Tampere, Medical School, Finn Medi 2, FI 33521 Tampere, Finland
    Eur Heart J 30:2939-46. 2009
    ..We examined the process by which this polymorphism alters the risk of SCD and coronary artery disease (CAD) by analysing the interactions between this polymorphism and environmental factors...
  19. ncbi request reprint Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians
    Riikka Rontu
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Centre for Laboratory Medicine and Department of Clinical Chemistry, University of Tampere, Medical School, Finland
    Clin Endocrinol (Oxf) 64:265-70. 2006
    ..The aim of the present study was to establish whether APOE genotype is related to plasma concentrations of CRP and lipids, or longevity among nonagenarians...
  20. ncbi request reprint Plasma concentrations of asymmetric-dimethyl-arginine in type 2 diabetes associate with glycemic control and glomerular filtration rate but not with risk factors of vasculopathy
    Hannu Päivä
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Metabolism 52:303-7. 2003
    ..In type 2 diabetic patients high GFR and poor glycemic control were related to low plasma ADMA concentrations...
  21. ncbi request reprint Relation of apolipoprotein E polymorphism to markers of early atherosclerotic changes in young adults--the Cardiovascular Risk in Young Finns Study
    Paula Grönroos
    Department of Clinical Chemistry, University of Turku, Turku, Finland
    Circ J 72:29-34. 2008
    ..Also brachial flow-mediated dilatation (FMD) and carotid artery compliance (CAC) were determined to clarify their relation to this genetic factor...
  22. doi request reprint Lifetime risk factors and arterial pulse wave velocity in adulthood: the cardiovascular risk in young Finns study
    Heikki Aatola
    Department of Clinical Physiology, Tampere University Hospital, PO Box 2000, FI 33521 Tampere, Finland
    Hypertension 55:806-11. 2010
    ..These results support efforts for a reduction of conventional risk factors both in childhood and adulthood in the primary prevention of atherosclerosis...
  23. doi request reprint Catechol-O-methyltransferase val108/158met genotype, major depressive disorder and response to selective serotonin reuptake inhibitors in major depressive disorder
    Ari Illi
    University of Tampere, Medical School, Tampere, Finland
    Psychiatry Res 176:85-7. 2010
    ....
  24. ncbi request reprint Osteopontin levels are associated with cholesterol synthesis markers in mildly hypercholesterolaemic patients
    Mari Luomala
    Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital, Finn Medi 5 7th floor, P O Box 2000, 33521, Tampere, Finland
    Acta Cardiol 62:177-81. 2007
    ..The purpose of our study was to find out whether plasma levels of OPN are associated with cholesterol metabolites in plasma or tissues...
  25. ncbi request reprint CYBA C242T gene polymorphism and flow-mediated vasodilation in a population of young adults: the Cardiovascular Risk in Young Finns Study
    Meng Fan
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Finland
    J Hypertens 25:1381-7. 2007
    ..We examined the relationship of the C242T polymorphism with endothelial-dependent brachial artery flow-mediated vasodilatation (FMD) in a population-based sample of young healthy adults...
  26. ncbi request reprint Endothelial nitric oxide synthase genotype modulates the improvement of coronary blood flow by pravastatin: a placebo-controlled PET study
    Tarja A Kunnas
    University of Tampere, Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital and Medical School, Tampere, Finland
    J Mol Med (Berl) 80:802-7. 2002
    ..This effect is not dependent on the decrease of serum cholesterol...
  27. ncbi request reprint Polymorphism of the angiotensin-converting enzyme (ACE) and angiotesinogen (AGT) genes and their associations with blood pressure and carotid artery intima media thickness among healthy Finnish young adults--the Cardiovascular Risk in Young Finns Study
    Md Shaheenul Islam
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the University of Tampere, Medical School, Finland
    Atherosclerosis 188:316-22. 2006
    ..01 mm (95% CI: -0.04 to 0.02, p=0.59) lower mean IMT, respectively, compared to the MM genotype group. We conclude that ACE I/D and AGT m235t polymorphisms are not associated with carotid IMT in healthy young Finnish adults...
  28. ncbi request reprint Insulin resistance, LDL particle size, and LDL susceptibility to oxidation in pediatric kidney and liver recipients
    Arja Siirtola
    Paediatric Research Centre, University of Tampere, Tampere, Finland
    Kidney Int 67:2046-55. 2005
    ....
  29. ncbi request reprint Relations of APOE promoter polymorphisms to LDL cholesterol and markers of subclinical atherosclerosis in young adults
    Leena E Viiri
    Department of Forensic Medicine, University of Tampere Medical School, and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    J Lipid Res 47:1298-306. 2006
    ....
