M Hurme

Summary

Affiliation: University of Tampere
Country: Finland

Publications

  1. ncbi request reprint CRP gene is involved in the regulation of human longevity: a follow-up study in Finnish nonagenarians
    M Hurme
    University of Tampere Medical School, Tampere, Finland
    Mech Ageing Dev 128:574-6. 2007
  2. ncbi request reprint Interleukin-6 -174G/C polymorphism and longevity: a follow-up study
    M Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School, Tampere University Hospital, FIN 33014, Tampere, Finland
    Mech Ageing Dev 126:417-8. 2005
  3. ncbi request reprint Genetics of inflammation and atopy
    Mikko Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School, and Tampere University Hospital, Finland
    Ann Med 35:256-8. 2003
  4. ncbi request reprint IgA levels are predictors of mortality in Finnish nonagenarians
    Mikko Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School and Tampere University Hospital, Finland
    Mech Ageing Dev 126:829-31. 2005
  5. ncbi request reprint Autoimmunity and longevity: presence of antinuclear antibodies is not associated with the rate of inflammation or mortality in nonagenarians
    M Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School, Finland
    Mech Ageing Dev 128:407-8. 2007
  6. ncbi request reprint IL-10 gene polymorphism and herpesvirus infections
    M Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School and University Hospital, FIN 33014 Tampere, Finland
    J Med Virol 70:S48-50. 2003
  7. doi request reprint CRP and FCGR2A genes have an epistatic effect on carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns Study
    T Pessi
    Department of Microbiology and Immunology, Medical School, University of Tampere, Tempere, Finland
    Int J Immunogenet 36:39-45. 2009
  8. ncbi request reprint Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians
    X Y Wang
    Department of Gerontology, School of Public Health, University of Tampere, FIN 33014, Tampere, Finland
    Mech Ageing Dev 123:29-38. 2001
  9. pmc Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study
    J Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, Tampere, Finland
    Clin Exp Immunol 155:53-8. 2009
  10. ncbi request reprint A study of interleukin-1 cluster genes in susceptibility to and severity of multiple sclerosis
    M Luomala
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, FinnMedi 2 3 Floor, P O Box 2000 33521, Tampere, Finland
    J Neurol Sci 185:123-7. 2001

Detail Information

Publications139 found, 100 shown here

  1. ncbi request reprint CRP gene is involved in the regulation of human longevity: a follow-up study in Finnish nonagenarians
    M Hurme
    University of Tampere Medical School, Tampere, Finland
    Mech Ageing Dev 128:574-6. 2007
    ..Thus, the data imply that the CRP gene may be a longevity gene in humans...
  2. ncbi request reprint Interleukin-6 -174G/C polymorphism and longevity: a follow-up study
    M Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School, Tampere University Hospital, FIN 33014, Tampere, Finland
    Mech Ageing Dev 126:417-8. 2005
    ..The frequency of -174 allele G was clearly higher in the survivors (n = 114) than in the non-survivors (n = 171)...
  3. ncbi request reprint Genetics of inflammation and atopy
    Mikko Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School, and Tampere University Hospital, Finland
    Ann Med 35:256-8. 2003
    ..These data also suggest that the quantity (or quality) of the inflammation affects the priming phase of atopy, i.e., that induced by allergens or infectious agents in early childhood...
  4. ncbi request reprint IgA levels are predictors of mortality in Finnish nonagenarians
    Mikko Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School and Tampere University Hospital, Finland
    Mech Ageing Dev 126:829-31. 2005
    ..These data imply that elevated serum IgA level, i.e. indicator of intestinal inflammation and/or defect in mucosal defence, is a strong mortality predicting factor...
  5. ncbi request reprint Autoimmunity and longevity: presence of antinuclear antibodies is not associated with the rate of inflammation or mortality in nonagenarians
    M Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School, Finland
    Mech Ageing Dev 128:407-8. 2007
    ..8%). The mortality data of this cohort was collected after a 4-year follow-up. The ANA positivity at the age of 90 did not have any effect on the rate of survival, or on the levels of serum markers of inflammation...
  6. ncbi request reprint IL-10 gene polymorphism and herpesvirus infections
    M Hurme
    Department of Microbiology and Immunology, University of Tampere Medical School and University Hospital, FIN 33014 Tampere, Finland
    J Med Virol 70:S48-50. 2003
    ....
  7. doi request reprint CRP and FCGR2A genes have an epistatic effect on carotid artery intima-media thickness: the Cardiovascular Risk in Young Finns Study
    T Pessi
    Department of Microbiology and Immunology, Medical School, University of Tampere, Tempere, Finland
    Int J Immunogenet 36:39-45. 2009
    ..013 and P = 0.010, respectively. No associations were observed in women. In conclusion, this study showed that the effect of CRP genetics on early atherosclerotic changes is modulated by the FCGR2A genetics...
  8. ncbi request reprint Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians
    X Y Wang
    Department of Gerontology, School of Public Health, University of Tampere, FIN 33014, Tampere, Finland
    Mech Ageing Dev 123:29-38. 2001
    ..Thus, there is no evidence of an association of IL-1 complex, IL-6, IL-10, and TNF-alpha gene polymorphisms with longevity, alone or in combination...
  9. pmc Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study
    J Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, Tampere, Finland
    Clin Exp Immunol 155:53-8. 2009
    ..We conclude that the combined presence of CRP haplotype ATGTG and CFH 402His allele may be disadvantageous to carotid artery elasticity in males...
  10. ncbi request reprint A study of interleukin-1 cluster genes in susceptibility to and severity of multiple sclerosis
    M Luomala
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, FinnMedi 2 3 Floor, P O Box 2000 33521, Tampere, Finland
    J Neurol Sci 185:123-7. 2001
    ..02-4.72, p = 0.043, P(C) = ns). The data suggest that the IL-1 cluster genes make no major contribution to MS, but the tentative association between IL-1RA allele 2 and susceptibility of MS in women warrants further studies...
