Jussi Hirvonen

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. doi request reprint Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation
    Jussi Hirvonen
    Turku PET Centre, University of Turku and Turku University Hospital, P O Box 52, 20521, Turku, Finland
    Eur J Nucl Med Mol Imaging 37:606-12. 2010
  2. doi request reprint The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects
    Sargo Aalto
    Turku PET Centre, University of Turku, 20014 Turku, Finland
    Eur J Nucl Med Mol Imaging 36:475-83. 2009
  3. doi request reprint Effects of antidepressant drug treatment and psychotherapy on striatal and thalamic dopamine D2/3 receptors in major depressive disorder studied with [11C]raclopride PET
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Psychopharmacol 25:1329-36. 2011
  4. doi request reprint Striatal dopamine D2 receptors in medication-naive patients with major depressive disorder as assessed with [11C]raclopride PET
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    Psychopharmacology (Berl) 197:581-90. 2008
  5. doi request reprint Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography
    Anne Roivainen
    Turku PET Centre, Turku University Hospital, Turku, Finland
    Eur J Nucl Med Mol Imaging 36:671-82. 2009
  6. doi request reprint Measurement of central mu-opioid receptor binding in vivo with PET and [11C]carfentanil: a test-retest study in healthy subjects
    Jussi Hirvonen
    Turku PET Centre, University of Turku and Turku University Central Hospital, Turku, Finland
    Eur J Nucl Med Mol Imaging 36:275-86. 2009
  7. doi request reprint Bariatric Surgery Induces White and Grey Matter Density Recovery in the Morbidly Obese: A Voxel-Based Morphometric Study
    Jetro J Tuulari
    Turku PET Centre, University of Turku, Turku, Finland
    Hum Brain Mapp 37:3745-3756. 2016
  8. doi request reprint Measurement of GABAA receptor binding in vivo with [11C]flumazenil: a test-retest study in healthy subjects
    Elina Salmi
    Turku PET Centre, University of Turku and Department of Otorhinolaryngology Head and Neck Surgery, Turku University Hospital, Finland
    Neuroimage 41:260-9. 2008
  9. doi request reprint Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test-retest reproducibility
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Cereb Blood Flow Metab 28:1059-69. 2008
  10. ncbi request reprint Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635
    Jussi Hirvonen
    Department of Psychiatry, Turku PET Centre, University of Turku and Turku University Central Hospital, Turku, Finland
    Int J Neuropsychopharmacol 11:465-76. 2008