  30. ncbi request reprint Diet does not explain the high prevalence of dyslipidaemia in paediatric renal transplant recipients
    Arja Siirtola
    Paediatric Research Centre, University of Tampere, Tampere, 33014, Finland
    Pediatr Nephrol 23:297-305. 2008
    ..However, the type of fat consumed implicates the counselling for a healthier dietary lifestyle, with an increase in the ingestion of polyunsaturated fats and a decrease in that of saturated fats...
  31. doi request reprint TPH1 218A/C polymorphism is associated with major depressive disorder and its treatment response
    Merja Viikki
    University of Tampere, Medical School, Tampere, Finland Tampere Mental Health Centre, Tampere, Finland
    Neurosci Lett 468:80-4. 2010
    ..Further studies with larger samples will be required to confirm the results...
  32. ncbi request reprint Smoking-dependent association between paraoxonase 1 M/L55 genotype and coronary atherosclerosis in males: an autopsy study
    Riikka Rontu
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, FinnMedi 2, PO Box 2000, FIN 33521, Tampere, Finland
    Atherosclerosis 171:31-7. 2003
    ..These data suggest that the genetic variation of PON1 affects the formation of early atherosclerotic lesions and that the effect is modified by smoking...
  33. doi request reprint Effect of common KCNE1 and SCN5A ion channel gene variants on T-wave alternans, a marker of cardiac repolarization, during clinical exercise stress test: the Finnish Cardiovascular Study
    Jenni Koskela
    Department of Internal Medicine, Tampere University Hospital and Medical School at the University of Tampere, Tampere, Finland
    Transl Res 152:49-58. 2008
    ..The common KCNE1 gene variant rs1805127 is associated with TWA during an exercise test in a Finnish population, which provides additional evidence that KCNE1 genetics may influence cardiac repolarization and cardiovascular mortality...
  34. ncbi request reprint Apolipoprotein E polymorphism is associated with age of onset in schizophrenia
    Olli Kampman
    Medical School, University of Tampere, 33014 Tampere, Finland
    J Hum Genet 49:355-9. 2004
    ..APOE epsilon 4/epsilon 4 genotype may be associated with early onset schizophrenia. APOE epsilon 3 allele may function protectively in later onset in this disease...
  35. ncbi request reprint The influence of hepatic lipase C-480T polymorphism on coronary flow reserve in young men is independent of the plasma cholesterol level
    Yue Mei Fan
    Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital and University of Tampere, Medical School, Department of Clinical Chemistry, Finn Medi 2, 3rd Floor, P O Box 2000, FIN 33521 Tampere, Finland
    Atherosclerosis 188:391-7. 2006
    ..We hypothesized that the difference of plasma cholesterol level may not influence the effect of HL genotype on coronary reactivity...
  36. ncbi request reprint Microcrystalline chitosan is ineffective to decrease plasma lipids in both apolipoprotein E epsilon 4 carriers and non-carriers: a long-term placebo-controlled trial in hypercholesterolaemic volunteers
    Terho Lehtimaki
    Department of Clinical Chemistry, Tampere University Hospital and University of Tampere, Tampere, Finland
    Basic Clin Pharmacol Toxicol 97:98-103. 2005
    ..In conclusions, chitosan is ineffective to decrease plasma lipids in apolipoprotein E epsilon 4 carrier and non-carrier phenotypes with mildly-to-moderately increased plasma cholesterol...
  37. ncbi request reprint High-dose statins and skeletal muscle metabolism in humans: a randomized, controlled trial
    Hannu Päivä
    Department of Internal Medicine, University Hospital of Tampere, Finland
    Clin Pharmacol Ther 78:60-8. 2005
    ..This study was designed to assess the effect of high-dose statin treatment on cholesterol and ubiquinone metabolism and mitochondrial function in human skeletal muscle...
  38. doi request reprint Systemic hemodynamics in young adults with the metabolic syndrome: the Cardiovascular Risk in Young Finns Study
    Teemu Koivistoinen
    Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
    Ann Med 42:612-21. 2010
    ..In addition, the objective of the study was to examine associations of spontaneous recovery from MetS over 6 years' follow-up to systemic hemodynamics...
  39. doi request reprint ACE polymorphism and response to electroconvulsive therapy in major depression
    Juhani Akseli Stewart
    University of Tampere, Medical School, 33014 Tampere, Finland
    Neurosci Lett 458:122-5. 2009
    ..Distributions of these genotypes or alleles did not differ between patients and controls. The studied ACE genotype was not associated with ECT results but may be associated with age of onset of the illness in patients with MDD...