  11. pmc A common IL-1 complex haplotype is associated with an increased risk of atopy
    T Pessi
    Department of Microbiology and Immunology, Medical School, University of Tampere, Finland
    J Med Genet 40:e66. 2003
  12. pmc Relation of high cytomegalovirus antibody titres to blood pressure and brachial artery flow-mediated dilation in young men: the Cardiovascular Risk in Young Finns Study
    A Haarala
    Department of Microbiology and Immunology, University of Tampere, Medical School, Tampere, Finland
    Clin Exp Immunol 167:309-16. 2012
    ..This association supports the hypothesis that common CMV infection and/or an immune response to CMV may lead to impaired vascular function at a young age...
  13. pmc Pentraxin 3 (PTX3) is associated with cardiovascular risk factors: the Health 2000 Survey
    J Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, Finland
    Clin Exp Immunol 164:211-7. 2011
    ..These results indicate that, in individuals at high risk of CVD, the PTX3 concentration is associated with cardiovascular risk factors but not with subclinical atherosclerosis...
  14. ncbi request reprint The IL1A genotype is associated with nasal polyposis in asthmatic adults
    J Karjalainen
    Department of Respiratory Medicine, Tampere University Hospital, Tampere, Finland
    Allergy 58:393-6. 2003
    ..As this disorder tends to cluster in families, a genetic predisposition has been suggested. Interleukin-1 (IL-1) has been proposed to play a role in the pathogenesis of NP...
  15. ncbi request reprint Interleukin-1 beta, interleukin-1 receptor antagonist and interleukin-6 plasma levels and cytokine gene polymorphisms in chronic lymphocytic leukemia: correlation with prognostic parameters
    J Hulkkonen
    Department of Microbiology and Immunology, University of Tampere Medical School, Tampere, Finland
    Haematologica 85:600-6. 2000
    ..As the plasma levels of IL-6, IL-1 beta and IL-1Ra have been suggested to be partly dependent on gene polymorphism, the previously described polymorphisms of the IL-1 complex genes and the IL-6 gene were also studied...
  16. pmc The activity of the immunoregulatory enzyme indoleamine 2,3-dioxygenase is decreased in smokers
    M Pertovaara
    Department of Microbiology and Immunology, University of Tampere, Medical School, Tampere, Finland
    Clin Exp Immunol 145:469-73. 2006
    ..In conclusion, the activity of the IDO enzyme is decreased in smoking subjects, and the reduction in IDO-dependent immunosuppression could thus be responsible for the known immunostimulatory effects of smoking...
  17. pmc Th2 cytokine genotypes are associated with a milder form of primary Sjogren's syndrome
    M Pertovaara
    Department of Internal Medicine, Section of Rheumatology, Tampere University Hospital, PO Box 2000, FIN 33521 Tampere, Finland
    Ann Rheum Dis 65:666-70. 2006
    ..Immunohistological studies on salivary and lacrimal glands have yielded conflicting results on the Th1/Th2 balance in primary Sjögren's syndrome (pSS)...
  18. doi request reprint Serum amyloid A is independently associated with metabolic risk factors but not with early atherosclerosis: the Cardiovascular Risk in Young Finns Study
    J Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, Tampere, Finland
    J Intern Med 266:286-95. 2009
    ..We investigated which factors explain the variation in SAA and analysed whether SAA could be associated with preclinical atherosclerosis...
  19. ncbi request reprint Indoleamine 2,3-dioxygenase activity in nonagenarians is markedly increased and predicts mortality
    M Pertovaara
    Department of Microbiology and Immunology, University of Tampere, Medical School, Finland
    Mech Ageing Dev 127:497-9. 2006
    ..Thus, increased IDO activity might be a mechanism involved in the decline of T cell responses in immunosenescence...
  20. ncbi request reprint The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults
    S Kilpinen
    Department of Microbiology and Immunology, University of Tampere Medical School, POB 607, FIN 33 101, Tampere, Finland
    Eur Cytokine Netw 12:62-8. 2001
    ..This indicates that the genetic regulation of IL-6 production can be observed in naive cells, while in adult cells previous contact with exogenous antigens probably modifies their responses...
  21. ncbi request reprint A rare allele combination of the interleukin-1 gene complex is associated with high interleukin-1 beta plasma levels in healthy individuals
    J Hulkkonen
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Eur Cytokine Netw 11:251-5. 2000
    ..This effect of IL-1 alpha 2.2 homozygosity was more pronounced in donors, who also were carriers of the IL-1 beta allele 2. Thus these data suggest that this allele combination has a regulatory effect on basal IL-1 beta production...
  22. ncbi request reprint Matrix metalloproteinase 9 (MMP-9) gene polymorphism and MMP-9 plasma levels in primary Sjogren's syndrome
    J Hulkkonen
    Department of Microbiology and Immunology, Medical School, FIN 33014, University of Tampere, Finland
    Rheumatology (Oxford) 43:1476-9. 2004
    ..To determine whether plasma matrix metalloproteinase 9 (MMP-9) and MMP9 (-1562C-->T) polymorphism have an effect on the disease phenotype in primary Sjogren's syndrome (pSS)...
  23. doi request reprint Plasma level of soluble urokinase-type plasminogen activator receptor as a predictor of disease severity and case fatality in patients with bacteraemia: a prospective cohort study
    R Huttunen
    Department of Internal Medicine, Tampere University Hospital, University of Tampere Medical School, University of Tampere, Tampere, Finland
    J Intern Med 270:32-40. 2011
    ..Previous studies indicate that a high plasma concentration of the soluble form of the receptor (suPAR) predicts poor outcome in infectious diseases...
