J Heino

Summary

Affiliation: University of Turku
Country: Finland

Publications

  1. ncbi request reprint The cell adhesion domain of type XVII collagen promotes integrin-mediated cell spreading by a novel mechanism
    P Nykvist
    Department of Biological and Environmental Science, University of Jyvaskyla, FIN 40351 Jyvaskyla, Finland
    J Biol Chem 276:38673-9. 2001
  2. doi request reprint Cellular signaling by collagen-binding integrins
    Jyrki Heino
    Department of Biochemistry, University of Turku, 20014, Turku, Finland
    Adv Exp Med Biol 819:143-55. 2014
  3. pmc Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail
    J Ivaska
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, FIN 20520 Turku
    J Cell Biol 147:401-16. 1999
  4. pmc Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes
    Johanna Ivaska
    VTT Technical Research Centre of Finland, Turku, Finland
    Cell Tissue Res 339:111-20. 2010
  5. ncbi request reprint Cellular receptors of extracellular matrix molecules
    Jyrki Heino
    University of Turku, Department of Biochemistry and Food Chemistry, 20014 Turku, Finland
    Curr Pharm Des 15:1309-17. 2009
  6. ncbi request reprint The collagen receptor integrins have distinct ligand recognition and signaling functions
    J Heino
    Department of Biology, University of Jyvaskyla, P O Box 35, FIN 40351, Jyvaskyla, Finland
    Matrix Biol 19:319-23. 2000
  7. doi request reprint Evolution of collagen-based adhesion systems
    Jyrki Heino
    Department of Biochemistry and Food Chemistry, University of Turku, FI 20014 Turku, Finland
    Int J Biochem Cell Biol 41:341-8. 2009
  8. pmc Echovirus 1 replication, not only virus binding to its receptor, VLA-2, is required for the induction of cellular immediate-early genes
    P Huttunen
    Department of Virology, University of Turku, Finland
    J Virol 71:4176-80. 1997
  9. ncbi request reprint Integrin alpha(2)I domain recognizes type I and type IV collagens by different mechanisms
    J Kapyla
    Department of Biological Science, University of Jyvaskyla, FIN 40351 Jyvaskyla, Finland
    J Biol Chem 275:3348-54. 2000
  10. ncbi request reprint Selective binding of collagen subtypes by integrin alpha 1I, alpha 2I, and alpha 10I domains
    M Tulla
    Department of Biological and Environmental Science, University of Jyvaskyla, Jyväskylä FIN 40351, Finland
    J Biol Chem 276:48206-12. 2001