  40. doi request reprint Combined assessment of heart rate recovery and T-wave alternans during routine exercise testing improves prediction of total and cardiovascular mortality: the Finnish Cardiovascular Study
    Johanna Leino
    Medical School, University of Tampere, Tampere, Finland
    Heart Rhythm 6:1765-71. 2009
    ..Derangements in autonomic function acting upon an electrically unstable substrate are thought to be critical elements in triggering cardiovascular events...
  41. ncbi request reprint Toll-like receptor 4 gene (Asp299Gly) polymorphism associates with carotid artery elasticity. The cardiovascular risk in young Finns study
    Jussi A Hernesniemi
    Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Finland
    Atherosclerosis 198:152-9. 2008
    ..We wanted to examine the association of this polymorphism with carotid IMT and compliance in a population of young Finnish Caucasian adults...
  42. ncbi request reprint Age and gender biases in secondary prevention of coronary heart disease in a Finnish university hospital setting
    Sanna Maria Michou
    Department of Pharmacological Sciences, Medical School, University of Tampere, Tampere, Finland
    Clin Drug Investig 27:673-81. 2007
    ..The aim of this study was to investigate the adequacy of CHD drug treatment and secondary prevention measures, particularly with respect to age and gender biases, in a Finnish university hospital setting...
  43. ncbi request reprint Plasma asymmetric dimethylarginine and retinal vessel diameters in middle-aged men
    Virpi Hemminki
    Department of Clinical Physiology, Medical School, University of Tampere, 33014 Tampere, Finland
    Metabolism 56:1305-10. 2007
    ..These results suggest that plasma ADMA is associated with vascular phenomenon seen in early hypertension and that ADMA may be a potential biomarker candidate for development of hypertension...
  44. ncbi request reprint Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms and their association with carotid artery intima-media thickness in the Finnish population. The Cardiovascular Risk in Young Finns Study
    Md Shaheenul Islam
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Medical School, Tampere University Hospital, The University of Tampere, Tampere, Finland
    Atherosclerosis 180:79-86. 2005
    ..However, serum total and LDL cholesterol and apoB concentrations were significantly different among apoB genotype groups (p<0.001 for all traits). The apoA-I/C-III/A-IV SstI polymorphism is associated with carotid IMT in young Finns...
  45. ncbi request reprint Association of paraoxonase-1 M55L genotype and alcohol consumption with coronary atherosclerosis: the Helsinki Sudden Death Study
    Riikka Rontu
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Centre for Laboratory Medicine and Department of Clinical Chemistry, University of Tampere, Medical School, Tampere, Finland
    Pharmacogenetics 14:479-85. 2004
    ..0001) (for the PON1 genotype by alcohol interaction, P = 0.009). The areas of atherosclerotic lesions in LAD appear to be dependent on the amount of alcohol consumption, especially in men carrying the PON1 M55 allele...
  46. ncbi request reprint Interaction of tumor necrosis alpha - G308A and epidermal growth factor gene polymorphisms in early-onset schizophrenia
    Olli Kampman
    University of Tampere, Medical School, 33014 Tampere, Finland
    Eur Arch Psychiatry Clin Neurosci 255:279-83. 2005
    ..On the other hand, the role of cytokines in schizophrenia may involve genetic interactions predisposing early onset of illness...
  47. ncbi request reprint Dietary composition as a determinant of plasma asymmetric dimethylarginine in subjects with mild hypercholesterolemia
    Hannu Päivä
    Department of Internal Medicine, Tampere University Hospital, Finland
    Metabolism 53:1072-5. 2004
    ..In conclusion, a high amount of dietary carbohydrates is strongly associated with low levels of plasma ADMA. Concentration of ADMA in plasma seems to be higher in alcohol drinkers than in abstainers...
  48. doi request reprint Common variation in the ADAM8 gene affects serum sADAM8 concentrations and the risk of myocardial infarction in two independent cohorts
    Emma Raitoharju
    Department of Clinical Chemistry, Tampere University Hospital and Medical School at University of Tampere, Tampere, Finland
    Atherosclerosis 218:127-33. 2011
    ..This study was set up to further investigate the role of ADAM8 in MI...
  49. ncbi request reprint Interleukin-18 promoter polymorphism associates with the occurrence of sudden cardiac death among Caucasian males: the Helsinki Sudden Death Study
    Jussi A Hernesniemi
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital and Department of Clinical Chemistry, Medical School, University of Tampere, Tampere, Finland
    Atherosclerosis 196:643-9. 2008
    ..The C allele carriage is associated with attenuated IL-18 production. The effect of IL-18 genotype on SCD is unknown. We studied the association of the IL-18 gene -137G/C polymorphism with the occurrence of sudden cardiac death (SCD)...