  24. ncbi request reprint The significance of mannan-binding lectin gene alleles in patients with primary Sjögren's syndrome
    J Aittoniemi
    Department of Clinical Microbiology, Centre for Laboratory Medicine, Tampere University Hospital, Finland
    Scand J Rheumatol 31:362-5. 2002
    ..To investigate the significance or mannan-binding lectin (MBL) gene alleles in patients with primary Sjogren's syndrome (pSS). Genotypes were determined in 65 pSS patients and 138 controls...
  25. ncbi request reprint C-reactive protein genetics is associated with carotid artery compliance in men in The Cardiovascular Risk in Young Finns Study
    C Eklund
    Department of Microbiology and Immunology, University of Tampere Medical School, 33014 University of Tampere, Finland
    Atherosclerosis 196:841-8. 2008
    ..Men carrying the SNP -286 allele C had increased CAC after adjusting for risk factors. These data suggest that the presence of high producer CRP genotype is deleterious to carotid elasticity in men...
  26. pmc Indoleamine 2,3-dioxygenase enzyme activity correlates with risk factors for atherosclerosis: the Cardiovascular Risk in Young Finns Study
    M Pertovaara
    Department of Microbiology and Immunology, University of Tampere, Medical School, Finland
    Clin Exp Immunol 148:106-11. 2007
    ....
  27. ncbi request reprint Presence of apolipoprotein E epsilon4 allele predisposes to early onset of primary Sjogren's syndrome
    M Pertovaara
    Department of Internal Medicine, Section of Rheumatology, Tampere University Hospital, P O Box 2000, FIN 33521 Tampere, Finland
    Rheumatology (Oxford) 43:1484-7. 2004
    ..Apolipoprotein E (apoE) polymorphism plays a central role in lipid metabolism, but has recently also been suggested to regulate inflammation, as judged by levels of serum C-reactive protein (CRP)...
  28. ncbi request reprint Epistatic effect of C-reactive protein (CRP) single nucleotide polymorphism (SNP) +1059 and interleukin-1B SNP +3954 on CRP concentration in healthy male blood donors
    C Eklund
    Department of Microbiology and Immunology, University of Tampere Medical School, FIN 33014, Tampere, Finland
    Int J Immunogenet 32:229-32. 2005
    ..These polymorphisms might be predictive markers of persons prone to cardiovascular diseases...
  29. doi request reprint Gene-environment interaction between MBL2 genotype and smoking, and the risk of gram-positive bacteraemia
    R Huttunen
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Scand J Immunol 68:438-44. 2008
    ....
  30. ncbi request reprint Epistatic effect of IL1A and IL4RA genes on the risk of atopy
    Kati Adjers
    Department of Microbiology and Immunology, Medical School, University of Tampere, Finland
    J Allergy Clin Immunol 113:445-7. 2004
    ..We have recently shown that polymorphism of the pro-inflammatory cytokine IL1A gene is strongly associated with atopy...
  31. ncbi request reprint Association of chest radiography findings with host-related genetic factors in patients with nephropathia epidemica
    Antti Paakkala
    Departments of Radiology, Tampere University Hospital, Helsinki, Finland
    Scand J Infect Dis 40:254-8. 2008
    ..Pleural effusion is a sign of increased capillary permeability, an important feature in NE. Host genetic factors may contribute to increased capillary permeability observed in NE patients...
  32. doi request reprint High pentraxin-3 plasma levels associate with thrombocytopenia in acute Puumala hantavirus-induced nephropathia epidemica
    T K Outinen
    Department of Internal Medicine, Tampere University Hospital, P O Box 2000, 33521, Tampere, Finland
    Eur J Clin Microbiol Infect Dis 31:957-63. 2012
    ..They also had longer hospital stays (8 vs. 5 days, p = 0.015) compared to patients with low PTX3 level. High plasma PTX3 levels are associated with thrombocytopenia and the overall severity of NE...
  33. ncbi request reprint Allele 2 of interleukin-1 receptor antagonist gene increases the risk of thyroid peroxidase antibodies in subacute thyroiditis
    K Luotola
    Department of Medicine, Tampere University Hospital, Finland
    APMIS 109:454-60. 2001
    ..IL-1ra may have a significant anti-inflammatory role in SAT. Presence of IL-1ra allele 2 increases the risk of developing TPOab...
  34. ncbi request reprint Promoter polymorphism of IL-10 and severity of multiple sclerosis
    M Luomala
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, and University of Tampere, Medical School, Tampere, Finland
    Acta Neurol Scand 108:396-400. 2003
    ..010), the effect being increased over the years (10 years; OR=0.33, P=0.043, 15 years; OR=0.21, P=0.025 or 20 years; OR=0.14, P=0.026). Our results suggest that differential production of IL-10 might be a factor in the severity of MS...
  35. pmc Autoimmunity and atherosclerosis: functional polymorphism of PTPN22 is associated with phenotypes related to the risk of atherosclerosis. The Cardiovascular Risk in Young Finns Study
    M Pertovaara
    Department of Microbiology and Immunology, University of Tampere, Medical School, Tampere, Finland
    Clin Exp Immunol 147:265-9. 2007
    ..Our results indicate that the genetic polymorphism of PTPN22 + 1858 known to predispose to autoimmunity also enhances the development of atherosclerosis and thereby links the genetics of autoimmunity and atherosclerosis...
  36. doi request reprint Indoleamine 2,3-dioxygenase activity associates with cardiovascular risk factors: the Health 2000 study
    P Niinisalo
    Department of Clinical Chemistry, Laboratory of Atherosclerosis Genetics, University of Tampere, Medical School, Tampere, Finland
    Scand J Clin Lab Invest 68:767-70. 2008
    ..It is thus concluded that IDO is a sensitive marker of atherosclerosis--or the inflammatory response associated with it--but does not have an independent role in the pathogenesis of this disease...