Collaborators

Detail Information

Publications21

  1. ncbi request reprint The cell adhesion domain of type XVII collagen promotes integrin-mediated cell spreading by a novel mechanism
    P Nykvist
    Department of Biological and Environmental Science, University of Jyvaskyla, FIN 40351 Jyvaskyla, Finland
    J Biol Chem 276:38673-9. 2001
    ..After being shed from the cell surface, it may support keratinocyte spreading and migration...
  2. doi request reprint Cellular signaling by collagen-binding integrins
    Jyrki Heino
    Department of Biochemistry, University of Turku, 20014, Turku, Finland
    Adv Exp Med Biol 819:143-55. 2014
    ..Additionally the structure and the organization of collagenous matrix play a critic role. Many recent studies have also stressed the importance of the crosstalk between the integrins and other cell surface receptors. ..
  3. pmc Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail
    J Ivaska
    MediCity Research Laboratory, Department of Medical Biochemistry, University of Turku, FIN 20520 Turku
    J Cell Biol 147:401-16. 1999
    ..These observations reveal a novel signaling mechanism of alpha2beta1 integrin that is distinct from ones previously described for other integrins...
  4. pmc Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes
    Johanna Ivaska
    VTT Technical Research Centre of Finland, Turku, Finland
    Cell Tissue Res 339:111-20. 2010
    ..Here, we review the present information concerning the role of integrins as assisting growth factor receptors and the interplay between the receptors in cell signaling and in the orchestration of receptor recycling...
  5. ncbi request reprint Cellular receptors of extracellular matrix molecules
    Jyrki Heino
    University of Turku, Department of Biochemistry and Food Chemistry, 20014 Turku, Finland
    Curr Pharm Des 15:1309-17. 2009
    ..Several other cellular receptors have also evolved to bind to various matrix components. Here, we review the basic facts about these receptors and shortly describe their role in human diseases, including cancer and inflammation...
  6. ncbi request reprint The collagen receptor integrins have distinct ligand recognition and signaling functions
    J Heino
    Department of Biology, University of Jyvaskyla, P O Box 35, FIN 40351, Jyvaskyla, Finland
    Matrix Biol 19:319-23. 2000
    ..Furthermore, the two receptors are connected to distinct signaling pathways and their ligation may lead to opposite cellular responses...
  7. doi request reprint Evolution of collagen-based adhesion systems
    Jyrki Heino
    Department of Biochemistry and Food Chemistry, University of Turku, FI 20014 Turku, Finland
    Int J Biochem Cell Biol 41:341-8. 2009
    ..Interestingly, both integrin and DDR families seem to have members that favor either one or the other of these two groups of collagens...
  8. pmc Echovirus 1 replication, not only virus binding to its receptor, VLA-2, is required for the induction of cellular immediate-early genes
    P Huttunen
    Department of Virology, University of Turku, Finland
    J Virol 71:4176-80. 1997
    ..The induction of these genes may have a role in viral replication and in the pathogenesis of infection...
  9. ncbi request reprint Integrin alpha(2)I domain recognizes type I and type IV collagens by different mechanisms
    J Kapyla
    Department of Biological Science, University of Jyvaskyla, FIN 40351 Jyvaskyla, Finland
    J Biol Chem 275:3348-54. 2000
    ..The data indicate that alpha(2)I domain binds to type I collagen with a different mechanism than to type IV collagen...
  10. ncbi request reprint Selective binding of collagen subtypes by integrin alpha 1I, alpha 2I, and alpha 10I domains
    M Tulla
    Department of Biological and Environmental Science, University of Jyvaskyla, Jyväskylä FIN 40351, Finland
    J Biol Chem 276:48206-12. 2001
    ..Thus, all three collagen receptors appear to differ in their ability to recognize distinct collagen subtypes. The relatively small structural differences on their collagen binding surfaces may explain the functional specifics...
  11. ncbi request reprint Echovirus 1 infection induces both stress- and growth-activated mitogen-activated protein kinase pathways and regulates the transcription of cellular immediate-early genes
    P Huttunen
    MediCity Research Laboratory, Department of Virology, Department of Medical Biochemistry, University of Turku, Tykistokatu 6A, Turku, FIN 20520, Finland
    Virology 250:85-93. 1998
    ....
  12. ncbi request reprint Distinct recognition of collagen subtypes by alpha(1)beta(1) and alpha(2)beta(1) integrins. Alpha(1)beta(1) mediates cell adhesion to type XIII collagen
    P Nykvist
    Department of Biological and Environmental Science, University of Jyvaskyla, FIN 40351 Jyvaskyla, Finland
    J Biol Chem 275:8255-61. 2000
    ..However, despite the fact that CHO-alpha1beta1 cells could not spread on type II collagen alpha(1)I domain could bind to this collagen type. Thus, the cell spreading on collagens may also be regulated by factors other than the integrins...
  13. pmc Expression of integrin family of cell adhesion receptors in rheumatoid synovium. Alpha 6 integrin subunit in normal and hyperplastic synovial lining cell layer
    L Nikkari
    Department of Medical Biochemistry, University of Turku, Finland
    Am J Pathol 142:1019-27. 1993
    ..A potential connection between altered expression of cell adhesion receptors and the pathological behavior of rheumatoid lining cells is suggested...
  14. doi request reprint A small-molecule inhibitor of integrin alpha2 beta1 introduces a new strategy for antithrombotic therapy
    L Nissinen
    Biochemistry, University of Turku, FI 20014 Turku, Finland
    Thromb Haemost 103:387-97. 2010
    ..We suggest that the alpha2beta1 inhibiting strategy could be further developed for the prevention and treatment of arterial thrombosis...
  15. ncbi request reprint Interferon-gamma-induced inhibition of wound healing in vivo and in vitro
    M Laato
    Department of Surgery, University of Turku, Turku, Finland
    Ann Chir Gynaecol Suppl . 2001
    ..IFN-gamma treatment also decreased type I procollagen mRNA levels maximally by 41 per cent from the control level. It is concluded that IFN-gamma inhibits the formation of new granulation tissue by decreasing collagen synthesis...
  16. ncbi request reprint Prognostic value of beta1 integrin expression in metastatic melanoma
    P Vihinen
    Department of Medical Biochemistry and MediCity Research Laboratory, University of Turku, Finland
    Melanoma Res 10:243-51. 2000
    ..014). Our results indicate that the expression of beta1 integrins might have some major tumour growth regulatory role and can be used as a predictor for prognosis in patients with metastatic melanoma...
  17. ncbi request reprint Abnormal dermal proteoglycan in aspartylglycosaminuria: a possible mechanism for ultrastructural changes of collagen fibrils in a glycoprotein storage disorder
    K Nanto-Salonen
    Department of Medical Chemistry, University of Turku, Finland
    Connect Tissue Res 16:367-76. 1987
    ..This is indirect evidence for abnormal epimerization of dermatan sulfate in the skin of aspartylglycosaminuria patients, which may be associated with the changes in collagen fibril formation...
  18. ncbi request reprint Identification of alpha6beta1 integrin positive cells in synovial lining layer as type B synoviocytes
    L Pirila
    MediCity Research Laboratory, Medical Biochemistry, University of Turku, Finland
    J Rheumatol 28:478-84. 2001
    ..We investigated the laminin adhesion mechanism of synovial lining cells by analyzing the presence of its receptor, alpha6beta1 integrin, on type A and type B synoviocytes...
  19. ncbi request reprint Interferon-gamma-induced inhibition of wound healing in vivo and in vitro
    M Laato
    Department of Surgery, University of Turku, Finland
    Ann Chir Gynaecol 90:19-23. 2001
    ..IFN-gamma treatment also decreased type I procollagen mRNA levels maximally by 41 per cent from the control level. It is concluded that IFN-gamma inhibits the formation of new granulation tissue by decreasing collagen synthesis...
  20. ncbi request reprint Enterovirus receptors and virus replication in human leukocytes
    T Vuorinen
    Department of Virology, University of Turku, Finland
    J Gen Virol 80:921-7. 1999
    ..Neither CBV3 nor EV1 replicated in PBMC and all haematopoietic cells studied seemed to be poorly permissive for PV1 replication...
  21. ncbi request reprint Measles virus enhances the expression of cellular immediate-early genes and DNA-binding of transcription factor AP-1 in lung epithelial A549 cells
    E Helin
    Department of Virology, University of Turku, Finland
    Arch Virol 147:1721-32. 2002
    ..Our results suggest that changes in the expression of immediate-early genes and in the activation of AP-1 DNA-binding may have an important role in many cellular events detected in MV-infected cells...