  50. ncbi request reprint Myeloperoxidase gene variation as a determinant of atherosclerosis progression in the abdominal and thoracic aorta: an autopsy study
    Riikka Mäkelä
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital, University of Tampere Medical School, Tampere, Finland
    Lab Invest 83:919-25. 2003
    ..001) lesion area in the abdominal aorta after adjustment for age, body mass index, diabetes, hypertension, and smoking. MPO gene variation may modify the extent of advanced atherosclerotic lesions in the human aorta in early middle age...
  51. ncbi request reprint Interaction between matrix metalloproteinase 3 and the epsilon4 allele of apolipoprotein E increases the risk of Alzheimer's disease in Finns
    Marika S Saarela
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital, PO Box 2000, FIN 33521, Finland
    Neurosci Lett 367:336-9. 2004
    ..7, 95% CI: 5.8-144.9, P < 0.0001) compared to those who possess neither MMP3*5A nor APOE 4. In conclusion, our finding suggests that the MMP3 gene, especially together with APOE 4, may contribute to the development of AD...
  52. ncbi request reprint Influence of apolipoprotein E polymorphism on serum lipid and lipoprotein changes: a 21-year follow-up study from childhood to adulthood. The Cardiovascular Risk in Young Finns Study
    Paula Grönroos
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, Medical School at the University of Tampere, Tampere, Finland
    Clin Chem Lab Med 45:592-8. 2007
    ..We examined the influence of apolipoprotein E (apoE) polymorphism on longitudinal changes in serum lipids by following the subjects participating in The Cardiovascular Risk in Young Finns Study over a 21-year period...
  53. ncbi request reprint Studies of LDL particle size and susceptibility to oxidation and association with glucose metabolism in children after heart transplantation
    Arja Siirtola
    Paediatric Research Centre, University of Tampere, Tampere, Finland
    J Heart Lung Transplant 23:418-26. 2004
    ..There have been no previous studies of LDL particle size and LDL susceptibility to oxidation in children after HTx...
  54. doi request reprint Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study
    Hannu Päivä
    Emergency Department, University Hospital of Tampere, Tampere, Finland
    Am J Hypertens 21:873-8. 2008
    ..ADMA, as an endogenous nitric oxide (NO) synthase inhibitor, has been demonstrated to associate with hypertension and vascular reactivity in experimental but not undoubtedly in physiological settings...
  55. doi request reprint Estrogen receptor 2 polymorphism and carotid intima-media thickness
    Seppo T Nikkari
    Department of Medical Biochemistry, University of Tampere Medical School, Tampere, Finland
    Genet Test 12:537-40. 2008
    ..The present study was designed to investigate the effects of estrogen receptor 2 gene (ESR2) rs1256049 polymorphism to carotid artery intima-media thickness (CIMT), as part of the Cardiovascular Risk in Young Finns Study...
  56. ncbi request reprint Age-dependent association between hepatic lipase gene C-480T polymorphism and the risk of pre-hospital sudden cardiac death: the Helsinki Sudden Death Study
    Yue Mei Fan
    Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    Atherosclerosis 192:421-7. 2007
    ..We investigated the association between hepatic lipase (HL) C-480T polymorphism and the risk of acute myocardial infarction (AMI) as well as pre-hospital sudden cardiac death (SCD)...
  57. ncbi request reprint No association between the brain-derived neurotrophic factor 196 G>A or 270 C>T polymorphisms and Alzheimer's or Parkinson's disease
    Marika S Saarela
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University, Tampere, Finland
    Folia Neuropathol 44:12-6. 2006
    ..Moreover, no interaction between either BDNF polymorphism and the epsilon 4 allele of apolipoprotein E was found. In conclusion, it seems that the BDNF gene does not contribute significantly to the risk of AD or PD in Finnish patients...
  58. ncbi request reprint Matrix metalloproteinase3 and 9 gene promoter polymorphisms: joint action of two loci as a risk factor for coronary artery complicated plaques
    Perttu J Pöllänen
    Laboratory of Atherosclerosis Genetics, FinnMedi 2, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, P O Box 2000, 33521 Tampere, Finland
    Atherosclerosis 180:73-8. 2005
    ....
  59. doi request reprint IL-18 gene polymorphism, cardiovascular mortality and coronary artery disease
    Jussi A Hernesniemi
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, Centre for Laboratory Medicine, Tampere, Finland Medical School, University of Tampere, Tampere, Finland
    Eur J Clin Invest 40:994-1001. 2010
    ....