  37. ncbi request reprint Susceptibility to primary Epstein-Barr virus infection is associated with interleukin-10 gene promoter polymorphism
    M E Helminen
    Department of Pediatrics, Tampere University Hospital, Tampere, Finland
    J Infect Dis 184:777-80. 2001
    ..These data suggest that the IL-10 ATA haplotype confers protection against primary EBV infection and that the effect is mediated by high IL-10 levels...
  38. pmc Mannose-binding lectin 2 (MBL2) gene polymorphism in asthma and atopy among adults
    J Aittoniemi
    Department of Clinical Microbiology, Centre for Laboratory Medicine, Pirkanmaa Hospital District, Tampere, Finland
    Clin Exp Immunol 142:120-4. 2005
    ....
  39. ncbi request reprint Allergic rhinitis and polymorphisms of the interleukin 1 gene complex
    Veli Pekka Joki-Erkkilä
    Department of Otorhinolaryngology, Tampere University Hospital, Tampere, Finland
    Ann Allergy Asthma Immunol 91:275-9. 2003
    ..Allergic rhinitis is a chronic inflammatory disease with a genetic background. Inflammatory reactions are regulated by cytokines. Cytokine genes are polymorphic and have been implicated as candidate genes in allergy...
  40. pmc Mechanisms dependent on tryptophan catabolism regulate immune responses in primary Sjögren's syndrome
    M Pertovaara
    Tampere University Hospital, Finland
    Clin Exp Immunol 142:155-61. 2005
    ..0). These data suggest that mechanisms dependent on tryptophan catabolism regulate immune responses in pSS. Tryptophan degradation is enhanced in patients with pSS, and high IDO activity is associated with severity of pSS...
  41. ncbi request reprint Elevated interleukin-6 plasma levels are regulated by the promoter region polymorphism of the IL6 gene in primary Sjögren's syndrome and correlate with the clinical manifestations of the disease
    J Hulkkonen
    Institute of Medical Technology, University of Tampere, Tampere, Finland
    Rheumatology (Oxford) 40:656-61. 2001
    ..To determine whether plasma interleukin-6 (IL-6) and G/C base exchange polymorphism at position -174 of the IL6 gene have an effect on the clinical manifestations of primary Sjögren's syndrome (pSS)...
  42. doi request reprint Interaction between CD14-159C>T polymorphism and Helicobacter pylori is associated with serum total immunoglobulin E
    M Virta
    Department of Microbiology and Immunology, University of Tampere Medical School, Tampere, Finland
    Clin Exp Allergy 38:1929-34. 2008
    ..It seems that gene-environment interactions are involved in this regulation...
  43. doi request reprint IL-10 gene polymorphism at -1082 A/G is associated with severe rhinovirus bronchiolitis in infants
    Merja Helminen
    Paediatric Research Centre, Tampere University and University Hospital, Tampere, Finland
    Pediatr Pulmonol 43:391-5. 2008
    ..This finding suggests a different pathogenic mechanism for RSV bronchiolitis as compared with wheezing associated with other viral infections, for example, rhinovirus in infants under 6 months of age...
  44. ncbi request reprint The IL-1beta genotype carries asthma susceptibility only in men
    Jussi Karjalainen
    Tampere University Hospital, Department of Respiratory Medicine, Finland
    J Allergy Clin Immunol 109:514-6. 2002
    ..In men this might make a significant contribution to the total asthma prevalence because of the high number of functional genotypes (ie, 50/50 IL-1beta homozygote/heterozygote ratio)...
  45. ncbi request reprint Cytokine gene polymorphism in recurrent acute otitis media
    Veli Pekka Joki-Erkkilä
    Department of Otorhinolaryngology, Head and Neck Surgery, Tampere University Hospital, PO Box 2000, FIN 33521 Tampere, Finland
    Arch Otolaryngol Head Neck Surg 128:17-20. 2002
    ..Cytokines play a key role in the pathogenesis of otitis media. Constitutional polymorphisms in cytokine genes may lead to individual variations in cytokine secretion...
  46. pmc The trajectory of the blood DNA methylome ageing rate is largely set before adulthood: evidence from two longitudinal studies
    L Kananen
    Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland
    Age (Dordr) 38:65. 2016
    ..Overall, these observations contribute to the understanding of the longitudinal aspects of the DNAmAge estimate. ..
  47. pmc Aging-associated DNA methylation changes in middle-aged individuals: the Young Finns study
    L Kananen
    Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland
    BMC Genomics 17:103. 2016
    ....
  48. ncbi request reprint Interleukin-10 gene promoter region polymorphism is associated with eosinophil count and circulating immunoglobulin E in adult asthma
    J Karjalainen
    Department of Respiratory Medicine, Tampere University Hospital, Tampere, Finland
    Clin Exp Allergy 33:78-83. 2003
    ..IL-10 has several functional effects relevant to asthma. It can modulate IgE production and induce apoptosis in eosinophils. Polymorphisms of IL-10 gene have been shown to affect IL-10 production...
  49. ncbi request reprint Genetic and environmental factors in the immunopathogenesis of atopy: interaction of Helicobacter pylori infection and IL4 genetics
    T Pessi
    Department of Microbiology and Immunology, Medical School, University of Tampere, Finland
    Int Arch Allergy Immunol 137:282-8. 2005
    ..Both genetic and environmental factors, e.g. early childhood infections, have a role in the pathogenesis of atopic diseases...
  50. ncbi request reprint Genetic association between interleukin-10 promoter region polymorphisms and primary Sjögren's syndrome
    J Hulkkonen
    Department of Microbiology and Immunology, University of Tampere Medical School and Institute of Medical Technology, Finland
    Arthritis Rheum 44:176-9. 2001
    ..To determine whether the haplotypes formed on the basis of single-base-exchange polymorphisms at positions -1082, -819, or -592 of the interleukin-10 (IL-10) gene predispose subjects to primary Sjögren's syndrome (SS)...
