Affiliation: University of Kuopio
- Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1H Huopio
Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
J Clin Invest 106:897-906. 2000..In conclusion, we describe the first dominantly inherited SUR1 mutation that causes CHI in early life and predisposes to later insulin deficiency...
- Acute insulin response tests for the differential diagnosis of congenital hyperinsulinismH Huopio
Department of Pediatrics, Kuopio University Hospital, FIN 70211 Kuopio, Finland
J Clin Endocrinol Metab 87:4502-7. 2002..Our results, however, also demonstrate the complexity of these responses and the difficulties in their interpretation...
- K(ATP) channels and insulin secretion disordersH Huopio
Department of Pediatrics, Kuopio University Hospital, Kuopio 70211, Finland
Am J Physiol Endocrinol Metab 283:E207-16. 2002....
- A point mutation inactivating the sulfonylurea receptor causes the severe form of persistent hyperinsulinemic hypoglycemia of infancy in FinlandT Otonkoski
Transplantation Laboratory, Haartman Institute, and University of Helsinki, Finland
Diabetes 48:408-15. 1999..This unique SUR1 mutation explains the majority of PHHI cases in Finland and is strongly associated with a severe form of the disease. These findings provide diagnostic and prognostic utility for suspected PHHI patients...
- Characterisation of new KATP-channel mutations associated with congenital hyperinsulinism in the Finnish populationF Reimann
Department of Clinical Biochemistry, University of Cambridge, UK
Diabetologia 46:241-9. 2003..The aim of this study was to analyse the functional consequences of four CHI mutations (A1457T, V1550D and L1551V in SUR1, and K67N in Kir6.2) recently identified in the Finnish population...