  60. pmc No association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study
    Kati Lähteelä
    Department of Medical Biochemistry, University of Tampere Medical School, Tampere, Finland
    BMC Med Genet 13:32. 2012
    ....
  61. doi request reprint Interactions of functional apolipoprotein E gene promoter polymorphisms with smoking on aortic atherosclerosis
    Leena E Viiri
    Department of Forensic Medicine, University of Tampere Medical School and Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland
    Circ Cardiovasc Genet 1:107-16. 2008
    ..We also studied the previously unknown effects of +113G/C on transcriptional activity...
  62. doi request reprint Polymorphism in the IL6 promoter region is associated with the risk factors and markers of subclinical atherosclerosis in men: The Cardiovascular Risk in Young Finns Study
    Janne Hulkkonen
    Department of Clinical Physiology, Tampere University Hospital, Finland
    Atherosclerosis 203:454-8. 2009
    ..We investigated whether IL6 -174 G>C associates with the risk factors of atherosclerosis and carotid artery compliance (CAC) in young subjects...
  63. ncbi request reprint Plasma asymmetric dimethylarginine (ADMA), nitrate and the indices of low-density lipoprotein oxidation
    Hannu Päivä
    Department of Internal Medicine, University Hospital of Tampere, Tampere, Finland
    Clin Chim Acta 371:97-101. 2006
    ..This study was performed to evaluate how plasma ADMA is related to plasma nitric oxide production, oxidized LDL and ex vivo susceptibility of LDL to oxidation in mildly hypercholesterolemic otherwise healthy subjects...
  64. doi request reprint RGS4 polymorphism and response to electroconvulsive therapy in major depressive disorder
    Kaija Huuhka
    University of Tampere, Medical School, Department of Psychiatry, Tampere University Hospital, Tampere, Finland
    Neurosci Lett 437:25-8. 2008
    ..According to the present data, the impact of RGS4 genotype is not decisive in major depressive disorder. The results provide preliminary data on the impact of RGS4 polymorphism in treatment response in ECT...
  65. doi request reprint Levels of asymmetrical dimethylarginine are predictive of brachial artery flow-mediated dilation 6 years later. The Cardiovascular Risk in Young Finns Study
    Hannu Päivä
    Division of Emergency, University Hospital of Tampere and University of Tampere Medical School, Tampere, Finland
    Atherosclerosis 212:512-5. 2010
    ..In the present study our aim was to investigate whether plasma ADMA levels are predictive of brachial artery endothelial function in a prospective setting...
  66. doi request reprint The association of myeloperoxidase promoter polymorphism with carotid atherosclerosis is abolished in patients with type 2 diabetes
    Riikka Mäkelä
    Tampere University Hospital, Centre for Laboratory Medicine, Department of Clinical Chemistry, Tampere, Finland
    Clin Biochem 41:532-7. 2008
    ..MPO gene has a functional promoter polymorphism -463G/A which leads to high- (GG) and low-expression (AG, AA) genotypes...
  67. ncbi request reprint Catechol-O-methyltransferase and monoamine oxidase A genotypes and drug response to conventional neuroleptics in schizophrenia
    Ari Illi
    Department of Psychiatry, Tampere University Hospital, Tampere, Finland
    J Clin Psychopharmacol 23:429-34. 2003
    ..The role of monoamine oxidase A genotype seems to be additive in this respect...
  68. doi request reprint Vascular endothelial growth factor (VEGF) polymorphism is associated with treatment resistant depression
    Merja Viikki
    University of Tampere, Medical School, Tampere, Finland
    Neurosci Lett 477:105-8. 2010
    ..The finding suggests an association between VEGF 2578 C/A polymorphism and treatment resistant depression which is reported for the first time. Further studies with larger samples will be required to confirm the results...
  69. ncbi request reprint Estrogen receptor genotype modulates myocardial perfusion in young men
    Tarja A Kunnas
    Department of Medical Biochemistry, Medical School, University of Tampere, 33014 Tampere, Finland
    J Mol Med (Berl) 82:821-5. 2004
    ..Our results suggest that adenosine-stimulated myocardial perfusion is lower in subjects with ESR1 long alleles than the other TA repeat genotypes...
  70. doi request reprint Apolipoprotein B is related to arterial pulse wave velocity in young adults: the Cardiovascular Risk in Young Finns Study
    Teemu Koivistoinen
    Department of Clinical Physiology, Tampere University Hospital, FI 33521 Tampere, Finland
    Atherosclerosis 214:220-4. 2011
    ..Moreover, we examined whether ApoB and ApoA-1 measured in young adulthood are predictive of PWV assessed 6 years later...