Collaborators

Detail Information

Publications29

  1. doi request reprint Human biodistribution and radiation dosimetry of 11C-(R)-PK11195, the prototypic PET ligand to image inflammation
    Jussi Hirvonen
    Turku PET Centre, University of Turku and Turku University Hospital, P O Box 52, 20521, Turku, Finland
    Eur J Nucl Med Mol Imaging 37:606-12. 2010
    ..Despite its widespread use, the radiation burden associated with (11)C-(R)-PK11195 in humans is not known. To examine this, we performed dynamic whole-body imaging with PET and (11)C-(R)-PK11195 in healthy humans...
  2. doi request reprint The effects of d-amphetamine on extrastriatal dopamine D2/D3 receptors: a randomized, double-blind, placebo-controlled PET study with [11C]FLB 457 in healthy subjects
    Sargo Aalto
    Turku PET Centre, University of Turku, 20014 Turku, Finland
    Eur J Nucl Med Mol Imaging 36:475-83. 2009
    ..The dopamine D(2)/D(3) receptor ligand [(11)C]FLB 457 and PET enable quantification of low-density extrastriatal D(2)/D(3) receptors, but it is uncertain whether [(11)C]FLB 457 can be used for measuring extrastriatal dopamine release...
  3. doi request reprint Effects of antidepressant drug treatment and psychotherapy on striatal and thalamic dopamine D2/3 receptors in major depressive disorder studied with [11C]raclopride PET
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Psychopharmacol 25:1329-36. 2011
    ..The effects of fluoxetine on thalamic dopamine systems need to be further explored...
  4. doi request reprint Striatal dopamine D2 receptors in medication-naive patients with major depressive disorder as assessed with [11C]raclopride PET
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    Psychopharmacology (Berl) 197:581-90. 2008
    ..Previous in vivo imaging studies have studied striatal dopamine D2 receptor availability in depression but the results are equivocal thus far...
  5. doi request reprint Whole-body distribution and metabolism of [N-methyl-11C](R)-1-(2-chlorophenyl)-N-(1-methylpropyl)-3-isoquinolinecarboxamide in humans; an imaging agent for in vivo assessment of peripheral benzodiazepine receptor activity with positron emission tomography
    Anne Roivainen
    Turku PET Centre, Turku University Hospital, Turku, Finland
    Eur J Nucl Med Mol Imaging 36:671-82. 2009
    ..We sought to clarify the metabolic fate of (11)C-PK11195 in a test-retest setting using radio-HPLC in comparison with radio-TLC, and the whole-body distribution in humans...
  6. doi request reprint Measurement of central mu-opioid receptor binding in vivo with PET and [11C]carfentanil: a test-retest study in healthy subjects
    Jussi Hirvonen
    Turku PET Centre, University of Turku and Turku University Central Hospital, Turku, Finland
    Eur J Nucl Med Mol Imaging 36:275-86. 2009
    ..11)C]Carfentanil has been widely used in positron emission tomography (PET) studies for measuring micro-opioid receptor binding in humans, but the reproducibility of the binding parameter estimates is unknown...
  7. doi request reprint Bariatric Surgery Induces White and Grey Matter Density Recovery in the Morbidly Obese: A Voxel-Based Morphometric Study
    Jetro J Tuulari
    Turku PET Centre, University of Turku, Turku, Finland
    Hum Brain Mapp 37:3745-3756. 2016
    ..These changes likely reflect improved brain tissue integrity. Hum Brain Mapp 37:3745-3756, 2016. © 2016 Wiley Periodicals, Inc...
  8. doi request reprint Measurement of GABAA receptor binding in vivo with [11C]flumazenil: a test-retest study in healthy subjects
    Elina Salmi
    Turku PET Centre, University of Turku and Department of Otorhinolaryngology Head and Neck Surgery, Turku University Hospital, Finland
    Neuroimage 41:260-9. 2008
    ..The voxel-based analysis methods are proper alternative as the reliability is preserved and analysis automated...
  9. doi request reprint Measurement of striatal and extrastriatal dopamine transporter binding with high-resolution PET and [11C]PE2I: quantitative modeling and test-retest reproducibility
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Cereb Blood Flow Metab 28:1059-69. 2008
    ..The previously suggested involvement of the potentially brain-penetrant radioactive metabolite in the quantification should be further studied...
  10. ncbi request reprint Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635
    Jussi Hirvonen
    Department of Psychiatry, Turku PET Centre, University of Turku and Turku University Central Hospital, Turku, Finland
    Int J Neuropsychopharmacol 11:465-76. 2008
    ..Lack of correlation with overall severity of the illness may relate to a largely trait-like nature of this abnormality in depressive disorders...
  11. pmc Weight loss after bariatric surgery reverses insulin-induced increases in brain glucose metabolism of the morbidly obese
    Jetro J Tuulari
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Diabetes 62:2747-51. 2013
    ..We conclude that obesity is associated with increased insulin-stimulated glucose metabolism in the brain and that this abnormality can be reversed by bariatric surgery. ..
  12. doi request reprint Obesity is associated with white matter atrophy: a combined diffusion tensor imaging and voxel-based morphometric study
    Henry K Karlsson
    Turku PET Centre, Turku, Finland
    Obesity (Silver Spring) 21:2530-7. 2013
    ..Little is known about the mechanisms by which obesity influences brain structure. In this study, the obesity-related changes in brain white and gray matter integrity were examined...
  13. ncbi request reprint Correlation of human cold pressor pain responses with 5-HT(1A) receptor binding in the brain
    Ilkka K Martikainen
    Department of Physiology, Institute of Biomedicine, University of Turku, Turku, Finland
    Brain Res 1172:21-31. 2007
    ..In general, subjects with high availability of 5-HT(1A) receptors have low CPP intensity accompanied by a high capacity for central suppression of pain or a sympathetic vasoconstriction response by a Valsalva maneuver...
  14. doi request reprint Cortical dopamine D2/D3 receptors and verbal memory in man