  51. ncbi request reprint Surface membrane antigen expression changes induced in vitro by exogenous growth factors in chronic lymphocytic leukemia cells
    J Vilpo
    Department of Clinical Chemistry, University of Tampere Medical School and Laboratory Centre of Tampere University Hospital, Tampere, Finland
    Leukemia 16:1691-8. 2002
    ..Upregulation of proteins mediating positive growth signals (eg CD25, CD40) and negative signals or apoptosis (eg CD95) may be used to sensitize cells to chemotherapy and programmed cell death...
  52. ncbi request reprint Polymorphism of the interleukin-10 gene is associated with susceptibility to Epstein-Barr virus infection
    M Helminen
    Department of Pediatrics, Tampere University Hospital, P O Box 2000, FIN 33521, Tampere, Finland
    J Infect Dis 180:496-9. 1999
    ....
  53. ncbi request reprint The IL1A genotype associates with atopy in nonasthmatic adults
    Jussi Karjalainen
    Tampere University Hospital, the Department of Respiratory Medicine and the Centre for Laboratory Medicine, Tampere, Finland
    J Allergy Clin Immunol 110:429-34. 2002
    ..Generally, results accord well with anamnestic information on atopy. Several genetic factors probably affect the strength of allergen-mediated skin test reactions...
  54. pmc C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk
    C M Eklund
    Department of Microbiology and Immunology, University of Tampere, Biokatu 6, Tampere 33520, Finland
    Br J Cancer 100:1846-51. 2009
    ..CRP alleles previously found to protect against increased CRP levels are now suggested to be associated with metastatic PC, indicated by elevated PSA...
  55. ncbi request reprint Gene polymorphisms of interleukins 1 and 10 in infectious and autoimmune diseases
    M Hurme
    Department of Microbiology and Immunology, University of Tampere and Tampere University Hospital, Finland
    Ann Med 30:469-73. 1998
    ..In this review we describe the polymorphisms of the two inflammatory cytokines, IL-1 and IL-10, and their significance in various diseases of autoimmune or inflammatory nature...
  56. ncbi request reprint Increased in vitro production of interleukin 6 in response to trimethoprim among persons with trimethoprim induced systemic adverse reactions
    J Antonen
    Department of Medicine, Tampere University Hospital, Medical School, University of Tampere, Finland
    J Rheumatol 26:2585-90. 1999
    ....
  57. ncbi request reprint Immunoglobulin G3 and immunoglobulin M isotype plasma levels are influenced by interleukin-1alpha genotype
    S Kilpinen
    Department of Microbiology and Immunology, Tampere University Medical School and Tampere University Hospital, Tampere, Finland
    Scand J Immunol 57:296-302. 2003
    ..2 homozygotes (P = 0.03, Mann-Whitney U-test). The data suggest that IL-1alpha-mediated signals are critical for IgG3 and IgM responses, which are induced by thymus-independent antigens and are important in activating complement...
  58. ncbi request reprint Interaction between 5-HT1A and BDNF genotypes increases the risk of treatment-resistant depression
    S Anttila
    Medical School, University of Tampere, Tampere, Finland
    J Neural Transm (Vienna) 114:1065-8. 2007
    ..5-HT1A C1019G and BDNF G196A (Val66Met) polymorphisms were studied. The combination of 5-HT1A GG and BDNF GA + AA genotypes is associated with an increased risk of depression...
  59. pmc Indoleamine 2,3-dioxygenase activity is increased in patients with systemic lupus erythematosus and predicts disease activation in the sunny season
    M Pertovaara
    Department of Internal Medicine, Section of Rheumatology, Tampere University Hospital, Tampere, Finland
    Clin Exp Immunol 150:274-8. 2007
    ..High IDO activity in winter predicts activation of SLE in the sunny season...
  60. ncbi request reprint Increased plasma levels of pro- and anti-inflammatory cytokines in patients with febrile seizures
    Miia Virta
    Department of Microbiology and Immunology, University of Tampere Medical School and Tampere University Hospital, Finland
    Epilepsia 43:920-3. 2002
    ..Activation of the cytokine network has been shown in previous studies of FSs and cytokines. In this study, the association between cytokines and FSs was further investigated...
  61. doi request reprint Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response
    T Kuparinen
    Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland
    Genes Immun 13:184-90. 2012
    ..86 × 10(-6)). The results indicate that there is no strong evidence of major host genetic factors involved in either susceptibility to or the strength of antibody response to human CMV infection...
  62. ncbi request reprint Anti-inflammatory cytokine response and the development of multiple organ failure in severe sepsis
    P Loisa
    Departments of Anaesthesia and Intensive Care, Tampere University Hospital, Tampere, Finland
    Acta Anaesthesiol Scand 47:319-25. 2003
    ..In this prospective study, we investigated the relationship between the pro- and anti-inflammatory cytokine profiles in severe sepsis and their role in the development of multiple organ failure (MOF)...
  63. ncbi request reprint Polymorphisms within the tumor necrosis factor locus and prevalence of coronary artery disease in middle-aged men
    T Keso
    Medical School, FIN 33014 University of Tampere, Tampere, Finland
    Atherosclerosis 154:691-7. 2001
    ..Men with TNFA22 or TNFB11 genotype tended to have more fibrous lesions and calcification in their coronary arteries. TNFA and TNFB polymorphisms are unlikely to contribute to progression of atherosclerosis in a way clinically important...