  71. doi request reprint Systemic hemodynamics in relation to glucose tolerance: the Health 2000 Survey
    Teemu Koivistoinen
    Department of Clinical Physiology, Tampere University Hospital, PO Box 2000, FI 33521 Tampere, Finland
    Metabolism 60:557-63. 2011
    ..These findings support the systematic evaluation of glucose tolerance status in the estimation of cardiovascular risk among the middle-aged population...
  72. ncbi request reprint Brain-derived neurotrophic factor (BDNF) polymorphisms G196A and C270T are not associated with response to electroconvulsive therapy in major depressive disorder
    Kaija Huuhka
    Medical School, University of Tampere, 33014 Tampere, Finland
    Eur Arch Psychiatry Clin Neurosci 257:31-5. 2007
    ..However, within subgroups such as in psychotic and in late-onset depression CC genotype of C270T may predict good response. BDNF may not be associated with response to ECT in general, but some association in subgroups may exist...
  73. doi request reprint Enhanced predictive power of quantitative TWA during routine exercise testing in the Finnish Cardiovascular Study
    Mikko Minkkinen
    Medical School, University of Tampere, Tampere, Finland
    J Cardiovasc Electrophysiol 20:408-15. 2009
    ..We examined whether quantification of T-wave alternans (TWA) enhances this parameter's capacity to evaluate the risk for total and cardiovascular mortality and sudden cardiac death (SCD)...
  74. doi request reprint Carbonic anhydrases II and XII are up-regulated in osteoclast-like cells in advanced human atherosclerotic plaques-Tampere Vascular Study
    Niku Oksala
    Centre for Laboratory Medicine, Tampere University Hospital and Department of Clinical Chemistry, Medical School, University of Tampere, Tampere, Finland
    Ann Med 42:360-70. 2010
    ..According to previous histochemical studies, advanced atherosclerotic plaques share similarities with bone. However, whether CAs are expressed in plaques is not known...
  75. doi request reprint Association of high sensitive C-reactive protein with apolipoprotein E polymorphism in children and young adults: the Cardiovascular Risk in Young Finns Study
    Paula Grönroos
    Department of Clinical Chemistry, University of Turku, Turku, Finland
    Clin Chem Lab Med 46:179-86. 2008
    ..We studied whether serum hsCRP levels are linked with common APOE (epsilon 2, epsilon 3, epsilon 4) polymorphism already in children and young adults...
  76. ncbi request reprint Impact of long-term hormone replacement therapy on in vivo and in vitro markers of lipid oxidation
    Riikka Rontu
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Centre for Laboratory Medicine, FinnMedi 2, P O Box 2000, FIN 33521 Tampere, Finland
    Free Radic Res 38:129-37. 2004
    ..According to these results, estrogen and combined HRT do not differ in their abilities to oppose LDL oxidation in vitro or systemic oxidative stress in vivo, but have differential effects on blood lipids...
  77. ncbi request reprint Myeloperoxidase gene variation and coronary flow reserve in young healthy men
    Riikka Mäkelä
    Department of Clinical Chemistry, Laboratory of Atherosclerosis, Tampere University Hospital and University of Tampere Medical School, FinnMedi 2, 3rd Floor, FI 33521 Tampere, Finland
    J Biomed Sci 11:59-64. 2004
    ..049). These findings provide evidence that MPO polymorphism is associated with coronary artery reactivity. However, the number of individuals investigated was low and our observation should be confirmed by a larger number of subjects...
  78. ncbi request reprint Coronary artery calcification is related to functional polymorphism of matrix metalloproteinase 3: the Helsinki Sudden Death Study
    Perttu J Pöllänen
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, FinnMedi 2 3rd fl, PO Box 2000, FIN 33521, Tampere, Finland
    Atherosclerosis 164:329-35. 2002
    ..These data provide evidence that the proposed effect of MMP3 in the process of atherogenesis may be modified by the MMP3 genotype...
  79. pmc A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle
    Reijo Laaksonen
    Research Unit, University Hospital of Tampere, Tampere, Finland
    PLoS ONE 1:e97. 2006
    ..However, the cellular mechanisms leading to muscle damage are not known and sensitive biomarkers are needed to identify patients at risk of developing statin-induced serious side effects...
  80. ncbi request reprint Effect of long-term hormone replacement therapy on atherosclerosis progression in postmenopausal women relates to myeloperoxidase promoter polymorphism
    Riikka Mäkelä
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Center for Laboratory Medicine, University Hospital of Tampere, Finland
    J Clin Endocrinol Metab 88:3823-8. 2003
    ..These results may help us understand in greater detail the benefit and possible risk of HRT in atherosclerotic diseases...