    Ville Lumme
    Turku PET Centre, Turku University Hospital, 20521 Turku, Finland
    Neuroimage 51:918-22. 2010
    ..We tested this hypothesis further and studied whether cortical dopamine D2/D3 receptor availability in vivo is associated with verbal memory as assessed with the revised Wechsler Memory Scale (WMS-R)...
  15. doi request reprint Visual assessment of [(11)C]PIB PET in patients with cognitive impairment
    Timo Suotunen
    Turku PET Centre, P O Box 52, 20521, Turku, Finland
    Eur J Nucl Med Mol Imaging 37:1141-7. 2010
    ....
  16. pmc Neural circuits for cognitive appetite control in healthy and obese individuals: an fMRI study
    Jetro J Tuulari
    Turku PET Centre, University of Turku, Turku, Finland
    PLoS ONE 10:e0116640. 2015
    ..Functional connectivity of the control circuit was increased in morbidly obese versus control subjects during appetite control, which might reflect impaired integrative and executive function in obesity. ..
  17. ncbi request reprint Measurement of serotonin 5-HT1A receptor binding using positron emission tomography and [carbonyl-(11)C]WAY-100635-considerations on the validity of cerebellum as a reference region
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Cereb Blood Flow Metab 27:185-95. 2007
    ....
  18. pmc Effects of insulin on brain glucose metabolism in impaired glucose tolerance
    Jussi Hirvonen
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Diabetes 60:443-7. 2011
    ..It is not known whether insulin is able to stimulate glucose metabolism above fasting concentrations in patients with impaired glucose tolerance...
  19. pmc Increased brain fatty acid uptake in metabolic syndrome
    Anna Karmi
    Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
    Diabetes 59:2171-7. 2010
    ..To test whether brain fatty acid uptake is enhanced in obese subjects with metabolic syndrome (MS) and whether weight reduction modifies it...
  20. ncbi request reprint Striatal dopamine D1 and D2 receptor balance in twins at increased genetic risk for schizophrenia
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, 20520, Finland
    Psychiatry Res 146:13-20. 2006
    ..In this sample, we did not find evidence for an association between increased genetic risk for schizophrenia and altered D1/D2 receptor balance in the striatum...
  21. ncbi request reprint Ketamine does not decrease striatal dopamine D2 receptor binding in man
    Sargo Aalto
    Neuropsychiatric Imaging, Turku PET Centre, Turku University Central Hospital, Kiinamyllynkatu 4 8, 20520 Turku, Finland
    Psychopharmacology (Berl) 164:401-6. 2002
    ..However, recent imaging studies addressing striatal glutamate-dopamine interaction directly in vivo in man have been controversial...
  22. doi request reprint Differential associations between brain 5-HT(1A) receptor binding and response to pain versus touch
    Ilkka K Martikainen
    Department of Physiology, Institute of Biomedicine, University of Turku, Kiinamyllynkatu 10, Turku 20520, Finland
    J Neural Transm (Vienna) 116:821-30. 2009
    ..Certainty ratings of the responses, but not hit rates, in the pain memory task were correlated with 5-HT(1A) BP (ND) in the dorsal raphe...
  23. doi request reprint Dopamine and Opioid Neurotransmission in Behavioral Addictions: A Comparative PET Study in Pathological Gambling and Binge Eating
    Joonas Majuri
    Division of Clinical Neurosciences, Turku University Hospital, Turku, Finland
    Neuropsychopharmacology . 2016
    ..Neuropsychopharmacology accepted article preview online, 24 November 2016. doi:10.1038/npp.2016.265...
  24. doi request reprint Adult attachment style is associated with cerebral μ-opioid receptor availability in humans
    Lauri Nummenmaa
    Turku PET Centre, University of Turku, Turku, 20520, Finland
    Hum Brain Mapp 36:3621-8. 2015
    ....
  25. doi request reprint Neuroticism and serotonin 5-HT1A receptors in healthy subjects
    Jussi Hirvonen
    Department of Radiology, University of Turku, Turku, Finland Turku PET Centre, University of Turku and Turku University Central Hospital, Turku, Finland
    Psychiatry Res 234:1-6. 2015
    ..The link between personality traits and 5-HT1A receptors should be studied in patients with major depression. ..
  26. doi request reprint Serotonin transporter in attention-deficit hyperactivity disorder--preliminary results from a positron emission tomography study
    Linnea Karlsson
    Turku University Hospital, Department of Child Psychiatry, P O Box 52, 20521 Turku, Finland
    Psychiatry Res 212:164-5. 2013
    ..We measured SERT availability in female ADHD patients (n=8) and healthy controls (n=14) with PET and [11C]MADAM as a tracer. No significant group differences in [11C]MADAM binding potential were noted...
  27. ncbi request reprint Comparison of 2D and 3D performance for FDG PET with different acquisition times in oncological patients
    Gaber Komar
    Turku PET Centre, Finland
    Nucl Med Commun 30:16-24. 2009
    ..The objective of our study was to compare VUE Point iterative reconstruction algorithm in positron emission tomography data obtained in 3D and two-dimensional (2D) mode in routine clinical diagnostic setting in oncological patients...
  28. ncbi request reprint Cortical glutamate-dopamine interaction and ketamine-induced psychotic symptoms in man
    Sargo Aalto
    Turku PET Centre, University of Turku, 20520, Turku, Finland
    Psychopharmacology (Berl) 182:375-83. 2005
    ..The noncompetitive glutamate N-methyl-D: -aspartate receptor antagonist ketamine induces transient psychotic symptoms in man. Involvement of dopaminergic mechanisms in these effects has been suggested...
  29. doi request reprint Dysfunctional brain networks and genetic risk for schizophrenia: specific neurotransmitter systems
    Jussi Hirvonen
    Department of Radiology, Turku University Hospital and University of Turku, Turku, Finland
    CNS Neurosci Ther 17:89-96. 2011
    ..g., cannabis, childhood trauma, and other psychosocial stress) in genetically vulnerable individuals...