  64. ncbi request reprint Increased frequency of interleukin-1beta (-511) allele 2 in febrile seizures
    Miia Virta
    Department of Microbiology and Immunology, University of Tampere Medical School Tampere, Finland
    Pediatr Neurol 26:192-5. 2002
    ..Children with febrile seizures may therefore have an increased pro-inflammatory reaction during fever. This pro-inflammatory reaction may also predispose some children to the development of epilepsy...
  65. ncbi request reprint Polymorphism of the IL-10 gene is associated with susceptibility to herpes zoster
    Maija Haanpää
    Department of Neurology and Rehabilitation, Tampere University Hospital, Finland
    Scand J Infect Dis 34:112-4. 2002
    ..In a cohort of 60 HZV patients, the number of carriers of the ATA haplotype was 32 (53%), while in blood donors the frequency was 151/400 (38%) (p < 0.05)...
  66. pmc Transcriptomic and epigenetic analyses reveal a gender difference in aging-associated inflammation: the Vitality 90+ study
    T Nevalainen
    Department of Microbiology and Immunology, School of Medicine, University of Tampere, Tampere, Finland
    Age (Dordr) 37:9814. 2015
    ..These differences point to the genomic regulation of inflammatory response and suggest that the gender-specific immune system dimorphism in older individuals could be accounted for, in part, by DNA methylation. ..
  67. doi request reprint Are body mass index, waist circumference and waist-to-hip ratio associated with leptin in 90-year-old people?
    I Lisko
    Gerontology Research Center and School of Health Sciences, University of Tampere, Tampere, Finland
    Eur J Clin Nutr 67:420-2. 2013
    ..In conclusion, based on the circulating level of leptin, BMI and WC, and WHR in men, reflect body fat in 90-year-old people, but WHR seems to be a poor indicator of body fat in 90-year-old women...
  68. ncbi request reprint Pre-exposure to oxidative stress decreases the nuclear factor-kappa B-dependent transcription in T lymphocytes
    N Lahdenpohja
    Department of Microbiology and Immunology, University of Tampere Medical School, Finland
    J Immunol 160:1354-8. 1998
    ....
  69. doi request reprint Indoleamine 2,3-dioxygenase expression is associated with chronic rhinosinusitis with nasal polyps and antrochoanal polyps
    T Honkanen
    Department of Pathology, University of Tampere, Tampere, Finland
    Rhinology 49:356-63. 2011
    ..The different expression of IDO could putatively indicate the differences in the pathomechanisms of CRSsNP, CRSwNP and ACP. Further studies on the role of IDO in upper airways pathologies are required...
  70. ncbi request reprint Association of interferon-gamma +874(T/A) single nucleotide polymorphism with the rate of tryptophan catabolism in healthy individuals
    A Raitala
    Department of Microbiology and Immunology, Medical School, University of Tampere, Tampere, Finland
    Scand J Immunol 61:387-90. 2005
    ..These data show that trp catabolism is genetically controlled by the IFN-gamma gene and may thus be operative in those disease conditions associated with the polymorphisms of the IFN-gamma gene...
  71. doi request reprint Hormonal deficiencies during and after Puumala hantavirus infection
    S Makela
    Department of Internal Medicine, Tampere University Hospital, P O Box 2000, 33521, Tampere, Finland
    Eur J Clin Microbiol Infect Dis 29:705-13. 2010
    ..Hormonal defects are common during acute NE and, surprisingly, many patients develop chronic hormonal deficiencies after NE. The occurrence of long-term hormonal defects cannot be predicted by the severity of acute NE...
  72. ncbi request reprint CD28-mediated activation in CD45RA+ and CD45RO+ T cells: enhanced levels of reactive oxygen intermediates and c-Rel nuclear translocation in CD45RA+ cells
    N Lahdenpohja
    Department of Microbiology and Immunology, University of Tampere Medical School, Finland
    J Leukoc Biol 63:775-80. 1998
    ..ROIs were produced in both cell types, but more strongly in CD45RA+ cells. The data presented in this study further emphasize the differences between CD45RA+ and CD45RO+ T lymphocytes in ROI-dependent signaling pathways...
  73. ncbi request reprint Regulation of IL-6 system in cerebrospinal fluid and serum compartments by seizures: the effect of seizure type and duration
    K A Lehtimäki
    Department of Neurology and Rehabilitation, University of Tampere and Tampere University Hospital, 33521 Tampere, Finland
    J Neuroimmunol 152:121-5. 2004
    ..These results provide further support for a hypothesis of cytokine production induced by seizure activity per se...
  74. ncbi request reprint Toll-like receptor 4 polymorphism is associated with coronary stenosis but not with the occurrence of acute or old myocardial infarctions
    J Hernesniemi
    Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Tampere University Hospital and the Medical School at the University of Tampere, Finland
    Scand J Clin Lab Invest 66:667-75. 2006
    ..TLR-4 is activated by, for example, lipopolysaccharides. The purpose of this study was to investigate the role of a common Asp299Gly polymorphism of the TLR-4 gene in atherosclerosis...
  75. pmc Allergic sensitization and microbial load--a comparison between Finland and Russian Karelia
    T Seiskari
    Department of Virology, University of Tampere, Finland
    Clin Exp Immunol 148:47-52. 2007
    ..Enterovirus infections represent a new candidate to the list of markers of such a protective environment. However, possible causal relationship needs to be confirmed in further studies...
  76. ncbi request reprint Interleukin-18 promoter polymorphism associates with the occurrence of sudden cardiac death among Caucasian males: the Helsinki Sudden Death Study
    Jussi A Hernesniemi
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital and Department of Clinical Chemistry, Medical School, University of Tampere, Tampere, Finland
    Atherosclerosis 196:643-9. 2008
    ..The C allele carriage is associated with attenuated IL-18 production. The effect of IL-18 genotype on SCD is unknown. We studied the association of the IL-18 gene -137G/C polymorphism with the occurrence of sudden cardiac death (SCD)...