  81. ncbi request reprint Apolipoprotein E gene polymorphism, hypercholesterolemia and glomerular filtration rate in type 2 diabetic subjects: a 9-year follow-up study
    Saara Lehtinen
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere, Finland
    J Biomed Sci 10:260-5. 2003
    ..To study the association between apolipoprotein E (apoE) genotype and the rate of decline in glomerular filtration rate (GFR) in type 2 diabetic patients in a 9-year prospective study...
  82. ncbi request reprint Catechol-O-methyltransferase (COMT) polymorphisms predict treatment response in electroconvulsive therapy
    Sami Anttila
    University of Tampere Medical School, University of Tampere, Tampere, Finland
    Pharmacogenomics J 8:113-6. 2008
    ..In the present sample, those homozygous to high-active allele of COMT responded significantly more frequently to ECT...
  83. doi request reprint Diagnostic performance of plasma high sensitive C-reactive protein in detecting three-vessel coronary artery disease: modification by apolipoprotein E genotype
    Ari Mennander
    Heart Center, Tampere University Hospital and Tampere University Medical School, Tampere, Finland
    Scand J Clin Lab Invest 68:714-9. 2008
    ..We investigated whether the diagnostic performance of plasma hsCRP in detecting severe 3-vessel CAD may be modified by apoE epsilon4 carrier status...
  84. ncbi request reprint Antibody titer against malondialdehyde-modified LDL compares with HDL cholesterol concentration in identifying angiographically verified coronary artery disease. Comparison of tests by ROC analysis
    Riikka Rontu
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Centre for Laboratory Medicine and Department of Clinical Chemistry, University of Tampere, Finland
    Clin Chem Lab Med 43:357-60. 2005
    ..Moreover, the antibody titer against MDA-modified LDL is inversely correlated with the risk of severe CAD...
  85. ncbi request reprint Effects of long-term estrogen replacement therapy versus combined hormone replacement therapy on nitric oxide-dependent vasomotor function
    Hannu Jokela
    Center for Laboratory Medicine and Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Finland
    J Clin Endocrinol Metab 88:4348-54. 2003
    ..Our results suggest that the favorable effects of long-term estrogen treatment on blood flow are at least partly mediated through NO. The addition of levonorgestrel to the treatment regimen appears to abolish this effect...
  86. ncbi request reprint Genetic variant of the SREBF-1 gene is significantly related to cholesterol synthesis in man
    Reijo Laaksonen
    Department of Internal Medicine, University Hospital of Tampere, Tampere, Finland
    Atherosclerosis 185:206-9. 2006
    ..Similarly muscle cholesterol (p=0.045) and lathosterol (p=0.054) concentrations were elevated in the CC homozygotes supporting the view that endogenous cholesterol synthesis rate is SREBF-1 genotype-dependent...
  87. ncbi request reprint The effect of hormone replacement therapy on atherosclerotic severity in relation to ESR1 genotype in postmenopausal women
    Tommi A Koivu
    Laboratory of Atherosclerosis Genetics, Center for Laboratory Medicine, University Hospital of Tampere, Finland
    Maturitas 44:29-38. 2003
    ..The effects of hormone replacement therapy (HRT) and ESR1 PvuII genotypes on atherosclerosis have not previously been studied prospectively in postmenopausal women...
  88. ncbi request reprint Oxidized LDL autoantibodies are related to apolipoprotein E phenotype, independently of postprandial change in plasma triglycerides and LDL size, among patients with angiographically verified coronary artery disease and healthy controls
    Saara Metso
    Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Tampere University Hospital, PO Box 2000, FIN 33521 Tampere, Finland
    J Biomed Sci 10:345-51. 2003
    ..Our aim was to study the interaction between these new risk factors among patients with CAD and healthy controls...
  89. ncbi request reprint The relationship of sterol regulatory element-binding protein cleavage-activation protein and apolipoprotein E gene polymorphisms with metabolic changes during weight reduction
    Tuomo Nieminen
    Department of Pharmacological Sciences, Medical School, University of Tampere, 33014 Tampere, Finland
    Metabolism 56:876-80. 2007
    ..However, the apo E-but not SCAP genotype-seems to be one of the modifying factors for serum cholesterol concentrations during very low-energy diet in obese premenopausal women...
  90. ncbi request reprint T-wave alternans predicts mortality in a population undergoing a clinically indicated exercise test
    Tuomo Nieminen
    Department of Pharmacological Sciences, Medical School, University of Tampere, and Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital, Finland
    Eur Heart J 28:2332-7. 2007
    ..As a part of the Finnish Cardiovascular Study, we tested the hypothesis that T-wave alternans (TWA) predicts mortality in a general population of patients referred for a clinical exercise test...