  77. doi request reprint Autoimmunity and atherosclerosis: the presence of antinuclear antibodies is associated with decreased carotid elasticity in young women. The Cardiovascular Risk in Young Finns Study
    Marja Pertovaara
    Department of Internal Medicine, Section of Rheumatology, Tampere UniversityHospital, Tampere, Finland
    Rheumatology (Oxford) 48:1553-6. 2009
    ..Our aim was to investigate whether positive ANAs in young adults are associated with risk factors for atherosclerosis or subclinical markers of atherosclerosis...
  78. ncbi request reprint Interleukin 1B gene polymorphism is associated with baseline C-reactive protein levels in healthy individuals
    Carita Eklund
    Department of Microbiology and Immunology, University of Tampere Medical School, Tampere, Finland
    Eur Cytokine Netw 14:168-71. 2003
    ..72 mg/l), and composite genotype analysis of IL1B-511/IL1B + 3954 supported this finding. Our findings suggest that in healthy people, basal CRP levels are regulated by IL1B but not by IL6 genetics...
  79. ncbi request reprint Urinary excretion of interleukin-6 correlates with proteinuria in acute Puumala hantavirus-induced nephritis
    Satu Makela
    Medical School, University of Tampere and Tampere University Hospital, Tampere, Finland
    Am J Kidney Dis 43:809-16. 2004
    ..Cytokines are thought to have an important role in the pathogenesis of NE. The aim of this study is to evaluate whether cytokines contribute to renal involvement in NE...
  80. ncbi request reprint Catechol-O-methyltransferase val108/158met genotype and response to antipsychotic medication in schizophrenia
    Ari Illi
    University of Tampere, Medical School, and Tampere University Hospital, Department of Psychiatry, Finland
    Hum Psychopharmacol 22:211-5. 2007
    ..We could not demonstrate any clearly significant effect of this particular COMT genotype in relation to the daily maintenance dosages of antipsychotics in patients with schizophrenia...
  81. ncbi request reprint Interleukin-1B genotype modulates the improvement of coronary artery reactivity by lipid-lowering therapy with pravastatin: a placebo-controlled positron emission tomography study in young healthy men
    Terho Lehtimaki
    Laboratory of Atherosclerosis Genetics, Centre for Laboratory Medicine, Department of Clinical Chemistry, Tampere University Hospital and University of Tampere Medical School, Tampere, Finland
    Pharmacogenetics 13:633-9. 2003
    ..0001 for both). In conclusion, coronary function improves after 6 months of pravastatin therapy in subjects with the IL-1B A2- allele but not in those with the IL-1B A2+ allele...
  82. ncbi request reprint [New knowledge about cytokines]
    Olli Silvennoinen
    Lääketieteellisen teknologian instituutti 33014 Tampereen yliopisto
    Duodecim 119:773-9. 2003
  83. doi request reprint Endothelial nitric oxide synthase G894T (GLU298ASP) polymorphism is associated with hypotension in patients with E. coli bacteremia but not in bacteremia caused by a gram-positive organism
    Reetta Huttunen
    Department of Internal Medicine, Tampere University Hospital, Tampere, Finland
    Shock 31:448-53. 2009
    ..Carriage of the T allele of the eNOS gene is a risk factor for hypotension in patients with E. coli bacteremia but not in bacteremia caused by a gram-positive organism...
  84. ncbi request reprint Human leukocyte antigen-B8-DR3 is a more important risk factor for severe Puumala hantavirus infection than the tumor necrosis factor-alpha(-308) G/A polymorphism
    Satu Makela
    Medical School, University of Tampere and Tampere University Hospital, Tampere, Tampere, Finland
    J Infect Dis 186:843-6. 2002
    ..It is concluded that the HLA-B8-DR3 haplotype is an important contributor to the course of NE. The data indicate that the TNF-2 allele is not an independent risk factor for severe NE but a passive component in the extended haplotype...
  85. doi request reprint Complement factor H 402His variant confers an increased mortality risk in Finnish nonagenarians: the Vitality 90+ study
    Juulia Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, FIN 33014 Tampere, Finland
    Exp Gerontol 44:297-9. 2009
    ..016). We propose that the increased mortality is inflammation-related and mediated by aberrant complement regulation by the CFH 402His variant...
  86. ncbi request reprint Interleukin-1 receptor antagonist, interleukin-6, and C-reactive protein as predictors of mortality in nonagenarians: the vitality 90+ study
    Marja Jylha
    Tampere School of Public Health, FIN 33014 University of Tampere, Finland
    J Gerontol A Biol Sci Med Sci 62:1016-21. 2007
    ..We investigated blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra), and their combinations as predictors of mortality in nonagenarians...
  87. doi request reprint Use of combined oral contraceptives alters metabolic determinants and genetic regulation of C-reactive protein. The Cardiovascular Risk in Young Finns Study
    Atte Haarala
    Department of Microbiology and Immunology, University of Tampere, Tampere, Finland
    Scand J Clin Lab Invest 69:168-74. 2009
    ..The aim of this study was to find out whether the metabolic, lifestyle and genetic determinants of CRP differ between women who use COCs and those who do not use any hormonal contraceptives (non-users)...
  88. ncbi request reprint The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals
    Sanna Kilpinen
    Department of Microbiology and Immunology, University of Tampere Medical School, POB 607, FIN 33 101, Tampere, Finland
    Eur Cytokine Netw 13:66-71. 2002
    ..Until now, data on the feedback loop between IL-1 and IL-10 cytokines have been based on studies in vitro, but now our results suggest that this relationship may also exist in vivo...
  89. doi request reprint More than half of the patients with acute Puumala hantavirus infection have abnormal cardiac findings
    Satu Makela
    Medical School, University of Tampere, Finland
    Scand J Infect Dis 41:57-62. 2009
    ..During the follow-up, all acute-phase changes in ECG and ECHO reverted to normal, which probably reflects their benign nature. We conclude that abnormal cardiac findings are surprisingly common during NE...