  91. pmc Delta-6-desaturase gene polymorphism is associated with lipoprotein oxidation in vitro
    Tiina Solakivi
    Department of Medical Biochemistry, University of Tampere Medical School, Tampere, Finland
    Lipids Health Dis 12:80. 2013
    ..To investigate the possible role of rs 3834458 in lipoprotein modification, oxidation of LDL with HDL₂ or HDL₃ were analyzed from plasma of 58 free-living individuals...
  92. pmc Lipoprotein docosapentaenoic acid is associated with serum matrix metalloproteinase-9 concentration
    Tiina Solakivi
    Department of Medical Biochemistry, Medical School, University of Tampere, Tampere, Finland
    Lipids Health Dis 4:8. 2005
    ....
  93. doi request reprint Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study
    Juulia Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, FIN 33014 Tampere, Finland
    Exp Gerontol 44:297-9. 2009
    ..016). We propose that the increased mortality is inflammation-related and mediated by aberrant complement regulation by the CFH 402His variant...
  94. pmc Expression of sterol regulatory element-binding transcription factor (SREBF) 2 and SREBF cleavage-activating protein (SCAP) in human atheroma and the association of their allelic variants with sudden cardiac death
    Yue Mei Fan
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital and Medical School, University of Tampere, Tampere, Finland
    Thromb J 6:17. 2008
    ....
  95. ncbi request reprint Effect of high-dose statin treatment on plasma concentrations of endogenous nitric oxide synthase inhibitors
    Hannu Päivä
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    J Cardiovasc Pharmacol 41:219-22. 2003
    ..This study indicates that statin treatment has no clear influence on plasma ADMA or LMMA concentrations...
  96. ncbi request reprint Dopamine receptor D2 -141C Insertion/Deletion polymorphism in a Finnish population with schizophrenia
    Olli Kampman
    Department of Psychiatry, University of Tampere, Medical School, Tampere, FIN 33014, Finland
    Psychiatry Res 121:89-92. 2003
    ..The findings suggest that the frequency of the -141C Ins/Del polymorphism is lower in Northern Europe compared to other Caucasian and Japanese populations...
  97. ncbi request reprint Hepatic lipase C-480T genotype-dependent benefit from long-term hormone replacement therapy for atherosclerosis progression in postmenopausal women
    Yue Mei Fan
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Center for Laboratory Medicine, Tampere University Hospital, FinnMedi 2, 3rd Floor, P O Box 2000, FIN 33521 Tampere, Finland
    J Clin Endocrinol Metab 90:3786-92. 2005
    ..These results may help us understand in greater detail the benefits and possible risks associated with HRT in atherosclerotic diseases...
  98. ncbi request reprint Serum lipids in children 3 to 5 years after kidney, liver, and heart transplantation
    Arja Siirtola
    Paediatric Research Centre, University of Tampere, 33014 Tampere, Finland
    Transpl Int 17:109-19. 2004
    ..Dyslipidemia, especially hypertriglyceridaemia, was common 3-5 years after Tx. The aetiology is multifactorial and depends on the transplanted organ...
  99. ncbi request reprint Suppression of immune system genes by methylprednisolone in exacerbations of multiple sclerosis. Preliminary results
    Nina Airla
    Tampere University Hospital, Centre for Laboratory Medicine, Laboratory of Atherosclerosis Genetics Finn Medi 2, 3rd Floor, P O Box 2000, 33521 Tampere, Finland
    J Neurol 251:1215-9. 2004
    ..05). The suppression of expression of genes associated with T-cell differentiation and antigen-specific T-cell activation detected in this study may contribute to the beneficial effect of MP in relapses of MS...
  100. ncbi request reprint Carotid atherosclerosis in chronic renal failure-the central role of increased plaque burden
    Yrjö Leskinen
    Department of Internal Medicine, Tampere University Hospital, P O Box 2000 FIN 33521, Tampere, Finland
    Atherosclerosis 171:295-302. 2003
    ..The present study shows that the characteristic alterations of the carotid arteries in CRF include increased plaque burden, calcification and increased arterial stiffness...
  101. ncbi request reprint Valvular calcification and its relationship to atherosclerosis in chronic kidney disease
    Yrjö Leskinen
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    J Heart Valve Dis 18:429-38. 2009
    ..The study aim was to identify the characteristics and risk factors of valvular calcification, and its relationship to atherosclerosis, in CKD...