  90. ncbi request reprint Polymorphism of the cytokine genes and IgA nephropathy
    Jaana Syrjanen
    Medical School, University Hospital, FIN 33014 University of Tampere, Tampere, Finland
    Kidney Int 61:1079-85. 2002
    ..Cytokine gene polymorphisms regulate cytokine production and play a role in immune and inflammatory responses; these immunological responses thus are possibly involved in the etiology and pathogenesis of IgAN...
  91. ncbi request reprint Interleukin-6 modulates plasma cholesterol and C-reactive protein concentrations in nonagenarians
    Terho Lehtimaki
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Tampere, Finland
    J Am Geriatr Soc 53:1552-8. 2005
    ..To establish whether the relationship between interleukin-6 (IL-6) and plasma lipid and C-reactive protein (CRP) concentrations is different in Finnish nonagenarians than in middle-aged subjects with lower inflammatory status...
  92. doi request reprint Activation of indoleamine 2,3-dioxygenase-induced tryptophan degradation in advanced atherosclerotic plaques: Tampere vascular study
    Petri Niinisalo
    Department of Clinical Chemistry, University of Tampere, Medical School, and Tampere University Hospital, Centre for Laboratory Medicine, Tampere, Finland
    Ann Med 42:55-63. 2010
    ..We aimed to characterize the expression of indoleamine 2,3-dioxygenase (IDO) or IDO-induced tryptophan degradation-dependent pathways, which may lead to suppression of T cells and possible protection against atherosclerosis...
  93. doi request reprint Serum amyloid A and C-reactive protein concentrations are differently associated with markers of autoimmunity in patients with primary Sjögren's syndrome
    Marja Pertovaara
    Department of Internal Medicine, Section of Rheumatology, Tampere University Hospital, Tampere, Finland
    J Rheumatol 36:2487-90. 2009
    ..We investigated whether levels of another acute-phase protein, serum amyloid A (SAA), are increased in patients with pSS and whether the immunological markers in patients with pSS are associated with variation in SAA levels...
  94. ncbi request reprint Epistatic effect of TLR4 and IL4 genes on the risk of asthma in females
    Kati Adjers
    Department of Microbiology and Immunology, Medical School, University of Tampere, Tampere, Finland
    Int Arch Allergy Immunol 138:251-6. 2005
    ..We examined whether the polymorphisms of the TLR4 (A/G at +896) and IL4 (C/T at -590) showed an epistatic effect on the risk of asthma or atopy...
  95. ncbi request reprint Apolipoprotein E genotype is related to plasma levels of C-reactive protein and lipids and to longevity in nonagenarians
    Riikka Rontu
    Laboratory of Atherosclerosis Genetics, Tampere University Hospital, Centre for Laboratory Medicine and Department of Clinical Chemistry, University of Tampere, Medical School, Finland
    Clin Endocrinol (Oxf) 64:265-70. 2006
    ..The aim of the present study was to establish whether APOE genotype is related to plasma concentrations of CRP and lipids, or longevity among nonagenarians...
  96. ncbi request reprint Indoleamine 2,3-dioxygenase (IDO) activity is lower in atopic than in non-atopic individuals and is enhanced by environmental factors protecting from atopy
    Annika Raitala
    University of Tampere Medical School, Tampere, Finland
    Mol Immunol 43:1054-6. 2006
    ..As expected, IDO activity was significantly higher in their presence than absence...
  97. ncbi request reprint Helicobacter pylori-induced indoleamine 2,3-dioxygenase activity in vivo is regulated by TGFB1 and CTLA4 polymorphisms
    Annika Raitala
    University of Tampere Medical School, Tampere, Finland
    Mol Immunol 44:1011-4. 2007
    ..This suggests that H. pylori induced IDO activity is regulated by TGFB1 and CTLA4, and that IDO is a mediator of the T cell suppressive effects of these genes...
  98. doi request reprint Gene polymorphism of IFNG +874 T/A and TLR4 +896 A/G and recurrent infections and wheezing in toddlers with history of bronchiolitis
    Kirsi Nuolivirta
    Paediatric Research Centre, University of Tampere and Seinäjoki Central Hospital, Tampere, Finland
    Pediatr Infect Dis J 28:1121-3. 2009
    ..The carriers of IFNG +874 T/A allele A had fewer infections and use of inhaled corticosteroids and the carriers of TLR4+896 A/G allele G were more likely to need tympanostomy than noncarriers...
  99. ncbi request reprint Association of the IL6-174(G/C) polymorphism with C-reactive protein concentration after weight loss in obese men
    Carita Eklund
    Department of Microbiology and Immunology, University of Tampere Medical School, FI 33014 Tampere, Finland
    Eur Cytokine Netw 17:131-5. 2006
    ....
  100. doi request reprint Expression profiling of immune-associated genes in peripheral blood mononuclear cells reveals baseline differences in co-stimulatory signalling between nonagenarians and younger controls: the vitality 90+ study
    Juulia Jylhävä
    Department of Microbiology and Immunology, University of Tampere, Finland
    Biogerontology 11:671-7. 2010
    ..Further research is, however, required to establish the relationship between these changes and the mechanisms of immunosenescence...
  101. doi request reprint Gene variants as determinants of longevity: focus on the inflammatory factors
    Juulia Jylhävä
    Department of Microbiology and Immunology, Medical School, University of Tampere, Biokatu 6, Finn Medi 1, 33520 Tampere, Finland
    Pflugers Arch 459:239-46. 2010
    ..Besides describing the pre-existing inflammatory and immune-related longevity gene variants, in this review, we also explain some of the theoretical and practical challenges that genetic longevity studies often encounter...